Molecular Education, Technology and Research Innovation Center

Recent Works

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Sorted by most recent date added to the index first, which may not be the same as publication date order.

2025 journal article

Illuminating the mechanistic impacts of an Fe-quaterpyridine functionalized crystalline poly(triazine imide) semiconductor for photocatalytic CO2 reduction

Inorganic Chemistry Frontiers.

By: S. McGuigan, S. Tereniak, A. Smith, S. Jana, C. Donley, L. Collins*, N. Ghorai, Y. Xu ...

topics (OpenAlex): Covalent Organic Framework Applications; Advanced Photocatalysis Techniques; CO2 Reduction Techniques and Catalysts
Source: ORCID
Added: June 25, 2025

2025 journal article

Mitochondrial Preparation from Microglia for Glycan Analysis

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 5(219).

By: M. Madabhushi, T. Palomino*, M. Patil, D. Muddiman*, D. Tyrrell & J. Samal

MeSH headings : Microglia / chemistry; Microglia / metabolism; Polysaccharides / analysis; Mitochondria / chemistry; Mitochondria / metabolism; Animals; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Mitochondrial Proteins / chemistry; Mitochondrial Proteins / analysis; Mitochondrial Proteins / isolation & purification; Mitochondrial Proteins / metabolism; Mice
topics (OpenAlex): Neuroinflammation and Neurodegeneration Mechanisms; Glycosylation and Glycoproteins Research; Neurological Disease Mechanisms and Treatments
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 16, 2025

2025 article

Unraveling the molecular dynamics of wound healing: integrating spatially resolved lipidomics and temporally resolved proteomics

Bai, H., Arnedo, A. S., Liu, Y., Segura, T., & Muddiman, D. (2025, April 24). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 4.

By: H. Bai n, A. Arnedo*, Y. Liu*, T. Segura* & D. Muddiman n

author keywords: Wound healing; Mass spectrometry imaging; 3D; IR-MALDESI; Multi-omics
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Forensic Entomology and Diptera Studies; Spectroscopy Techniques in Biomedical and Chemical Research
Sources: Web Of Science, NC State University Libraries
Added: May 6, 2025

2025 journal article

Feasibility of IR-MALDESI Mass Spectrometry Imaging of PFAS

JOURNAL OF MASS SPECTROMETRY, 60(2).

author keywords: IR-MALDESI; LC-MS/MS; mass spectrometry imaging; PFAS; zebrafish
MeSH headings : Fluorocarbons / analysis; Animals; Mice; Limit of Detection; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Liver / chemistry; Liver / metabolism; Alkanesulfonic Acids / analysis; Caprylates / analysis; Feasibility Studies; Environmental Pollutants / analysis; Tandem Mass Spectrometry / methods; Zebrafish / metabolism
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Lanthanide and Transition Metal Complexes; Mass Spectrometry Techniques and Applications
Sources: Web Of Science, NC State University Libraries
Added: April 28, 2025

2025 article

Distinguishing the Metabolic Effect of Fetal and Adult Fibrinogen on Human Fibroblast Cell Culture by IR-MALDESI Mass Spectrometry Imaging

Joignant, A. N., Sheridan, A., Brown, A. C., & Muddiman, D. C. (2025, April 7). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 4.

author keywords: IR-MALDESI; mass spectrometry imaging; fibroblast; fibrinogen
topics (OpenAlex): Blood properties and coagulation; Erythrocyte Function and Pathophysiology; Adipokines, Inflammation, and Metabolic Diseases
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 21, 2025

2025 article

Trophic Transfer of Perfluoroalkyl Acids in a Periphyton-Mayfly-Zebrafish Food Chain

Farrell, M. R., Buchwalter, D. B., Weed, R. A., Enders, J. R., & Planchart, A. J. (2025, April 15).

By: M. Farrell, D. Buchwalter*, R. Weed, J. Enders* & A. Planchart

topics (OpenAlex): Per- and polyfluoroalkyl substances research
Source: ORCID
Added: April 15, 2025

2025 article

Infrared Matrix-Assisted Laser Desorption Electrospray Ionization (IR-MALDESI) Mass Spectrometry Imaging of Per- and Polyfluoroalkyl Substances (PFAS) in Stabilized Soil Cores

Guillette, T., Stutts, W., Baumeister, A., Liles, D., Olechiw, T., & Lang, J. (2025, March 18). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY.

