Molecular Education, Technology and Research Innovation Center

Works Published in 2017

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Displaying works 1 - 20 of 44 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2017 patent

METHODS OF MONITORING FOR ADHERENCE TO BREXPIPRAZOLE (REXULTI®) THERAPY

https://www.lens.org/141-517-997-208-481

By: M. L, E. Jeffrey & S. Erin

Source: ORCID
Added: July 16, 2022

2017 patent

METHODS OF MONITORING ADHERENCE TO LURASIDONE THERAPY

https://www.lens.org/119-736-087-516-250

By: E. Jeffrey, S. Erin, M. L & M. Ayodele

Source: ORCID
Added: July 16, 2022

2017 patent

Methods of monitoring adherence to lurasidone therapy

https://www.lens.org/102-095-827-858-797

By: E. Jeffrey, S. Erin, M. L & M. Ayodele

Source: ORCID
Added: July 16, 2022

2017 journal article

Evidence that endogenous formaldehyde produces immunogenic and atherogenic adduct epitopes

Scientific Reports, 7(1).

By: J. Nakamura*, T. Shimomoto*, L. Collins*, D. Holley*, Z. Zhang*, J. Barbee*, V. Sharma*, X. Tian* ...

MeSH headings : Animals; Apolipoproteins E / deficiency; Atherosclerosis / immunology; Atherosclerosis / metabolism; Chromatography, Liquid; Epitopes / immunology; Formaldehyde / chemistry; Formaldehyde / metabolism; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Mice, Knockout; Molecular Structure; Peroxidase / metabolism; Plaque, Atherosclerotic / immunology; Plaque, Atherosclerotic / metabolism
TL;DR: The results strongly suggest that the 1,4-dihydropyridine-type of lysine adducts observed in atherosclerosis lesions are likely produced by endogenous formaldehyde and malondialdehyde with lysines, which may play important roles in human inflammatory and degenerative diseases. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 5, 2021

2017 journal article

Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats

Archives of Toxicology, 91(10), 3427–3438.

By: V. Klaus*, H. Bastek*, K. Damme*, L. Collins*, R. Frötschl*, N. Benda*, D. Lutter*, H. Ellinger-Ziegelbauer* ...

author keywords: Methylazoxymethanol acetate; DNA adducts; Kidney cancer; Eker rat; Biomarkers of effect; Biomarkers of exposure
MeSH headings : Animals; Cell Proliferation / drug effects; Cell Transformation, Neoplastic / drug effects; Cell Transformation, Neoplastic / pathology; DNA Adducts / analysis; DNA Damage / drug effects; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Guanine / analogs & derivatives; Guanine / metabolism; Kidney / drug effects; Kidney / metabolism; Kidney / pathology; Male; Methylazoxymethanol Acetate / administration & dosage; Methylazoxymethanol Acetate / toxicity; Rats, Mutant Strains; Time Factors
TL;DR: It is hypothesize that the combined analysis of pro-mutagenic DNA adducts along with time-matched gene expression changes could serve as a superior prediction tool for genotoxic carcinogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID
Added: September 5, 2021

2017 journal article

DNA Product Formation in Female Sprague–Dawley Rats Following Polyhalogenated Aromatic Hydrocarbon (PHAH) Exposure

Chemical Research in Toxicology, 30(3), 794–803.

By: L. Gao, E. Mutlu*, L. Collins*, N. Walker*, H. Hartwell, J. Olson*, W. Sun*, A. Gold, L. Ball, J. Swenberg

MeSH headings : Animals; DNA / drug effects; Female; Polycyclic Aromatic Hydrocarbons / toxicity; Rats; Rats, Sprague-Dawley
TL;DR: Exposure to TCDD significantly induced 1,N6-εdAdo at 31 and 53 weeks, while no increase of 8-oxo-dGuo was observed and the simple TEF methodology cannot be applied to evaluate the diverse patterns of toxic effects induced by DLCs. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 5, 2021

2017 journal article

Nontarget Analysis Reveals a Bacterial Metabolite of Pyrene Implicated in the Genotoxicity of Contaminated Soil after Bioremediation

Environmental Science & Technology, 51(12), 7091–7100.

By: Z. Tian*, A. Gold*, J. Nakamura*, Z. Zhang*, J. Vila*, D. Singleton*, L. Collins*, M. Aitken*

MeSH headings : Biodegradation, Environmental; Polycyclic Aromatic Hydrocarbons; Pyrenes; Soil; Soil Microbiology; Soil Pollutants
TL;DR: This work pursued a nontarget analytical approach combining effect-directed analysis (EDA) and metabolite profiling to compare extracts of PAH-contaminated soil from a former manufactured-gas plant site before and after treatment in a laboratory-scale aerobic bioreactor, and found a compound purified from soil extracts was determined to be genotoxic. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 5, 2021

2017 journal article

A purified MAA-based ELISA is a useful tool for determining anti-MAA antibody titer with high sensitivity

PLOS ONE, 12(2), e0172172.

