Works Published in 2009
Displaying works 41 - 60 of 78 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2009 journal article
Placental overgrowth and fertility defects in mice with a hypermorphic allele of epidermal growth factor receptor
MAMMALIAN GENOME, 20(6), 339–349.
MeSH headings : Alleles; Animals; ErbB Receptors / genetics; ErbB Receptors / metabolism; Female; Fertility; Gene Expression; Male; Mice / genetics; Mice / growth & development; Mice / physiology; Mice, Inbred Strains; Mice, Transgenic; Ovary / physiology; Placenta / metabolism; Placentation; Signal Transduction; Uterus / growth & development; Uterus / physiology
TL;DR:
It is demonstrated that mice with increased levels of EGFR signaling exhibit an extensive level of genetic background-dependent phenotypic variability and EGFR expressed in the uterine stroma may play an underappreciated role in preparation of the uterus for embryo implantation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 review
Murine models of colorectal cancer
[Review of ]. MAMMALIAN GENOME, 20(5), 261–268.
MeSH headings : Animals; Colorectal Neoplasms / genetics; Colorectal Neoplasms / metabolism; Colorectal Neoplasms / pathology; Disease Models, Animal; Humans; Mice; Mice, Inbred Strains; Proto-Oncogene Proteins c-myc / genetics; Proto-Oncogene Proteins c-myc / metabolism; Signal Transduction
TL;DR:
This review focuses on the variety of murine models of human colorectal cancer that are available to the research community and on their use to identify common and distinct characteristics of coloreCTal cancer.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Modulated Modularity Clustering as an Exploratory Tool for Functional Genomic Inference
PLOS GENETICS, 5(5).
MeSH headings : Animals; Cluster Analysis; Computer Simulation; Data Interpretation, Statistical; Databases, Genetic; Drosophila melanogaster / genetics; Gene Expression Profiling / statistics & numerical data; Genetic Techniques; Genomics / statistics & numerical data; Humans; Lymphocytes / immunology; Lymphocytes / metabolism; Models, Genetic; Multigene Family; Systems Biology
TL;DR:
A new objective-based clustering method, modulated modularity clustering (MMC), which modulates the connection strengths of edges in a weighted graph to maximize an objective function (called modularity) that quantifies community structure in graphical data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Local auxin biosynthesis modulates gradient-directed planar polarity in Arabidopsis
NATURE CELL BIOLOGY, 11(6), 731–U70.
Contributors: Y. Ikeda *, S. Men *, U. Fischer*, A. Stepanova n , J. Alonso n, K. Ljung *, M. Grebe *
MeSH headings : Animals; Arabidopsis / anatomy & histology; Arabidopsis / metabolism; Arabidopsis Proteins / biosynthesis; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Cell Polarity; Genes, Reporter; Morphogenesis / physiology; Mutation; Plant Roots / cytology; Plant Roots / growth & development; Plants, Genetically Modified; Protein Kinases / genetics; Protein Kinases / metabolism; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism
TL;DR:
It is demonstrated that the Raf-like kinase CONSTITUTIVE TRIPLE RESPONSE1 (CTR1) acts as a concentration-dependent repressor of a biosynthesis-dependent auxin gradient that modulates planar polarity in the root tip that contributes to gradient homeostasis during long-range coordination of cellular morphogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Dynamic Localization of the DNA Replication Proteins MCM5 and MCM7 in Plants
PLANT PHYSIOLOGY, 150(2), 658–669.
MeSH headings : Arabidopsis / cytology; Arabidopsis / genetics; Arabidopsis / metabolism; Arabidopsis Proteins / metabolism; Cell Cycle; Cell Cycle Proteins / metabolism; Cell Nucleus / metabolism; Chromatin / metabolism; DNA Replication; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Minichromosome Maintenance Complex Component 7; Multiprotein Complexes / genetics; Multiprotein Complexes / metabolism; Origin Recognition Complex / metabolism; Plant Roots / cytology; Plant Roots / metabolism; Protein Binding; Protein Subunits / genetics; Protein Subunits / metabolism; Protein Transport; Tobacco / cytology; Tobacco / metabolism
TL;DR:
It is demonstrated that subunits of the MCM2-7 complex are coordinately expressed during Arabidopsis (Arabidopsis thaliana) development and are abundant in proliferating and endocycling tissues, indicative of a role in DNA replication.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2009 journal article
Development and Application of a upp-Based Counterselective Gene Replacement System for the Study of the S-Layer Protein SlpX of Lactobacillus acidophilus NCFM
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 75(10), 3093–3105.
MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Drug Resistance, Bacterial; Fluorouracil / pharmacology; Gene Deletion; Genetic Complementation Test; Lactobacillus acidophilus / genetics; Membrane Glycoproteins / genetics; Molecular Sequence Data; Mutagenesis, Insertional / methods; Pentosyltransferases / genetics; Pentosyltransferases / metabolism; Plasmids; Recombination, Genetic; Selection, Genetic
TL;DR:
Use of the upp-encoded uracil phosphoribosyltransferase (UPRTase) of L. acidophilus NCFM was explored as a counterselection marker to positively select for recombinants that have resolved from chromosomal integration of pORI-based plasmids.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Arabidopsis Protein Kinases GRIK1 and GRIK2 Specifically Activate SnRK1 by Phosphorylating Its Activation Loop
PLANT PHYSIOLOGY, 150(2), 996–1005.
MeSH headings : Adenosine Monophosphate / pharmacology; Amino Acid Sequence; Arabidopsis / drug effects; Arabidopsis / enzymology; Arabidopsis Proteins / chemistry; Arabidopsis Proteins / metabolism; Benzimidazoles / pharmacology; Cations / pharmacology; Conserved Sequence; Enzyme Activation / drug effects; Molecular Sequence Data; Naphthalimides / pharmacology; Phosphorylation / drug effects; Phosphothreonine / metabolism; Protein Binding / drug effects; Protein Serine-Threonine Kinases / chemistry; Protein Serine-Threonine Kinases / metabolism; Substrate Specificity / drug effects
TL;DR:
The GRIK-SnRK1 cascade may function in a developmentally regulated fashion and coordinate the unique metabolic requirements of rapidly growing cells and geminivirus-infected cells that have been induced to reenter the cell cycle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 journal article
Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity
JOURNAL OF MEDICINAL CHEMISTRY, 52(15), 4582–4585.
MeSH headings : Amides / chemical synthesis; Amides / pharmacology; Amides / toxicity; Animals; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Caenorhabditis elegans / drug effects; Pseudomonas aeruginosa / drug effects; Pseudomonas aeruginosa / physiology; Pyrroles / chemical synthesis; Pyrroles / pharmacology; Pyrroles / toxicity; Structure-Activity Relationship; Sulfonamides / chemical synthesis; Sulfonamides / pharmacology; Thiourea / chemical synthesis; Thiourea / pharmacology; Urea / chemical synthesis; Urea / pharmacology
TL;DR:
The synthesis and antibiofilm activities of sulfonamide, urea, and thiourea oroidin analogues are described and the most active derivative was able to selectively inhibit P. aeruginosa biofilm development and is also shown to be nontoxic upward of 1 mM to the development of C. elegans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
A method for accelerated trait conversion in plant breeding
THEORETICAL AND APPLIED GENETICS, 118(8), 1499–1508.
MeSH headings : Crosses, Genetic; Flowers / metabolism; Gene Expression Regulation, Plant; Gene Transfer Techniques; Genes, Plant; Mutagenesis, Insertional; Photoperiod; Plants, Genetically Modified; Time Factors; Tobacco / genetics; Tobacco / metabolism; Transformation, Genetic; Transgenes
TL;DR:
It is demonstrated here that constitutive FT overexpression functions to dramatically reduce days-to-flower similarly in diverse tobacco genetic backgrounds, suggesting the possible value of this modified backcrossing system for tobacco or other crop species where long generation times or photoperiod sensitivity may impede timely trait conversion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(OpenAlex)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Multiple interval mapping for gene expression QTL analysis
GENETICA, 137(2), 125–134.
author keywords: eQTL; FDR; MIM; Model selection
MeSH headings : Chromosome Mapping / methods; Computer Simulation; Gene Expression; Genomics / methods; Models, Genetic; Quantitative Trait Loci / genetics; Yeasts
TL;DR:
A statistical method to claim expression quantitative trait loci (eQTL) in a genome is developed based on multiple interval mapping (MIM), a model selection procedure, and uses false discovery rate (FDR) to measure the statistical significance of the large number of eQTL.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Improving phylogenetic analyses by incorporating additional information from genetic sequence databases
BIOINFORMATICS, 25(19), 2530–2536.
