Works Published in 2012
Displaying works 1 - 20 of 58 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
Epistasis dominates the genetic architecture of Drosophila quantitative traits
Proceedings of the National Academy of Sciences, 109(39), 15553–15559.
author keywords: chill coma recovery; genetic interaction networks; genome-wide association studies; startle response; starvation resistance
MeSH headings : Animals; Drosophila melanogaster; Epistasis, Genetic / physiology; Genes, Insect / physiology; Polymorphism, Single Nucleotide; Quantitative Trait, Heritable
TL;DR:
The analysis underscores the importance of epistasis as a principal factor that determines variation for quantitative traits and provides a means to uncover genetic networks affecting these traits.
(via Semantic Scholar)
www.pnas.org (publisher PDF)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 28, 2020
2012 journal article
The Drosophila melanogaster Genetic Reference Panel
Nature, 482(7384), 173–178.
MeSH headings : Alleles; Animals; Centromere / genetics; Chromosomes, Insect / genetics; Drosophila melanogaster / genetics; Genome-Wide Association Study; Genomics; Genotype; Phenotype; Polymorphism, Single Nucleotide / genetics; Quantitative Trait Loci / genetics; Selection, Genetic / genetics; Starvation / genetics; Telomere / genetics; X Chromosome / genetics
TL;DR:
The Drosophila melanogaster Genetic Reference Panel is described, a community resource for analysis of population genomics and quantitative traits, which reveals reduced polymorphism in centromeric autosomal regions and the X chromosomes, evidence for positive and negative selection, and rapid evolution of the X chromosome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 28, 2020
2012 journal article
The interface of protein structure, protein biophysics, and molecular evolution
Protein Science, 21(6), 769–785.
author keywords: evolutionary modeling; domain evolution; sequence-structure-function relationships; protein dynamics; protein thermodynamics; gene duplication; protein expression; ancestral sequence reconstruction
MeSH headings : Amino Acid Sequence; Animals; Evolution, Molecular; Humans; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Folding; Proteins / chemistry; Proteins / genetics; RNA, Messenger / genetics; Sequence Alignment
TL;DR:
The relationship between modeling and needed high‐throughput experimental data as well as experimental examination of protein evolution using ancestral sequence resurrection and in vitro biochemistry are presented, towards an aim of ultimately generating better models for biological inference and prediction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 28, 2020
2012 journal article
AUX/LAX genes encode a family of auxin influx transporters that perform distinct functions during Arabidopsis development
The Plant Cell Online, 24(7), 2874–2885.
Contributors: B. Péret *, K. Swarup*, A. Ferguson*, M. Seth*, Y. Yang *, S. Dhondt *, N. James *, I. Casimiro *, P. Perry*, A. Syed *
MeSH headings : Arabidopsis / cytology; Arabidopsis / genetics; Arabidopsis / growth & development; Arabidopsis / metabolism; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Biological Transport; Body Patterning; Cotyledon / cytology; Cotyledon / genetics; Cotyledon / growth & development; Cotyledon / metabolism; Gene Knockout Techniques; Indoleacetic Acids / metabolism; Membrane Transport Proteins / genetics; Membrane Transport Proteins / metabolism; Multigene Family; Mutagenesis, Insertional; Phenotype; Plant Roots / cytology; Plant Roots / genetics; Plant Roots / growth & development; Plant Roots / metabolism; Plant Vascular Bundle / cytology; Plant Vascular Bundle / genetics; Plant Vascular Bundle / growth & development; Plant Vascular Bundle / metabolism; Plants, Genetically Modified; Seedlings / cytology; Seedlings / genetics; Seedlings / growth & development; Seedlings / metabolism
TL;DR:
It is reported that LAX2 regulates vascular patterning in cotyledons and is concluded that Arabidopsis AUX/LAX genes encode a family of auxin influx transporters that perform distinct developmental functions and have evolved distinct regulatory mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Source: ORCID
Added: December 19, 2019
2012 journal article
Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus
Proceedings of the National Academy of Sciences, 109(17), 6590–6595.
author keywords: base excision repair; BRCA
MeSH headings : Blotting, Western; Cell Cycle; DNA Damage; DNA Repair; Enzyme Inhibitors / pharmacology; Herpesvirus 4, Human / physiology; Humans; Infrared Rays; Plasmids / physiology; Poly(ADP-ribose) Polymerase Inhibitors; Polymerase Chain Reaction; Tumor Suppressor Protein p53 / physiology
TL;DR:
An in vivo repair assay based on large endogenous Epstein–Barr virus (EBV) circular episomes assessed quantitatively and simultaneously the induction and repair of SSBs and DSBs in human cells and demonstrated that the PARP1 protein was not essential for SSB repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 28, 2019
2012 chapter
Composite Interval Mapping and Multiple Interval Mapping: Procedures and Guidelines for Using Windows QTL Cartographer
In Methods in Molecular Biology (pp. 75–119).
