Works Published in 2017

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Displaying works 61 - 80 of 289 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2017 journal article

Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities.

PloS One.

Paul Hess

MeSH headings : Antiviral Agents / pharmacology; CD8-Positive T-Lymphocytes / drug effects; CD8-Positive T-Lymphocytes / immunology; Endocytosis / drug effects; HIV Infections / drug therapy; HIV Infections / immunology; Humans; Lymphocyte Depletion; Protein Multimerization; Ribosome Inactivating Proteins, Type 1 / therapeutic use; Saporins
TL;DR: The utility of cytotoxic saporin-conjugated tetramers is demonstrated here in identifying the CD8+ T-cell specificity most effective in preventing HIV progression in HIV-infected HLA-B*27-positive immune controllers. (via Semantic Scholar)
Source: ORCID
Added: September 9, 2019

2017 journal article

Oral melphalan for the treatment of relapsed canine lymphoma

Veterinary and Comparative Oncology, 16(1), E123–E129.

By: M. Mastromauro n, S. Suter n, M. Hauck n & P. Hess n

author keywords: canine; chemotherapy; lymphoma; melphalan; rescue
MeSH headings : Administration, Oral; Animals; Antineoplastic Agents, Alkylating / administration & dosage; Antineoplastic Agents, Alkylating / adverse effects; Antineoplastic Agents, Alkylating / therapeutic use; Dog Diseases / drug therapy; Dogs; Female; Lymphoma / drug therapy; Lymphoma / veterinary; Male; Melphalan / administration & dosage; Melphalan / adverse effects; Melphalan / therapeutic use; Recurrence; Retrospective Studies
TL;DR: Although treatment resulted in limited clinical benefit and non-durable responses, oral melphalan was well-tolerated and may be a reasonable rescue option in cases where minimal effective agents remain. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Crossref
Added: September 9, 2019

2017 journal article

Canine scent detection of canine cancer: a feasibility study.

Veterinary Medicine (Auckland, N.Z.).

Paul Hess

author keywords: urinary tract cancer; cancer detection dogs; cancer odor; olfactory memory; multiple sample learning
TL;DR: The study illustrates the need to consider canine olfactory memory and the use of double-blind methods to avoid erroneous conclusions regarding the ability of dogs to alert on specimens from canine cancer patients and suggests that sample storage, confounding odors, and other factors need to be considered in the design of future studies that evaluate the detection of canine cancers by scent detection dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: ORCID
Added: September 9, 2019

2017 conference paper

Identification of Salmonella Typhimurium genes essential to induce the neutrophil oxidative burst

Poster presented at the Mid-Atlantic Microbial Pathogenesis Meeting, Nellysford, Virginia.

By: T. Westerman, M. Sheats, S. Jones & J. Elfenbein

Event: Mid-Atlantic Microbial Pathogenesis Meeting at Nellysford, Virginia on February 12-14, 2017

Source: NC State University Libraries
Added: September 8, 2019

2017 journal article

Sensitivity and specificity levels of two rapid assays for antibodies to Anaplasma spp. in dogs

Journal of Veterinary Diagnostic Investigation, 30(2), 290–293.

By: J. Liu n, M. Eberts n, H. Bewsey n, T. O’Connor n, R. Chandrashekar n & E. Breitschwerdt n

author keywords: Anaplasma phagocytophilum; dogs; tick-borne diseases
MeSH headings : Anaplasma / immunology; Anaplasma phagocytophilum / immunology; Anaplasmosis / blood; Anaplasmosis / epidemiology; Anaplasmosis / microbiology; Animals; Antibodies, Bacterial / blood; Dog Diseases / blood; Dog Diseases / epidemiology; Dog Diseases / microbiology; Dogs; Enzyme-Linked Immunosorbent Assay / methods; Enzyme-Linked Immunosorbent Assay / veterinary; Female; Fluorescent Antibody Technique, Indirect / methods; Fluorescent Antibody Technique, Indirect / veterinary; Male; Reagent Kits, Diagnostic / veterinary; Sensitivity and Specificity; Tick-Borne Diseases / epidemiology; Tick-Borne Diseases / veterinary; United States / epidemiology
TL;DR: The SNAP 4Dx Plus test and the VetScan Canine Anaplasmosis Rapid test are commercial in-house rapid tests for the detection of antibody to these 2 antigenically related Anaplasma species and demonstrate significantly higher sensitivity and specificity. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: September 5, 2019

2017 journal article

Doxycycline treatment efficacy in dogs with naturally occurring Anaplasma phagocytophilum infection

Journal of Small Animal Practice, 59(5), 286–293.

