Molecular Education, Technology and Research Innovation Center

Recent Works

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Sorted by most recent date added to the index first, which may not be the same as publication date order.

2026 article

Resolving the glycosaminoglycan signature of ischemic stroke brain using PRM-based IR-MALDESI mass spectrometry imaging

Palomino, T. V., Campbell, N., Ouyang, Y., Naik, N., Hawkridge, A. M., Segura, T., & Muddiman, D. C. (2026, January 23). Analytical and Bioanalytical Chemistry, Vol. 1.

By: T. Palomino n, N. Campbell*, Y. Ouyang*, N. Naik*, A. Hawkridge*, T. Segura*, D. Muddiman n

topics (OpenAlex): Proteoglycans and glycosaminoglycans research; Mass Spectrometry Techniques and Applications; Glycosylation and Glycoproteins Research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: January 26, 2026

2026 article

Spatially resolved lipids in a mouse brain model of globoid cell leukodystrophy via IR-MALDESI MSI and parallel reaction monitoring MSI

Hunter, S. N., Wang, M. F., Thomas, B. N., Filiano, A. J., & Muddiman, D. C. (2026, January 23). Analytical and Bioanalytical Chemistry, Vol. 1.

topics (OpenAlex): Mass Spectrometry Techniques and Applications; Lysosomal Storage Disorders Research; Metabolomics and Mass Spectrometry Studies
Sources: NC State University Libraries, NC State University Libraries
Added: January 26, 2026

2026 article

Integrating Remote Sensing and Metabolomics to Assess Synergistic Effects of Phosphate Deficiency, Drought, and AMF Symbiosis in Soybean

Hassan, M. A., Kibbe, R. R., Muddiman, D. C., & Chang, C. Y. Y. (2026, January 1). Physiologia Plantarum, Vol. 1.

By: M. Hassan*, R. Kibbe n, D. Muddiman n & C. Chang*

MeSH headings : Mycorrhizae / physiology; Symbiosis / physiology; Glycine max / physiology; Glycine max / microbiology; Glycine max / metabolism; Droughts; Metabolomics / methods; Phosphates / deficiency; Phosphates / metabolism; Plant Roots / physiology; Plant Roots / microbiology; Plant Roots / metabolism; Photosynthesis; Chlorophyll / metabolism; Remote Sensing Technology / methods; Plant Leaves / physiology; Stress, Physiological; Genotype
topics (OpenAlex): Mycorrhizal Fungi and Plant Interactions; Plant nutrient uptake and metabolism; Biocrusts and Microbial Ecology
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: January 21, 2026

2026 article

Demonstrating Voxel‐by‐Voxel (V × V) Single‐Point Calibration in Whole‐Body Zebrafish by IR‐MALDESI Quantitative MSI

Joignant, A. N., Vega, S. J., & Muddiman, D. C. (2026, January 12). Journal of Mass Spectrometry, Vol. 1.

By: A. Joignant n, S. Vega n & D. Muddiman n

MeSH headings : Animals; Zebrafish / metabolism; Calibration; Arachidonic Acid / analysis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Ion-surface interactions and analysis
Sources: NC State University Libraries, NC State University Libraries
Added: January 14, 2026

2025 article

Modernizing the platform process of antibody purification for enhanced impurity clearance

LeBarre, J., Bhandari, D., Barbieri, E., Shu, Q., Li, X., Chandra, D., … Menegatti, S. (2025, November 20). Separation and Purification Technology, Vol. 11.

By: J. LeBarre n, D. Bhandari*, E. Barbieri*, Q. Shu n, X. Li*, D. Chandra*, X. Xu*, M. Phillips* ...

co-author countries: Germany 🇩🇪 Indonesia 🇮🇩
topics (OpenAlex): Protein purification and stability; Monoclonal and Polyclonal Antibodies Research; Viral Infectious Diseases and Gene Expression in Insects
Sources: NC State University Libraries, NC State University Libraries
Added: January 22, 2026

2025 article

Comparative proteomic analysis of skin wound healing responses to biomaterial treatments identifies key pathways which govern differential regenerative outcomes

Suarez-Arnedo, A., Caston, E. L. P., Liu, Y., Baia, H., Muddiman, D., & Segura, T. (2025, May 24). (Vol. 5). Vol. 5.

topics (OpenAlex): Wound Healing and Treatments; Tendon Structure and Treatment; Periodontal Regeneration and Treatments
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: January 18, 2026

2025 article

Adrenodoxin alters human cytochrome P450 27A1 structure and reaction efficiency beyond supplying electrons

Vu, Q. T., May, K. C., Collins, L. B., Davis, Z. B., Bartholomew-Schoch, J. L., Vaughn, L. R., … Reddish, M. J. (2025, December 23). Archives of Biochemistry and Biophysics, Vol. 12.

