Center for Environmental and Health Effects of PFAS

Works Published in 2011

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Displaying works 21 - 40 of 94 in total

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2011 journal article

Absolute quantification of free glutathione and cysteine in aquatic insects using isotope dilution and selected reaction monitoring

Analytical and Bioanalytical Chemistry, 402(1), 357–366.

author keywords: Glutathione; Cysteine; Selected reaction monitoring; Absolute quantification; Isotope dilution
MeSH headings : Animals; Aquatic Organisms / chemistry; Carbon Isotopes / analysis; Chromatography, High Pressure Liquid / methods; Cysteine / analysis; Glutathione / analysis; Indicator Dilution Techniques; Insecta / chemistry; Nitrogen Isotopes / analysis
TL;DR: A simple and robust isotope dilution mass spectrometry-based assay was developed for the determination of free cysteine and glutathione in aquatic insects and was demonstrated to have a quantitative dynamic range spanning nearly three orders of magnitude. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: January 21, 2021

2011 journal article

High pesticide exposure events and central nervous system function among pesticide applicators in the Agricultural Health Study

International Archives of Occupational and Environmental Health, 85(5), 505–515.

By: S. Starks*, F. Gerr*, F. Kamel*, C. Lynch*, M. Alavanja*, D. Sandler*, J. Hoppin*

author keywords: Agricultural workers; Epidemiology; Neurobehavioral testing; Pesticide exposure; High pesticide exposure event
MeSH headings : Aged; Aged, 80 and over; Agriculture; Central Nervous System / drug effects; Humans; Iowa; Linear Models; Male; Middle Aged; North Carolina; Occupational Diseases / chemically induced; Occupational Diseases / diagnosis; Occupational Exposure / adverse effects; Occupational Exposure / analysis; Pesticides / poisoning; Prospective Studies; Surveys and Questionnaires
TL;DR: One or more HPEE may contribute to adverse CNS outcomes independent of diagnosed pesticide poisoning, and no significant associations were observed between participants who ever had an HPEE and the remaining neurobehavioral tests. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, ORCID
Added: September 2, 2020

2011 journal article

Predicting Drug-Induced Hepatotoxicity Using QSAR and Toxicogenomics Approaches

Chemical Research in Toxicology, 24(8), 1251–1262.

By: Y. Low*, T. Uehara*, Y. Minowa*, H. Yamada*, Y. Ohno*, T. Urushidani*, A. Sedykh*, E. Muratov* ...

MeSH headings : Animals; Chemical and Drug Induced Liver Injury / metabolism; Chemical and Drug Induced Liver Injury / pathology; Databases, Factual; Hepatocyte Nuclear Factor 4 / metabolism; Male; Models, Statistical; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Small Molecule Libraries / chemistry; Small Molecule Libraries / toxicity; Toxicogenetics
TL;DR: Results suggest that concurrent exploration of the chemical features and acute treatment-induced changes in transcript levels will both enrich the mechanistic understanding of subchronic liver injury and afford models capable of accurate prediction of hepatotoxicity from chemical structure and short-term assay results. (via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions (OpenAlex)
Source: Crossref
Added: August 28, 2020

2011 journal article

Assessment of bisphenol A released from reusable plastic, aluminium and stainless steel water bottles

Chemosphere, 85(6), 943–947.

By: J. Cooper*, E. Kendig* & S. Belcher*

Contributors: J. Cooper*, E. Kendig* & S. Belcher*

author keywords: Bisphenol A; Copolyester; Epoxy resins; Endocrine disrupting chemicals; Polycarbonate; Water bottles
MeSH headings : Aluminum / chemistry; Benzhydryl Compounds; Endocrine Disruptors / analysis; Endocrine Disruptors / chemistry; Food Packaging / methods; Phenols / analysis; Phenols / chemistry; Plastics / chemistry; Recycling; Stainless Steel / chemistry; Water / chemistry
TL;DR: The results from this study demonstrate that when used according to manufacturers' recommendations reusable water bottles constructed from "BPA-free" alternative materials are suitable for consumption of beverages free of BPA contamination. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020

2011 journal article

Foreword

International Journal of Mass Spectrometry, 300(2-3), 72–73.

Sources: Crossref, ORCID
Added: February 24, 2020

2011 journal article

Control of skin cancer by the circadian rhythm

Proceedings of the National Academy of Sciences, 108(46), 18790–18795.

