Works Published in 2012
Displaying works 21 - 40 of 58 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
Transcriptome analysis reveals novel patterning and pigmentation genes underlying Heliconius butterfly wing pattern variation
BMC Genomics, 13.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Status and access to the Collaborative Cross population
MAMMALIAN GENOME, 23(9-10), 706–712.
MeSH headings : Animals; Cooperative Behavior; Genome; Internet; Male; Mice; Mice, Inbred Strains / genetics
TL;DR:
The three breeding sites, in the US, Israel, and Australia, are actively collaborating to accelerate the inbreeding process through marker-assisted inbreeding and to expedite community access of CC lines deemed to have reached defined thresholds of inbreeding.
(via Semantic Scholar)
link.springer.com (publisher PDF)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Precipitation in the Yellow River drainage basin and East Asian monsoon strength on a decadal time scale
Quaternary Research, 78(3), 486–491.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Near-field enhanced ultraviolet resonance Raman spectroscopy using aluminum bow-tie nano-antenna
Applied Physics Letters, 101(11).
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis
CANCER CELL, 22(3), 304–317.
MeSH headings : ADAM Proteins / genetics; ADAM Proteins / metabolism; ADAM17 Protein; Animals; Carcinoma, Pancreatic Ductal / genetics; Carcinoma, Pancreatic Ductal / metabolism; Carcinoma, Pancreatic Ductal / pathology; Cell Line, Tumor; Cell Transformation, Neoplastic; Epithelial Cells; ErbB Receptors / biosynthesis; ErbB Receptors / genetics; ErbB Receptors / metabolism; Extracellular Signal-Regulated MAP Kinases / metabolism; Genes, ras; Humans; Mice; Mice, Transgenic; Pancreas / metabolism; Pancreas / pathology; Pancreatic Neoplasms / genetics; Pancreatic Neoplasms / metabolism; Pancreatic Neoplasms / pathology; Proto-Oncogene Proteins p21(ras) / biosynthesis; Proto-Oncogene Proteins p21(ras) / genetics; Proto-Oncogene Proteins p21(ras) / metabolism
TL;DR:
It is shown that oncogenic KRAS upregulates endogenous EGFR expression and activation, the latter being dependent on the EGFR ligand sheddase, ADAM17, which effectively eliminates KRAS-driven tumorigenesis in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 article
Classical Genetics Meets Next-Generation Sequencing: Uncovering a Genome-Wide Recombination Drosophila melanogaster
Singh, N. D. (2012, October). PLOS GENETICS, Vol. 8.
MeSH headings : Animals; Chromosome Mapping; Drosophila melanogaster / genetics; Genome; High-Throughput Nucleotide Sequencing; Recombination, Genetic
TL;DR:
The power of classical genetics with next-generation sequencing is combined to provide for the first time a high-resolution recombination map of the D. melanogaster genome, showing that although crossover and nonc crossover rates are both significantly variable genome-wide, rates of crossing-over are ten times more variable than noncrossover rates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Cerebrospinal Fluid Metabolome in Mood Disorders-Remission State has a Unique Metabolic Profile
Scientific Reports, 2(1).
MeSH headings : Adult; Biogenic Monoamines / cerebrospinal fluid; Biosynthetic Pathways; Case-Control Studies; Depressive Disorder, Major / cerebrospinal fluid; Female; Humans; Male; Metabolome; Middle Aged; Multivariate Analysis; Remission, Spontaneous; Severity of Illness Index
TL;DR:
The reductions in metabolites associated with tryptophan and tyrosine pathways in rMDD may relate to the vulnerability this population shows for developing depressive symptoms under tryPTophan or catecholamine depletion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018
2012 journal article
Transcriptional Analysis of Prebiotic Uptake and Catabolism by Lactobacillus acidophilus NCFM
PLOS ONE, 7(9).
