Works Published in 2009
Displaying works 1 - 20 of 38 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2009 conference paper
Microfluidic-ion mobility-mass spectrometry for assessing cellular response in real time
Presented at the Quantitative Understanding in Biology (q-bio) Annual Conference, Santa Fe, NM.
Event: Quantitative Understanding in Biology (q-bio) Annual Conference at Santa Fe, NM
Source: NC State University Libraries
Added: March 12, 2022
2009 conference paper
Measuring real-time cellular responses to chemical and biological warfare agents using structural mass spectrometry techniques
Presented at the Chemical and Biological Defense Science and Technology (CBD S&T) Conference, Dallas, TX.
Event: Chemical and Biological Defense Science and Technology (CBD S&T) Conference at Dallas, TX
Source: NC State University Libraries
Added: March 12, 2022
2009 conference paper
Real time analysis of cell signaling and response using microfluidic cell trapping-ion mobility-mass spectrometry
Presented at the Federation of Analytical Chemistry and Spectroscopy Societies Conference, Louisville, KY.
Event: Federation of Analytical Chemistry and Spectroscopy Societies Conference at Louisville, KY
Source: NC State University Libraries
Added: March 12, 2022
2009 conference paper
Microfluidic-ion mobility-mass spectrometry for assessing cellular response in real time
Presented at the Quantitative Understanding in Biology (q-bio) Annual Conference, Santa Fe, NM.
Event: Quantitative Understanding in Biology (q-bio) Annual Conference at Santa Fe, NM
Source: NC State University Libraries
Added: March 12, 2022
2009 conference paper
Combining microfluidic cell trapping with real time monitoring of biomolecular exudates by ion mobility-mass spectrometry
Presented at the American Society for Mass Spectrometry Annual Conference, Philadelphia, PA.
Event: American Society for Mass Spectrometry Annual Conference at Philadelphia, PA
Source: NC State University Libraries
Added: March 12, 2022
2009 conference paper
Proteomic Profiling of Populus trichocarpa for the Interrogation of Molecular Mechanisms behind Wood Formation
Presented at the American Society for Mass Spectrometry, Philadelphia, PA.
Event: American Society for Mass Spectrometry at Philadelphia, PA
Source: NC State University Libraries
Added: March 6, 2022
2009 conference paper
The Development of Nano LC Mass Spectrometric Methods for Profiling Glycans in Epithelial Ovarian Cancer (EOC) and Control Plasma
Presented at the 60th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Chicago, IL.
Event: 60th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy at Chicago, IL
Source: NC State University Libraries
Added: March 6, 2022
2009 conference paper
Accurate Mass Measurements in FTMS with Automatic Gain Control
Presented at the Pharmaceutical Interest Group, American Society for Mass Spectrometry, Philadelphia, PA.
Event: Pharmaceutical Interest Group, American Society for Mass Spectrometry at Philadelphia, PA
Source: NC State University Libraries
Added: March 6, 2022
2009 journal article
Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-l-cysteine
Toxicology and Applied Pharmacology, 238(1), 90–99.
author keywords: Trichloroethylene; Metabolism; Pharmacokinetics; Trichloroacetic acid; Dichloroacetic acid; S-(1,2-dichlorovinyl)glutathione; S-(1,2-dichlorovinyl)-L-cysteine
MeSH headings : Administration, Oral; Animals; Biological Availability; Carcinogens / pharmacokinetics; Cysteine / analogs & derivatives; Cysteine / pharmacokinetics; Dichloroacetic Acid / pharmacokinetics; Glutathione / analogs & derivatives; Glutathione / metabolism; Glutathione / pharmacokinetics; Half-Life; Male; Mice; Models, Biological; Oxidation-Reduction; Risk Assessment; Time Factors; Trichloroacetic Acid / pharmacokinetics; Trichloroethylene / pharmacokinetics
TL;DR:
In B6C3F1 mice, oxidative metabolites are formed in much greater quantities than glutathione-conjugative metabolites, and TCE-oxide is the most likely source of DCA, while most of DCVG is converted into DCVC.
