Works Published in 2009
Displaying works 61 - 78 of 78 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2009 journal article
Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans
GENOME RESEARCH, 19(9), 1507–1515.
MeSH headings : Acetaminophen / administration & dosage; Acetaminophen / adverse effects; Alanine Transaminase / blood; Animals; Chemical and Drug Induced Liver Injury / genetics; Chemical and Drug Induced Liver Injury / physiopathology; Cohort Studies; Genetic Predisposition to Disease; Humans; Hyaluronan Receptors / chemistry; Hyaluronan Receptors / genetics; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Polymorphism, Genetic; Sequence Analysis, DNA / methods; Species Specificity
TL;DR:
A diverse mouse population can be used to understand and predict adverse toxicity in heterogeneous human populations through guided resequencing and it is demonstrated that variation in the orthologous human gene, CD44, is associated with susceptibility to acetaminophen in two independent cohorts.
(via Semantic Scholar)
genome.cshlp.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Dietary Fat Alters Body Composition, Mammary Development, and Cytochrome P450 Induction after Maternal TCDD Exposure in DBA/2J Mice with Low-Responsive Aryl Hydrocarbon Receptors
ENVIRONMENTAL HEALTH PERSPECTIVES, 117(9), 1414–1419.
author keywords: aryl hydrocarbon receptor; fetal loss; gene-environment interactions; mouse; obesity; 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
MeSH headings : Animals; Body Composition; Cytochrome P-450 Enzyme System / biosynthesis; Dietary Fats / administration & dosage; Enzyme Induction; Female; Mammary Glands, Animal / growth & development; Mammary Glands, Animal / metabolism; Maternal Exposure; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Polychlorinated Dibenzodioxins / toxicity; Pregnancy; Receptors, Aryl Hydrocarbon / metabolism
TL;DR:
D2 progeny fed a diet similar to that consumed by most people are susceptible to TCDD and DMBA exposure effects blood glucose levels, mammary differentiation, and hepatic Cyp1 expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Effect of a Chromosome Segment Marked by the Ph-p Gene for Resistance to Phytophthora nicotianae on Reproduction of Tobacco Cyst Nematodes
PLANT DISEASE, 93(3), 309–315.
TL;DR:
Results indicate a close linkage or association between a likely single, dominant gene (Php) for resistance to P. nicotianae and suppressed reproduction by G. tabacum subsp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(OpenAlex)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Dendritic cell targeting of Bacillus anthracis protective antigen expressed by Lactobacillus acidophilus protects mice from lethal challenge
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(11), 4331–4336.
author keywords: anthrax; lactic acid bacteria; mucosal immunity; oral; vaccine
MeSH headings : Administration, Oral; Animals; Anthrax / prevention & control; Anthrax Vaccines / administration & dosage; Anthrax Vaccines / immunology; Antibody Formation; Antigen Presentation; Antigens, Bacterial / administration & dosage; Antigens, Bacterial / genetics; Antigens, Bacterial / therapeutic use; Bacillus anthracis / immunology; Dendritic Cells / immunology; Immunity; Lactobacillus acidophilus / genetics; Mice
TL;DR:
Development of this strategy for oral delivery of DC-targeted antigens provides a safe and protective vaccine via a bacterial adjuvant that may potentiate mucosal immune responses against deadly pathogens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 review
The secret(ion) life of worms
[Review of ]. GENOME BIOLOGY, 10(1).
MeSH headings : Animals; Helminth Proteins / analysis; Helminth Proteins / metabolism; Host-Parasite Interactions / immunology; Humans; Nematoda / chemistry; Nematoda / immunology; Nematoda / metabolism; Plants / immunology; Plants / parasitology; Proteomics
TL;DR:
Tandem mass spectrographic analysis of the secreted proteins of plant- and human-parasitic nematodes reveals molecular similarities that reflect the shared need to counter host defenses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Systems genetics of complex traits in Drosophila melanogaster
NATURE GENETICS, 41(3), 299–307.
