Works Published in 2004
Displaying works 21 - 40 of 86 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2004 journal article
Discovery of Ovarian Cancer Biomarkers in Serum Using NanoLC Electrospray Ionization TOF and FT-ICR Mass Spectrometry
Disease Markers, 19(4-5), 239–249.
MeSH headings : Amino Acid Sequence; Biomarkers, Tumor / blood; Chromatography; Female; Humans; Middle Aged; Molecular Sequence Data; Nanotechnology; Neoplasm Staging; Ovarian Neoplasms / blood; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization
TL;DR:
A set of protocols for the isolation and identification of serum biomarkers for ovarian cancer that exist in the low molecular weight serum fraction is delineated and one of these contains the sequence of fibrinopeptide-A known to be elevated in many types of cancer including ovarian cancer.
(via Semantic Scholar)
doi.org (publisher)
Sources: Crossref, ORCID
Added: February 12, 2021
2004 journal article
Identification and Characterization of Novel, Naturally Processed Measles Virus Class II HLA-DRB1 Peptides
Journal of Virology, 78(1), 42–51.
MeSH headings : Alleles; Cytokines / biosynthesis; Cytokines / genetics; HLA-DR Antigens / chemistry; HLA-DR Antigens / metabolism; HLA-DRB1 Chains; Humans; Interferon-gamma / biosynthesis; Interferon-gamma / genetics; Interleukin-4 / biosynthesis; Interleukin-4 / genetics; Measles / immunology; Measles / prevention & control; Measles virus / immunology; Measles virus / metabolism; Measles-Mumps-Rubella Vaccine / administration & dosage; Nucleocapsid Proteins; Nucleoproteins / chemistry; Nucleoproteins / immunology; Nucleoproteins / metabolism; Peptides / chemical synthesis; Peptides / chemistry; Peptides / immunology; Peptides / metabolism; T-Lymphocytes / immunology; Viral Proteins / chemistry; Viral Proteins / immunology; Viral Proteins / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: February 12, 2021
2004 journal article
“In Silico” Design of New Uranyl Extractants Based on Phosphoryl-Containing Podands: QSPR Studies, Generation and Screening of Virtual Combinatorial Library, and Experimental Tests
Journal of Chemical Information and Computer Sciences, 44(4), 1365–1382.
TL;DR:
Computer-aided design of new extractants of the uranyl cation involving three main steps: a QSPR study, generation and screening of a virtual combinatorial library, and synthesis of several predicted compounds and their experimental extraction studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Crossref
Added: January 21, 2021
2004 journal article
Factor analysis of pesticide use patterns among pesticide applicators in the Agricultural Health Study
Journal of Exposure Science & Environmental Epidemiology, 15(3), 225–233.
author keywords: pesticides; farmers; custom applicators; factor analysis; herbicides; insecticides; fungicides; fumigants; Iowa; North Carolina
MeSH headings : Adult; Age Factors; Agriculture; Cohort Studies; Factor Analysis, Statistical; Female; Humans; Iowa; Life Style; Male; Middle Aged; Occupational Exposure; Pesticides / analysis; Risk Assessment; Spouses
TL;DR:
Heterogeneity in exposure patterns to pesticides did not correlate with lifestyle characteristics such as race, smoking status or education, which may be used to guide etiologic studies of health effects of farmers and other groups exposed to pesticides.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: January 21, 2021
2004 journal article
Roles of uptake, biotransformation, and target site sensitivity in determining the differential toxicity of chlorpyrifos to second to fourth instar Chironomous riparius (Meigen)
Aquatic Toxicology, 66(2), 149–157.
author keywords: chlorpyrifos; acetylcholinesterase; biotransformation; life stages; Chironomous
MeSH headings : Acetylcholinesterase / metabolism; Animals; Chironomidae / metabolism; Chlorpyrifos / metabolism; Chlorpyrifos / pharmacokinetics; Chlorpyrifos / toxicity; Dose-Response Relationship, Drug; Down-Regulation / drug effects; Larva / metabolism; Toxicity Tests
TL;DR:
It appeared that chlorpyrifos sensitivity differences among second to fourth instar C. riparius were largely determined by differences in uptake rates, which could potentially offset the apparent increased sensitivity to the oxon.
(via Semantic Scholar)
Source: Crossref
Added: January 21, 2021
2004 journal article
Estrogen receptor expression in a human primitive neuroectodermal tumor cell line from the cerebral cortex: estrogen stimulates rapid ERK1/2 activation and receptor-dependent cell migration
Biochemical and Biophysical Research Communications, 319(3), 753–758.
