Works Published in 2012
Displaying works 1 - 20 of 26 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 conference paper
Development of a Platform for Online Analysis of the Metabolic Footprint
Presented at the Association for Mass Spectrometry: Applications to the Clinical Laboratory (MSACL) Annual Conference, San Diego, CA.
Event: Association for Mass Spectrometry: Applications to the Clinical Laboratory (MSACL) Annual Conference at San Diego, CA
Source: NC State University Libraries
Added: March 12, 2022
2012 conference paper
Online analysis of a constant-perfusion cell culture microfluidic device for exometabolomic measurements
Presented at the 60th American Society for Mass Spectrometry Annual Conference, Vancouver, BC.
Event: 60th American Society for Mass Spectrometry Annual Conference at Vancouver, BC
Source: NC State University Libraries
Added: March 12, 2022
2012 conference paper
Strategies and Challenges in Dynamic Systems Biology Analysis Using Structural Mass Spectrometry”
Strategies and Challenges in Dynamic Systems Biology Analysis Using Structural Mass Spectrometry.” Ion Mobility MS: Applying Ion Mobility-Mass Spectrometry to Challenges in Proteomics and Systems Biology. Workshop presented at the American Society for Mass Spectrometry (ASMS) Annual Conference, Vancouver, BC Canada.
Event: American Society for Mass Spectrometry (ASMS) Annual Conference at Vancouver, BC Canada
Source: NC State University Libraries
Added: March 12, 2022
2012 journal article
A New LC-MS/MS Method for the Quantification of Endogenous and Vinyl Chloride-Induced 7-(2-Oxoethyl)Guanine in Sprague–Dawley Rats
Chemical Research in Toxicology, 25(2), 391–399.
MeSH headings : Animals; Brain / metabolism; Chromatography, Liquid; DNA Adducts / analysis; DNA Adducts / metabolism; Guanine / analogs & derivatives; Guanine / analysis; Guanine / metabolism; Kidney / metabolism; Liver / metabolism; Lung / metabolism; Male; Rats; Rats, Sprague-Dawley; Spleen / metabolism; Tandem Mass Spectrometry; Testis / metabolism; Vinyl Chloride / pharmacokinetics
TL;DR:
A new sensitive LC-MS/MS method is reported to analyze the major DNA adduct formed by VC, 7-(2-oxoethylguanine) (7-OEG) to demonstrate for the first time that endogenous 7-Oeg was present in tissue DNA.
(via Semantic Scholar)
europepmc.org (repository)
Sources: Crossref, NC State University Libraries
Added: September 5, 2021
2012 journal article
The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation
Molecular Cell, 48(4), 612–626.
MeSH headings : Acetylation; Butyrates / metabolism; Cell Proliferation; HCT116 Cells; HT29 Cells; Histones / metabolism; Humans; Models, Biological; Tumor Cells, Cultured
TL;DR:
It is demonstrated that metabolic transformation plays an important role in the development of cancer cells and that butyrate stimulated the proliferation of normal colonocytes and cancerous colonocytes when the Warburg effect was prevented from occurring.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 5, 2021
2012 journal article
MALDI mass spectrometric imaging of cardiac tissue following myocardial infarction in a rat coronary artery ligation model
Analytical Chemistry, 84(2), 1117–1125.
Contributors: R. Menger*, W. Stutts* , D. Anbukumar *, J. Bowden *, D. Ford * & R. Yost *
MeSH headings : Animals; Coronary Vessels / metabolism; Coronary Vessels / pathology; Heart / physiology; Image Processing, Computer-Assisted; Ligation; Male; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry
TL;DR:
The investigation of an in vivo rat model of MI using mass spectrometric imaging (MSI) and multivariate data analysis suggests increased activity of phospholipase A(2), an enzyme that has been implicated in coronary heart disease and inflammation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 20, 2021
2012 journal article
Re-evaluating the role of ascorbic acid and phenolic glycosides in ozone scavenging in the leaf apoplast of Arabidopsis thaliana L.
Plant, Cell & Environment, 8.
author keywords: Air pollution; flavonoids; kaempferol; reactive oxygen; sinapoyl malate; vitamin C
MeSH headings : Arabidopsis / metabolism; Ascorbic Acid / metabolism; Biomass; Glycosides / metabolism; Ozone / metabolism; Phenols / metabolism; Plant Leaves / metabolism; Reactive Oxygen Species / metabolism
TL;DR:
Current understanding of O(3) defence schemes deserves reassessment as mechanisms other than direct scavenging of O (3) by extracellular AA and antioxidant activity of some phenolics may predominate in some plant species.
(via Semantic Scholar)
Source: ORCID
Added: April 8, 2021
2012 journal article
Polyubiquitin Is Required for Growth, Development and Pathogenicity in the Rice Blast Fungus Magnaporthe oryzae
PLoS ONE, 7(8), e42868.