By: S. Gaddameedhi*, C. Selby, W. Kaufmann*, R. Smart n & A. Sancar*

author keywords: circadian clock; cryptochrome; sunbathing; tanning salons
MeSH headings : Animals; Carcinoma, Squamous Cell / etiology; Carcinoma, Squamous Cell / physiopathology; Circadian Rhythm / physiology; DNA Damage; DNA Repair; Disease Models, Animal; Humans; Immunohistochemistry / methods; Mice; Mice, Inbred C57BL; Mice, Transgenic; Skin / radiation effects; Skin Neoplasms / etiology; Skin Neoplasms / physiopathology; Sunlight; Time Factors; Xeroderma Pigmentosum Group A Protein / biosynthesis; Xeroderma Pigmentosum Group A Protein / genetics
TL;DR: It is concluded that time of day of exposure to UVR is a contributing factor to its carcinogenicity in mice, and possibly in humans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: February 24, 2020

2011 chapter

New Developments in LC-MS and Other Hyphenated Techniques

In Sample Preparation in Biological Mass Spectrometry (pp. 981–1030).

By: M. Belov*, R. Kurulugama*, D. Lopez-Ferrer*, Y. Ibrahim* & E. Baker*

author keywords: Reversed-phase HPLC; Strong cation exchange; Capillary zone electrophoresis; Ion mobility spectrometry; High-field asymmetric waveform ion mobility spectrometry
Sources: Crossref, ORCID
Added: December 16, 2019

2011 journal article

Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer

Pharmacogenetics and Genomics, 21(10), 615–623.

By: S. Koutros*, G. Andreotti*, S. Berndt*, K. Hughes Barry*, J. Lubin*, J. Hoppin*, F. Kamel*, D. Sandler* ...

Contributors: S. Koutros*, G. Andreotti*, S. Berndt*, K. Hughes Barry*, J. Lubin*, J. Hoppin*, F. Kamel*, D. Sandler* ...

author keywords: interaction; pesticides; prostate cancer; single nucleotide polymorphism; xenobiotic-metabolizing enzymes
MeSH headings : Alleles; Epoxide Hydrolases / genetics; Genetic Association Studies; Glutamate-Cysteine Ligase / genetics; Humans; Logistic Models; Male; Occupational Exposure; Oxidative Stress / genetics; Peroxidase / genetics; Pesticides / adverse effects; Polymorphism, Single Nucleotide; Prostatic Neoplasms / genetics; Risk Factors; Thioredoxin Reductase 2 / genetics; Xenobiotics / metabolism
TL;DR: The number of observed interactions in XMEs was comparable with the number expected by chance alone, and several pesticide–SNP interactions in oxidative stress and phase I/II enzyme genes and risk of prostate cancer were observed. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: September 13, 2019

2011 journal article

Mortality in the agricultural health study, 1993-2007

American Journal of Epidemiology, 173(1), 71–83.

By: J. Waggoner*, G. Kullman, P. Henneberger, D. Umbach, A. Blair, M. Alavanja, F. Kamel, C. Lynch ...

Contributors: J. Waggoner*, G. Kullman, P. Henneberger, D. Umbach, A. Blair, M. Alavanja, F. Kamel, C. Lynch ...

author keywords: agriculture; healthy worker effect; mortality; neoplasms; pesticides; wounds and injuries
MeSH headings : Adult; Aged; Aged, 80 and over; Agricultural Workers' Diseases / mortality; Cause of Death / trends; Female; Humans; Iowa / epidemiology; Male; Middle Aged; North Carolina / epidemiology; Occupational Exposure / adverse effects; Pesticides / adverse effects; Retrospective Studies; Survival Rate / trends
TL;DR: Using data from the Agricultural Health Study, a cohort of 89,656 pesticide applicators and their spouses in North Carolina and Iowa, standardized mortality ratios (SMRs) were computed comparing deaths from time of the enrollment through 2007 to state-specific rates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: September 13, 2019

2011 journal article

Neurologic Symptoms Associated With Raising Poultry and Swine Among Participants in the Agricultural Health Study

Journal of Occupational and Environmental Medicine, 53(2), 190–195.