MeSH headings : ATP-Binding Cassette Transporters / metabolism; Cellobiose / pharmacology; Gene Expression Regulation, Bacterial / drug effects; Glucans / pharmacology; Isomaltose / analogs & derivatives; Isomaltose / pharmacology; Lactobacillus acidophilus / drug effects; Lactobacillus acidophilus / enzymology; Lactobacillus acidophilus / metabolism; Oligosaccharides / pharmacology; Phosphoenolpyruvate Sugar Phosphotransferase System / metabolism; Prebiotics; Raffinose / pharmacology; Sugar Alcohols / pharmacology
TL;DR:
Differential transcriptomics and functional genomics were used to identify genes in Lactobacillus acidophilus NCFM involved in the uptake and catabolism of 11 potential prebiotic compounds consisting of α- and β- linked galactosides and glucosides, highlighting the broad oligosaccharide metabolic repertoire of L. acidophillus NCFM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Ten Years of the Collaborative Cross
G3-GENES GENOMES GENETICS, 2(2), 153–156.
TL;DR:
The February 2012 issues of GENETICS and G3: Genes, Genomes, Genetics present a collection of articles reporting recent advances from the international Collaborative Cross (CC) project, which aims to develop a new resource that will enhance quantitative trait locus (QTL) and systems genetic analyses in mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Mapping Six New Susceptibility to Colon Cancer (Scc) Loci Using a Mouse Interspecific Backcross
G3-GENES GENOMES GENETICS, 2(12), 1577–1584.
author keywords: spretus; cancer modifier; colorectal cancer
MeSH headings : Alleles; Animals; Chromosome Mapping; Chromosomes / genetics; Colonic Neoplasms / genetics; Colonic Neoplasms / metabolism; Crosses, Genetic; Genetic Predisposition to Disease; Genome; Genotype; Mice; Phenotype; Quantitative Trait Loci
TL;DR:
This work confirms genetic models suggesting that CRC is caused by many small effect alleles and brings the catalog of reported CRC modifier loci to 23 spread across 13 chromosomes, and provides the foundation for large population-level epistatic interaction tests to identify combinations of low effect allele that may have large effects on CRC susceptibility.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Genetic Analysis of Hematological Parameters in Incipient Lines of the Collaborative Cross
G3-GENES GENOMES GENETICS, 2(2), 157–165.
author keywords: Mouse Genetic Resource; Mouse Collaborative Cross hematology hemoglobin beta mean red cell volume; QTL mouse genetics complex traits shared ancestry
TL;DR:
This work used a newly developed mouse resource population, the Collaborative Cross, to identify genetic determinants of hematological parameters and used evolutionary principles and unique bioinformatics resources to reduce the size of candidate intervals and to view functional variation in the context of phylogeny.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Expression quantitative trait loci for extreme host response to influenza a in pre-collaborative cross mice
G3-Genes Genomes Genetics, 2(2), 213–221.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts
CARCINOGENESIS, 33(10), 1930–1939.
MeSH headings : Animals; Apoptosis; Cell Transformation, Neoplastic; Coculture Techniques; Colonic Neoplasms / metabolism; Colonic Neoplasms / pathology; ErbB Receptors / metabolism; HCT116 Cells; Humans; Interleukin-1beta / metabolism; Mice; Stromal Cells / metabolism; Transfection; Transplantation, Heterologous
TL;DR:
Stromal cell and colonocyte EGFRs are required for robust EGFR signals and efficient tumor growth, which involve EGFR-interleukin-1 crosstalk.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 review
The interface of protein structure, protein biophysics, and molecular evolution
[Review of ]. Protein Science, 21(6), 769–785.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
On Dorsal Prothoracic Appendages in Treehoppers (Hemiptera: Membracidae) and the Nature of Morphological Evidence
PLOS ONE, 7(1).
MeSH headings : Animals; Biological Evolution; Extremities / anatomy & histology; Hemiptera / anatomy & histology; Hemiptera / classification; Microscopy, Confocal; Species Specificity; Thorax / anatomy & histology; Wings, Animal / anatomy & histology; X-Ray Microtomography
TL;DR:
It is concluded that there is no dorsal, articulated appendage on the membracid T1, and the presence of this structure in Membracidae is not an evolutionary novelty for this clade.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
A novel N-terminal domain may dictate the glucose response of Mondo proteins
PLoS One, 7(4).
