Molecular Education, Technology and Research Innovation Center

Works Published in 2024

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Displaying all 14 works

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2024 journal article

Data-dependent and -independent acquisition lipidomics analysis reveals the tissue-dependent effect of metformin on lipid metabolism

METABOLOMICS, 20(3).

By: G. Scheidemantle n, L. Duan n, M. Lodge n, M. Cummings n, D. Hilovsky n, E. Pham n, X. Wang n, A. Kennedy n, X. Liu n

author keywords: Metformin; Intestinal metabolism; Lipidomics; DIA
Source: Web Of Science
Added: May 20, 2024

2024 article

Comparison of the Backbone Dynamics of Dehaloperoxidase-Hemoglobin Isoenzymes

Gonzalez-Delgado, J. M., Thompson, P. M., Andralojc, W., Gdaniec, Z., Ghiladi, R. A., & Franzen, S. (2024, April 2). JOURNAL OF PHYSICAL CHEMISTRY B, Vol. 4.

By: J. Gonzalez-Delgado n, P. Thompson n, W. Andralojc*, Z. Gdaniec*, R. Ghiladi n & S. Franzen n

Sources: Web Of Science, NC State University Libraries
Added: April 15, 2024

2024 journal article

Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation

Nature Communications.

By: N. Huang, T. Winans, B. Wyman, Z. Oaks, T. Faludi, G. Choudhary, Z. Lai, J. Lewis ...

TL;DR: A functional role is identified for Rab4A-directed endosome traffic in CD98 receptor recycling, mTOR activation, and accumulation of mitochondria that connect metabolic pathways with immune cell lineage development and lupus pathogenesis. (via Semantic Scholar)
Source: ORCID
Added: April 1, 2024

2024 journal article

Fructose regulates the pentose phosphate pathway and induces an inflammatory and resolution phenotype in Kupffer cells

SCIENTIFIC REPORTS, 14(1).

By: M. Lodge, G. Scheidemantle, V. Adams*, M. Cottam, D. Richard, D. Breuer, P. Thompson*, K. Shrestha*, X. Liu*, A. Kennedy*

TL;DR: It is demonstrated that chronic fructose diet decreased Kupffer cell populations while increasing transitioning monocytes and upregulating resolution and anti-inflammatory associated genes in Kupffer cells. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 25, 2024

2024 journal article

Quantitative mass spectrometry imaging (qMSI): A tutorial

JOURNAL OF MASS SPECTROMETRY, 59(4).

By: R. Kibbe n & D. Muddiman n

author keywords: absolute quantification; mass spectrometry imaging; qMSI; relative quantification
TL;DR: This tutorial will detail the main factors to consider when designing a qMSI experiment and highlight the methods that have been developed to overcome these added complexities, specifically for those newer to the field of MSI. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 25, 2024

2024 journal article

A statistical approach to system suitability testing for mass spectrometry imaging

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 38(9).

By: A. Sohn n, R. Kibbe n, O. Dioli n, E. Hector n, H. Bai n, K. Garrard n, D. Muddiman n

Sources: Web Of Science, NC State University Libraries
Added: March 18, 2024

2024 journal article

Characterization of an Injectable Chitosan Hydrogel for the Tunable, Localized Delivery of Immunotherapeutics

ACS BIOMATERIALS SCIENCE & ENGINEERING, 10(2), 905–920.

author keywords: hydrogel; chitosan; immunotherapy; intratumoral
TL;DR: The goal of the present work was to construct a novel, injectable hydrogel that could be tuned for localized immunotherapy delivery and displayed several clinically important features, including injectability, biocompatibility, and imageability. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 4, 2024

2024 journal article

TL;DR: R reverse metabolomics is presented as a discovery strategy, whereby tandem mass spectrometry spectra acquired from newly synthesized compounds are searched for in public metabolomics datasets to uncover phenotypic associations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: March 4, 2024

2024 journal article

Developmental regulation of cellular metabolism is required for intestinal elongation and rotation

DEVELOPMENT, 151(1).

By: J. Grzymkowski n, Y. Chiu, D. Jima n, B. Wyatt n, S. Jayachandran n, W. Stutts n, N. Nascone-Yoder n

author keywords: Intestine; Metabolism; Rotation; Electron transport chain; Elongation; Atrazine; Xenopus
TL;DR: Roles for metabolism in gut morphogenesis are revealed and implicate defective gut tube elongation and/or metabolic perturbations in the etiology of intestinal malrotation. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 22, 2024

2024 journal article

Myeloid cell MHC I expression drives CD8<SUP>+</SUP> T cell activation in nonalcoholic steatohepatitis

FRONTIERS IN IMMUNOLOGY, 14.

By: V. Adams n, L. Collins n, T. Williams n, J. Holmes n, P. Hess n, H. Atkins n, G. Scheidemantle n, X. Liu n ...

Contributors: T. Williams n, V. Adams n, L. Collins n, J. Holmes n, P. Hess n, H. Atkins n, G. Scheidemantle n, X. Liu n ...

Ed(s): T. Williams n, L. Collins n & A. Kennedy n

author keywords: liver; NASH; fibrosis; H2Kb; CD8(+) T cells; immunopeptidome
TL;DR: Activated hepatic CD8+ T cells are dependent on myeloid cell MHC class I expression in diet induced NASH to promote inflammation and fibrosis and a role of NADPH oxidase in the production of Ncf2 peptide generation is suggested. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 28, 2024

2024 article

RCM protocols: improving reproducibility in the field of mass spectrometry

Holman, S. W., Langley, G. J., Muddiman, D. C., & Novak-Mitchell, C. (2024, January 2). RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol. 1.

By: S. Holman*, G. Langley*, D. Muddiman n & C. Novak-Mitchell*

Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024

2024 journal article

Prototyping an ionization source for non-engineers

JOURNAL OF MASS SPECTROMETRY, 59(1).

author keywords: computer-aided design; hardware interfacing; instrumentation prototyping; microcontroller; software development
Sources: Web Of Science, NC State University Libraries
Added: January 2, 2024

2024 journal article

A bottom‐up proteomics workflow for a system containing multiple organisms

Rapid Communications in Mass Spectrometry.

By: H. Bai n, L. Collins n, M. André n, E. Breitschwerdt n & T. Williams n

TL;DR: A bottom-up proteomics workflow was developed to study a system containing multiple organisms to promote a thorough understanding of how each interacts with the others and can be readily applied to other label-free proteomics work involving multiple proteomes from taxonomically distinct organisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: ORCID
Added: November 25, 2022

2024 journal article

Discovery proteomics of human placental tissue

Rapid Communications in Mass Spectrometry.

By: A. Mellinger n, K. McCoy*, D. Minior* & T. Williams n

TL;DR: A label-free proteomics protocol for the interrogation of the placental proteome is described, which has been applied towards exploring differential protein expression patterns in placentas from women who have been exposed to drugs during pregnancy relative to those who have not. (via Semantic Scholar)
Source: ORCID
Added: September 8, 2021

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