MeSH headings : Amino Acid Sequence; Animals; Animals, Inbred Strains; Base Sequence; Chromosome Mapping; Drosophila melanogaster / genetics; Female; Gene Regulatory Networks / physiology; Genetic Variation / physiology; Genetics, Population / methods; Male; Molecular Sequence Data; Phenotype; Quantitative Trait, Heritable; RNA, Messenger / analysis; RNA, Messenger / genetics; RNA, Messenger / metabolism; Sequence Homology, Amino Acid; Tissue Distribution
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Genetic, ecological and morphological differences among populations of the cactophilic Drosophila mojavensis from southwestern USA and northwestern Mexico, with descriptions of two new subspecies
JOURNAL OF NATURAL HISTORY, 43(15-16), 923–938.
author keywords: desert Drosophila; geographic isolation; incipient speciation; population differentiation
TL;DR:
Evidence from studies on population genetics, ecology and behaviour that supports the subspecies assignments in D. mojavensis is reviewed, and descriptions of D. m.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep
NATURE GENETICS, 41(3), 371–375.
MeSH headings : Animals; Animals, Genetically Modified; Animals, Inbred Strains; Drosophila / genetics; Drosophila Proteins / genetics; Female; Gene Expression Regulation / physiology; Gene Regulatory Networks / physiology; Genes, Insect; Genetic Variation / physiology; Genome, Insect; Genome-Wide Association Study / veterinary; Male; Models, Biological; Molecular Sequence Data; Polymorphism, Genetic; Sleep / genetics
TL;DR:
It is independently confirmed that molecular polymorphisms in Catsup (Catecholamines up) are associated with variation in sleep and that P-element mutations in four candidate genes affect sleep and gene expression and co-regulated gene expression using P- element mutants are confirmed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Temporal gene expression and probiotic attributes of Lactobacillus acidophilus during growth in milk
JOURNAL OF DAIRY SCIENCE, 92(3), 870–886.
author keywords: Lactobacillus acidophilus; probiotic; microarray analysis; dairy
MeSH headings : Animals; Bacterial Adhesion / genetics; Caco-2 Cells; Carbohydrate Metabolism / genetics; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Humans; Hydrogen-Ion Concentration; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Lactobacillus acidophilus / metabolism; Milk / microbiology; Mucins / metabolism; Mutation; Peptide Hydrolases / genetics; Probiotics; Quorum Sensing / genetics; Stress, Physiological / genetics; Time Factors
TL;DR:
Some of the most interesting genes found to be expressed in milk were correlated with signaling (autoinducer-2) and adherence to mucin and intestinal epithelial cells, in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Complex Rearrangements Lead to Novel Chimeric Gene Fusion Polymorphisms at the Arabidopsis thaliana MAF2-5 Flowering Time Gene Cluster
MOLECULAR BIOLOGY AND EVOLUTION, 26(3), 699–711.
author keywords: alternative splicing; gene origin; gene fusion; MADS-box; quantitative trait loci
MeSH headings : Arabidopsis / genetics; Arabidopsis Proteins / genetics; Flowers / genetics; Gene Fusion; Gene Rearrangement; Genes, Plant; MADS Domain Proteins / genetics; Multigene Family; Polymorphism, Genetic; Polymorphism, Single Nucleotide
TL;DR:
The finding that complex rearrangements within gene clusters, such as those observed for MAF2, might play a role in the generation of ecologically important phenotypic variation, emphasize the need for emerging high throughput genotyping and sequencing techniques to correctly reconstruct gene chimeras and other complex polymorphisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018
2009 article
Measuring and partitioning the high-order linkage disequilibrium by multiple order Markov chains (vol 32, pg 301, 2008)
Genetic Epidemiology, Vol. 33, pp. 181–181.