(via Semantic Scholar)
europepmc.org (repository)
Sources: Crossref, NC State University Libraries
Added: September 5, 2021
2009 journal article
Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine
Toxicology, 262(3), 230–238.
author keywords: Trichloroethylene metabolites; HPLC-ESI-MS/MS; Dichloroacetic acid; Trichloroacetic acid; S-(1,2-dichlorovinyl)-L-cysteine; S-(1,2-dichlorovinyl)glutathione; HILIC
MeSH headings : Animals; Chromatography, High Pressure Liquid / methods; Cysteine / analogs & derivatives; Cysteine / blood; Dichloroacetic Acid / blood; Glutathione / analogs & derivatives; Glutathione / blood; Male; Mice; Spectrometry, Mass, Electrospray Ionization / methods; Tandem Mass Spectrometry / methods; Trichloroacetic Acid / blood; Trichloroethylene / metabolism
TL;DR:
This method was applied successfully to measure all 4 TCE metabolites in as little as 50 microl of serum from mice orally exposed to TCE, opening new opportunities to increase throughput and decrease number of animals required for mechanistic studies on TCE in rodents.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 5, 2021
2009 journal article
Accurate quantitation of standard peptides used for quantitative proteomics
Proteomics, 9(15), 3939–3944.
author keywords: Peptide standards; Quality control; Quantitative analysis
MeSH headings : Chromatography, Liquid / economics; Chromatography, Liquid / methods; Peptides / analysis; Proteomics / economics; Proteomics / methods; Sensitivity and Specificity; Tandem Mass Spectrometry / economics; Tandem Mass Spectrometry / methods
TL;DR:
The presented method utilizes ultra performance LC‐ MS/MS (UPLC‐MS/MS) to accurately quantify peptide standards at concentrations of 0.1–10 μM, and the high sensitivity of the method minimizes the amounts required.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 5, 2021
2009 journal article
Development of an Ultraperformance Liquid Chromatography/Mass Spectrometry Method To Quantify Cisplatin 1,2 Intrastrand Guanine−Guanine Adducts
Chemical Research in Toxicology, 22(5), 905–912.
MeSH headings : Animals; Carboplatin / chemistry; Cattle; Cell Line, Tumor; Chromatography, High Pressure Liquid / methods; Cisplatin / chemistry; DNA / chemistry; Female; Guanine / chemistry; Mice; Mice, Inbred C57BL; Ribonucleosides / chemistry; Tandem Mass Spectrometry / methods
TL;DR:
An ultraperformance liquid chromatography tandem mass spectrometry assay for quantification of 1,2 guanine-guanine intrastrand cisplatin adducts, using (15)N(10) CP-d(GpG) as an internal standard, was developed and suggested that this method is suitable for in vitro and in vivo assessment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 5, 2021
2009 journal article
Comparison of three oxidative stress biomarkers in a sample of healthy adults
Biomarkers, 14(8), 587–595.
author keywords: Oxidation DNA damage; lipid peroxidation; 8-hydroxy-2-deoxyguanosine; comet assay; isoprostanes
MeSH headings : 8-Hydroxy-2'-Deoxyguanosine; Adult; Biomarkers / analysis; Biomarkers / metabolism; Comet Assay; DNA Damage; DNA-Formamidopyrimidine Glycosylase; Deoxyguanosine / analogs & derivatives; Deoxyguanosine / metabolism; F2-Isoprostanes / metabolism; Female; Humans; Lipid Peroxidation; Male; Middle Aged; Oxidative Stress
TL;DR:
Results are informative for researchers seeking to compare results pertaining to oxidative stress across studies and/or assessment methods in healthy disease-free populations and additional validation studies are necessary to establish accuracy and comparability across oxidative stress biomarkers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 5, 2021
2009 journal article
Enhanced analysis of steroids by gas chromatography/mass spectrometry using microwave-accelerated derivatization
Analytical Chemistry, 81(16), 6725–6734.
Contributors: J. Bowden *, D. Colosi*, W. Stutts* , D. Mora-Montero*, T. Garrett * & R. Yost *
MeSH headings : Gas Chromatography-Mass Spectrometry / methods; Microwaves; Reproducibility of Results; Steroids / analysis
TL;DR:
This study highlights the best methods for analyzing a comprehensive variety of steroids and also provides ideal strategies for MAD of steroids on an individual or class level.
(via Semantic Scholar)
Source: ORCID
Added: May 20, 2021
2009 journal article
The soluble proteome of the Drosophila antenna.
Chemical Senses, 1(1), 21–30.
Contributors: R. Anholt n & T. Williams n
author keywords: chemosensation; mass spectrometry; odorant-binding proteins; olfaction; proteomics
MeSH headings : Amino Acid Sequence; Animals; Drosophila melanogaster / metabolism; Female; Male; Mass Spectrometry; Molecular Sequence Data; Nanotechnology; Proteome / chemistry; Proteome / metabolism; Receptors, Odorant / metabolism; Smell; Trypsin / metabolism
TL;DR:
A simple method for the large-scale detection of soluble proteins from the Drosophila antenna by chromatographic separation of tryptic peptides followed by tandem mass spectrometry with femtomole detection sensitivities is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, NC State University Libraries
Added: April 8, 2021
2009 journal article
Hyaluronidase Activity of Human Hyal1 Requires Active Site Acidic and Tyrosine Residues
Journal of Biological Chemistry, 284(14), 9433–9442.