Contributors: M. Kirby*, A. Zsarnovszky* & S. Belcher*
author keywords: ER alpha; ER beta; ERK1/2; estrogen; estrogen receptor; growth; hormone responsive; MAPK; migration; non-genomic; PNET; signal transduction
MeSH headings : Animals; Brain Neoplasms / metabolism; Cell Line, Tumor; Cell Movement / physiology; Cerebral Cortex / metabolism; Cerebral Cortex / pathology; Enzyme Activation; Estrogens / metabolism; Humans; MAP Kinase Signaling System / physiology; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases / metabolism; Neuroectodermal Tumors, Primitive / metabolism; Receptors, Estrogen / metabolism; Transcriptional Activation
TL;DR:
Results of immunoblot studies using ER-specific antiserum indicate that both ERalpha and ERbeta are expressed in PFSK1 cells, suggesting that rapid actions of E(2) and ER-mediated processes might contribute to the metastatic phenotype of some PNETs.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 21, 2021
2004 journal article
Detection of Purkinje cell loss following drug exposures to developing rat pups using reverse transcriptase-polymerase chain reaction (RT-PCR) analysis for calbindin-D28k mRNA expression
Toxicology Letters, 150(3), 325–334.
Contributors: Y. Ge *, S. Belcher* , D. Pierce* & K. Light*
MeSH headings : Administration, Oral; Animals; Animals, Newborn; Calbindin 1; Calbindins; Cell Count; Dose-Response Relationship, Drug; Ethanol / toxicity; Female; Male; Pregnancy; Prenatal Exposure Delayed Effects; Purkinje Cells / cytology; Purkinje Cells / drug effects; Purkinje Cells / metabolism; RNA, Messenger / biosynthesis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; S100 Calcium Binding Protein G / biosynthesis; Valproic Acid / toxicity
TL;DR:
Analysis of mRNA expression specific to calbindin-D28k by comparison to matched controls provides a reliable means of determining whether cell loss has occurred, regardless of whether the cell loss was induced by prenatal valproic acid or postnatal ethanol exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: January 21, 2021
2004 journal article
Analytical Performance of a Venturi Device Integrated into an Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometer for Analysis of Nucleic Acids
Analytical Chemistry, 76(14), 4118–4122.
MeSH headings : Cyclotrons; Fourier Analysis; Mass Spectrometry / instrumentation; Mass Spectrometry / methods; Oligonucleotides / analysis; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
A voltage-assisted venturi device modeled after an industrial air amplifier was used to improve the ion transmission efficiency of a 16.2 kDa oligonucleotide and a 53-mer PCR product in the high-pressure region between an electrospray ionization emitter and the sampling orifices of two Fourier transform ion cyclotron resonance mass spectrometers (FT-ICR-MS).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Sources: Crossref, ORCID
Added: January 18, 2021
2004 journal article
Utility of accurate monoisotopic mass measurements to confidently identify lambda exonuclease generated single-stranded amplicons containing 7-deaza analogs by electrospray ionization FT-ICR mass spectrometry
International Journal of Mass Spectrometry, 234(1-3), 79–87.
Sources: Crossref, ORCID
Added: January 18, 2021
2004 journal article
Pendimethalin exposure and cancer risk among pesticide applicators: a report from the U.S.-based agricultural health study
Annals of Epidemiology, 14(8), 608.
TL;DR:
The findings suggest a possible association between pendimethalin exposure and incidence of rectum and lung cancers among pesticide applicators in the U.S. Agricultural Health Study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, ORCID
Added: September 10, 2020
2004 journal article
Phthalate exposure and pulmonary function.
Environmental Health Perspectives, 112(5), 571–574.
author keywords: monobutyl phthalate; pulmonary function; urine samples
MeSH headings : Adult; Biomarkers; Environmental Exposure; Female; Humans; Linear Models; Lung / drug effects; Lung / physiology; Male; Middle Aged; Nutrition Surveys; Phthalic Acids / toxicity; Phthalic Acids / urine; Respiratory Function Tests; Sex Factors
TL;DR:
It is suggested that MBP and MEP, but not MEHP, may influence pulmonary function among adult males, and the metabolite of the plasticizer commonly used in medical tubing was not adversely associated with any of the pulmonary function parameters evaluated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: September 3, 2020
2004 journal article
Cancer risk and parental pesticide application in children of Agricultural Health Study participants.