By: C. Yancey n, P. Diniz*, E. Breitschwerdt n, B. Hegarty n, C. Wiesen* & B. Qurollo n

MeSH headings : Anaplasma phagocytophilum / drug effects; Anaplasma phagocytophilum / genetics; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / therapeutic use; DNA, Bacterial / blood; DNA, Bacterial / isolation & purification; Dog Diseases / drug therapy; Dog Diseases / microbiology; Dogs; Doxycycline / administration & dosage; Doxycycline / therapeutic use; Ehrlichiosis / veterinary; Lymph Nodes / microbiology; Polymerase Chain Reaction / veterinary; United States
TL;DR: The results of this study support the efficacy of doxycycline therapy for clinical treatment of dogs naturally infected with A. phagocytophilum in the USA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Crossref
Added: September 5, 2019

2017 journal article

Mandibular thickening due to periodontal and endodontic disease in a dog

Journal of the American Veterinary Medical Association, 250, 1101–1103.

By: A. Castejon Gonzalez, L. Villamizar-Martinez & M. Reiter

Source: NC State University Libraries
Added: August 30, 2019

2017 speech

Investigating the MARCKS protein as a novel therapeutic target for the treatment of equine asthma

Poster presented at the Merial National Veterinary Research Scholars Symposium, National Institutes of Health, Bethesa, MD.

By: A. Bowyer, K. Davis & M. Sheats

Event: Merial National Veterinary Research Scholars Symposium at National Institutes of Health, Bethesa, MD

Source: NC State University Libraries
Added: August 30, 2019

2017 journal article

Fecal glucocorticoids and anthropogenic injury and mortality in North Atlantic right whales Eubalaena glacialis

Endangered Species Research, 34, 417–429.

By: R. Rolland*, W. McLellan*, M. Moore*, C. Harms n, E. Burgess* & K. Hunt*

author keywords: North Atlantic right whale; Stress; Glucocorticoids; Fecal hormones; Entanglement
TL;DR: Results provide biological validation for using fGCs as a biomarker of chronic stress in NARWs and show meaningful patterns in fGC concentration related to acute vs. chronic impacts persisted despite potential for bacterial degradation of hormone meta bolites in dead whales. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 29, 2019

2017 journal article

Evaluation of Three Anticoagulants Used for Short-Term Storage of Loggerhead Sea Turtle (Caretta caretta) Whole Blood

Journal of Herpetological Medicine and Surgery, 27(3), 97.

By: B. Phillips n, M. Stoskopf n, J. Beasley* & C. Harms n

TL;DR: Loggerhead sea turtle blood stored in CPDA-1, and sodium citrate had more significant blood gas and electrolyte changes over 24 h, indicating a greater degree of erythrocyte leakage or lysis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 29, 2019

2017 journal article

Ketoprofen pharmacokinetics of R - and S -isomers in juvenile loggerhead sea turtles (Caretta caretta ) after single intravenous and single- and multidose intramuscular administration

Journal of Veterinary Pharmacology and Therapeutics, 41(2), 340–348.

By: K. Thompson*, M. Papich n, B. Higgins*, J. Flanagan, E. Christiansen* & C. Harms n

author keywords: Caretta caretta; ketoprofen; loggerhead; nonsteroidal anti-inflammatory; pharmacokinetics
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Drug Administration Schedule / veterinary; Female; Injections, Intramuscular / veterinary; Injections, Intravenous / veterinary; Ketoprofen / administration & dosage; Ketoprofen / pharmacokinetics; Turtles / metabolism
TL;DR: The S-isomer is the predominant isomer in loggerhead sea turtles, similar to most mammals, despite administration of a 50:50 racemic mixture, and a dose of 2 mg/kg either IM or IV every 24 hr is likely appropriate for loggerhead turtles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 29, 2019

2017 journal article

Therapeutic effectiveness of calcineurin inhibitors in canine vesicular cutaneous lupus erythematosus

Veterinary Dermatology, 28(5), 493–e115.

