College of Veterinary Medicine - General

Works Published in 2019

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Displaying works 1 - 20 of 22 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2019 journal article

Diversity and structure of the bacterial microbiome of the American dog tick, Dermacentor variabilis, is dominated by the endosymbiont Francisella

SYMBIOSIS, 79(3), 239–250.

author keywords: Dermacentor variabilis; American dog tick; Microbiome; 16S rDNA; QIIME 2 analysis; Francisella endosymbiont
TL;DR: The high-throughput amplicon sequencing of the 16S rRNA gene revealed that most Francisella were similar to Francisella-like endosymbionts of D. variabilis, which sets the foundation for further studies to determine the influence of microbiota on vector susceptibility to pathogens. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 27, 2020

2019 journal article

INVOLVEMENT OF SEROTONIN IN A CANINE MODEL OF MITRAL VALVE PROLAPSE: A COMPLEX GENETIC APPROACH

Journal of the American College of Cardiology, 73(9), 957.

By: B. Williams n, S. Friedenberg n & K. Meurs n

TL;DR: In humans, mitral valve prolapse is a common heritable condition and dogs serve as a spontaneous animal model of familial MVP, with several breeds genetically predisposed. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: December 16, 2019

2019 journal article

Crude Oil and Dispersant Cause Acute Clinicopathological Abnormalities in Hatchling Loggerhead Sea Turtles (Caretta caretta)

FRONTIERS IN VETERINARY SCIENCE, 6.

author keywords: Caretta caretta; corexit; crude oil; dispersant; hematology; loggerhead sea turtle; plasma biochemistry
TL;DR: Clinopathological findings were supported by a failure to gain weight (associated with normal hatchling hydration in seawater) in dispersant and combination exposed hatchlings, and indicate potential impacts on wildlife to consider when deploying dispersants in an oil spill response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (Web of Science; OpenAlex)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: December 9, 2019

2019 journal article

Use of Nasal Pathology in the Derivation of Inhalation Toxicity Values for Hydrogen Sulfide

TOXICOLOGIC PATHOLOGY, 47(8), 1043–1048.

By: D. Dorman n

author keywords: hydrogen sulfide; nasal toxicity; risk assessment; CFD modeling
MeSH headings : Animals; Dose-Response Relationship, Drug; Humans; Hydrogen Sulfide / toxicity; Inhalation Exposure / adverse effects; Nasal Mucosa / drug effects; Nasal Mucosa / pathology; No-Observed-Adverse-Effect Level; Nose / anatomy & histology; Nose / drug effects; Nose / pathology; Toxicity Tests
TL;DR: Three major areas of focus for this review include a brief description of nasal anatomy, H 2S-induced ONL in rodents, derivation of a chronic inhalation reference concentration for H2S, and the use of CFD models to derive alternative toxicity values for this gas. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 18, 2019

2019 journal article

Successful vascularized jejunal patch graft to treat severe orad duodenal injury secondary to foreign body obstruction in a dog

VETERINARY SURGERY, 48(7), 1338–1343.

By: A. Putterman*, B. Trumpatori* & K. Mathews n

MeSH headings : Anastomosis, Surgical / veterinary; Animals; Dogs; Duodenum / injuries; Duodenum / surgery; Foreign Bodies / pathology; Foreign Bodies / surgery; Foreign Bodies / veterinary; Free Tissue Flaps / veterinary; Intestinal Diseases / etiology; Intestinal Diseases / surgery; Intestinal Diseases / veterinary; Jejunum / surgery; Male
TL;DR: A vascularized jejunal patch graft is a feasible option for successful surgical repair of duodenal injury in the dog and is described a novel surgical repair technique for treatment of gastrointestinal injuries. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 4, 2019

2019 journal article

The R9H phospholamban mutation is associated with highly penetrant dilated cardiomyopathy and sudden death in a spontaneous canine model

Gene, 697, 118–122.