By: T. Guillette*, W. Stutts n, A. Baumeister*, D. Liles*, T. Olechiw* & J. Lang*

topics (OpenAlex): Mass Spectrometry Techniques and Applications; Per- and polyfluoroalkyl substances research; Analytical Chemistry and Chromatography
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: March 31, 2025

2025 article

Detection and Quantitation of Per- and Polyfluoroalkyl Substances in Sea Foam and the Corresponding Sea Water

Enders, J., Weed, R., Donovan, E., Phelps, D., Campbell, G., May, K., & Baker, E. (2025, March 27).

By: J. Enders n, R. Weed n, E. Donovan, D. Phelps n, G. Campbell n, K. May n, E. Baker*

topics (OpenAlex): Per- and polyfluoroalkyl substances research; Toxic Organic Pollutants Impact
Source: ORCID
Added: March 27, 2025

2025 article

Topographic imaging with automatic z-axis correction of <i>Brassica oleracea</i> var. <i>viridis</i> leaves by IR-MALDESI mass spectrometry imaging

Mills, Q., Ashbacher, S. M., Sohn, A. L., & Muddiman, D. C. (2025, March 15). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 3.

By: Q. Mills n, S. Ashbacher n, A. Sohn n & D. Muddiman n

author keywords: IR-MALDESI; Mass spectrometry imaging; Plant imaging; Plant metabolomics; Plant biology; <italic>Brassica oleracea</italic> var. <italic>viridis</italic>
MeSH headings : Brassica / chemistry; Plant Leaves / chemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Spectrometry, Mass, Electrospray Ionization / methods
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Analytical Chemistry and Chromatography
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 19, 2025

2025 article

Glycosaminoglycan Mass Spectrometry Imaging by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization

Palomino, T. V., & Muddiman, D. C. (2025, March 4). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 3.

By: T. Palomino n & D. Muddiman n

author keywords: Chondroitin Sulfate; Glycosaminoglycans; MassSpectrometry Imaging; IR-MALDESI
MeSH headings : Animals; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Chondroitin Sulfates / analysis; Chondroitin Sulfates / chemistry; Spectrometry, Mass, Electrospray Ionization / methods; Brain Chemistry; Glycosaminoglycans / analysis; Glycosaminoglycans / chemistry; Rats; Disaccharides / analysis; Disaccharides / chemistry; Male; Mice; Brain / diagnostic imaging; Brain / metabolism
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Proteoglycans and glycosaminoglycans research; Analytical Chemistry and Chromatography
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: March 17, 2025

2025 article

Release of Per- and Polyfluoroalkyl Substances from Municipal and Construction and Demolition Waste Landfills and Wastewater Treatment Plants in North Carolina

Thelusmond, J.-R., Sardarmehni, M., Destefano, N., Weed, R., Knappe, D. R. U., & Barlaz, M. A. (2025, March 6). ACS ES&T WATER, Vol. 3.

By: J. Thelusmond n, M. Sardarmehni n, N. Destefano n, R. Weed n, D. Knappe n & M. Barlaz n

author keywords: landfill leachate; domesticwastewater; municipalsolid waste; perfluoroalkyl sulfonic acids; perfluoroalkylcarboxylic acids; fluorotelomer acids; per- andpolyfluoroalkyl ether acids
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Toxic Organic Pollutants Impact; Atmospheric chemistry and aerosols
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 6, 2025

2025 journal article

Part A: Implementing an Analyte Panel and Sampling Protocol for Quality Control in Mass Spectrometry Imaging

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 39(8).

By: Q. Mills n, R. Kibbe n, A. Sohn n, A. Percy*, K. Backiel* & D. Muddiman n

author keywords: IR-MALDESI; mass spectrometry imaging; quality control; stable isotope labeled; system suitability testing
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Analytical Chemistry and Chromatography
Sources: Web Of Science, NC State University Libraries
Added: March 3, 2025

2025 journal article

Part B: SLICE-MSI-A Machine Learning Interface for System Suitability Testing of Mass Spectrometry Imaging Platforms

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 39(8).

By: R. Kibbe n, Q. Mills n, A. Sohn n & D. Muddiman n

author keywords: graphical user interface; machine learning; mass spectrometry imaging; quality control; system suitability testing
topics (OpenAlex): Machine Learning in Materials Science; Metabolomics and Mass Spectrometry Studies; Mass Spectrometry Techniques and Applications
Sources: Web Of Science, NC State University Libraries
Added: March 3, 2025

2025 journal article

Comparison of Mid-Infrared and Ultraviolet Lasers Coupled to the MALDESI Source for the Detection of Secondary Metabolites and Structural Lipids in <i>Arabidopsis thaliana</i>

JOURNAL OF MASS SPECTROMETRY, 60(3).