By: M. Davis*, F. Kamel*, J. Hoppin*, M. Alavanja*, L. Freeman*, G. Gray*, K. Nelson*, E. Silbergeld*

Contributors: M. Davis*, F. Kamel*, J. Hoppin*, M. Alavanja*, L. Freeman*, G. Gray*, K. Nelson*, E. Silbergeld*

MeSH headings : Adult; Agricultural Workers' Diseases / diagnosis; Agricultural Workers' Diseases / epidemiology; Alcohol Drinking / epidemiology; Animals; Female; Guillain-Barre Syndrome / epidemiology; Humans; Hypesthesia / diagnosis; Hypesthesia / epidemiology; Male; Middle Aged; Muscle Weakness / diagnosis; Muscle Weakness / epidemiology; Nervous System Diseases / diagnosis; Nervous System Diseases / epidemiology; Poultry; Prevalence; Smoking / epidemiology; Swine
TL;DR: Occupational contact with live poultry or swine, potentially related to C. jejuni exposure, was associated with increased reporting of GBS-like symptoms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Crossref
Added: September 13, 2019

2011 journal article

Questionnaire Predictors of Atopy in a US Population Sample: Findings From the National Health and Nutrition Examination Survey, 2005-2006

American Journal of Epidemiology, 173(5), 544–552.

author keywords: hypersensitivity; immunoglobulin E; questionnaires; sensitivity and specificity
MeSH headings : Adolescent; Adult; Biomarkers / blood; Child; Child, Preschool; Eczema / epidemiology; Eczema / immunology; Female; Health Surveys / statistics & numerical data; Humans; Hypersensitivity / epidemiology; Hypersensitivity / immunology; Hypersensitivity, Immediate / epidemiology; Immunoglobulin E / blood; Immunologic Factors / blood; Infant; Male; Middle Aged; Nutrition Surveys / statistics & numerical data; Predictive Value of Tests; Rhinitis, Allergic, Seasonal / epidemiology; Sampling Studies; Sensitivity and Specificity; Surveys and Questionnaires; United States / epidemiology
TL;DR: To assess questionnaires' ability to predict biochemical measures of atopy, the authors used data on 5 allergic conditions and serum-specific immunoglobulin E (IgE) levels from the 2005-2006 National Health and Nutrition Examination Survey to identify participants found to be atopic by biochemical measures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Crossref
Added: September 13, 2019

2011 journal article

Rotenone, Paraquat, and Parkinson’s Disease

Environmental Health Perspectives, 119(6), 866–872.

By: C. Tanner*, F. Kamel*, G. Ross*, J. Hoppin*, S. Goldman*, M. Korell*, C. Marras*, G. Bhudhikanok* ...

Contributors: C. Tanner*, F. Kame*, G. Ross*, J. Hoppin*, S. Goldman*, M. Korell*, C. Marras*, G. Bhudhikanok* ...

author keywords: aging; agricultural epidemiology; environmental epidemiology; epidemiology; fungicides; herbicides; insecticides; persistent organic pollutants; pesticides
MeSH headings : Aged; Case-Control Studies; Female; Herbicides / toxicity; Humans; Insecticides / toxicity; Iowa / epidemiology; Male; Middle Aged; Mitochondria / metabolism; North Carolina / epidemiology; Occupational Exposure; Oxidative Stress; Paraquat / toxicity; Parkinson Disease / epidemiology; Parkinson Disease / etiology; Parkinsonian Disorders / epidemiology; Parkinsonian Disorders / etiology; Rotenone / toxicity
TL;DR: PD was positively associated with two groups of pesticides defined by mechanisms implicated experimentally—those that impair mitochondrial function and those that increase oxidative stress—supporting a role for these mechanisms in PD pathophysiology. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: September 13, 2019

2011 journal article

Job Activities and Respiratory Symptoms Among Farmworkers in North Carolina

Archives of Environmental & Occupational Health, 66(3), 178–182.

author keywords: agriculture; asthma; epidemiology; occupational lung disease; respiratory diseases
MeSH headings : Age Factors; Agricultural Workers' Diseases / epidemiology; Agricultural Workers' Diseases / etiology; Agriculture / statistics & numerical data; Female; Humans; Logistic Models; Male; North Carolina / epidemiology; Occupational Exposure / adverse effects; Occupational Exposure / statistics & numerical data; Prevalence; Respiratory Sounds; Respiratory Tract Diseases / epidemiology; Respiratory Tract Diseases / etiology; Smoking / adverse effects; Smoking / epidemiology; Surveys and Questionnaires
TL;DR: Though not statistically significant, the odds of wheezing were elevated for individuals who reported performing tobacco-related work in the last 3 days and the odds were decreased among individuals who report harvesting activities. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref
Added: September 13, 2019

2011 journal article

Impact of pesticide exposure misclassification on estimates of relative risks in the Agricultural Health Study

Occupational and Environmental Medicine, 68(7), 537–541.

