Molecular Education, Technology and Research Innovation Center

Works Published in 2008

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Displaying works 1 - 20 of 33 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2008 conference paper

Dynamic Biomolecular Measurements of Cellular Response by Ion Mobility-Mass Spectrometry: A New Strategy for Systems Biology

Presented at the Southeast Regional Meeting of the American Chemical Society, Nashville, TN.

By: J. Enders , S. Sundarapandian, K. Seale, J. Wikswo & J. McLean

Event: Southeast Regional Meeting of the American Chemical Society at Nashville, TN

Source: NC State University Libraries
Added: March 12, 2022

2008 conference paper

Ion Mobility Mass Spectrometry of the products of oligomerization of activated nucleotides with Montmorillonite

Presented at the American Society for Mass Spectrometry Annual Conference, Denver, CO.

By: J. Enders , L. Fenn, M. Aldersley, J. Ferris, P. Joshi, J. Mclean, D. Zagorevski

Event: American Society for Mass Spectrometry Annual Conference at Denver, CO

Source: NC State University Libraries
Added: March 12, 2022

2008 conference paper

The Development of a Nano-LC Mass Spectrometric Method for Profiling Glycans in Epithelial Ovarian Cancer (EOC) and Control Plasma

Presented at the Triangle Chromatography Symposium and Instrument Exhibit, Raleigh, NC.

By: M. Bereman, T. Williams & D. Muddiman

Event: Triangle Chromatography Symposium and Instrument Exhibit at Raleigh, NC

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

Analysis of O-linked Glycans Derived from Normal and Diseased EOC Plasma by Nano LC-ESI-FTICR Mass Spectrometry

Presented at the American Society for Mass Spectrometry, Denver, CO.

By: M. Bereman, T. Williams, A. Hawkridge & D. Muddiman

Event: American Society for Mass Spectrometry at Denver, CO

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

Innovative Technology Development Directed at the Elucidation of Biomarkers for the Detection of Early-Stage Ovarian Cancer

Presented at the Meeting for the Innovative Molecular Analysis Technologies (IMAT) Program of the National Cancer Institute, Cambridge, MA.

By: T. Williams, M. Bereman, D. Williams & D. Muddiman

Event: Meeting for the Innovative Molecular Analysis Technologies (IMAT) Program of the National Cancer Institute at Cambridge, MA

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

In Search of Epithelial Ovarian Cancer Molecular Markers by MALDI-FT-ICR-MS and NANO-LC-LTQ-ORBITRAP-MS

Presented at the Mass Spectrometry Applications to the Clinical Laboratory, University of California - San Diego, San Diego, CA.

By: T. Williams, M. Bereman, D. Nielsen, K. Kalli, W. Cliby & D. Muddiman

Event: Mass Spectrometry Applications to the Clinical Laboratory at University of California - San Diego, San Diego, CA

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

Glycan Profiling in Plasma: Fundamentals and Applications to Ovarian Cancer

Presented at the Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, New Orleans, LA.

By: T. Williams & D. Muddiman

Event: Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy at New Orleans, LA

Source: NC State University Libraries
Added: March 6, 2022

2008 speech

Applications of Carbohydrate Profiling in Ovarian Cancer Plasma Glycoproteins

Presented at the Longwood University, Farmville, VA.

By: T. Williams & D. Muddiman

Event: Longwood University at Farmville, VA

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

Epithelial Ovarian Cancer Detection by Glycan Profiling in Blood

Presented at the North Carolina State University, Raleigh, NC.

By: T. Williams & D. Muddiman

Event: North Carolina State University at Raleigh, NC

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

Mining the Plasma Glycome for Epithelial Ovarian Cancer Biomarker Discovery

Presented at the American Society for Mass Spectrometry, Denver, CO.

By: T. Williams, D. Nielsen, W. Cliby, K. Kalli & D. Muddiman

Event: American Society for Mass Spectrometry at Denver, CO

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

A Combinatorial Approach: The Use of MALDI-MS and Nano LC-MS for Glycan Biomarker Discovery

Presented at the Protein Biomarkers Meeting, Philadelphia, PA.