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Transgenic Stra8-EYFP pigs: a model for developing male germ cell technologies
TRANSGENIC RESEARCH, 21(2), 383–392.
author keywords: Pig; Transgenic; Stra8; Spermatogonia; Marker gene
MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / metabolism; Blotting, Western; Cells, Cultured; Cloning, Molecular; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Gene Expression Regulation, Developmental; Genes, Reporter; Germ Cells / cytology; Germ Cells / metabolism; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Immunohistochemistry; Luminescent Proteins / genetics; Luminescent Proteins / metabolism; Male; Mice; Microscopy, Fluorescence / methods; Mitochondria / genetics; Mitochondria / metabolism; Nuclear Transfer Techniques; Plasmids / genetics; Plasmids / metabolism; Promoter Regions, Genetic; Proteins / genetics; Proteins / metabolism; Swine; Testis / cytology; Testis / metabolism; Transfection; Transgenes; Tretinoin / pharmacology
TL;DR:
Transgenic pigs expressing mitochondrial localized enhanced yellow fluorescent protein (EYFP-mito) under control of the germ cell specific Stimulated by Retinoic Acid 8 (Stra8) promoter indicates that these pigs will be useful by providing labelled cells for use in such technologies such as germ cell transplantation and in vitro spermatogenic studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Raffinose family oligosaccharide utilisation by probiotic bacteria: insight into substrate recognition, molecular architecture and diversity of GH36 alpha-galactosidases
BIOCATALYSIS AND BIOTRANSFORMATION, 30(3), 316–325.
author keywords: prebiotic; probiotic; tetrameric alpha-galactosidases; raffinose; clan GH-D
TL;DR:
The structure of the GH36 homotetrameric α-galactosidase from L. acidophilus NCFM (LaMel36A) was determined, which explains the preference of tetrameric GH36 enzymes for RFO and their lack of activity on polymeric galacto(gluco)mannan.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Organization and expression of the Australian sheep blowfly (<i>Lucilia cuprina</i>) <i>hsp23</i>, <i>hsp24, hsp70</i> and <i>hsp83</i> genes
Insect Molecular Biology, 21(2), 169–180.
author keywords: heat shock; hsp70; hsp23; hsp83; Lucilia cuprina; HSF
MeSH headings : Amino Acid Sequence; Animals; Binding Sites; Conserved Sequence; Diptera / genetics; Diptera / growth & development; Diptera / metabolism; Female; Gene Expression; Genes, Insect; Heat-Shock Proteins / genetics; Heat-Shock Proteins / metabolism; Hot Temperature; Insect Proteins / genetics; Insect Proteins / metabolism; Male; Molecular Sequence Data; Phylogeny; Promoter Regions, Genetic; Sequence Alignment
TL;DR:
The isolation and characterization of a heat shock protein 70 (hsp70) gene, the hsp83 gene and two genes that encode small Hsps from the Australian sheep blowfly, Lucilia cuprina, a major agricultural pest are reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2012 journal article
Merging pharmacometabolomics with pharmacogenomics using ‘1000 Genomes’ single-nucleotide polymorphism imputation
Pharmacogenetics and Genomics, 22(4), 247–253.
author keywords: 1000 Genomes; HapMap; imputation; major depressive disorder; pharmacometabolomics; pharmacogenomics; selective serotonin reuptake inhibitors; tag single-nucleotide polymorphisms
MeSH headings : Citalopram / adverse effects; Citalopram / therapeutic use; Depressive Disorder / drug therapy; Depressive Disorder / genetics; Genome-Wide Association Study / methods; Glycine / biosynthesis; Glycine / genetics; Glycine / metabolism; Glycine Dehydrogenase / genetics; HapMap Project; Haplotypes; Humans; Metabolic Networks and Pathways / genetics; Metabolomics; Pharmacogenetics; Polymorphism, Single Nucleotide / genetics; Selective Serotonin Reuptake Inhibitors / metabolism
TL;DR:
The results indicate that the use of GWAS data to impute SNPs for genes in pathways identified by other ‘omics’ approaches makes it possible to rapidly and cost efficiently identify SNP markers to ‘broaden’ and accelerate pharmacogenomic studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
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