Works Published in 2021
Displaying works 1 - 20 of 29 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2021 journal article
Species-specific quantification of circulating ebolavirus burden using VP40-derived peptide variants
PLOS Pathogens, 17(11), e1010039.
Ed(s): A. Hartman
MeSH headings : Animals; Ebolavirus / immunology; Hemorrhagic Fever, Ebola / blood; Hemorrhagic Fever, Ebola / diagnosis; Hemorrhagic Fever, Ebola / immunology; Hemorrhagic Fever, Ebola / virology; Humans; Macaca mulatta; Peptide Fragments / immunology; Recombinant Proteins / immunology; Species Specificity; Viral Matrix Proteins / immunology
TL;DR:
An immunoprecipitation-coupled mass spectrometry (IP-MS) assay for VP40 antigen detection and quantification that differentiates four of the six known EBV species in one assay, through a combination of p8 and p12 data.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: May 2, 2023
2021 journal article
Application of (V)UV/O3 technology for post-treatment of biologically treated wastewater: A pilot-scale study
Chemosphere, 275, 130080.
author keywords: UV-C; VUV/UV; Photooxidation; Drug residues; Microbiological inactivation; Toxicity test
MeSH headings : Oxidation-Reduction; Technology; Ultraviolet Rays; Wastewater; Water Pollutants, Chemical / analysis; Water Purification
TL;DR:
High energy VUV photons and generation of O3 by (V)UV lamps were applied together for removal of active pharmaceutical ingredients (APIs) from biologically treated wastewater (BTWW) in pilot-scale and electric energy per order values were calculated for the first time.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: August 19, 2022
2021 journal article
Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer
Oncotarget, 12(19), 1886–1902.
TL;DR:
A role for UGDH in androgen responsiveness and a target for therapeutic strategies in advanced prostate cancer is supported by a comparison of protein and metabolite levels relevant to the glucuronidation pathway in patient-derived xenograft models paired with isogenic counterparts selected in vivo for castration resistant prostate cancer recurrence.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: July 16, 2022
2021 article
Teosinte <i>mexicana</i> introgression modulates phosphatidylcholine levels and maize flowering time
Barnes, A. C., Rodrı́guez-Zapata Fausto, Blöcher-Juárez, K. A., Gates, D. J., Kur, A., Wang, L., … Rellán-Álvarez, R. (2021, January 26). [], Vol. 1.
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: April 12, 2022
2021 journal article
Enhancing Metabolomic Coverage in Positive Ionization Mode Using Dicationic Reagents by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization
METABOLITES, 11(12).
author keywords: metabolites; dicationic reagent; ambient ionization; IR-MALDESI; mass spectrometry imaging
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: January 10, 2022
2021 article
Discovery proteomics of human placental tissue
Mellinger, A. L., McCoy, K., Minior, D. A. T., & Williams, T. I. (2021, December 23). RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol. 9.
Contributors: A. Mellinger n, K. McCoy*, D. Minior* & T. Williams n
TL;DR:
A label-free proteomics protocol for the interrogation of the placental proteome is described, which has been applied towards exploring differential protein expression patterns in placentas from women who have been exposed to drugs during pregnancy relative to those who have not.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 3, 2022
2021 journal article
Ritalinic acid in urine: Impact of age and dose
PRACTICAL LABORATORY MEDICINE, 27.
author keywords: Methylphenidate; Ritalinic acid; LC/MSMS; Urine drug testing
TL;DR:
Study of urine drug testing for ritalinic acid, the major urinary metabolite of methylphenidate (MP), indicates that school age children under the age of 18 have much higher levels of RA than adult patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 23, 2021
2021 journal article
Enzyme Complexes of Ptr4CL and PtrHCT Modulate Co-enzyme A Ligation of Hydroxycinnamic Acids for Monolignol Biosynthesis in Populus trichocarpa
FRONTIERS IN PLANT SCIENCE, 12.