By: O. Yost n, S. Friedenberg*, S. Jesty, N. Olby n & K. Meurs n

author keywords: Canine; Phospholamban; Dilated cardiomyopathy; Sudden death; Genetic
MeSH headings : Animals; Calcium-Binding Proteins / genetics; Calcium-Binding Proteins / physiology; Cardiomyopathy, Dilated / genetics; Death, Sudden / etiology; Death, Sudden / veterinary; Dogs; Female; Genetic Predisposition to Disease / genetics; Male; Mutation / genetics; Pedigree; Polymorphism, Single Nucleotide / genetics; Sequence Analysis, DNA
TL;DR: A spontaneous canine model of familial DCM and sudden death with the R9H mutation is described, which was highly penetrant and resulted in sudden death in comparison to a reported human family. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 29, 2019

2019 journal article

Ability of positive and negative contrast computed tomographic peritoneography to delineate canine liver lobe fissures

VETERINARY SURGERY, 48(8), 1444–1449.

By: L. Rivas n, G. Seiler n, I. Robertson n, H. Ryu n & K. Mathews n

MeSH headings : Animals; Cadaver; Contrast Media; Cross-Sectional Studies; Dogs; Humans; Liver / diagnostic imaging; Liver / injuries; Prospective Studies; Tomography, X-Ray Computed / veterinary
TL;DR: Positive contrast CT peritoneography improved the delineation of hepatic interlobar fissures in normal canine cadavers and may assist treatment planning in dogs with large hepatic tumors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: September 23, 2019

2019 journal article

Interferon-lambda 3 Promotes Epithelial Defense and Barrier Function Against Cryptosporidium parvum Infection

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 8(1), 1–20.

author keywords: Cryptosporidiosis; Cytokine; Enterocyte; Protozoa
MeSH headings : Animals; Cell Line; Cryptosporidiosis / genetics; Cryptosporidiosis / immunology; Cryptosporidiosis / parasitology; Cryptosporidium parvum / physiology; Cytokines / genetics; Cytokines / metabolism; Disease Models, Animal; Gene Expression Profiling; Intestinal Mucosa / immunology; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Swine; Up-Regulation
TL;DR: These studies identify IFN-λ2/3 as a key epithelial defense mechanism against C parvum infection and Priming of IECs with recombinant human IFn-λ3 promoted cellular defense against CParvum infections and abrogated C parVum–induced loss of barrier function by decreasing paracellular permeability to sodium. (via Semantic Scholar)
Source: Web Of Science
Added: July 15, 2019

2019 journal article

THE MESOPTERYGIAL VEIN: A RELIABLE VENIPUNCTURE SITE FOR INTRAVASCULAR ACCESS IN BATOIDS

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 50(2), 369–374.

By: L. Westmoreland n, K. Archibald n, E. Christiansen n, H. Broadhurst n & M. Stoskopf n

author keywords: Batoid; elasmobranch; intravascular access; mesopterygial vein; pectoral vasculature
MeSH headings : Aging; Animals; Blood Specimen Collection / veterinary; Female; Male; Skates, Fish / anatomy & histology; Species Specificity
TL;DR: Postmortem contrast radiography and gross dissection are used to develop landmarks for a new, dependable vascular access in three Myliobatiform species commonly maintained in captivity, finding the mesopterygial vein is an alternate site of quick and reliable venous access in batoid species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 8, 2019

2019 journal article

A missense variant in the titin gene in Doberman pinscher dogs with familial dilated cardiomyopathy and sudden cardiac death

Human Genetics, 138(5), 515–524.

By: K. Meurs n, S. Friedenberg*, J. Kolb*, C. Saripalli*, P. Tonino*, K. Woodruff n, N. Olby n, B. Keene n ...

MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / veterinary; Connectin / genetics; Death, Sudden, Cardiac / etiology; Death, Sudden, Cardiac / veterinary; Disease Models, Animal; Dogs; Female; Genetic Predisposition to Disease / genetics; Male; Mutation, Missense / genetics; Protein Kinases / genetics; Whole Genome Sequencing
TL;DR: The dog provides a large animal model of familial dilated cardiomyopathy and is an excellent model to improve the understanding of the genotypic phenotypic relationships, penetrance, expression and the pathophysiology of variants in the titin gene. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 17, 2019

2019 journal article

Development and validation of a hemangiosarcoma likelihood prediction model in dogs presenting with spontaneous hemoabdomen: The HeLP score

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 29(3), 239–245.

