TY - JOUR TI - Modeling the Thermoproteaceae RNase P RNA AU - Chan, Patricia P. AU - Brown, James W. AU - Lowe, Todd M. T2 - RNA BIOLOGY AB - The RNA component of the RNase P complex is found throughout most branches of the tree of life and is principally responsible for removing the 5′ leader sequence from pre-tRNA transcripts during tRNA maturation. RNase P RNA has a number of universal core features, however variations in sequence and structure found in homologs across the tree of life require multiple Rfam covariance search models to detect accurately. We describe a new Rfam search model to enable efficient detection of the diminutive archaeal Type T RNase P RNAs, which are missed by existing Rfam models. Using the new model, we establish effective score detection thresholds, and detect four new RNase P RNA genes in recently completed genomes from the crenarchaeal family Thermoproteaceae. DA - 2012/9// PY - 2012/9// DO - 10.4161/rna.21502 VL - 9 IS - 9 SP - 1155-1160 SN - 1547-6286 KW - RNase P KW - Archaea KW - tRNA processing KW - RNA catalysis KW - RNA secondary structure ER -