Works Published in 2015
Displaying works 1 - 20 of 52 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
Proteomic Comparison and MRM-Based Comparative Analysis of Metabolites Reveal Metabolic Shift in Human Prostate Cancer Cell Lines
Journal of Proteome Research.
MeSH headings : AMP-Activated Protein Kinases / metabolism; Acetyl Coenzyme A / metabolism; Adenylate Kinase / metabolism; Cell Line, Tumor; Chromatography, Liquid / methods; Cluster Analysis; Fatty Acids / metabolism; Humans; Isotope Labeling / methods; Male; Mitochondria / metabolism; Models, Biological; Nucleotides / metabolism; Peptides / metabolism; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology; Proteome / classification; Proteome / metabolism; Proteomics / methods; Receptors, Androgen / metabolism; Reproducibility of Results; Signal Transduction; Tandem Mass Spectrometry / methods
TL;DR:
Most of the differentially expressed proteins between each pair function in metabolism, indicating a metabolic shift between AS and AI cells, as validated by multiple reaction monitoring (MRM)-based quantification of nucleotides and relative comparison of fatty acids between these cell lines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 2, 2023
2015 journal article
Profiling and Relative Quantitation of Phosphoinositides by Multiple Precursor Ion Scanning Based on Phosphate Methylation and Isotopic Labeling
Analytical Chemistry.
MeSH headings : Animals; Cattle; Chromatography, Liquid; Diazomethane / chemistry; Humans; Isotope Labeling; Lipids / analysis; Male; Methylation; Phosphates / chemistry; Phosphatidylinositols / analysis; Prostatic Neoplasms / metabolism; Spectrometry, Mass, Secondary Ion / methods
TL;DR:
DAG(+)-specific MPIS and isotopic labeling based MS analysis of phosphoinositides offers unique advantages over existing approaches and presents a powerful tool for research ofosphoinositide metabolism.
(via Semantic Scholar)
Source: ORCID
Added: May 2, 2023
2015 patent
METHODS OF MONITORING ADHERENCE TO LURASIDONE THERAPY
https://www.lens.org/142-044-808-933-676
Source: ORCID
Added: July 16, 2022
2015 conference paper
Rapid Mass Spectrometry Based Urine Drug Screening of 27 Antipsychotic and Antidepressant Medications
Presented at the Association for Mass Spectrometry Applications to the Clinical Lab (MSACL) 7th Annual Conference, San Diego, CA.
Event: Association for Mass Spectrometry Applications to the Clinical Lab (MSACL) 7th Annual Conference at San Diego, CA on March 28 - April 1, 2015
Source: NC State University Libraries
Added: March 12, 2022
2015 journal article
Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung
Cancer Research, 75(15), 3108–3117.
MeSH headings : Base Sequence; Chromosomes, Human, Pair 15 / genetics; DNA Methylation; DNA Modification Methylases / genetics; DNA Modification Methylases / metabolism; DNA Repair Enzymes / genetics; DNA Repair Enzymes / metabolism; Epithelial Cells / drug effects; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Genome-Wide Association Study; Guanine / analogs & derivatives; Guanine / metabolism; Humans; Longitudinal Studies; Lung Neoplasms / genetics; Male; Methylation; Methylnitrosourea / pharmacology; Molecular Sequence Data; Polymorphism, Single Nucleotide; Smoking / genetics; Tumor Suppressor Proteins / genetics; Tumor Suppressor Proteins / metabolism; Ubiquitin-Protein Ligases / genetics
TL;DR:
Results substantiate reduced gene transcription as a major mechanism for predisposition to MGMT methylation in the lungs of smokers, and support the importance of UBR1 in regulating MGMT homeostasis and DNA repair of alkylated DNA adducts in cells.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 5, 2021
2015 journal article
Effects of a Proline Endopeptidase on the Detection and Quantitation of Gluten by Antibody-Based Methods during the Fermentation of a Model Sorghum Beer
Journal of Agricultural and Food Chemistry, 63(48), 10525–10535.
Contributors: R. Panda *, K. Fiedler*, C. Cho*, R. Cheng *, W. Stutts* , L. Jackson *, E. Garber*
author keywords: gluten; proline endopeptidase; beer; fermentation
MeSH headings : Antibodies / analysis; Beer / analysis; Beer / microbiology; Enzyme-Linked Immunosorbent Assay / instrumentation; Enzyme-Linked Immunosorbent Assay / methods; Fermentation; Food Contamination / analysis; Glutens / analysis; Glutens / metabolism; Mass Spectrometry / methods; Prolyl Oligopeptidases; Serine Endopeptidases / analysis; Sorghum / chemistry; Sorghum / microbiology; Triticum / chemistry; Triticum / microbiology
TL;DR:
Western blot results indicated partial resistance of the high molecular weight (HMW) glutenins to the action of PEP, questioning the ability of P EP in digesting all immunopathogenic sequences present in gluten.