By: T. Shimomoto*, L. Collins*, X. Yi*, D. Holley*, Z. Zhang*, X. Tian*, K. Uchida*, C. Wang* ...

Ed(s): C. Hagemeyer

MeSH headings : Acetaldehyde / immunology; Animals; Autoantibodies / blood; Autoantibodies / immunology; Enzyme-Linked Immunosorbent Assay / methods; Female; Magnetic Resonance Spectroscopy; Malondialdehyde / immunology; Mice; Mice, Inbred C57BL; Sensitivity and Specificity
TL;DR: It is demonstrated that pure MAA-modified residues can be chemically conjugated to large proteins without by-product contamination and established a purified M AA-ELISA, with which a marked increase in anti-MAA antibody titer was determined at a very early stage of atherosclerosis in 3-month ApoE-/- mice fed with a normal diet. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID
Added: September 5, 2021

2017 journal article

Identification of Azadinium species and a new azaspiracid from Azadinium poporum in Puget Sound, Washington State, USA

Harmful Algae, 68, 152–167.

By: J. Kim*, U. Tillmann*, N. Adams*, B. Krock*, W. Stutts*, J. Deeds*, M. Han*, V. Trainer*

Contributors: J. Kim*, U. Tillmann*, N. Adams*, B. Krock*, W. Stutts*, J. Deeds*, M. Han*, V. Trainer*

author keywords: Azadinium; Azaspiracid; Puget sound; Washington state; Harmful algae
MeSH headings : Dinoflagellida / chemistry; Dinoflagellida / isolation & purification; Dinoflagellida / ultrastructure; Geography; Likelihood Functions; Marine Toxins / chemistry; Marine Toxins / toxicity; Nucleic Acid Conformation; Phylogeny; Spiro Compounds / chemistry; Spiro Compounds / toxicity; Washington
TL;DR: Using a combination of molecular methods for species detection and solid phase resin deployment to target shellfish monitoring of toxin at high-risk sites, the risk of azaspiracid shellfish poisoning can be minimized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: ORCID
Added: May 20, 2021

2017 journal article

A Structural Model for Vinculin Insertion into PIP<sub>2</sub>-Containing Membranes and the Effect of Insertion on Vinculin Activation and Localization.

Structure (London, England : 1993).

Peter Thompson

MeSH headings : Actin Cytoskeleton / genetics; Actin Cytoskeleton / metabolism; Actins / genetics; Actins / metabolism; Amino Acid Motifs; Animals; Binding Sites; Embryo, Mammalian; Fibroblasts / metabolism; Fibroblasts / ultrastructure; Focal Adhesions / metabolism; Focal Adhesions / ultrastructure; Gene Expression; Hydrophobic and Hydrophilic Interactions; Lipid Bilayers / chemistry; Lipid Bilayers / metabolism; Mechanotransduction, Cellular; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutation; Nuclear Magnetic Resonance, Biomolecular; Phosphatidylinositol 4,5-Diphosphate / chemistry; Phosphatidylinositol 4,5-Diphosphate / metabolism; Protein Binding; Protein Conformation, alpha-Helical; Protein Interaction Domains and Motifs; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Thermodynamics; Vinculin / chemistry; Vinculin / genetics; Vinculin / metabolism
TL;DR: Results indicate that PIP2 binding is not required for localization of vinculin to FAs or FA strengthening, but is required for vincul activation and turnover at FAs to promote its association with the force transduction FA nanodomain. (via Semantic Scholar)
Source: ORCID
Added: May 12, 2021

2017 report

Methods of Monitoring for Adherence to Brexpiprazole (Rexulti®) Therapy

(U.S. Patent Application No. 2017/0276692 A1).

By: G. McIntire, J. Enders & E. Strickland

Source: NC State University Libraries
Added: May 3, 2021

2017 report

Methods of Monitoring Adherence to Lurasidone Therapy

(U.S. Patent No. 2015/0168431 A1).

By: J. Enders, E. Strickland, G. McIntire & A. Morris

Source: NC State University Libraries
Added: May 3, 2021

2017 conference paper

Evaluation of Non-Specific Binding to Different Organic Polymeric Components in Flow-Based Advanced Cell Culture Systems for Toxicity Testing

Enders, J. R., Balbuena-Venancio, P., Billings, D., Rao, L., Burgunder, E., Phillips, M., & Yoon, M. (2017, March). Presented at the Society of Toxicology (SOT) Annual Conference, Baltimore, MD.