By: Q. Vu*, K. May*, L. Collins n, Z. Davis*, J. Bartholomew-Schoch*, L. Vaughn*, K. Provost*, N. Arnold* ...

MeSH headings : Adrenodoxin / chemistry; Adrenodoxin / metabolism; Humans; Kinetics; Cholestanetriol 26-Monooxygenase / chemistry; Cholestanetriol 26-Monooxygenase / metabolism; Electrons; Protein Conformation; Protein Binding
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Eicosanoids and Hypertension Pharmacology; Neurotransmitter Receptor Influence on Behavior
Sources: NC State University Libraries, NC State University Libraries
Added: January 13, 2026

2025 article

Development and Optimization of an Electrospray Diverter for Reduced Background Signal in Ambient Ionization Sources

Eisenberg, S. M., Joignant, A. N., Trumbull, J. D., Hernandez, D., Chang-Yen, D., Wouters, E. R., … Muddiman, D. C. (2025, December 8). Journal of the American Society for Mass Spectrometry, Vol. 12.

topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Electrohydrodynamics and Fluid Dynamics
Sources: NC State University Libraries, NC State University Libraries
Added: December 9, 2025

2025 article

Exploring ammonium salt doping to enhance ion abundance for quantitative mass spectrometry imaging

Dunnavant, A. R., Eisenberg, S. M., & Muddiman, D. C. (2025, November 4). Analytical and Bioanalytical Chemistry.

topics (OpenAlex): Mass Spectrometry Techniques and Applications; Advanced Proteomics Techniques and Applications; Metabolomics and Mass Spectrometry Studies
Sources: NC State University Libraries, NC State University Libraries
Added: November 22, 2025

2025 article

Investigations of gold(I) complexes as inhibitors of caspase-1

Ranganathan, S., Reda, I. D., Gustafson, H. A., Polasek, C. G., Camacho, E. J. M., Sommer, R. D., … Karver, C. E. (2025, October 30). Journal of Inorganic Biochemistry.

By: S. Ranganathan*, I. Reda*, H. Gustafson*, C. Polasek*, E. Camacho*, R. Sommer n, K. Grice*, C. Karver*

topics (OpenAlex): Metal complexes synthesis and properties; Trace Elements in Health; Organometallic Compounds Synthesis and Characterization
Source: NC State University Libraries
Added: November 22, 2025

2025 article

Progress in monitoring molecular, cellular and metabolic dynamics using mass spectrometry imaging

Gamcsik, M. P., Bruce, E. R., & Muddiman, D. C. (2025, October 30). Bioanalysis.

By: M. Gamcsik n, E. Bruce n & D. Muddiman n

topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Advanced Proteomics Techniques and Applications
Sources: NC State University Libraries, NC State University Libraries
Added: November 21, 2025

2025 article

Signal enhancement of lipids and glycans using ammonium fluoride for IR-MALDESI mass spectrometry imaging

Eisenberg, S. M., Dunnavant, A. R., Palomino, T. V., Muddiman, D. C., Eisenberg, S. M., Dunnavant, A. R., … Muddiman, D. C. (2025, November 18). Analytical and Bioanalytical Chemistry.

By: S. Eisenberg n, A. Dunnavant n, T. Palomino n, D. Muddiman n, S. Eisenberg, A. Dunnavant, T. Palomino, D. Muddiman

topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Advanced Proteomics Techniques and Applications
Sources: NC State University Libraries, NC State University Libraries
Added: November 20, 2025

2025 article

Native mass spectrometry enabled by infrared matrix-assisted laser desorption electrospray ionization for rapid measurement of protein-ligand biophysical parameters

Adepoju, A. A., Ghiladi, R. A., Muddiman, D. C., Adepoju, A. A., Ghiladi, R. A., & Muddiman, D. C. (2025, November 14). Analytical and Bioanalytical Chemistry.