author keywords: protein interaction; monolignol biosynthesis; wood formation; Populus trichocarpa; BiFC; metabolic flux
TL;DR:
It is proposed that Ptr4CL/PtrHCT complexes modulate the metabolic flux of CoA ligation for monolignol biosynthesis during wood formation in P. trichocarpa.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: November 8, 2021
2021 journal article
Vitamin D deficiency promotes accumulation of bioactive lipids and increased endocannabinoid tone in zebrafish
JOURNAL OF LIPID RESEARCH, 62.
author keywords: MS; metabolomics; lipidomics; lipids; nutrition; endocannabinoid biosynthesis; MSI; IR-MALDESI; anandamide
MeSH headings : Animals; Endocannabinoids / metabolism; Lipid Metabolism; Lipids / chemistry; Vitamin D Deficiency / metabolism; Zebrafish
TL;DR:
Investigation of putative linkages between vitamin D deficiency and metabolic disruption of bioactive lipids by MS imaging and expression of genes involved in EC biosynthesis, metabolism, and receptor signaling in adipose tissue and liver suggest that VDD may promote accumulation of bio active lipids and increased EC tone in zebrafish.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 19, 2021
2021 article
Utilizing liquid chromatography, ion mobility spectrometry, and mass spectrometry to assess INLIGHT (TM) derivatized N-linked glycans in biological samples
Butler, K. E., Kalmar, J. G., Muddiman, D. C., & Baker, E. S. (2021, August 4). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 8.
author keywords: Glycomics; Ion mobility spectrometry; INLIGHT (TM); N-Linked glycans; LC-IMS-MS
TL;DR:
The combination of IMS and the natural (NAT) and stable-isotope label (SIL) in the INLIGHT™ strategy provided additional confidence for each glycan identification due to the mobility aligned NAT- and SIL-labeled glycans and further capabilities for isomer examinations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 16, 2021
2021 journal article
Spatially resolved metabolomic characterization of muscle invasive bladder cancer by mass spectrometry imaging
METABOLOMICS, 17(8).
author keywords: Bladder cancer; IR-MALDESI mass spectrometry imaging; Metabolomics; Lipidomics; Intratumor heterogeneity
MeSH headings : Feasibility Studies; Humans; Metabolomics / methods; Muscle, Smooth / metabolism; Muscle, Smooth / pathology; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Urinary Bladder Neoplasms / diagnostic imaging; Urinary Bladder Neoplasms / metabolism; Urinary Bladder Neoplasms / pathology
TL;DR:
Great promise is demonstrated of IR-MALDESI MSI to identify molecular changes derived from cancer and unveil tumor heterogeneity, which can potentially promote the discovery of clinically relevant biomarkers and allow for applications in precision medicine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 2, 2021
2021 article
Understanding the electrospray ionization response factors of per- and poly-fluoroalkyl substances (PFAS)
Enders, J. R., Grace M. O'Neill, Whitten, J. L., & Muddiman, D. C. (2021, July 21). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 7.
author keywords: Electrospray ionization; PFAS; logP; Surface activity
TL;DR:
A method for predicting the behavior of individual PFAS compounds, including relative retention order in chromatography, is presented which is simply based on the number of fluorine atoms in the molecule as well as the class of the compound.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 2, 2021
2021 journal article
Investigations of beta-carotene radical cation formation in infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI)
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 35(16).
MeSH headings : Cations / analysis; Cations / chemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Tandem Mass Spectrometry; beta Carotene / analysis; beta Carotene / chemistry
TL;DR:
There are several potential mechanisms for β-carotene radical cationization prior to IR-MALDESI analysis with multiphoton-ionization, thermal degradation, and/or reaction with oxygen, but changing certain aspects of sample conditions can result in significant mixed-mode ionization with competing protonation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID
Added: July 26, 2021
2021 journal article
Homoseongomycin, a compound isolated from marine actinomycete bacteria K3-1, is a potent inhibitor of encephalitic alphaviruses
ANTIVIRAL RESEARCH, 191.