MeSH headings : Animals; Drosophila melanogaster / genetics; Inbreeding; Models, Statistical; Quantitative Trait Loci / genetics; Software
TL;DR:
This chapter provides an introduction of composite interval mapping and multiple interval mapping methods for mapping QTL from inbred line crosses and also detailed instructions to perform the analyses in Windows QTL Cartographer.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2012 journal article
Metabolomics Reveals Amino Acids Contribute to Variation in Response to Simvastatin Treatment
PLoS ONE, 7(7), e38386.
Ed(s): M. Oresic
MeSH headings : Adult; Amino Acids, Essential / blood; Biomarkers, Pharmacological / blood; Cholesterol, LDL / blood; Citrulline / blood; Cystine / blood; Female; Fructose / blood; Gas Chromatography-Mass Spectrometry; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology; Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use; Lauric Acids / blood; Male; Metabolomics; Nitric Oxide Synthase / blood; Ornithine / blood; Simvastatin / pharmacology; Simvastatin / therapeutic use; Stearic Acids / blood; Succinic Acid / blood; Xanthine / blood; alpha-Tocopherol / blood
TL;DR:
The findings from this study indicate that clusters of metabolites involved in multiple pathways not directly connected with cholesterol metabolism may play a role in modulating the response to simvastatin treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: July 20, 2019
2012 journal article
Evolution of bract development and B-class MADS box gene expression in petaloid bracts of cornus s. l. (cornaceae)
New Phytologist, 196(2), 631–643.
Contributors: C. Feng n, X. Liu n, Y. Yu n, D. Xie n, R. Franks n & Q. Xiang n
author keywords: APETALA3; B-class gene expression; Cornus; development; Evo-Devo; evolution of petaloid bracts; heterotopic petaloidy; PISTILLATA
MeSH headings : Biological Evolution; Cell Shape; Cornaceae / anatomy & histology; Cornaceae / genetics; Cornaceae / growth & development; Cornaceae / ultrastructure; Flowers / cytology; Flowers / genetics; Flowers / growth & development; Flowers / ultrastructure; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Genes, Plant / genetics; Inflorescence / growth & development; MADS Domain Proteins / genetics; MADS Domain Proteins / metabolism; Phylogeny; Plant Epidermis / cytology; Plant Epidermis / ultrastructure; Plant Leaves / cytology; Plant Leaves / genetics; Plant Leaves / growth & development; Plant Leaves / ultrastructure; Plant Proteins / genetics; Plant Proteins / metabolism; Seasons; Time Factors
TL;DR:
Phylogeny-based analysis identified developmental and gene expression changes that are correlated with the evolution of petaloid bracts in C. florida and C. canadensis, and it is suggested that functional transference within B-class gene families may have contributed to the origin of bract petaloids in these species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: ORCID
Added: January 22, 2019
2012 journal article
Photoreceptor Differentiation following Transplantation of Allogeneic Retinal Progenitor Cells to the Dystrophic Rhodopsin Pro347Leu Transgenic Pig
STEM CELLS INTERNATIONAL, 2012.
TL;DR:
Together, these data support the tolerance of RPCs as allografts and demonstrate the high level of rod photoreceptor development that can be obtained from cultured RPCs following transplantation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Multiple trait multiple interval mapping of quantitative trait loci from inbred line crosses
BMC Genetics, 13.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Influence of Exposure Time on Gene Expression by Human Intestinal Epithelial Cells Exposed to Lactobacillus acidophilus
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 78(14), 5028–5032.
MeSH headings : Caco-2 Cells; Epithelial Cells / immunology; Epithelial Cells / metabolism; Epithelial Cells / microbiology; Flagellin / metabolism; Flagellin / pharmacology; Gene Expression Profiling; Gene Expression Regulation; Humans; Intestinal Mucosa / metabolism; Intestines / cytology; Intestines / immunology; Intestines / microbiology; Lactobacillus acidophilus / immunology; Molecular Sequence Data; NF-kappa B / genetics; NF-kappa B / metabolism; Probiotics / pharmacology; Recombinant Proteins / metabolism; Recombinant Proteins / pharmacology; Time Factors
TL;DR:
Analysis of global temporal gene expression by human intestinal cells when exposed to Lactobacillus acidophilus revealed induction of immune-related pathways and NF-κB target genes after a 1-h exposure, compared to a 4- or 8-H exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Construction and Immunological Evaluation of Dual Cell Surface Display of HIV-1 Gag and Salmonella enterica Serovar Typhimurium FliC in Lactobacillus acidophilus for Vaccine Delivery
CLINICAL AND VACCINE IMMUNOLOGY, 19(9), 1374–1381.