By: A. Adepoju n, R. Ghiladi n, D. Muddiman n, A. Adepoju, R. Ghiladi & D. Muddiman

topics (OpenAlex): Mass Spectrometry Techniques and Applications; Enzyme function and inhibition; Protein Interaction Studies and Fluorescence Analysis
Sources: NC State University Libraries, NC State University Libraries
Added: November 16, 2025

2025 article

Use of Synthetic Standard Peptides in Standardized Digests to Evaluate Both Sample and Instrument Suitability in Proteomics

Collins, L. B., Williams, T. I., Sohn, A. L., Kalmar, J. G., Bereman, M. S., Muddiman, D. C., … Muddiman, D. C. (2025, November 13). Journal of Proteome Research.

co-author countries: Canada 🇨🇦
topics (OpenAlex): Advanced Proteomics Techniques and Applications; Mass Spectrometry Techniques and Applications; Advanced Biosensing Techniques and Applications
Source: ORCID
Added: November 13, 2025

2025 article

Historical Blood Serum Samples from Wilmington, North Carolina: The Importance of Ultrashort-Chain Per- and Polyfluoroalkyl Substances

Cheng, L., Teagle, S., Enders, J. R., Weed, R. A., Nichols, H. B., Knappe, D. R. U., & Hoppin, J. A. (2025, October 27). Environmental Science & Technology.

By: L. Cheng n, S. Teagle n, J. Enders n, R. Weed n, H. Nichols*, D. Knappe n, J. Hoppin n

topics (OpenAlex): Per- and polyfluoroalkyl substances research
Source: ORCID
Added: October 27, 2025

2025 article

Phosphorylation of UDP-glucose dehydrogenase increases glycosaminoglycan biosynthesis and promotes tumor cell motility, spheroid growth, and therapeutic resistance

Utz, A. R., Ma, L., Hilovsky, D., Zimmer, B. M., Allego, E., Fluharty, J., … Simpson, M. A. (2025, October 17). Matrix Biology.

By: A. Utz n, L. Ma n, D. Hilovsky n, B. Zimmer n, E. Allego n, J. Fluharty n, P. Narasimhan n, J. Enders n ...

MeSH headings : Humans; Phosphorylation; Uridine Diphosphate Glucose Dehydrogenase / metabolism; Uridine Diphosphate Glucose Dehydrogenase / genetics; Uridine Diphosphate Glucose Dehydrogenase / chemistry; Cell Movement; Cell Line, Tumor; Male; Spheroids, Cellular / metabolism; Spheroids, Cellular / drug effects; Glycosaminoglycans / biosynthesis; Drug Resistance, Neoplasm; Cell Proliferation; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology; Prostatic Neoplasms / genetics; Prostatic Neoplasms / drug therapy
topics (OpenAlex): Proteoglycans and glycosaminoglycans research; Glycosylation and Glycoproteins Research; Liver physiology and pathology
Source: ORCID
Added: October 17, 2025

2025 article

A Strategy to Achieve Sub‐Parts‐per‐Million Mass Measurement Accuracy of N‐Linked Glycans Using Infrared Matrix‐Assisted Laser Desorption Electrospray Ionization

Adepoju, A. A., Palomino, T. V., Sohn, A. L., & Muddiman, D. C. (2025, September 29). Journal of Mass Spectrometry, Vol. 60.

author keywords: custom calibration; IR-MALDESI; mass calibration; mass measurement accuracy; N-linked glycans
MeSH headings : Polysaccharides / chemistry; Polysaccharides / analysis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Animals; Cattle; Calibration; Spectrometry, Mass, Electrospray Ionization / methods; Fetuins / chemistry
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Glycosylation and Glycoproteins Research; Analytical Chemistry and Chromatography
Sources: Web Of Science, NC State University Libraries
Added: October 13, 2025

2025 article

Demonstrating voxel-by-voxel (V × V) single-point calibration in liver tissue by IR-MALDESI quantitative MSI

Bruce, E. R., Kibbe, R. R., Opperman, L. J., & Muddiman, D. C. (2025, September 29). Analytical and Bioanalytical Chemistry, Vol. 9.

By: E. Bruce n, R. Kibbe n, L. Opperman n & D. Muddiman n

author keywords: IR-MALDESI; Quantitative mass spectrometry imaging; Single-point calibration; Quantitative sampling
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Analytical Chemistry and Chromatography
Sources: Web Of Science, NC State University Libraries
Added: October 7, 2025

2025 article

Trophic transfer of per- and polyfluoroalkyl acids in a periphyton-mayfly-zebrafish food chain

Farrell, M. R., Buchwalter, D. B., Weed, R. A., Enders, J. R., & Planchart, A. (2025, August 7). Aquatic Toxicology, Vol. 287.

By: M. Farrell n, D. Buchwalter n, R. Weed n, J. Enders n & A. Planchart n

author keywords: PFAS; Trophic; Bioaccumulation; Zebrafish; Invertebrate; Biofilm; Freshwater
MeSH headings : Animals; Food Chain; Water Pollutants, Chemical / metabolism; Water Pollutants, Chemical / analysis; Zebrafish / metabolism; Larva / metabolism; Fluorocarbons / metabolism; Fluorocarbons / analysis; Periphyton; Ephemeroptera / metabolism
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Toxic Organic Pollutants Impact; Atmospheric chemistry and aerosols
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 7, 2025

2025 article

Comparative proteomic analysis of skin wound healing responses to biomaterial treatments identifies key pathways which govern differential regenerative outcomes

Suarez-Arnedo, A., Caston, E. L. P., Liu, Y., Bai, H., Muddiman, D. C., & Segura, T. (2025, September 4). Biomaterials, Vol. 326.

