Works Published in 2022
Displaying works 1 - 20 of 39 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2022 journal article
A bottom-up proteomics workflow for a system containing multiple organisms
Rapid Communications in Mass Spectrometry.
Contributors: H. Bai n, L. Collins n, M. André n, E. Breitschwerdt n & T. Williams n
TL;DR:
A bottom-up proteomics workflow was developed to study a system containing multiple organisms to promote a thorough understanding of how each interacts with the others and can be readily applied to other label-free proteomics work involving multiple proteomes from taxonomically distinct organisms.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: January 28, 2024
2022 journal article
Peptidomic analysis of mycobacterial secreted proteins enables species identification
View.
Contributors: Q. Shu* , M. Rajagopal*, J. Fan *, L. Zhan*, X. Kong*, Y. He *, S. Rotcheewaphan *, C. Lyon *
TL;DR:
A novel immunoprecipitation‐coupled mass spectrometry assay that can distinguish Esx proteins that are expressed by slow‐growing mycobacterial species commonly detected in clinical isolates is described.
(via Semantic Scholar)
Source: ORCID
Added: May 2, 2023
2022 journal article
MS-based Detection of Pathogen Antigen Through Immunoprecipitation of Its Proteolytic Peptides
Molecular & Cellular Proteomics.
Contributors: Q. Shu , J. Fan, C. Lyon & T. Hu
Source: ORCID
Added: May 2, 2023
2022 journal article
Nanopore-based disease diagnosis using pathogen-derived tryptic peptides from serum
Nano Today.
Contributors: W. Zheng *, J. Saliba*, X. Wei *, Q. Shu* , L. Pierson*, L. Mao*, C. Liu *, C. Lyon *
TL;DR:
It is demonstrated that a peptide identified by this approach produced high-affinity antibodies and yielded a characteristic peptide signature that was detectable over a broad linear range, to detect and quantify a pathogen-derived peptide from digested human serum samples with high sensitivity and specificity.
(via Semantic Scholar)
Source: ORCID
Added: May 2, 2023
2022 journal article
Assay design for unambiguous identification and quantification of circulating pathogen-derived peptide biomarkers
Theranostics.
Contributors: Q. Shu* , S. Liu, T. Alonzi, S. LaCourse, D. Singh, D. Bao, D. Wamalwa, L. Jiang
MeSH headings : Animals; Biomarkers; Mycobacterium tuberculosis; Peptides; Sensitivity and Specificity; Tuberculosis / diagnosis; Tuberculosis / microbiology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 2, 2023
2022 journal article
Mapping glycine uptake and its metabolic conversion to glutathione in mouse mammary tumors using functional mass spectrometry imaging
FREE RADICAL BIOLOGY AND MEDICINE, 193, 677–684.
MeSH headings : Mice; Animals; Glycine; Biological Transport; Glutathione; Mammary Neoplasms, Animal; Mass Spectrometry
TL;DR:
A novel functional mass spectrometry imaging (fMSI) method that can map the variations in the conversion of glycine to glutathione metabolic activity across tumor tissue sections by tracking the fate of three glycine isotopologues administered in a timed sequence to tumor-bearing anesthetized mice is developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 23, 2023
2022 journal article
On the importance of color in mass spectrometry imaging
JOURNAL OF MASS SPECTROMETRY, 57(12).
author keywords: colormap; CVD; data visualization; MSI
MeSH headings : Humans; Mass Spectrometry
TL;DR:
Best practices for choosing a colormap to accurately display MSI data, improve readability, and accommodate all CVDs are presented.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 9, 2023
2022 journal article
Interrogating the Metabolomic Profile of Amyotrophic Lateral Sclerosis in the Post-Mortem Human Brain by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization (IR-MALDESI) Mass Spectrometry Imaging (MSI)
METABOLITES, 12(11).
author keywords: IR-MALDESI MSI; mass spectrometry imaging; Amyotrophic lateral sclerosis (ALS); neurodegenerative disease; multiomic
TL;DR:
This work is the first of its kind, reporting on the investigation of ALS post-mortem human brain tissue analyzed by multiomic MSI, and nearly 300 metabolites were identified across the sixteen samples where 25 were identified as dysregulated between disease cohorts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2023
2022 article
Towards a standardized multi-tissue decellularization protocol for the derivation of extracellular matrix materials
Biehl, A., Martins, A. M. G. M., Davis, Z. G. G., Sze, D., Collins, L., Mora-Navarro, C., … Freytes, D. O. O. (2022, December 12). BIOMATERIALS SCIENCE, Vol. 12.
MeSH headings : Tissue Engineering / methods; Proteomics; Extracellular Matrix / chemistry; Hydrogels / chemistry; Biocompatible Materials / analysis; Tissue Scaffolds
TL;DR:
The present study is the first proof-of-concept towards the development of a standardized protocol that can be used to derive multiple ECM biomaterials via a previously established automated system and showed gelation and rheological properties consistent with previous ECM hydrogels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2023
2022 article
Improving Therapeutic Protein Secretion in the Probiotic YeastSaccharomyces boulardiiusing a Multifactorial Engineering Approach
Durmusoglu, D., Al’Abri, I., Williams, T. I., Collins, L. B., Martínez, J. L., & Crook, N. (2022, December 31). BioRxiv.