(via Semantic Scholar)
Source: ORCID
Added: May 20, 2021
2015 journal article
Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Quantitation of Microcystins in Blue-Green Algal Dietary Supplements
Journal of Agricultural and Food Chemistry, 63(47), 10303–10312.
Contributors: C. Parker*, W. Stutts* & S. Degrasse*
author keywords: microcystin; cyanotoxin; blue-green algae; dietary supplements; Aphanizomenon flos-aquae; tandem mass spectrometry
MeSH headings : Bacterial Toxins / chemistry; Chromatography, High Pressure Liquid / methods; Cyanobacteria / chemistry; Dietary Supplements / analysis; Food Contamination / analysis; Microcystins / chemistry; Tandem Mass Spectrometry / methods
TL;DR:
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous detection and quantitation of seven microcystin congeners and nodularin-R in blue-green algal dietary supplements, confirming the presence of microcyStin contamination at the Oregon-mandated guidance concentration of 1.0 μg of microCystin-LReq/g.
(via Semantic Scholar)
Source: ORCID
Added: May 20, 2021
2015 speech
Broccoli and Your Life
Chiu, Y. C. (2015, March). Presented at the Kannapolis Middle School, Kannapolis, NC.
Event: Kannapolis Middle School at Kannapolis, NC
Source: NC State University Libraries
Added: May 3, 2021
2015 conference paper
QTL Mapping of Flavonoid and Hydroxycinnamic Acid Variation in Broccoli
Presented at the CROPS 2015, Huntsville, Alabama.
Event: CROPS 2015 at Huntsville, Alabama on May 18-21, 2015
Source: NC State University Libraries
Added: May 3, 2021
2015 journal article
Rapid Analysis of Selected Benzodiazepines by Automated SPE-MS/MS
Current Trends in Mass Spectrometry, 13(2), 8–15. https://www.chromatographyonline.com/view/rapid-analysis-selected-benzodiazepines-automated-spe-ms-ms
Source: NC State University Libraries
Added: November 16, 2020
2015 journal article
An Initial Look at Ketamine and Norketamine: Levels in a Pain Management Population
ToxTalk, 39(3), 7–10. https://www.soft-tox.org/files/toxtalk/SOFT_ToxTalk_v39-3.pdf
Source: NC State University Libraries
Added: November 16, 2020
2015 journal article
Haldol Analysis in Urine: The Impact of Beta-Glucuronidase Hydrolysis
ToxTalk, 39(3), 12–14. https://www.soft-tox.org/files/toxtalk/SOFT_ToxTalk_v39-3.pdf
Source: NC State University Libraries
Added: November 16, 2020
2015 journal article
Phosphorylation is an on/off switch for 5-hydroxyconiferaldehyde O-methyltransferase activity in poplar monolignol biosynthesis
Proceedings of the National Academy of Sciences, 112(27), 8481–8486.
author keywords: AldOMT; COMT; lignin; phosphoproteomics; phosphoregulation
MeSH headings : Acrolein / analogs & derivatives; Acrolein / metabolism; Amino Acid Sequence; Binding Sites / genetics; Biocatalysis; Catechols / metabolism; Chromatography, Liquid; Electrophoresis, Polyacrylamide Gel; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Isoenzymes / genetics; Isoenzymes / metabolism; Lignin / biosynthesis; Methyltransferases / genetics; Methyltransferases / metabolism; Microscopy, Confocal; Molecular Sequence Data; Mutation; Phosphoproteins / metabolism; Phosphorylation; Plant Proteins / genetics; Plant Proteins / metabolism; Populus / enzymology; Populus / genetics; Populus / metabolism; Proteomics / methods; Protoplasts / enzymology; Protoplasts / metabolism; Sequence Homology, Amino Acid; Tandem Mass Spectrometry
TL;DR:
It is shown that reversible monophosphorylation at Ser123 or Ser125 acts as an on/off switch for the activity of 5-hydroxyconiferaldehyde O-methyltransferase 2 (PtrAldOMT2), an enzyme central to monolignol biosynthesis for lignification in stem-differentiating xylem of Populus trichocarpa.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020
2015 journal article
Cytosolic Fe-S Cluster Protein Maturation and Iron Regulation Are Independent of the Mitochondrial Erv1/Mia40 Import System
Journal of Biological Chemistry, 290(46), 27829–27840.