author keywords: Antiviral; Venezuelan equine encephalitis virus; Eastern equine encephalitis virus; Marine microbe; Drug development; Therapeutic
MeSH headings : Actinobacteria / chemistry; Animals; Antiviral Agents / pharmacology; Aquatic Organisms / chemistry; Cell Line; Chlorocebus aethiops; Encephalitis Virus, Eastern Equine / drug effects; Encephalitis Virus, Venezuelan Equine / drug effects; Fluorenes / pharmacology; Humans; Vero Cells; Virus Replication / drug effects
TL;DR:
It is demonstrated that homoseongomycin is a potential anti-VEEV and anti-EEEV compound due to its low cytotoxicity and potent antiviral activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: July 12, 2021
2021 journal article
Probing the Hydrogen-Bonding Environment of Individual Bases in DNA Duplexes with Isotope-Edited Infrared Spectroscopy
JOURNAL OF PHYSICAL CHEMISTRY B, 125(28), 7613–7627.
MeSH headings : DNA; Hydrogen; Hydrogen Bonding; Isotopes; Spectrum Analysis
TL;DR:
A method using isotope editing and infrared (IR) spectroscopy to isolate IR signals from the thymine (T) C2=O carbonyl, consistent with the existence of a third, noncanonical CH···O H-bond between adenine and thymine in both Watson–Crick and Hoogsteen base pairs in DNA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science
Added: July 9, 2021
2021 journal article
In situ detection of fatty acid C=C positional isomers by coupling on-tissue mCPBA epoxidation with infrared matrix-assisted laser desorption electrospray ionization mass spectrometry
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 35(13).
TL;DR:
The on-tissue mCPBA epoxidation was implemented into an ambient MS imaging workflow to offer a rapid and simple way for in situ identification and relative quantification of double bond positional isomers without the requirement for instrument modification.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 6, 2021
2021 journal article
PFOS dominates PFAS composition in ambient fine particulate matter (PM2.5) collected across North Carolina nearly 20 years after the end of its US production
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS, 23(4), 580–587.
MeSH headings : Alkanesulfonic Acids / analysis; Canada; Europe; Fluorocarbons / analysis; North Carolina; Particulate Matter; Tandem Mass Spectrometry
TL;DR:
This is the first US study to provide insights into ambient PFAS concentrations in PM2.5, and the presence of PFOS in these samples raises questions about their sources, since PFOS production was phased out in the US ∼20 years ago.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021
2021 article
Obituary Michael S. Bereman (1981-2021)
Muddiman, D. C., & MacCoss, M. J. (2021, May 5). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 32, pp. 1272–1274.
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021
2021 article
The development and application of matrix assisted laser desorption electrospray ionization: The teenage years
Bagley, M. C., Garrard, K. P., & Muddiman, D. C. (2021, May 24). MASS SPECTROMETRY REVIEWS, Vol. 5.
author keywords: ambient ionization; direct analysis; FTMS; IR lasers; MALDESI; mass spectrometry imaging; MSiReader
MeSH headings : Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Lasers
TL;DR:
This review will discuss the developments of MALDESI since its first laboratory demonstration in 2005 to the most recent advances in 2021.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021
2021 journal article
Preliminary results of neutron and X-ray diffraction data collection on a lytic polysaccharide monooxygenase under reduced and acidic conditions
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 77, 128–133.
author keywords: lytic polysaccharide monooxygenases; Neurospora crassa; neutron protein crystallography; reduction; protonation; enzymatic mechanism.
MeSH headings : Data Collection / methods; Hydrogen-Ion Concentration; Mixed Function Oxygenases / analysis; Mixed Function Oxygenases / chemistry; Neurospora crassa / chemistry; Neutron Diffraction / methods; Polysaccharides / analysis; Polysaccharides / chemistry; Protein Structure, Secondary; X-Ray Diffraction / methods
TL;DR:
To characterize the reaction-mechanism intermediates of LPMO9D from Neurospora crassa, a cryo-neutron diffraction data set was collected from an ascorbate-reduced crystal to probe the protonation states of ionizable groups involved in catalysis under acidic conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Source: Web Of Science
Added: May 10, 2021
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