Contributors: D. Durmusoglu n, I. Al'Abri n, T. Williams n , L. Collins n , J. Martínez * & N. Crook n
Source: ORCID
Added: January 1, 2023
2022 journal article
Filtered Cerebrospinal Fluid From Patients With Amyotrophic Lateral Sclerosis Displays an Altered Proteome and Affects Motor Phenotype in a Mouse Model
Cureus, 12.
TL;DR:
The ability to filter proteins from the CSF of ALS patients and identified potentially pathologic proteins that were reduced in quantity is demonstrated and could be a novel solution for patients suffering from this deadly and irreversible condition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: December 29, 2022
2022 journal article
Electrolyte Solvation and Ionic Association: Part IX. Structures and Raman Spectroscopic Characterization of LiFSI Solvates
JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 169(11).
author keywords: LiFSI; solvate; Raman; bis(fluorosulfonyl)imide; crystal structure
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Sources: ORCID, Web Of Science
Added: November 29, 2022
2022 journal article
Solvate Structures and Computational/Spectroscopic Characterization of LiCF3SO3 Electrolytes
JOURNAL OF PHYSICAL CHEMISTRY C, 126(43), 18251–18265.
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 21, 2022
2022 article
Assessing the Fate of Dissolved Organic Compounds in Landfill Leachate and Wastewater Treatment Systems
Doyle, M. G., Odenkirk, M. T., Stewart, A. K., Nelson, J. P., Baker, E. S., & Cruz, F. (2022, November 1). ACS ES&T WATER.
author keywords: nontargeted analysis; anthropogenic chemicals; wastewater; landfill leachate; reverse osmosis
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Source: Web Of Science
Added: November 21, 2022
2022 article
Recovery of per- and polyfluoroalkyl substances after solvent evaporation
Weed, R. A., Boatman, A. K., & Enders, J. R. (2022, October 14). ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS, Vol. 10.
MeSH headings : Fluorocarbons / analysis; Solvents; Bioaccumulation; Fluorine; Water Pollutants, Chemical / analysis
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 26, 2022
2022 journal article
Improved spatial resolution of infrared matrix-assisted laser desorption electrospray ionization mass spectrometry imaging using a reflective objective
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 36(23).
MeSH headings : Animals; Spectrometry, Mass, Electrospray Ionization / methods; Ice; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Lasers; Mammals
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 17, 2022
2022 article
Next-Generation Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Source for Mass Spectrometry Imaging and High-Throughput Screening
Knizner, K. T., Guymon, J. P., Garrard, K. P., Bouvree, G., Manni, J., Hauschild, J.-P., … Muddiman, D. C. (2022, September 29). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 9.
author keywords: IR-MALDESI; High-Throughput Screening; Mass Spectrometry Imaging; Orbitrap Mass Spectrometer; Design of Experiments
MeSH headings : High-Throughput Screening Assays; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Lasers
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 17, 2022
2022 journal article
Developing transmission mode for infrared matrix-assisted laser desorption electrospray ionization mass spectrometry imaging
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 36(22).
MeSH headings : Animals; Glycerol; Ice; Lasers; Mammals; Mice; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR:
This work has successfully demonstrated the adaptation of the NextGen IR‐MAL DESI source through the feasibility of tm‐IR‐MALDESI mass spectrometry imaging on mammalian tissue, expanding future biological applications of the method.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 26, 2022
2022 journal article
Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para-aminobenzoate in Chlamydia trachomatis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(39).
Contributors: T. Williams n
author keywords: folate biosynthesis; radical transfer; spectroscopy; heterobinuclear cluster
MeSH headings : Bacterial Proteins / metabolism; Chlamydia trachomatis / enzymology; Folic Acid; Iron / metabolism; Manganese / metabolism; Oxygen / metabolism; Oxygenases / metabolism; Tyrosine / metabolism; para-Aminobenzoates / metabolism
TL;DR:
High in vitro activity relies on the stoichiometric addition of both Fe and Mn, and CADD is shown to activate O2 to self-sacrificially produce pABA from Tyr27.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 21, 2022
2022 journal article
UV and (V)UV irradiation of sitagliptin in ultrapure water and WWTP effluent: Kinetics, transformation products and degradation pathway
Chemosphere, 288, 132393.
author keywords: Antidiabetic drug; AOP; Transformation products; UV-C; VUV; UV; Wastewater treatment
MeSH headings : Kinetics; Physics; Sitagliptin Phosphate; Water
TL;DR:
The most characteristic reaction steps of the degradation of SITA involved nucleophilic aromatic photosubstitution whereas hydroxide ions acted as attacking nucleophiles and replaced F atoms of the phenyl moiety by hydroxides groups, in agreement with the increase in photolysis rate with increasing pH.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: August 19, 2022
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