By: F. Banovic n, D. Robson, M. Linek & T. Olivry n

Contributors: F. Banovic n, D. Robson, M. Linek & T. Olivry n

MeSH headings : Administration, Cutaneous; Administration, Oral; Animals; Calcineurin Inhibitors / administration & dosage; Calcineurin Inhibitors / therapeutic use; Cyclosporine / administration & dosage; Cyclosporine / adverse effects; Cyclosporine / therapeutic use; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Drug Therapy, Combination / veterinary; Female; Lupus Erythematosus, Cutaneous / drug therapy; Lupus Erythematosus, Cutaneous / pathology; Lupus Erythematosus, Cutaneous / veterinary; Male; Skin / pathology; Tacrolimus / administration & dosage; Tacrolimus / adverse effects; Tacrolimus / analogs & derivatives; Tacrolimus / therapeutic use; Treatment Outcome
TL;DR: Observations support CIs as the preferable therapeutic alternatives to long-term immunosuppression with oral glucocorticoids in dogs with VCLE. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Crossref
Added: August 29, 2019

2017 journal article

Apoptosis as a Mechanism for Keratinocyte Death in Canine Toxic Epidermal Necrolysis

Veterinary Pathology, 54(2), 249–253.

By: F. Banovic n, S. Dunston n, K. Linder n, P. Rakich* & T. Olivry n

Contributors: F. Banovic n, S. Dunston n, K. Linder n, P. Rakich* & T. Olivry n

author keywords: apoptosis; skin; erythema multiforme; toxic epidermal necrolysis
MeSH headings : Animals; Apoproteins / physiology; Caspase 3 / genetics; Caspase 3 / metabolism; DNA Nucleotidylexotransferase / metabolism; Deoxyuracil Nucleotides / metabolism; Dog Diseases / pathology; Dogs; Gene Expression Regulation, Enzymologic; In Situ Nick-End Labeling; Keratinocytes / pathology; Stevens-Johnson Syndrome / pathology; Stevens-Johnson Syndrome / veterinary
TL;DR: Results suggest that apoptosis of epidermal keratinocytes and lymphocytic satellitosis represent one of the early steps in the pathogenesis of canine TEN, as in the human disease counterpart. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: August 29, 2019

2017 journal article

Clinical, microscopic and microbial characterization of exfoliative superficial pyoderma-associated epidermal collarettes in dogs

Veterinary Dermatology, 28(1), 107–e23.

Contributors: F. Banovic n, K. Linder n & T. Olivry n

MeSH headings : Animals; Dog Diseases / diagnosis; Dog Diseases / microbiology; Dog Diseases / pathology; Dogs; Exotoxins / genetics; In Situ Hybridization, Fluorescence / veterinary; Male; Pyoderma / diagnosis; Pyoderma / microbiology; Pyoderma / pathology; Pyoderma / veterinary; Skin / microbiology; Skin / pathology; Staphylococcal Skin Infections / diagnosis; Staphylococcal Skin Infections / microbiology; Staphylococcal Skin Infections / pathology; Staphylococcal Skin Infections / veterinary; Staphylococcus / genetics
TL;DR: Epidermal collarettes represent unique clinical and histological lesions of exfoliative superficial pyodermas that are distinct from those of impetigo and superficial bacterial folliculitis and the role of corneodesmosin in collarette pathogenesis deserve further investigation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: ORCID
Added: August 29, 2019

2017 journal article

Translational animal models of atopic dermatitis for preclinical studies

Yale Journal of Biology and Medicine, 90(3), 389–402. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030250721&partnerID=MN8TOARS

By: B. Martel, P. Lovato, W. Bäumer & T. Olivry

Contributors: B. Martel, P. Lovato, W. Bäumer & T. Olivry

Source: ORCID
Added: August 29, 2019

2017 journal article

Evaluation of intraepidermal nerve fibres in the skin of normal and atopic dogs

Veterinary Dermatology, 28(4), 355–e80.