By: A. Schick*, G. Hayes*, A. Singh*, K. Mathews n, M. Higginbotham* & J. Sherwood

author keywords: canine; hemoperitoneum; prognostic indicator; scoring system
MeSH headings : Abdominal Neoplasms / complications; Abdominal Neoplasms / diagnosis; Abdominal Neoplasms / veterinary; Animals; Cohort Studies; Dog Diseases / blood; Dog Diseases / diagnosis; Dogs; Female; Hemangiosarcoma / complications; Hemangiosarcoma / diagnosis; Hemangiosarcoma / veterinary; Hemoperitoneum / etiology; Hemoperitoneum / veterinary; Male; Ontario; Reproducibility of Results; Retrospective Studies; Risk Factors; Severity of Illness Index; United States
TL;DR: The risk of HSA diagnosis in dogs presenting with nontraumatic hemoabdomen could be predicted using a simple risk score, which could aid in identification and treatment of dogs at lower risk for this diagnosis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: May 28, 2019

2019 journal article

BASELINE PLASMA THROMBOELASTOGRAPHY IN KEMP'S RIDLEY (LEPIDOCHELYS KEMPII), GREEN (CHELONIA MYDAS) AND LOGGERHEAD (CARETTA CARETTA) SEA TURTLES AND ITS USE TO DIAGNOSE COAGULOPATHIES IN COLD-STUNNED KEMP'S RIDLEY AND GREEN SEA TURTLES

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 50(1), 62–68.

By: A. Barratclough*, K. Tuxbury*, R. Hanel n, N. Stacy*, L. Ruterbories n, E. Christiansen*, C. Harms n

author keywords: Coagulation; coagulopathy; cold stunned; sea turtle; thromboelastography
MeSH headings : Animals; Cold Temperature / adverse effects; Hemostasis; Plasma / chemistry; Reference Values; Species Specificity; Thrombelastography / veterinary; Turtles / blood
TL;DR: Findings indicate that cold stunning may cause disorders in hemostasis that can contribute to the severity of the condition and early diagnosis of coagulopathies in the clinical assessment of a cold-stunned sea turtle may influence the treatment approach and clinical outcome of the case. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (Web of Science; OpenAlex)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: April 22, 2019

2019 journal article

Hematological parameters in largemouth bass (Micropterus salmoides) with formalin-preservation: comparison between wild tournament-caught and captive-raised fish

PEERJ, 7.

author keywords: Catch-and-release; Captive-reared; Micropterus salmoides; Health assessment; Formalin preservation; Hematology; Largemouth bass; Manual hemocytometer; Wild tournament-caught; Stress
TL;DR: It is concluded that wild largemouth bass captured via tournament angling have higher packed cell volume and total solids, and lower total leukocyte counts, compared to captive-reared individuals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 22, 2019

2019 review

Language Consideration and Methodological Transparency in "Systematic" Reviews of Animal Toxicity Studies

[Review of ]. INTERNATIONAL JOURNAL OF TOXICOLOGY, 38(2), 135–145.

By: K. Alpi n, T. Vo n & D. Dorman n

author keywords: toxicology; translation; foreign languages; publications; systematic review methodology; authorship
MeSH headings : Animals; Authorship; Language; Meta-Analysis as Topic; Research Design; Research Support as Topic; Systematic Reviews as Topic; Toxicity Tests
TL;DR: Neither the study type, grant funding, nor first author country of affiliation was associated with an increased consideration of NEL, and study quality reporting was more common in SRs that considered multiple languages. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 22, 2019

2019 journal article

Genome-wide association analysis in West Highland White Terriers with atopic dermatitis

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 209, 1–6.