Environmental Health Perspectives, 112(5), 631–635.
author keywords: agricultural workers; cancer; children; occupational exposure; pesticides
MeSH headings : Adolescent; Adult; Agriculture; Child; Child, Preschool; Female; Humans; Incidence; Infant; Iowa; Lymphoma / chemically induced; Lymphoma / epidemiology; Male; Maternal Exposure / adverse effects; Neoplasms / chemically induced; Neoplasms / epidemiology; Paternal Exposure / adverse effects; Pesticides / toxicity; Prospective Studies; Retrospective Studies; Risk
TL;DR:
Analysis of childhood cancer risk and associations with parental pesticide application in Iowa suggests that farm exposures including pesticides may play a role in the etiology of childhood lymphoma.
(via Semantic Scholar)
Source: Crossref
Added: September 3, 2020
2004 journal article
Altered expression of Bcl2, Bad and Bax mRNA occurs in the rat cerebellum within hours after ethanol exposure on postnatal day 4 but not on postnatal day 9
Molecular Brain Research, 129(1-2), 124–134.
Contributors: Y. Ge *, S. Belcher* , D. Pierce* & K. Light*
author keywords: apoptosis; Bcl2; Bad; Bax; RT-PCR; Purkinje; cerebellum; ethanol; mRNA
MeSH headings : Actins / metabolism; Animals; Animals, Newborn; Apoptosis / drug effects; Apoptosis / physiology; Calbindins; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cerebellum / cytology; Cerebellum / drug effects; Cerebellum / physiology; Dose-Response Relationship, Drug; Ethanol / administration & dosage; Ethanol / blood; Ethanol / pharmacology; Female; Humans; Male; Pregnancy; Proto-Oncogene Proteins c-bcl-2 / genetics; Proto-Oncogene Proteins c-bcl-2 / metabolism; RNA, Messenger / metabolism; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G / metabolism; bcl-2-Associated X Protein; bcl-Associated Death Protein
TL;DR:
The results of this study are in agreement with and provide further support for the hypothesis that ethanol interrupts the active suppression of apoptosis that is a crucial feature of Purkinje cell vulnerability during this time period.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020
2004 journal article
Alterations of cerebellar mRNA specific for BDNF, p75NTR, and TrkB receptor isoforms occur within hours of ethanol administration to 4-day-old rat pups
Developmental Brain Research, 151(1-2), 99–109.
Contributors: Y. Ge *, S. Belcher* & K. Light*
author keywords: Purkinje cell; TrkB isoform; ethanol exposure; RT-PCR; mRNA; neurotrophin; cerebellum; toxicity; apoptosis; BDNF signaling
MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor / genetics; Brain-Derived Neurotrophic Factor / metabolism; Central Nervous System Depressants / pharmacology; Cerebellum / drug effects; Cerebellum / metabolism; Dose-Response Relationship, Drug; Ethanol / pharmacology; Female; Male; Pregnancy; RNA, Messenger / drug effects; RNA, Messenger / metabolism; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Receptor, trkB / genetics; Receptor, trkB / metabolism; Receptors, Nerve Growth Factor / genetics; Receptors, Nerve Growth Factor / metabolism; Reverse Transcriptase Polymerase Chain Reaction / methods; Time Factors
TL;DR:
The hypothesis that ethanol induces a disruption of BDNF-TrkB signaling that results in loss of apoptotic suppression in vulnerable Purkinje cells by growth factor withdrawal is supported.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020
2004 journal article
Spatial, temporal, and cellular distribution of the activated extracellular signal regulated kinases 1 and 2 in the developing and mature rat cerebellum
Developmental Brain Research, 150(2), 199–209.
Contributors: A. Zsarnovszky* & S. Belcher*
author keywords: neurotransmitters, modulators, transporters and receptors; second messengers and phosphorylation; Bergmann glia; cerebellum; development; active EPK1/2; glia; granule cell; neuron; immunohistochemistry; kinase; MAPK; Purkinje cell; signal transduction
MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Cell Count / methods; Cerebellum / enzymology; Cerebellum / growth & development; Cerebellum / metabolism; Glial Fibrillary Acidic Protein / metabolism; Immunohistochemistry / methods; Indoles / metabolism; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases / metabolism; Purkinje Cells / metabolism; Rats; Rats, Sprague-Dawley
TL;DR:
A high degree of developmental plasticity was observed in the spatiotemporal distribution of cerebellar pERK-IR suggesting that the ERK-pathway plays a dynamic role in regulating neuronal and glial migration, proliferation and differentiation in the developing cerebellum.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020
2004 journal article
Analysis of medaka cytochrome P450 3A homotropic and heterotropic cooperativity
Marine Environmental Research, 58(2-5), 469–473.
MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases / metabolism; Catalysis; Coumarins / metabolism; Cytochrome P-450 CYP3A; Fluorescence; Kinetics; Models, Chemical; Oryzias / metabolism; Oxidoreductases, N-Demethylating / metabolism; Phenols / metabolism; Protein Binding; Substrate Specificity
TL;DR:
This study demonstrates that medaka CYP3A catalysis exhibits unusual kinetic behaviors consistent with allosteric interaction which cannot be described by hyperbolic kinetic models, and describes both homotropic and heterotropic cooperative interactions.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020
2004 journal article
Absolute Quantification of the Model Biomarker Prostate-Specific Antigen in Serum by LC−MS/MS Using Protein Cleavage and Isotope Dilution Mass Spectrometry
Journal of Proteome Research, 3(3), 644–652.
author keywords: LC-MS/MS; absolute quantification; serum; biomarker; prostate-specific antigen; protein
MeSH headings : Humans; Isotope Labeling; Male; Mass Spectrometry; Peptide Fragments / chemistry; Prostate-Specific Antigen / chemistry; Protein Processing, Post-Translational; Serum / chemistry; Trypsin / chemistry; Urea / chemistry
TL;DR:
absolute quantification can be performed on the model biomarker PSA introduced into denatured serum when analyzed by LC-MS/MS, and concerns still exist regarding sensitivity compared to existing immunoassays as well as the reproducibility of PC-IDMS performed in different matrixes.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020
2004 journal article
Evaluation of a Cleavable Stable Isotope Labeled Synthetic Peptide for Absolute Protein Quantification Using LC−MS/MS
Journal of Proteome Research, 3(3), 658–661.
author keywords: LC-MS/MS; absolute quantification; biomarker; cleavable internal standard
MeSH headings : Chromatography, Liquid; Isotope Labeling; Mass Spectrometry; Peptides / chemistry
TL;DR:
The work presented here evaluates the use of tryptic cleavage sites incorporated into the internal standard synthetic peptide in an attempt to create an internal standard that has cleavage characteristics more similar to the protein being quantified.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020
2004 journal article
Analysis of the Low Molecular Weight Fraction of Serum by LC-Dual ESI-FT-ICR Mass Spectrometry: Precision of Retention Time, Mass, and Ion Abundance
Analytical Chemistry, 76(17), 5097–5103.
MeSH headings : Algorithms; Biomarkers, Tumor / blood; Chromatography, Liquid / standards; Female; Humans; Ions / blood; Molecular Weight; Ovarian Neoplasms / blood; Reproducibility of Results; Serum / chemistry; Software; Spectrometry, Mass, Electrospray Ionization / standards
TL;DR:
These measures of analytical reproducibility establish a statistical rationale for differentiating healthy and disease patient populations for the elucidation of biomarkers in the low molecular fraction of serum.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020
2004 journal article
Androgens Negatively Regulate Forkhead Transcription Factor FKHR (FOXO1) through a Proteolytic Mechanism in Prostate Cancer Cells
Journal of Biological Chemistry, 279(14), 13866–13877.
MeSH headings : Amino Acid Sequence; Androgens / pharmacology; Apoptosis / drug effects; Apoptosis / physiology; Cell Line, Tumor / cytology; Cell Line, Tumor / drug effects; Cell Line, Tumor / physiology; Cell Nucleus / metabolism; Cysteine Endopeptidases / metabolism; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic / drug effects; Humans; Male; Metribolone / pharmacology; Molecular Sequence Data; Mutagenesis; Prostatic Neoplasms; Protease Inhibitors / pharmacology; RNA, Messenger / analysis; Transcription Factors / genetics; Transcription Factors / metabolism; Transcriptional Activation / drug effects; Transfection
TL;DR:
This work demonstrates that forkhead transcription factor FKHR (FOXO1)-induced death of LNCaP cells was blocked by a synthetic androgen R1881, and suggests that androgens induce increased activity of an acidic cysteine protease, which in turn cleaves FK HR.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: February 24, 2020
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