By: A. Laprais n, S. Dunston n, S. Torres*, C. Favrot* & T. Olivry n

Contributors: A. Laprais n, S. Dunston n, S. Torres*, C. Favrot* & T. Olivry n

MeSH headings : Animals; Biopsy; Dermatitis, Atopic / pathology; Dermatitis, Atopic / veterinary; Dog Diseases / pathology; Dogs; Nerve Fibers / pathology; Paraffin Embedding / veterinary; Skin / innervation; Skin / pathology
TL;DR: IENFs are detected more commonly in canine AD than in normal haired skin; these results are comparable to those seen for human AD. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Crossref
Added: August 29, 2019

2017 journal article

Proof of concept of the preventive efficacy of high‐dose recombinant mono‐allergen immunotherapy in atopic dogs sensitized to the Dermatophagoides farinae allergen Der f 2

Veterinary Dermatology, 28(2), 183–e40.

By: T. Olivry n, J. Paps n & S. Dunston n

Contributors: T. Olivry n, J. Paps n & S. Dunston n

MeSH headings : Animals; Antigens, Dermatophagoides / administration & dosage; Antigens, Dermatophagoides / immunology; Arthropod Proteins / administration & dosage; Arthropod Proteins / immunology; Dermatitis, Atopic / immunology; Dermatitis, Atopic / veterinary; Desensitization, Immunologic / veterinary; Dog Diseases / immunology; Dogs; Dose-Response Relationship, Immunologic; Intradermal Tests; Recombinant Proteins / immunology; Subcutaneous Absorption
TL;DR: The new mono-allergen SCIT appears safe and effective for reducing skin lesions after allergen challenges; it deserves further testing in dogs with spontaneous atopic dermatitis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: August 29, 2019

2017 journal article

The novel high molecular weight Dermatophagoides farinae protein Zen‐1 is a major allergen in North American and European mite allergic dogs with atopic dermatitis

Veterinary Dermatology, 28(2), 177–e38.

By: T. Olivry n, S. Dunston n, C. Favrot*, P. Prélaud & T. Tsukui*

Contributors: T. Olivry n, S. Dunston n, C. Favrot*, P. Prélaud & T. Tsukui*

MeSH headings : Animals; Antibody Specificity; Antigens, Dermatophagoides / immunology; Dermatitis, Atopic / epidemiology; Dermatitis, Atopic / immunology; Dermatitis, Atopic / veterinary; Dog Diseases / epidemiology; Dog Diseases / immunology; Dogs; Enzyme-Linked Immunosorbent Assay / veterinary; Europe / epidemiology; Immunoglobulin E / blood; Immunoglobulin E / immunology; Insect Proteins / immunology; Intradermal Tests / veterinary; United States / epidemiology
TL;DR: This study establishes Zen-1 as a major allergen in atopic dogs sensitized to Df in American and European Df-hypersensitive dogs and establishes the likely relevance of serological results. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: ORCID
Added: August 29, 2019

2017 journal article

Measured and calculated variables of global oxygenation in healthy neonatal foals

American Journal of Veterinary Research, 78(2), 230–238.

By: D. Wong, K. Hepworth-Warren, B. Sponseller, J. Howard & C. Wang

MeSH headings : Animals; Animals, Newborn / physiology; Blood Gas Analysis / veterinary; Carbon Dioxide / blood; Horses / physiology; Lactic Acid / blood; Oxygen / blood; Reference Values
TL;DR: This study provided information about several variables that reflect global oxygenation in healthy neonatal foals that may aid in treatment decisions and prognosis of clinical outcome for critically ill foals. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 20, 2019

2017 journal article

Porcine Esophageal Submucosal Gland Culture Model Shows Capacity for Proliferation and Differentiation

Cellular and Molecular Gastroenterology and Hepatology, 4(3), 385–404.

By: R. von Furstenberg*, J. Li*, C. Stolarchuk*, R. Feder*, A. Campbell*, L. Kruger n, L. Gonzalez n, A. Blikslager n ...

author keywords: Esophagus; Barrett's Esophagus; 3D Culture; Acinar Ductal Metaplasia; Adult Stem Cell
TL;DR: The results suggest that the activated ESMG state, seen in both human disease and the authors' porcine model, may provide a source of cells to repopulate damaged epithelium in a normal manner (squamous) or abnormally (columnar epithelia). (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019

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