By: T. Williams, M. Bereman, D. Nielsen, K. Kalli, W. Cliby & D. Muddiman

Event: Protein Biomarkers Meeting at Philadelphia, PA

Source: NC State University Libraries
Added: March 6, 2022

2008 conference paper

Glycan Analysis by Nano LC-MS: Applications for Biomarker Discovery in Epithelial Ovarian Cancer (EOC)

Presented at the Atlanta Athens Mass Spectrometry Discussion Group Symposium, University of Georgia, Athens, GA.

By: M. Bereman, T. Williams, K. Kalli, W. Cliby & D. Muddiman

Event: Atlanta Athens Mass Spectrometry Discussion Group Symposium at University of Georgia, Athens, GA

Source: NC State University Libraries
Added: March 6, 2022

2008 journal article

Formaldehyde-Induced Histone Modifications in Vitro

Chemical Research in Toxicology, 21(8), 1586–1593.

By: K. Lu *, G. Boysen *, L. Gao *, L. Collins*  & J. Swenberg*

MeSH headings : Binding Sites; Chromatography, High Pressure Liquid; Cross-Linking Reagents / chemistry; Cross-Linking Reagents / metabolism; DNA / drug effects; DNA Damage; Formaldehyde / chemistry; Formaldehyde / metabolism; Histones / chemistry; Histones / metabolism; In Vitro Techniques; Lysine / chemistry; Lysine / metabolism; Peptide Fragments / chemistry; Peptide Mapping; Protein Binding; Protein Structure, Tertiary; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry
TL;DR: The observation that only lysine residues without post-translational modification (PTM) can be attacked by formaldehyde indicates that PTM blocks the reaction betweenlysine and formaldehyde. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 5, 2021

2008 journal article

A mass spectrometric method to simultaneously measure a biomarker and dilution marker in exhaled breath condensate

Rapid Communications in Mass Spectrometry, 22(5), 701–705.

By: C. Esther *, H. Jasin*, L. Collins* , J. Swenberg* & G. Boysen *

MeSH headings : Adenosine / analysis; Adenosine / metabolism; Adenosine Monophosphate / analysis; Adenosine Monophosphate / metabolism; Biomarkers / analysis; Biomarkers / metabolism; Breath Tests / methods; Bronchi / metabolism; Child; Chromatography, High Pressure Liquid; Cystic Fibrosis / metabolism; Exhalation; Humans; Prospective Studies; Spectrometry, Mass, Electrospray Ionization / methods; Tandem Mass Spectrometry / methods; Urea / analysis; Urea / metabolism
TL;DR: It is demonstrated that mass spectrometry can be used successfully in EBC analysis to simultaneously detect a biomarker for airway inflammation and control for variable dilution. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 5, 2021

2008 journal article

Effect of Plasma Protein Depletion on BNP-32 Recovery

Clinical Chemistry, 54(5), 933–934.

By: A. Hawkridge  n, D. Muddiman n , D. Hebulein*, A. Cataliotti * & J. Burnett*

Sources: NC State University Libraries, NC State University Libraries
Added: March 5, 2021

2008 journal article

Human Proteinpedia enables sharing of human protein data

Nature Biotechnology, 26(2), 164–167.

By: S. Mathivanan *, M. Ahmed *, N. Ahn *, H. Alexandre*, R. Amanchy*, P. Andrews*, J. Bader *, B. Balgley ...

MeSH headings : Database Management Systems; Databases, Protein; Gene Expression Profiling / methods; Information Storage and Retrieval / methods; Internationality; Internet; Magnetic Resonance Spectroscopy / methods; Peptide Mapping / methods; Proteome / chemistry; Proteome / classification; Proteome / metabolism; Proteomics / methods; Software; User-Computer Interface
TL;DR: MMCD is a practical tool for expediting the time-consuming steps of identifying and researching small molecules and is compatible with both NMR and MS data and facilitates high-throughput metabolomics investigations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: February 24, 2020

2008 journal article

Synthesis, Characterization, and Application of Iodoacetamide Derivatives Utilized for the ALiPHAT Strategy

Journal of the American Chemical Society, 130(7), 2122–2123.