Ed(s): K. Nielsen
MeSH headings : Boronic Acids / pharmacology; Bortezomib; Cluster Analysis; Fungal Proteins / genetics; Fungal Proteins / metabolism; Gene Expression Profiling; Gene Expression Regulation, Fungal; Germination / genetics; Magnaporthe / genetics; Magnaporthe / growth & development; Magnaporthe / pathogenicity; Mutation; Nitrogen / metabolism; Oryza / microbiology; Plant Diseases / microbiology; Polyubiquitin / genetics; Polyubiquitin / metabolism; Proteasome Inhibitors / pharmacology; Proteolysis / drug effects; Proteomics; Pyrazines / pharmacology; Ubiquitination
TL;DR:
This study suggests that ubiquitination of target proteins plays an important role in nutrient assimilation, development and pathogenicity of M. oryzae.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: February 27, 2021
2012 journal article
Poly Specific trans-Acyltransferase Machinery Revealed via Engineered Acyl-CoA Synthetases
ACS Chemical Biology, 8(1), 200–208.
MeSH headings : Acyltransferases / chemistry; Acyltransferases / genetics; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Chromatography, Liquid; Coenzyme A Ligases / chemistry; Coenzyme A Ligases / genetics; Crystallography, X-Ray; Genetic Variation; Models, Molecular; Substrate Specificity
TL;DR:
Results reveal that polyketide biosynthetic machinery might be more tolerant to non-natural substrates than previously established, and that mutant synthetases are valuable tools for probing the specificity of biosynthetics machinery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: January 18, 2021
2012 journal article
Alexander R. Ivanov, Alexander V. Lazarev (Eds): Sample preparation in biological mass spectrometry
Analytical and Bioanalytical Chemistry, 404(5), 1331–1332.
Sources: Crossref, ORCID
Added: January 18, 2021
2012 journal article
UDP-glucose Dehydrogenase Polymorphisms from Patients with Congenital Heart Valve Defects Disrupt Enzyme Stability and Quaternary Assembly
Journal of Biological Chemistry, 287(39), 32708–32716.
MeSH headings : Amino Acid Substitution; Animals; Animals, Genetically Modified / embryology; Animals, Genetically Modified / genetics; Enzyme Stability / genetics; Escherichia coli; Heart Defects, Congenital / embryology; Heart Defects, Congenital / enzymology; Heart Defects, Congenital / genetics; Heart Valve Diseases / embryology; Heart Valve Diseases / enzymology; Heart Valve Diseases / genetics; Heart Valves / embryology; Heart Valves / enzymology; Muscle Proteins / genetics; Muscle Proteins / metabolism; Mutation, Missense; Polymorphism, Genetic; Protein Structure, Quaternary; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Uridine Diphosphate Glucose Dehydrogenase; Zebrafish / embryology; Zebrafish / genetics; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
UGDH loss of function mutations result in a subset of human congenital cardiac valve defects caused by reduced enzyme activity during morphogenesis, consistent with the reduced function of both missense mutations significantly reducing the ability of UGDH to provide precursors for cardiac cushion formation, which is essential to subsequent valve formation.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
Comprehensive Quantification of Monolignol-Pathway Enzymes in Populus trichocarpa by Protein Cleavage Isotope Dilution Mass Spectrometry
Journal of Proteome Research, 11(6), 3390–3404.
author keywords: quantification; isotope dilution mass spectrometry; selected reaction monitoring; filter-aided sample preparation; monolignol biosynthesis
MeSH headings : Amino Acid Sequence; Biosynthetic Pathways; Isotope Labeling; Molecular Sequence Data; Plant Proteins / chemistry; Plant Proteins / metabolism; Populus / enzymology; Proteome / chemistry; Proteome / metabolism; Reference Standards; Spectrometry, Mass, Electrospray Ionization / standards; Xylem / enzymology
TL;DR:
This represents the most comprehensive assay for quantification of proteins regulating monolignol biosynthesis and will lead to a better understanding of lignin formation at a systems level.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Crossref, ORCID
Added: February 24, 2020
2012 entry reference
Multidimensional Separations by Ion Mobility-Mass Spectrometry
TL;DR:
The unique advantages of IM-MS in biological fields ranging from systems biology to structural biology are introduced, the context of which is introduced by a historical perspective of key advances accomplished over the last century.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 4, 2020
2012 journal article
A Dual-Column Solid Phase Extraction Strategy for Online Collection and Preparation of Continuously Flowing Effluent Streams for Mass Spectrometry
Analytical Chemistry, 84(20), 8467–8474.