MeSH headings : Amino Acid Sequence; Cytosol / metabolism; Glutamate-Cysteine Ligase / metabolism; Glutathione / deficiency; Glutathione / metabolism; Iron / metabolism; Iron-Sulfur Proteins / metabolism; Mitochondria / metabolism; Mitochondrial Membrane Transport Proteins / genetics; Mitochondrial Membrane Transport Proteins / metabolism; Mitochondrial Precursor Protein Import Complex Proteins; Mitochondrial Proteins / genetics; Mitochondrial Proteins / metabolism; Molecular Sequence Data; Mutation; Oxidation-Reduction; Oxidoreductases / metabolism; Oxidoreductases Acting on Sulfur Group Donors / genetics; Oxidoreductases Acting on Sulfur Group Donors / metabolism; Protein Transport; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae / ultrastructure; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism
TL;DR:
These results confirm that GSH is critical for cytosolic Fe-S protein biogenesis and iron regulation, whereas ruling out significant roles for Erv1 or Mia40 in these pathways.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2015 journal article
Hyaluronidase Hyal1 Increases Tumor Cell Proliferation and Motility through Accelerated Vesicle Trafficking
Journal of Biological Chemistry, 290(21), 13144–13156.
MeSH headings : Adenocarcinoma / metabolism; Adenocarcinoma / pathology; Antigens, Neoplasm / metabolism; Apoptosis; Blotting, Western; Cell Movement; Cell Proliferation; Endocytosis / physiology; Endosomes / metabolism; Histone Acetyltransferases / metabolism; Humans; Hyaluronic Acid / metabolism; Hyaluronoglucosaminidase / metabolism; Male; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology; Protein Transport; Subcellular Fractions; Transferrin / metabolism; Transport Vesicles / metabolism; Tumor Cells, Cultured
TL;DR:
Overall, excess Hyal1 secretion accelerates endocytic vesicle trafficking in a substrate-dependent manner, promoting aggressive tumor cell behavior.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2015 journal article
Phosphoproteome Analysis Links Protein Phosphorylation to Cellular Remodeling and Metabolic Adaptation during Magnaporthe oryzae Appressorium Development
Journal of Proteome Research, 14(6), 2408–2424.
author keywords: Magnaporthe oryzae; quantitative phosphoproteomics; appressorium formation; network analysis; transcription factors
MeSH headings : Adaptation, Physiological; Basic Helix-Loop-Helix Transcription Factors / metabolism; Chromatography, Liquid; Fungal Proteins / metabolism; Magnaporthe / metabolism; Magnaporthe / physiology; Oryza / microbiology; Phosphoproteins / metabolism; Phosphorylation; Proteomics; Signal Transduction; Tandem Mass Spectrometry
TL;DR:
Network analysis incorporating regulation from transcriptomic, proteomic, and phosphoproteomic data revealed new insights into the regulation of the metabolism of conidial storage reserves and phospholipids, autophagy, actin dynamics, and cell wall metabolism during appressorium formation.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: February 24, 2020
2015 journal article
Real-time cellular exometabolome analysis with a microfluidic-mass spectrometry platform
PLoS ONE, 10(2).
Contributors: C. Marasco*, J. Enders* , K. Seale*, J. McLean* & J. Wikswo *
MeSH headings : Cocaine / metabolism; Extracellular Space / metabolism; Humans; Jurkat Cells; Mass Spectrometry / methods; Metabolome; Metabolomics / methods; Microfluidics / methods; Solid Phase Extraction / methods; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
The UPLC-ESI-IM-MS platform proved capable of detecting metabolomic variations between naïve and experienced Jurkat T cells and highlights the dynamics of the exometabolome over time.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 11, 2019
2015 journal article
A dilute-and-shoot LC-MS method for quantitating opioids in oral fluid
Journal of Analytical Toxicology, 39(8), 662–667.
Contributors: J. Enders* & G. McIntire
MeSH headings : Analgesics, Opioid / analysis; Chromatography, Liquid / methods; Humans; Limit of Detection; Saliva / chemistry; Tandem Mass Spectrometry / methods
TL;DR:
A fast, 'dilute-and-shoot' method that removes the unnecessary, costly and time-consuming extraction steps found in traditional methods and still surpasses all analytical requirements is highlighted.
(via Semantic Scholar)
Source: ORCID
Added: December 11, 2019
2015 article
Protein-Protein Interaction Analysis by Nuclear Magnetic Resonance Spectroscopy
Protein-Protein Interactions, pp. 267–279.
author keywords: Pulsed-field gel electrophoresis (PFGE); Salmonella enterica; Molecular typing; PulseNet; Agarose gel; Enteric pathogens
MeSH headings : Magnetic Resonance Spectroscopy / methods; Molecular Docking Simulation; Protein Binding; Protein Interaction Mapping / methods; Proteins / chemistry; Thermodynamics
TL;DR:
A straightforward method to map a protein-protein interface and design a structural model is described, using chemical shift perturbation, paramagnetic relaxation enhancement, and data-driven docking.
(via Semantic Scholar)
Source: ORCID
Added: December 10, 2019
2015 article
MDFF model of the vinculin tail domain bound to F-actin
Kim, L. Y., Thompson, P. M., Lee, H. T., Pershad, M., Campbell, S. L., & Alushin, G. M. (2015, November 4).
Source: ORCID
Added: December 10, 2019
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