MeSH headings : Algorithms; Computational Biology / methods; Databases, Genetic; Markov Chains; Phylogeny; Sequence Alignment
TL;DR:
A fully Bayesian semiparametric hierarchical model is constructed using hierarchical random effect models that combine additional datasets whose parameters are not of direct interest but are similar to the analysis of interest.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Genomic Consequences of Background Effects on scalloped Mutant Expressivity in the Wing of Drosophila melanogaster
GENETICS, 181(3), 1065–1076.
MeSH headings : Animals; Drosophila Proteins / genetics; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / cytology; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Epistasis, Genetic; Gene Expression Regulation; Genetic Linkage; Genetic Variation; Genome, Insect / genetics; Genomics; Molecular Sequence Data; Mutation; Nuclear Proteins / genetics; Oligonucleotide Array Sequence Analysis; Transcription Factors / genetics; Transcription, Genetic; Wings, Animal / metabolism
TL;DR:
This study demonstrates that phenotypic expressivity of the scallopedE3 (sdE3) mutation of Drosophila melanogaster is background dependent and is the result of at least one major modifier segregating between two standard lab wild-type strains and demonstrates that the epistatic interaction between sdE3 and an optomotor blind mutation is backgrounddependent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 review
Ethylene signaling and response: where different regulatory modules meet
[Review of ]. CURRENT OPINION IN PLANT BIOLOGY, 12(5), 548–555.
Contributors: A. Stepanova n & J. Alonso n
MeSH headings : Ethylenes / metabolism; Gene Expression Regulation, Plant; Indoleacetic Acids / metabolism; Plant Development; Plant Growth Regulators / metabolism; Plant Proteins / metabolism; Plants / metabolism; Receptors, Cell Surface / metabolism; Signal Transduction
TL;DR:
Tissue-specific regulation of auxin biosynthesis, transport, and response by ethylene is emerging as a key element in this signal integration process.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Contribution of genetic effects to genetic variance components with epistasis and linkage disequilibrium
BMC GENETICS, 10.
MeSH headings : Alleles; Epistasis, Genetic; Genetic Variation; Genotype; Linkage Disequilibrium; Models, Genetic; Quantitative Trait Loci; Regression Analysis
TL;DR:
The Cockerham type models are allelic based models with a focus on partition of genotypic variances into various genetic variance components, which are contributed by allelic effects and their interactions, while the F∞ regression models are genotype-based models focusing on modeling and testing of within-locusgenotypic effects and locus-by- locus genotypes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Antagonism between local dispersal and self-incompatibility systems in a continuous plant population
MOLECULAR ECOLOGY, 18(11), 2327–2336.
author keywords: genetic structure; isolation by distance; local dispersal; neighbourhood size; recombination; self-incompatibility
MeSH headings : Alleles; Computer Simulation; Evolution, Molecular; Gene Flow; Genetic Variation; Genetics, Population; Inbreeding; Models, Genetic; Plants / genetics; Pollen / genetics
TL;DR:
The results suggest that there is little to no difference between the effects of gametophytic and sporophytic self‐incompatibility systems (GSI and SSI) on unlinked loci, and both GSI andSSI affect un linked loci in a manner similar to obligate outcrossing without mating types.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium
JOURNAL OF CLINICAL INVESTIGATION, 119(9), 2702–2713.