By: C. Agler n, S. Friedenberg*, T. Olivry n, K. Meurs n & N. Olby n

author keywords: Allergy; Atopic; Canine; Dogs; Genetics; GWAS; Skin
MeSH headings : Animals; Cohort Studies; Dermatitis, Atopic / genetics; Dermatitis, Atopic / veterinary; Dog Diseases / genetics; Dogs; Female; Genome-Wide Association Study / veterinary; Genotyping Techniques / veterinary; Male; Polymorphism, Single Nucleotide
TL;DR: Atopic dermatitis in WHWT is associated with a region on CFA3 that contains several candidate genes and a homozygous variant in the F2R gene present in multiple breeds that also suffer from AD warrants further evaluation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 15, 2019

2019 article

Treatment of canine atopic dermatitis: time to revise our strategy?

Olivry, T., & Banovic, F. (2019, April). VETERINARY DERMATOLOGY, Vol. 30, pp. 87–90.

By: T. Olivry n & F. Banovic*

UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 2, 2019

2019 journal article

Echocardiographic phenotype of canine dilated cardiomyopathy differs based on diet type

JOURNAL OF VETERINARY CARDIOLOGY, 21, 1–9.

By: D. Adin n, T. DeFrancesco n, B. Keene n, S. Tou n, K. Meurs n, C. Atkins n, B. Aona n, K. Kurtz n ...

author keywords: Nutritional; Heart failure; Dog; Taurine
MeSH headings : Animals; Cardiomyopathy, Dilated / diagnostic imaging; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / veterinary; Diet / adverse effects; Diet / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Echocardiography / veterinary; Edible Grain / adverse effects; Female; Male; Phenotype
TL;DR: Dietary-associated DCM occurs with some GF diets and can improve with nutritional management, including diet change, and the role of taurine supplementation, even without deficiency, is uncertain. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID
Added: April 2, 2019

2019 journal article

Myxomatous mitral valve disease in the miniature poodle: A retrospective study

VETERINARY JOURNAL, 244, 94–97.

By: K. Meurs n, D. Adin n, . K. O'Donnell n, B. Keene n, C. Atkins n, T. DeFrancesco n, S. Tou n

author keywords: Canine; Genetic; Miniature poodle; Mitral valve; Myxomatous valve
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / epidemiology; Dog Diseases / genetics; Dogs; Female; Male; Mitral Valve Prolapse / diagnostic imaging; Mitral Valve Prolapse / epidemiology; Mitral Valve Prolapse / genetics; Mitral Valve Prolapse / veterinary; North Carolina / epidemiology; Pedigree; Records; Retrospective Studies; Severity of Illness Index
TL;DR: In the miniature poodles reported here, MMVD appears to be a fairly late onset disease and often is a mild phenotype. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: April 2, 2019

2019 article

Applications and efficiencies of the first cat 63 K DNA array (vol 8, 7024, 2018)

Gandolfi, B., Alhaddad, H., Abdi, M., Bach, L. H., Creighton, E. K., Davis, B. W., … Lyons, L. A. (2019, March 12). SCIENTIFIC REPORTS, Vol. 9.

By: B. Gandolfi*, H. Alhaddad*, M. Abdi*, L. Bach*, E. Creighton*, B. Davis*, J. Decker*, N. Dodman* ...

TL;DR: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: March 25, 2019

2019 journal article

A QIL1 Variant Associated with Ventricular Arrhythmias and Sudden Cardiac Death in the Juvenile Rhodesian Ridgeback Dog

GENES, 10(2).

By: K. Meurs n, S. Friedenberg*, N. Olby n, J. Condit n, J. Weidman*, S. Rosenthal*, G. Shelton*

author keywords: QIL1; Rhodesian ridgeback; arrhythmia; mitochondrial cristae
MeSH headings : Animals; Death, Sudden, Cardiac / veterinary; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Male; Mitochondria, Muscle / metabolism; Mitochondria, Muscle / ultrastructure; Mitochondrial Proteins / genetics; Mutation; Tachycardia, Ventricular / genetics; Tachycardia, Ventricular / pathology; Tachycardia, Ventricular / veterinary
TL;DR: A natural animal model of mitochondrial cardiomyopathy provides a large animal model with which to study the development and progression of disease as well as genotypic phenotypic relationships. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, ORCID
Added: March 25, 2019

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