By: A. Blair*, K. Thomas*, J. Coble*, D. Sandler*, C. Hines*, C. Lynch*, C. Knott*, M. Purdue* ...

Contributors: A. Blair*, K. Thomas*, J. Coble*, D. Sandler*, C. Hines*, C. Lynch*, C. Knott*, M. Purdue* ...

MeSH headings : 2,4-Dichlorophenoxyacetic Acid / urine; Agriculture / statistics & numerical data; Algorithms; Biomarkers / urine; Environmental Monitoring / methods; Humans; Occupational Exposure / adverse effects; Occupational Exposure / analysis; Occupational Exposure / statistics & numerical data; Pesticides / toxicity; Prospective Studies; Pyridones / urine; Risk Assessment / methods
TL;DR: Findings indicate that a priori expert-derived algorithm scores were more closely related to measured urinary levels than individual exposure determinants evaluated here, which indicates that non-differential misclassification of exposure would bias relative risk estimates in the AHS towards the null and diminish study power. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: September 13, 2019

2011 journal article

Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994–2007)

Environmental Health Perspectives, 119(9), 1253–1259.

By: L. Freeman*, J. Rusiecki*, J. Hoppin*, J. Lubin*, S. Koutros*, G. Andreotti*, S. Zahm*, C. Hines* ...

Contributors: L. Beane Freeman*, J. Rusiecki*, J. Hoppin*, J. Lubin*, S. Koutros*, G. Andreotti*, S. Zahm*, C. Hines* ...

author keywords: agriculture; atrazine; cancer; cohort study; epidemiology; pesticide
MeSH headings : Adult; Aged; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / epidemiology; Atrazine / toxicity; Carcinogens / toxicity; Cohort Studies; Confidence Intervals; Female; Herbicides / adverse effects; Humans; Iowa / epidemiology; Male; Middle Aged; Neoplasms / chemically induced; Neoplasms / epidemiology; North Carolina / epidemiology; Odds Ratio; Poisson Distribution; Prospective Studies; Surveys and Questionnaires; Thyroid Neoplasms / chemically induced; Thyroid Neoplasms / epidemiology
Sources: ORCID, Crossref
Added: September 13, 2019

2011 journal article

Suicide and Pesticide Use among Pesticide Applicators and Their Spouses in the Agricultural Health Study

Environmental Health Perspectives, 119(11), 1610–1615.

By: J. Beard*, D. Umbach*, J. Hoppin*, M. Richards*, M. Alavanja*, A. Blair*, D. Sandler*, F. Kamel*

Contributors: J. Beard*, D. Umbach*, J. Hoppin*, M. Richards*, M. Alavanja*, A. Blair*, D. Sandler*, F. Kamel*

author keywords: farmers; pesticide applicators; pesticides; spouses; suicide
MeSH headings : Adult; Aged; Cause of Death; Cohort Studies; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Health Surveys; Humans; Incidence; Iowa / epidemiology; Male; Middle Aged; North Carolina / epidemiology; Occupational Exposure; Pesticides / toxicity; Proportional Hazards Models; Prospective Studies; Risk Factors; Socioeconomic Factors; Spouses; Suicide / statistics & numerical data; Surveys and Questionnaires; Young Adult
TL;DR: Findings do not support an association between moderate pesticide use and suicide in applicators and their spouses, and were consistent across several measures of pesticide use. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref
Added: September 13, 2019

2011 journal article

Genetic Variation in Base Excision Repair Pathway Genes, Pesticide Exposure, and Prostate Cancer Risk

Environmental Health Perspectives, 119(12), 1726–1732.

By: K. Barry*, S. Koutros*, S. Berndt*, G. Andreotti*, J. Hoppin*, D. Sandler*, L. Burdette*, M. Yeager* ...