MeSH headings : AIDS Vaccines / administration & dosage; AIDS Vaccines / genetics; AIDS Vaccines / immunology; Administration, Oral; Animals; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / genetics; Bacterial Vaccines / immunology; Cell Surface Display Techniques / methods; Cells, Cultured; Dendritic Cells / immunology; Female; Flagellin / genetics; Flagellin / immunology; HIV-1 / genetics; HIV-1 / immunology; Humans; Intestinal Mucosa / immunology; Lactobacillus acidophilus / genetics; Leukocytes, Mononuclear / immunology; Mice; Mice, Inbred BALB C; Salmonella typhimurium / genetics; Salmonella typhimurium / immunology; Vaccines, Synthetic / administration & dosage; Vaccines, Synthetic / genetics; Vaccines, Synthetic / immunology; gag Gene Products, Human Immunodeficiency Virus / genetics; gag Gene Products, Human Immunodeficiency Virus / immunology
TL;DR:
Results suggested that the Gag-displaying L. acidophilus elicited specific immune responses and the coexistence of FliC conferred an adjuvant effect on local IgA production.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Characterization of the fecal microbiota using high-throughput sequencing reveals a stable microbial community during storage
PLoS One, 7(10).
MeSH headings : Bacteria / classification; Bacteria / genetics; Bacteria / growth & development; Biodiversity; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Feces / microbiology; Freezing; Genetic Variation; Humans; Intestines / microbiology; Irritable Bowel Syndrome / microbiology; Metagenome / genetics; RNA, Ribosomal, 16S / genetics; Sequence Analysis, DNA / methods; Specimen Handling / methods; Time Factors
TL;DR:
Fecal samples exposed to room or deep freezing temperatures for up to twenty four hours and six months, respectively, exhibit a microbial composition and diversity that shares more identity with its host of origin than any other sample.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
AUX/LAX genes encode a family of auxin influx transporters that perform distinct functions during arabidopsis development
Plant Cell, 24(7), 2874–2885.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
The impact of probiotics and prebiotics on the immune system
NATURE REVIEWS IMMUNOLOGY, 12(10), 728–734.
MeSH headings : Animals; Humans; Immune System; Immunomodulation; Prebiotics; Probiotics
TL;DR:
Four experts are asked to discuss the future application of probiotics as a disease therapy and provide their thoughts on the growth and function of beneficial intestinal microorganisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Impact of Genetic Architecture on the Relative Rates of X versus Autosomal Adaptive Substitution
MOLECULAR BIOLOGY AND EVOLUTION, 29(8), 1933–1942.
author keywords: dominance; epistasis; genetics of adaptation; soft sweeps; molecular evolution
MeSH headings : Adaptation, Physiological / genetics; Animals; Chromosomes, Human, X / genetics; Evolution, Molecular; Genes / genetics; Humans; Models, Genetic; Mutation / genetics; Phylogeny; Population Density; X Chromosome / genetics
TL;DR:
The new theory unites the previously separate analysis of adaptation using new mutations versus standing genetic variation and makes several useful predictions about the interaction between genetic architecture, evolutionary genetic constraints, and effective population size in determining the ratio of adaptive substitution between autosomal and X-linked genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Fitting nonstationary general-time-reversible models to obtain edge-lengths and frequencies for the barry-hartigan model
Systematic Biology, 61(6), 927–940.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Efficacy of EGFR Inhibition Is Modulated by Model, Sex, Genetic Background and Diet: Implications for Preclinical Cancer Prevention and Therapy Trials
PLOS ONE, 7(6).
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Azoxymethane / toxicity; Colorectal Neoplasms / chemically induced; Colorectal Neoplasms / drug therapy; Colorectal Neoplasms / genetics; Diet; Disease Models, Animal; ErbB Receptors / antagonists & inhibitors; ErbB Receptors / metabolism; Female; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Quinazolines / pharmacology; Quinazolines / therapeutic use; Sex Factors; Tyrphostins / pharmacology; Tyrphostins / therapeutic use
TL;DR:
Model-dependent interactions between genetic background and diet can dramatically impact preclinical results, and indicate that low predictive values of preclinical studies can be attributed to study designs that do not account for the heterogeneous patient population or the diets they consume.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Developmental plasticity and the evolution of parasitism in an unusual nematode, Parastrongyloides trichosuri
EvoDevo, 3(1).
TL;DR:
The role of dauer development in the nematode, Parastrongyloides trichosuri, is investigated, and it is shown that the developmental switch between these life histories is sensitive to the same environmental cues as dauer arrest in free-living nematodes, including sensitivity to a chemical cue produced by the free- living stages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2012 journal article
Age-specific variation in immune response in drosophila melanogaster has a genetic basis
Genetics, 191(3), 989–584.
Source: NC State University Libraries
Added: August 6, 2018
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