Works Published in 2010
Displaying works 21 - 40 of 119 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2010 journal article
Defining hormesis: Evaluation of a complex concentration response phenomenon
International Journal of Toxicology, 29(3), 235–246.
Contributors: E. Kendig*, H. Le* & S. Belcher*
author keywords: hormesis; dose-response relationship; threshold model; beta-curve; biphasic effects; nonmonotonic; low-dose effects; subthreshold response
MeSH headings : Animals; Dose-Response Relationship, Drug; History, 16th Century; History, 19th Century; History, Ancient; Humans; Models, Biological; Nonlinear Dynamics; Pharmacokinetics; Pharmacology / methods; Terminology as Topic; Toxicology / history; Toxicology / methods
TL;DR:
By examining the history of this dose-response theory, it is clear that both pharmacological and toxicological studies provide evidence for hormetic dose responses, but retrospective examination of studies can be problematic at best.
(via Semantic Scholar)
citeseerx.ist.psu.edu (repository)
Source: ORCID
Added: March 5, 2021
2010 journal article
Modeling Liver-Related Adverse Effects of Drugs UsingkNearest Neighbor Quantitative Structure−Activity Relationship Method
Chemical Research in Toxicology, 23(4), 724–732.
MeSH headings : Algorithms; Chemical and Drug Induced Liver Injury / etiology; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Models, Biological; Models, Molecular; Quantitative Structure-Activity Relationship
TL;DR:
Validated QSAR models of liver AEDs based on the data from the FDA spontaneous reporting system can be employed as sensitive and specific predictors of Aeds in preclinical screening of drug candidates for potential hepatotoxicity in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: January 24, 2021
2010 journal article
Framework for traits-based assessment in ecotoxicology
Integrated Environmental Assessment and Management, 7(2), 172–186.
MeSH headings : Animals; Ecotoxicology / methods; Environmental Pollutants; Risk Assessment / methods
TL;DR:
A framework for the application of traits‐based assessment based on the population vulnerability conceptual model of Van Straalen, in which vulnerability is determined by traits that can be grouped into 3 major categories, i.e., external exposure, intrinsic sensitivity, and population sustainability is developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: Crossref
Added: January 21, 2021
2010 journal article
Detection of Alternative Splice Variants at the Proteome Level inAspergillus flavus
Journal of Proteome Research, 9(3), 1209–1217.
author keywords: mass spectrometry; proteomics; alternative splicing; database; Aspergillus flavus
MeSH headings : Alternative Splicing; Aspergillus flavus / genetics; Aspergillus flavus / metabolism; Computer Simulation; Cytochrome-B(5) Reductase / chemistry; Cytochrome-B(5) Reductase / genetics; Databases, Protein; Fungal Proteins / biosynthesis; Fungal Proteins / chemistry; Fungal Proteins / genetics; Isotope Labeling; Mass Spectrometry; Models, Genetic; Protein Isoforms / biosynthesis; Protein Isoforms / chemistry; Protein Isoforms / genetics; Proteomics; Pyruvate Carboxylase / chemistry; Pyruvate Carboxylase / genetics; RNA Splice Sites; Reproducibility of Results
TL;DR:
The introduction of an alternative splicing database helps identify more proteins and unveils more information about a proteome, and shows potential to improve genome annotation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 18, 2021
2010 journal article
Pesticide Exposures and Uterine Fibroid Risk Among Farming Women
Annals of Epidemiology, 20(9), 707.
Sources: Crossref, NC State University Libraries
Added: September 10, 2020
2010 journal article
Mortality in the Agricultural Health Study, 1993-2007
American Journal of Epidemiology, 173(1), 71–83.
author keywords: agriculture; healthy worker effect; mortality; neoplasms; pesticides; wounds and injuries
MeSH headings : Adult; Aged; Aged, 80 and over; Agricultural Workers' Diseases / mortality; Cause of Death / trends; Female; Humans; Iowa / epidemiology; Male; Middle Aged; North Carolina / epidemiology; Occupational Exposure / adverse effects; Pesticides / adverse effects; Retrospective Studies; Survival Rate / trends
TL;DR:
Using data from the Agricultural Health Study, a cohort of 89,656 pesticide applicators and their spouses in North Carolina and Iowa, standardized mortality ratios (SMRs) were computed comparing deaths from time of the enrollment through 2007 to state-specific rates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 2, 2020
2010 journal article
Cheminformatics Analysis of Assertions Mined from Literature That Describe Drug-Induced Liver Injury in Different Species
Chemical Research in Toxicology, 23(1), 171–183.