By: D. Williams n, C. Meadows n, I. Bori n, A. Hawkridge  n, D. Comins n & D. Muddiman n 

MeSH headings : Alkylation; Amino Acid Sequence; Cysteine / chemistry; Factor VIIIa / antagonists & inhibitors; Hydrophobic and Hydrophilic Interactions; Iodoacetamide / analogs & derivatives; Iodoacetamide / chemical synthesis; Iodoacetamide / chemistry; Molecular Sequence Data; Peptides / analysis; Peptides / chemistry; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR: Hydrophobic tags, derived from iodoacetamide, were synthesized, characterized, and utilized to alkylate peptide E-76, a known inhibitor of coagulation factor VIIIa, and two other cysteine containing peptides to demonstrate an increase in electrospray response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2008 journal article

Phthalate Induction of CYP3A4 is Dependent on Glucocorticoid Regulation of PXR Expression

Toxicological Sciences, 103(2), 268–277.

By: B. Cooper n, T. Cho n, P. Thompson n  & A. Wallace n

author keywords: pregnane X receptor; CYP3A4; DEHP; MEHP; glucocorticoid
MeSH headings : Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome P-450 CYP3A / biosynthesis; Dexamethasone / pharmacology; Diethylhexyl Phthalate / analogs & derivatives; Diethylhexyl Phthalate / toxicity; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction / drug effects; Glucocorticoids / pharmacology; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Plasticizers / toxicity; Pregnane X Receptor; Rats; Receptors, Steroid / drug effects; Receptors, Steroid / metabolism; Transcription, Genetic / drug effects; Transfection
TL;DR: It is suggested that the magnitude of CYP3A4 induction by phthalates is dependent on the expression of PXR and may be significantly higher in the presence of glucocorticoids and may play a role in altered efficacy of pharmaceutical agents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: December 10, 2019

2008 journal article

Calibration laws based on multiple linear regression applied to matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry

JOURNAL OF MASS SPECTROMETRY, 43(12), 1659–1663.

By: D. Williams n, M. Chadwick n, T. Williams n  & D. Muddiman n 

Contributors: D. Williams Jr., M. Chadwick n, T. Williams n  & D. Muddiman n 

author keywords: multiple linear regression; polypropylene glycol; calibration; matrix-assisted laser desorption/ionization (MALDI); Fourier transform ion cyclotron mass spectrometry (FT-ICR-MS); space-charge effects
MeSH headings : Calibration; Cyclotrons; Fourier Analysis; Linear Models; Mass Spectrometry / methods; Multivariate Analysis; Peptide Mapping / methods; Peptide Mapping / statistics & numerical data; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: An evaluation of external mass calibration laws applied to MALDI-FT-ICR-MS is performed to achieve higher mass measurement accuracy (MMA) in Fourier transform ion cyclotron resonance mass spectrometry. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2008 journal article

Investigations with O-linked protein glycosylations by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry

JOURNAL OF MASS SPECTROMETRY, 43(9), 1215–1223.

By: T. Williams n , D. Saggese n, K. Toups n, J. Frahm n, H. An *, B. Li*, C. Lebrilla *, D. Muddiman n 

Contributors: T. Williams n , D. Saggese n, K. Toups n, J. Frahm n, H. An *, B. Li*, C. Lebrilla *, D. Muddiman n 

author keywords: Fourier transform ion cyclotron mass spectrometry (FT-ICR-MS); matrix-assisted laser desorption/ionization (MALDI); mucin; O-linked glycans; protein glycosylations
MeSH headings : Angiotensins / chemistry; Animals; Glycosylation; Mucins / chemistry; Oligosaccharides / chemistry; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Spectroscopy, Fourier Transform Infrared / methods; Swine; Tandem Mass Spectrometry / methods
TL;DR: A detailed examination of sample preparation and matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FT-ICR-MS) analysis of O-linked glycans globally cleaved from mucin glycoproteins is presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

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