Source: NC State University Libraries
Added: August 6, 2018
2009 review
Genomics of lactic acid bacteria
[Review of ]. FEMS MICROBIOLOGY LETTERS, 292(1), 1–6.
author keywords: lactic acid bacteria; genomics; fermentation; probiotics
MeSH headings : Evolution, Molecular; Genome, Bacterial; Genomics; Lactobacillaceae / genetics; Lactobacillaceae / physiology
TL;DR:
Although a general trend of genome reduction was observed, certain niche-specific genes appear to be recently acquired and appear on plasmids or adjacent to prophages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
A Joint Association Test for Multiple SNPs in Genetic Case-Control Studies
GENETIC EPIDEMIOLOGY, 33(2), 151–163.
author keywords: haplotype association; retrospective likelihood; latent variable; logistic mixture model; EM algorithm
MeSH headings : Algorithms; Alleles; Case-Control Studies; Gene Frequency; Genetic Markers; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Likelihood Functions; Linkage Disequilibrium; Logistic Models; Models, Genetic; Models, Statistical; Molecular Epidemiology / statistics & numerical data; Polymorphism, Single Nucleotide
TL;DR:
A latent variable approach to test for association of multiple tightly linked SNPs in case‐control studies and an expectation‐maximization (EM)‐based algorithm to fit the penetrance model and estimate the joint haplotype frequencies of the DSL and markers simultaneously are proposed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
X-ray structure of ILL2, an auxin-conjugate amidohydrolase from Arabidopsis thaliana
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 74(1), 61–71.
author keywords: M20D peptidase family; auxin homeostasis; metalloenzyme; X-ray structure
MeSH headings : Amidohydrolases / chemistry; Animals; Arabidopsis / enzymology; Arabidopsis Proteins / chemistry; Bacterial Proteins / chemistry; Binding Sites; Crystallography, X-Ray; Exopeptidases / chemistry; Indoleacetic Acids / chemistry; Metalloproteases / chemistry; Models, Chemical; Protein Structure, Quaternary; Substrate Specificity
TL;DR:
The structure of ILL2 suggests that this enzyme likely uses a catalytic mechanism that follows the paradigm established for the other enzymes of the M20 peptidase family, and a hydrophobic pocket nearby the catalytic dimetal center likely recognizes the indolyl moiety of the substrate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 review
Genome-scale analyses of health-promoting bacteria: probiogenomics
[Review of ]. NATURE REVIEWS MICROBIOLOGY, 7(1), 61–U77.
MeSH headings : Bifidobacterium / genetics; Bifidobacterium / metabolism; Genomics; Humans; Lactobacillus / genetics; Lactobacillus / metabolism; Probiotics
TL;DR:
The application of probiogenomics in the elucidation of the molecular basis of probiosis is discussed using the well-recognized model probiotic bacteria genera Bifidobacterium and Lactobacillus as examples.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Problems and Solutions for Estimating Indel Rates and Length Distributions
MOLECULAR BIOLOGY AND EVOLUTION, 26(2), 473–480.
MeSH headings : Algorithms; Animals; Humans; INDEL Mutation; Markov Chains; Models, Genetic
TL;DR:
An expectation-maximization algorithm built on a pair hidden Markov model that is able to properly handle indels in neutrally evolving DNA sequences is presented and it is found that a zeta power-law model of indel lengths provides a much better fit than the traditional geometric model and that indel processes are conserved between the authors' taxa.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 review
Genomic features of Lactobacillus species
[Review of ]. Frontiers in Bioscience, 14, 1362–1386.
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Simultaneous excision of two transgene flanking sequences and resolution of complex integration loci
PLANT MOLECULAR BIOLOGY, 69(1-2), 23–32.
author keywords: Site specific recombination; Sequence excision; Complex transgene locus resolution; Transgene expression; Plant transformation
MeSH headings : Electrophoresis, Polyacrylamide Gel; Escherichia coli / genetics; Genetic Vectors; Plants, Genetically Modified; Recombination, Genetic; Transgenes
TL;DR:
It is shown that a single SSR reaction can simultaneously carry out double excisions and resolve complex transgene loci at high frequency.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
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