By: S. Ashbacher n, J. Manni & D. Muddiman n

author keywords: MALDESI; mass spectrometry imaging; mid-infrared; plants; ultraviolet
MeSH headings : Arabidopsis / chemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Lasers; Ultraviolet Rays; Secondary Metabolism; Lipids / analysis; Lipids / chemistry; Flavonoids / analysis; Flavonoids / chemistry; Infrared Rays; Glucosinolates / analysis; Glucosinolates / chemistry; Plant Leaves / chemistry; Galactolipids / analysis; Galactolipids / chemistry; Fatty Acids / analysis; Fatty Acids / chemistry
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Metabolomics and Mass Spectrometry Studies
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 28, 2025

2025 article

Three-dimensional mass spectrometry imaging (3D MSI): incorporating top-hat IR-MALDESI and automatic <i>z</i>-axis correction

Sohn, A. L., Witherspoon, J. G., Smart, R. C., & Muddiman, D. C. (2025, February 3). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 2.

By: A. Sohn n, J. Witherspoon n, R. Smart n & D. Muddiman n

author keywords: 3D; Mass spectrometry imaging; Lipids; Automatic <italic>z</italic>-axis correction; Top-hat
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Metabolomics and Mass Spectrometry Studies
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 3, 2025

2024 book

Tissue Proteomics

In T. I. Williams (Ed.), Springer (Vol. 2700).

By: T. Williams

Contributors: T. Williams

Ed(s): T. Williams

topics (OpenAlex): Molecular Biology Techniques and Applications; Advanced Proteomics Techniques and Applications
Source: ORCID
Added: January 6, 2025

2024 journal article

In-depth characterization of <i>N</i>-glycosylation and sialic acid content in fetal and adult fibrinogen

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS, 8(8).

author keywords: fetal; fibrinogen; glycan; mass spectrometry; neonate; sialic acid
topics (OpenAlex): Blood properties and coagulation; Glycosylation and Glycoproteins Research; Proteoglycans and glycosaminoglycans research
Sources: Web Of Science, NC State University Libraries
Added: December 16, 2024

2024 journal article

Auranofin is lethal against feline<i> Tritrichomonas</i><i> foetus</i> in vitro but ineffective in cats with naturally occurring infection

VETERINARY PARASITOLOGY, 331.

By: J. Gookin n, M. Papich n, E. Meier n, J. Enders n, S. Stauffer n, E. Wassack n, G. Davidson n

author keywords: Gold salt; Protozoa; Diarrhea; Ion mobility mass spectrometry; High performance liquid chromatography; Inductively coupled plasma mass spectrometry; Colitis
MeSH headings : Animals; Tritrichomonas foetus / drug effects; Cats; Cat Diseases / drug therapy; Cat Diseases / parasitology; Auranofin / pharmacology; Auranofin / therapeutic use; Protozoan Infections, Animal / drug therapy; Protozoan Infections, Animal / parasitology; Antiprotozoal Agents / pharmacology; Antiprotozoal Agents / therapeutic use; Feces / parasitology; Male; Female
topics (OpenAlex): Reproductive tract infections research; Parasitic Infections and Diagnostics; Amoebic Infections and Treatments
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 9, 2024

2024 journal article

The biochemical effects of carotenoids in orange carrots on the colonic proteome in a mouse model of diet-induced obesity

FRONTIERS IN NUTRITION, 11.

By: E. Balbuena n, F. Milhem n, B. Kiremitci n, T. Williams n, L. Collins n, Q. Shu n, A. Eroglu n

Contributors: E. Balbuena n, F. Milhem n, B. Kiremitci n, T. Williams n, L. Collins n, Q. Shu n, A. Eroglu n

author keywords: carotenoids; quantitative proteomics; colon; intestinal barrier; diet-induced obesity
topics (OpenAlex): Antioxidant Activity and Oxidative Stress; Cholesterol and Lipid Metabolism; Adipokines, Inflammation, and Metabolic Diseases
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 2, 2024

2024 article

Quantitative sampling by IR-MALDESI is not susceptible to tissue heterogeneity in a multi-organ model

Joignant, A. N., Hector, E. C., Barnes, M. M., Kullman, S. W., & Muddiman, D. C. (2024, November 13). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 11.