MeSH headings : Animals; Apoptosis / genetics; Apoptosis / physiology; Base Sequence; Caspase 3 / metabolism; Cell Line, Tumor; Colorectal Neoplasms / enzymology; Colorectal Neoplasms / genetics; Colorectal Neoplasms / pathology; ErbB Receptors / antagonists & inhibitors; ErbB Receptors / genetics; Female; Genes, APC; Genes, erbB; Humans; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Male; Mice; Mice, Knockout; Mice, Transgenic; Models, Biological; RNA, Small Interfering / genetics; Receptor, ErbB-3 / antagonists & inhibitors; Receptor, ErbB-3 / deficiency; Receptor, ErbB-3 / genetics; Receptor, ErbB-4
TL;DR:
It is shown that the intestinal epithelium of mice with intestine-specific genetic ablation of Erbb3 exhibits no cytological abnormalities but does exhibit loss of expression of ERBB4 and sensitivity to intestinal damage, and this results indicate that the ERBB3 pseudo-kinase has essential roles in supporting intestinal tumorigenesis and suggest that ER BB3 may be a promising target for the treatment of colorectal cancers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 review
The gastrointestinal microbiome: a malleable, third genome of mammals
[Review of ]. MAMMALIAN GENOME, 20(7), 395–403.
MeSH headings : Animals; Bacteria / genetics; Bacteria / isolation & purification; Bacterial Infections / microbiology; Gastrointestinal Tract / microbiology; Genome, Bacterial; Humans; Mammals / microbiology; Metagenome
TL;DR:
The current knowledge of the gastrointestinal microbiome, its relationship to human health and disease with a particular focus on mammalian physiology, and efforts to alter its composition as a novel therapeutic approach are reviewed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Role of Transporter Proteins in Bile Tolerance of Lactobacillus acidophilus
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 75(18), 6013–6016.
MeSH headings : Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacology; Bile / chemistry; Bile / metabolism; Ciprofloxacin / metabolism; Ciprofloxacin / pharmacology; Detergents / metabolism; Detergents / pharmacology; Gene Deletion; Genes, Bacterial; Lactobacillus acidophilus / drug effects; Lactobacillus acidophilus / physiology; Membrane Transport Proteins / genetics; Membrane Transport Proteins / metabolism; Microbial Viability; Taurocholic Acid / metabolism; Taurocholic Acid / pharmacology
TL;DR:
These strains showed unique patterns of sensitivity to a variety of inhibitory compounds, as well as differential accumulations of ciprofloxacin and taurocholate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Analysis of neuronal proliferation, migration and differentiation in the postnatal brain using equine infectious anemia virus-based lentiviral vectors
GENE THERAPY, 16(8), 1021–1033.
author keywords: adult neural stem cells; adult neurogenesis; lentivirus; EIAV; olfactory bulb; neuronal migration
MeSH headings : Adult Stem Cells / physiology; Animals; Brain / cytology; Brain / physiology; Cell Differentiation; Cell Movement; Cell Proliferation; Defective Viruses; Gene Transfer Techniques; Genetic Vectors; Infectious Anemia Virus, Equine / genetics; Mice; Neural Stem Cells / physiology; Neurogenesis; Neurons / physiology; Olfactory Bulb / cytology; Stem Cell Niche / genetics; Transduction, Genetic
TL;DR:
It is shown that a replication-incompetent Equine Infectious Anemia Virus (EIAV) is highly suitable for stable and persistent gene transfer to adult neural stem cells and ishighly suitable for discovery and assessment of mechanisms that regulate proliferation, migration and differentiation in the postnatal brain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 297(1), H65–H75.
author keywords: epidermal growth factor receptor aortic sclerosis; hypertrophy; aortic stenosis; valvulogenesis
MeSH headings : Alleles; Animals; Aortic Valve Stenosis / diagnostic imaging; Aortic Valve Stenosis / etiology; Aortic Valve Stenosis / pathology; Blood Pressure / physiology; Calcinosis / diagnostic imaging; Calcinosis / etiology; Calcinosis / pathology; Echocardiography; ErbB Receptors / genetics; ErbB Receptors / physiology; Female; Heart Failure / etiology; Heart Failure / pathology; Heart Function Tests; Heart Valves / diagnostic imaging; Heart Valves / growth & development; Hypertrophy, Left Ventricular / diagnostic imaging; Hypertrophy, Left Ventricular / etiology; Hypertrophy, Left Ventricular / pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Phosphorylation; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity; Survival
TL;DR:
The results show the requirement of EGFR activity for normal valvulogenesis and demonstrate that dominantly acting genetic modifiers curtail pathological changes in congenitally deformed valves.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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