MeSH headings : Acids / chemistry; Biocatalysis; Catalytic Domain; Cell Line; Crystallography, X-Ray; Disulfides / chemistry; Glycosylation; Humans; Hyaluronoglucosaminidase / chemistry; Hyaluronoglucosaminidase / genetics; Hyaluronoglucosaminidase / metabolism; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mutation / genetics; Oligosaccharides / chemistry; Oligosaccharides / metabolism; Protein Structure, Tertiary; Tyrosine / genetics; Tyrosine / metabolism
TL;DR:
Structural information, site-directed mutagenesis, and steady state enzyme kinetics are used to probe molecular determinants of human Hyal1 function and define key components of Hyal 1 active site catalysis, and structural factors critical for stability.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2009 journal article
Mechanistic Details of Glutathione Biosynthesis Revealed by Crystal Structures of Saccharomyces cerevisiae Glutamate Cysteine Ligase
Journal of Biological Chemistry, 284(47), 32700–32708.
MeSH headings : Binding Sites; Catalytic Domain; Crystallography, X-Ray / methods; Escherichia coli / metabolism; Glutamate-Cysteine Ligase / chemistry; Glutathione / chemistry; Humans; Magnesium / chemistry; Magnesium Chloride / chemistry; Models, Molecular; Mutation; Protein Conformation; Protein Processing, Post-Translational; Saccharomyces cerevisiae / metabolism; Software; Sulfhydryl Compounds / chemistry
TL;DR:
Structural data are determined and Examination of the hGCLC model suggests that post-translational modifications of cysteine residues may be involved in the regulation of enzymatic activity, and elucidates the molecular basis of glutathione deficiency associated with patient hG CLC mutations.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2009 journal article
Crystal Structure of Acivicin-Inhibited γ-Glutamyltranspeptidase Reveals Critical Roles for Its C-Terminus in Autoprocessing and Catalysis†‡
Biochemistry, 48(11), 2459–2467.
MeSH headings : Amino Acid Motifs; Amino Acid Sequence; Bacterial Proteins / antagonists & inhibitors; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Catalysis; Crystallography, X-Ray; Enzyme Inhibitors / chemistry; Helicobacter pylori / chemistry; Helicobacter pylori / enzymology; Helicobacter pylori / genetics; Isoxazoles / chemistry; Kinetics; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Processing, Post-Translational; Sequence Alignment; Substrate Specificity; gamma-Glutamyltransferase / antagonists & inhibitors; gamma-Glutamyltransferase / chemistry; gamma-Glutamyltransferase / genetics; gamma-Glutamyltransferase / metabolism
TL;DR:
Structural determination of acivicin-modified HpGT demonstrates that ac civicin is accommodated within the gamma-glutamyl binding pocket of the enzyme, underscoring its importance in catalysis.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2009 journal article
Species-dependent hepatic metabolism of immunosuppressive agent tacrolimus (FK-506)
Xenobiotica, 39(10), 757–765.
author keywords: Tacrolimus; species differences; liver microsomes; cytochrome P-450; secondary ion mass spectrometry (SIMS); matrix-assisted laser desorption ionization (MALDI)
MeSH headings : Animals; Chromatography, High Pressure Liquid; Cricetinae; Cytochrome P-450 Enzyme System / metabolism; Dogs; Guinea Pigs; Humans; Immunosuppressive Agents / chemistry; Immunosuppressive Agents / metabolism; Kinetics; Microsomes, Liver / enzymology; Papio; Rabbits; Rats; Species Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tacrolimus / chemistry; Tacrolimus / metabolism
TL;DR:
From the current in-vitro metabolism studies, the pattern of tacroliums metabolism in baboons closely resembled that in humans and thus it is ideal for studying tacrolimus metabolism-related work of clinical relevance.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2009 journal article
Binding site on human immunoglobulin G for the affinity ligand HWRGWV
Journal of Molecular Recognition, n/a-n/a.
author keywords: hexamer ligand; immunoglobulin G; glycosylation; mass spectrometry; computational docking; binding site
MeSH headings : Amino Acid Sequence; Animals; Binding Sites; Endopeptidases / metabolism; Humans; Immunoglobulin Fc Fragments / metabolism; Immunoglobulin G / chemistry; Immunoglobulin G / metabolism; Ligands; Models, Molecular; Molecular Sequence Data; Nerve Tissue Proteins / metabolism; Oligopeptides / chemistry; Oligopeptides / genetics; Oligopeptides / metabolism; Pepsin A / metabolism; Protein Binding; Protein Structure, Tertiary; Sequence Alignment; Staphylococcal Protein A / metabolism
TL;DR:
The results support the fact that a peptide as small as a hexamer can have specific interactions with large proteins such as hIgG and the HWRGWV ligand.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 24, 2020
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