By: A. Joignant n, E. Hector n, M. Barnes n, S. Kullman n & D. Muddiman n

author keywords: IR-MALDESI; Mass spectrometry imaging; Quantitative; Zebrafish
MeSH headings : Animals; Zebrafish; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Liver / chemistry
topics (OpenAlex): Spectroscopy Techniques in Biomedical and Chemical Research; Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 25, 2024

2024 article

Obtaining 20 μm Spatial Resolution with a 2940 nm Laser by IR-MALDESI Mass Spectrometry Imaging

Eisenberg, S. M., Joignant, A. N., Knizner, K. T., Manni, J. G., & Muddiman, D. C. (2024, November 8). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 11.

By: S. Eisenberg n, A. Joignant n, K. Knizner n, J. Manni & D. Muddiman n

author keywords: IR-MALDESI; mass spectrometry imaging; mid-IRlaser; spatial resolution
MeSH headings : Animals; Mice; Lasers; Mass Spectrometry / methods; Liver / chemistry; Liver / diagnostic imaging; Brain / diagnostic imaging; Brain / metabolism; Brain Chemistry; Lipids / analysis; Lipids / chemistry; Neurotransmitter Agents / analysis
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Spectroscopy Techniques in Biomedical and Chemical Research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 18, 2024

2024 article

Assembly of a Heterobimetallic Fe/Mn Cofactor in the <i>para</i>-Aminobenzoate Synthase Chlamydia Protein Associating with Death Domains (CADD) Initiates Long-Range Radical Hole-Hopping

Phan, H. N., Swartz, P. D., Gangopadhyay, M., Guo, Y., Smirnov, A. I., & Makris, T. M. (2024, October 29). BIOCHEMISTRY, Vol. 10.

By: H. Phan n, P. Swartz n, M. Gangopadhyay*, Y. Guo*, A. Smirnov n & T. Makris n

MeSH headings : Manganese / metabolism; Manganese / chemistry; Iron / metabolism; Iron / chemistry; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Bacterial Proteins / genetics; Chlamydia trachomatis / enzymology; Chlamydia trachomatis / metabolism; Crystallography, X-Ray; Catalytic Domain; Models, Molecular; 4-Aminobenzoic Acid / chemistry; 4-Aminobenzoic Acid / metabolism; Electron Spin Resonance Spectroscopy
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Porphyrin Metabolism and Disorders; Enzyme Structure and Function
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 29, 2024

2024 journal article

Absolute Quantification of Glutathione Using Top-Hat Optics for IR-MALDESI Mass Spectrometry Imaging

JOURNAL OF MASS SPECTROMETRY, 59(10).

By: E. Bruce n, R. Kibbe n, E. Hector n & D. Muddiman n

author keywords: diffractive optical element; mass spectrometry imaging; qMSI; top-hat IR-MALDESI
MeSH headings : Glutathione / analysis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Animals
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Metabolomics and Mass Spectrometry Studies
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 30, 2024

2024 article

Turning the Tide Toward Equity: Gender Disparities in Scientific Publishing in Biomedical Mass Spectrometry

Sahoo, A., Chie, C., Muddiman, D. C., & Samal, J. (2024, September 24). GEN BIOTECHNOLOGY, Vol. 9.

By: A. Sahoo*, C. Chie*, D. Muddiman n & J. Samal*

topics (OpenAlex): Diversity and Career in Medicine; scientometrics and bibliometrics research; Health and Medical Research Impacts
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
4. Quality Education (Web of Science)
5. Gender Equality (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 30, 2024

2024 article

Leveraging Supervised Machine Learning Algorithms for System Suitability Testing of Mass Spectrometry Imaging Platforms

Kibbe, R. R., Sohn, A. L., & Muddiman, D. C. (2024, September 3). JOURNAL OF PROTEOME RESEARCH, Vol. 9.

By: R. Kibbe n, A. Sohn n & D. Muddiman n

author keywords: mass spectrometry imaging; machine learning; quality control; system suitability testing; IR-MALDESI
MeSH headings : Supervised Machine Learning; Algorithms; Mass Spectrometry / methods; Quality Control; Reproducibility of Results; Humans
topics (OpenAlex): Metabolomics and Mass Spectrometry Studies; Mass Spectrometry Techniques and Applications; Machine Learning in Materials Science
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: September 23, 2024

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