By: A. Suarez-Arnedo, E. Caston, Y. Liu, H. Bai n, D. Muddiman n & T. Segura

author keywords: Proteomics; Gene ontology; MAP scaffold; Chirality; Regeneration; Wound healing
topics (OpenAlex): Wound Healing and Treatments; Tendon Structure and Treatment; Periodontal Regeneration and Treatments
Sources: Web Of Science, NC State University Libraries
Added: September 29, 2025

2025 article

Structural features of 11 synthetic bacteriochlorins — comparisons with chlorins and porphyrins

Tran, V.-P., Taniguchi, M., Sommer, R. D., Boyle, P. D., Nalaoh, P., & Lindsey, J. S. (2025, September 1). Journal of Porphyrins and Phthalocyanines, Vol. 9.

author keywords: bacteriochlorin; distortion; hydroporphyrin; space group; unit cell; X-ray diffraction
topics (OpenAlex): Porphyrin and Phthalocyanine Chemistry; Photodynamic Therapy Research Studies; Porphyrin Metabolism and Disorders
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 15, 2025

2025 article

A versatile and efficient method to quantify purity and degree of substitution in alginate derivatives

Carpio, M. B., Thompson, P. M., Moody, C., Pierce, J. G., & Brudno, Y. (2025, August 27). Carbohydrate Polymers.

MeSH headings : Alginates / chemistry; Reproducibility of Results; Magnetic Resonance Spectroscopy / methods; Proton Magnetic Resonance Spectroscopy / methods
topics (OpenAlex): 3D Printing in Biomedical Research; Hydrogels: synthesis, properties, applications; Biopolymer Synthesis and Applications
Source: ORCID
Added: September 2, 2025

2025 article

Recent insights into the implications of UGDH mutations for human developmental disease

Harwood, H., Zimmer, B. M., Utz, A. R., Barycki, J. J., & Simpson, M. A. (2025, August 28). Biochemical Society Transactions, Vol. 8.

By: H. Harwood n, B. Zimmer n, A. Utz n, J. Barycki n & M. Simpson n

MeSH headings : Humans; Mutation; Uridine Diphosphate Glucose Dehydrogenase / genetics; Uridine Diphosphate Glucose Dehydrogenase / metabolism; Animals; Congenital Disorders of Glycosylation / genetics
topics (OpenAlex): Glycosylation and Glycoproteins Research; Carbohydrate Chemistry and Synthesis; Metabolism and Genetic Disorders
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 29, 2025

2025 article

Detection and Quantitation of Per- and Polyfluoroalkyl Substances in North Carolina Sea Foam and the Corresponding Sea Water

Enders, J. R., Weed, R. A., Donovan, E., Phelps, D., Campbell, G., May, K., & Baker, E. S. (2025, August 27). Environmental Science & Technology, Vol. 8.

By: J. Enders n, R. Weed n, E. Donovan*, D. Phelps n, G. Campbell n, K. May n, E. Baker*

author keywords: PFAS contamination; sea foam accumulation; high-resolution mass spectrometry (HRMS); quantitative analysis; nontargeted analysis; per- and polyfluoroalkyl substances(PFAS); emerging PFAS compounds
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Toxic Organic Pollutants Impact; Atmospheric chemistry and aerosols
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 27, 2025

2025 article

Characterization of an isobutylene epoxide hydrolase (IbcK) from the isobutylene-catabolizing bacterium Mycolicibacterium sp. ELW1

Faulkner, N. W., Joyce, J. B., Smith, C., Swartz, P., Rose, R. B., Miller, E. S., & Hyman, M. R. (2025, August 26). (M. Vives, Ed.). Applied and Environmental Microbiology, Vol. 8.

By: N. Faulkner n, J. Joyce n, C. Smith n, P. Swartz n, R. Rose n, E. Miller n, M. Hyman n

Ed(s): M. Vives

author keywords: epoxide hydrolase; isobutylene; isobutylene oxide; MTBE; alkenes; bioremediation
topics (OpenAlex): Microbial Metabolic Engineering and Bioproduction; Enzyme Catalysis and Immobilization; Pharmacogenetics and Drug Metabolism
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 26, 2025

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