MeSH headings : Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship
TL;DR:
This is the first study for chemical toxicity prediction that applied QSAR modeling and other cheminformatics techniques to observational data generated by the means of automated text mining with limited manual curation, opening up new opportunities for generating and modeling chemical toxicology data.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Quantitative Nanostructure−Activity Relationship Modeling
ACS Nano, 4(10), 5703–5712.
author keywords: nanoparticles; QSAR; cheminformatics; nanotoxicity; modeling
MeSH headings : Animals; Cell Line, Tumor; Humans; Metal Nanoparticles / chemistry; Microscopy, Atomic Force / methods; Models, Statistical; Models, Theoretical; Nanotechnology / methods; Oxides / chemistry; Quantitative Structure-Activity Relationship; Rats; Regression Analysis; Surface Properties; U937 Cells
TL;DR:
The results suggest that QNAR models can be employed for: (i) predicting biological activity profiles of novel nanomaterials, and (ii) prioritizing the design and manufacturing of nanom material toward better and safer products.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Applicability Domains for Classification Problems: Benchmarking of Distance to Models for Ames Mutagenicity Set
Journal of Chemical Information and Modeling, 50(12), 2094–2111.
MeSH headings : Benchmarking / methods; Classification / methods; Mutagenicity Tests / methods; Mutagenicity Tests / standards; Principal Component Analysis; Quantitative Structure-Activity Relationship
TL;DR:
This work demonstrates that the DMs based on an ensemble (consensus) model provide systematically better performance than other DMs and can be used to halve the cost of experimental measurements by providing a similar prediction accuracy.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Trust, But Verify: On the Importance of Chemical Structure Curation in Cheminformatics and QSAR Modeling Research
Journal of Chemical Information and Modeling, 50(7), 1189–1204.
MeSH headings : Animals; Models, Chemical; Molecular Structure; Organometallic Compounds / chemistry; Quantitative Structure-Activity Relationship
TL;DR:
The need for a standardized chemical data curation strategy that should be followed at the onset of any molecular modeling investigation is emphasized and it is demonstrated that in some cases rigorously developed QSAR models could be even used to correct erroneous biological data associated with chemical compounds.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 conference paper
Seamless Integration of Weather and Climate Information in Developing Operational Streamflow Forecasts
World Environmental and Water Resources Congress 2010. Presented at the World Environmental and Water Resources Congress 2010.
Event: World Environmental and Water Resources Congress 2010
UN Sustainable Development Goal Categories
13. Climate Action
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2010 conference paper
Identification of Reactive Contaminant Sources in a Water Distribution System under the Conditions of Data Uncertainties
World Environmental and Water Resources Congress 2010. Presented at the World Environmental and Water Resources Congress 2010.
Event: World Environmental and Water Resources Congress 2010
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2010 conference paper
Detection of Leaks in Water Distribution System Using Routine Water Quality Measurements
World Environmental and Water Resources Congress 2010. Presented at the World Environmental and Water Resources Congress 2010.
Event: World Environmental and Water Resources Congress 2010
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2010 conference paper
Utility of Climate Forecasts in Promoting Inter-Basin Transfer in the North Carolina Triangle Area
World Environmental and Water Resources Congress 2010. Presented at the World Environmental and Water Resources Congress 2010.
Event: World Environmental and Water Resources Congress 2010
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2010 conference paper
Bayesian Inference of Groundwater Contamination Source
World Environmental and Water Resources Congress 2010. Presented at the World Environmental and Water Resources Congress 2010.
Event: World Environmental and Water Resources Congress 2010
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2010 journal article
Special Issue on Innovations in Solid Waste Engineering and Management: The 2008 Global Waste Management Symposium
Journal of Environmental Engineering, 136(8), 743–743.
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2010 journal article
Models for waste life cycle assessment: Review of technical assumptions
Waste Management, 30(12), 2636–2648.
MeSH headings : Environmental Pollution / prevention & control; Models, Theoretical; Waste Management; Waste Products / analysis; Waste Products / statistics & numerical data
TL;DR:
This paper is an attempt to identify, review and analyse methodologies and technical assumptions used in various parts of selected waste LCA models, and concludes that more effort should be employed to harmonise and validate non-geographic assumptions to strengthen waste L CA modelling.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Crossref, ORCID
Added: January 19, 2020
2010 chapter
Anaerobic Biodegradation of Solid Waste
In Environmental Microbiology (pp. 281–299).
Sources: Crossref, NC State University Libraries
Added: January 19, 2020
2010 chapter
Landfilling: Gas Production, Extraction and Utilization
In Solid Waste Technology & Management (pp. 841–857).
Sources: Crossref, ORCID
Added: January 19, 2020
2010 chapter
LCA in Waste Management: Introduction to Principle and Method
In Solid Waste Technology & Management (pp. 111–136).
Sources: Crossref, ORCID
Added: January 19, 2020
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