By: J. Enders, P. Balbuena-Venancio, D. Billings, L. Rao, E. Burgunder, M. Phillips, M. Yoon

Event: Society of Toxicology (SOT) Annual Conference at Baltimore, MD

Source: NC State University Libraries
Added: May 3, 2021

2017 conference paper

Cultivar-Specific Changes in Primary and Secondary Metabolites in Pak Choi (Brassica Rapa, Chinensis Group) by Methyl Jasmonate

Presented at the Joint meeting of the Inaugural Conference on Food and Nutritional Metabolomics and 14th Annual Ohio Mass Spectrometry Symposium, Columbus, Ohio, USA.

By: Y. Chiu, M. Kim, N. Kim, H. Park, C. Lee, J. Juvik, K. Ku

Event: Joint meeting of the Inaugural Conference on Food and Nutritional Metabolomics and 14th Annual Ohio Mass Spectrometry Symposium at Columbus, Ohio, USA on May 14-16, 2017

Source: NC State University Libraries
Added: May 3, 2021

2017 conference paper

Metabolites change under insect herbivory and exogenous MeJA application in ‘Red Russian’ kale

Presented at the American Society for Horticultural Science, Waikoloa, Hawaii, USA.

By: Y. Chiu & K. Ku

Event: American Society for Horticultural Science at Waikoloa, Hawaii, USA on September 19-22, 2017

Source: NC State University Libraries
Added: May 3, 2021

2017 conference paper

Difference in attachment of Salmonella enterica to waxy or glossy salad leaves

Presented at the American Society of Horticultural Science, Waikoloa, Hawaii, USA.

By: Y. Chiu, K. Li, M. Kim, C. Shen & K. Ku

Event: American Society of Horticultural Science at Waikoloa, Hawaii, USA on September 19-22, 2017

Source: NC State University Libraries
Added: May 3, 2021

2017 journal article

Demonstrating the Effect of Surfactant on Water Retention of Waxy Leaf Surfaces

Journal of Chemical Education, 94(2), 230–234.

author keywords: High School/Introductory Chemistry; First-Year Undergraduate/General; Biochemistry; Laboratory Instruction; Hands-On Learning/Manipulatives; Agricultural Chemistry; Plant Chemistry; Surface Science
Sources: Crossref, ORCID
Added: May 3, 2021

2017 journal article

Cultivar-Specific Changes in Primary and Secondary Metabolites in Pak Choi (Brassica Rapa, Chinensis Group) by Methyl Jasmonate

International Journal of Molecular Sciences, 18(5), 1004.

By: M. Kim*, Y. Chiu*, N. Kim*, H. Park*, C. Lee*, J. Juvik*, K. Ku*

author keywords: glucosinolate; isothiocyanate; methyl jasmonate; pak choi; Brassica rapa
MeSH headings : Acetates / pharmacology; Brassica rapa / drug effects; Brassica rapa / metabolism; Cyclopentanes / pharmacology; Glucosinolates / metabolism; Isothiocyanates / metabolism; Oxylipins / pharmacology; Plant Growth Regulators / pharmacology
TL;DR: The result of the present study suggests that MeJA can be an effective agent to elevate indole glucosinolates and their hydrolysis products and to reduce a goitrogenic compound in pak choi. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: April 28, 2021

2017 journal article

Glucosinolates, Carotenoids, and Vitamins E and K Variation from Selected Kale and Collard Cultivars

Journal of Food Quality, 2017, 1–8.

By: M. Kim*, Y. Chiu* & K. Ku*

TL;DR: The result indicates that cultivar selection may play an important role in consumption of kale and collard with greater nutritional benefit, and will provide a more thorough profile of essential and nonessential phytonutrients of kaleand collard cultivars for consumers’ choice and for future research on nutritional value of these crops. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, ORCID
Added: April 28, 2021

2017 journal article

MSiReader v1.0: Evolving Open-Source Mass Spectrometry Imaging Software for Targeted and Untargeted Analyses

Journal of The American Society for Mass Spectrometry, 29(1), 8–16.

By: M. Bokhart, M. Nazari, K. Garrard n & D. Muddiman*

author keywords: Mass spectrometry imaging; Mass spectrometry software; Data analysis; Image processing; High mass resolving power; Open-source; Orbitrap
TL;DR: A major update to the mass spectrometry imaging (MSI) software MSiReader is presented, offering a multitude of newly added features critical to MSI analyses, enabling the MSI community to evaluate their data in greater depth and in less time. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: February 21, 2020

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