Contributors: J. Enders* , C. Marasco*, J. Wikswo * & J. McLean*
MeSH headings : Bioreactors; Equipment Design; Mass Spectrometry / instrumentation; Microfluidic Analytical Techniques / instrumentation; Salts / isolation & purification; Solid Phase Extraction / instrumentation
TL;DR:
This work demonstrates that this dual-column online solid phase extraction (SPE) approach may be used for flow rates as low as 500 nL/min, with temporal resolving power on the order of 3 min, with analyte loadings ranging from femtomoles to picomoles for metabolites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 11, 2019
2012 journal article
Targeted Proteomics of the Secretory Pathway Reveals the Secretome of Mouse Embryonic Fibroblasts and Human Embryonic Stem Cells
MOLECULAR & CELLULAR PROTEOMICS, 11(12), 1829–1839.
MeSH headings : Animals; Cell Differentiation; Cells, Cultured; Culture Media, Conditioned / analysis; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Fibroblasts / cytology; Fibroblasts / metabolism; Humans; Mice; Proteins / analysis; Secretory Pathway; Subcellular Fractions / chemistry
TL;DR:
Targeted proteomics of secretory pathway organelles is shown to be a powerful alternate approach for interrogating the cellular secretome and expected to be particularly valuable in two contexts highly relevant to hESC biology: obtaining a temporal snapshot of proteins secreted in response to a differentiation trigger, and identifying proteinssecreted by cells that are isolated from a heterogeneous population.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 review
Analytical strategies for the global quantification of intact proteins
[Review of ]. AMINO ACIDS, 43(3), 1109–1117.
author keywords: Proteomics; Intact proteins; Quantitation; Mass spectrometry
MeSH headings : Animals; Humans; Mass Spectrometry; Proteome / chemistry; Proteome / isolation & purification; Proteome / metabolism; Proteomics; Staining and Labeling; Two-Dimensional Difference Gel Electrophoresis
TL;DR:
Techniques contained in this review include the more traditional and widely employed methodology of differential gel electrophoresis and more recently developed mass spectrometry-based techniques including metabolic labeling, chemical labeling, and label-free methodologies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Peptide Production and Decay Rates Affect the Quantitative Accuracy of Protein Cleavage Isotope Dilution Mass Spectrometry (PC-IDMS)
MOLECULAR & CELLULAR PROTEOMICS, 11(9), 814–823.
MeSH headings : Indicator Dilution Techniques; Isotope Labeling; Mass Spectrometry; Peptide Biosynthesis; Peptides / analysis; Peptides / chemistry; Peptides / metabolism; Populus / enzymology; Populus / metabolism; Proteolysis; Xylem / enzymology
TL;DR:
It is concluded that the instability of peptides can often significantly bias the protein quantities measured in protein cleavage isotope dilution mass spectrometry-based assays and suggest peptide stability be made a priority when selecting peptides to use for quantification.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Functional redundancy of the two 5-hydroxylases in monolignol biosynthesis of Populus trichocarpa: LC-MS/MS based protein quantification and metabolic flux analysis
PLANTA, 236(3), 795–808.
author keywords: Lignin; Syringyl lignin; Angiosperm; Kinetics; Subcellular localization
MeSH headings : Cloning, Molecular; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Hydroxylation; Kinetics; Lignin / analysis; Lignin / biosynthesis; Mixed Function Oxygenases / metabolism; Plants, Genetically Modified; Populus / metabolism; Xylem / enzymology; Yeasts / metabolism
TL;DR:
The combination of genetic analysis, absolute protein quantitation-based enzyme kinetics, homologous CPR specificity, SNP characterization, and ER localization provides a more rigorous basis for a comprehensive systems understanding of 5-hydroxylation in lignin biosynthesis.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
In-Depth Analysis of the Magnaporthe oryzae Conidial Proteome
JOURNAL OF PROTEOME RESEARCH, 11(12), 5827–5835.
author keywords: proteomics; mass spectrometry; Magnaporthe oryzae; FASP; statistical tests; differential protein expression
MeSH headings : Cell Nucleus / chemistry; Chemical Fractionation / methods; Chromatography, Liquid / methods; Cytoplasm / chemistry; Fungal Proteins / analysis; Fungal Proteins / chemistry; Magnaporthe / chemistry; Mass Spectrometry / methods; Nanotechnology; Nuclear Proteins / analysis; Nuclear Proteins / chemistry; Peptides / analysis; Peptides / chemistry; Proteome / analysis; Proteome / chemistry; Reproducibility of Results; Sensitivity and Specificity; Spores, Fungal / chemistry; Time Factors
TL;DR:
The identification of 2912 conidial proteins at a 1% protein false discovery rate (FDR) is reported and the most extensive study performed on M. oryzae conidia to date is presented, suggesting the detected proteins build a representative portion of the predicted proteome.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Coordination-Driven Self-Assembly of Charged and Neutral Dendritic Tetrakis(ferrocenyl) Rhomboids
ORGANOMETALLICS, 31(20), 7241–7247.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
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