Contributors: K. Barry*, S. Koutros*, S. Berndt*, G. Andreotti*, J. Hoppin*, D. Sandler*, L. Burdette*, M. Yeager* ...

author keywords: DNA repair; gene-environment interactions; pesticide; polymorphisms; prostate cancer
MeSH headings : Case-Control Studies; DNA Repair / genetics; Fonofos / adverse effects; Genetic Variation; Genotype; Humans; Likelihood Functions; Logistic Models; Male; N-Glycosyl Hydrolases / genetics; North Carolina / epidemiology; Occupational Exposure / adverse effects; Odds Ratio; Pesticides / adverse effects; Polymorphism, Single Nucleotide / genetics; Prostatic Neoplasms / chemically induced; Prostatic Neoplasms / epidemiology; Prostatic Neoplasms / genetics; Risk Assessment
TL;DR: A role of BER genetic variation in pesticide-associated prostate cancer risk is suggested in a nested case–control study of white Agricultural Health Study pesticide applicators. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 13, 2019

2011 journal article

An Updated Algorithm for Estimation of Pesticide Exposure Intensity in the Agricultural Health Study

International Journal of Environmental Research and Public Health, 8(12), 4608–4622.

By: J. Coble*, K. Thomas*, C. Hines*, J. Hoppin*, M. Dosemeci*, B. Curwin*, J. Lubin*, L. Freeman* ...

Contributors: J. Coble*, K. Thomas*, C. Hines*, J. Hoppin*, M. Dosemeci*, B. Curwin*, J. Lubin*, L. Freeman* ...

author keywords: pesticides; exposure algorithm; epidemiology; 2,4-D; chlorpyrifos; captan
MeSH headings : Agriculture; Algorithms; Environmental Exposure; Humans; Pesticides / toxicity
TL;DR: The weighting factors for the revised algorithm now incorporate exposure measurements taken on Agricultural Health Study (AHS) participants for the application methods and personal protective equipment (PPE) commonly reported by study participants. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: September 13, 2019

2011 journal article

Allergy-related outcomes in relation to serum IgE: Results from the National Health and Nutrition Examination Survey 2005-2006

Journal of Allergy and Clinical Immunology, 127(5), 1226–1235.e7.

By: P. Salo*, A. Calatroni*, P. Gergen*, J. Hoppin*, M. Sever*, R. Jaramillo*, S. Arbes*, D. Zeldin*

Contributors: P. Salo*, A. Calatroni*, P. Gergen*, J. Hoppin*, M. Sever*, R. Jaramillo*, S. Arbes Jr., D. Zeldin*

author keywords: Allergen; allergy; allergic sensitization; serum IgE
MeSH headings : Allergens / immunology; Animals; Antibody Specificity; Cats; Cattle; Cross-Sectional Studies; Dogs; Female; Fungi / immunology; Humans; Hypersensitivity, Immediate / epidemiology; Hypersensitivity, Immediate / immunology; Immunoglobulin E / blood; Male; Mice; Nutrition Surveys; Pets / immunology; Plants / immunology; Prevalence; Rats; Rhinitis, Allergic, Seasonal / epidemiology; Rhinitis, Allergic, Seasonal / immunology; Surveys and Questionnaires; United States / epidemiology
TL;DR: In the US population self-reported allergy symptoms are most consistently associated with increased levels of plant-, pet-, and mold-specific IgE, which contributed independently to allergy-related symptoms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Crossref
Added: September 13, 2019

2011 journal article

AGRICOH: A Consortium of Agricultural Cohorts

International Journal of Environmental Research and Public Health, 8(5), 1341–1357.

By: M. Leon*, L. Freeman*, J. Douwes*, J. Hoppin*, H. Kromhout*, P. Lebailly*, K. Nordby*, M. Schenker* ...

Contributors: M. Leon*, L. Beane Freeman*, J. Douwes*, J. Hoppin*, H. Kromhout*, P. Lebailly*, K. Nordby*, M. Schenker* ...

author keywords: agriculture; cohort studies; consortium, pesticides; occupational exposures
MeSH headings : Agricultural Workers' Diseases; Agriculture; Cohort Studies; Humans; International Cooperation; Occupational Exposure
TL;DR: Altogether, AGRICOH provides excellent opportunities for studying cancer, respiratory, neurologic, and auto-immune diseases as well as reproductive and allergic disorders, injuries and overall mortality in association with a wide array of exposures, prominent among these the application of pesticides. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: September 13, 2019

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