Works Published in 2016
Displaying works 21 - 40 of 117 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2016 journal article
Ultra-High Resolution Ion Mobility Separations Utilizing Traveling Waves in a 13 m Serpentine Path Length Structures for Lossless Ion Manipulations Module
Analytical Chemistry, 88(18), 8957–8964.
Contributors: L. Deng *, Y. Ibrahim *, A. Hamid *, S. Garimella *, I. Webb *, X. Zheng *, S. Prost*, J. Sandoval*
MeSH headings : Animals; Cattle; Electrodes; Electromagnetic Phenomena; Equipment Design; Ions / analysis; Isomerism; Mass Spectrometry / instrumentation; Mass Spectrometry / methods; Oligosaccharides / analysis; Oligosaccharides / chemistry; Peptides / analysis; Serum Albumin, Bovine / chemistry
TL;DR:
The development and initial evaluation of a 13 m path length Structures for Lossless Manipulations (SLIM) module for achieving high resolution separations using traveling waves (TW) with ion mobility (IM) spectrometry and it provides a foundation for the development of much higher resolution SLIM devices based upon both considerably longer path lengths and multipass designs.
(via Semantic Scholar)
europepmc.org (repository)
Source: ORCID
Added: December 5, 2019
2016 journal article
Uncovering biologically significant lipid isomers with liquid chromatography, ion mobility spectrometry and mass spectrometry
Analyst, 141(5), 1649–1659.
Contributors: J. Kyle *, X. Zhang *, K. Weitz *, M. Monroe *, Y. Ibrahim *, R. Moore *, J. Cha*, X. Sun *
MeSH headings : Chromatography, Liquid / methods; Fatty Acids / chemistry; Fatty Acids / metabolism; Lipids / chemistry; Lipids / isolation & purification; Mass Spectrometry / methods; Metabolomics / methods; Stereoisomerism
TL;DR:
It is shown that combining liquid chromatography and structurally-based ion mobility spectrometry (IMS) measurement with MS analyses distinguishes lipid isomers and allows insight into biological and disease processes.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
The past, present and future of microbiome analyses
Nature Protocols, 11(11), 4–8.
Contributors: R. White *, S. Callister*, R. Moore *, E. Baker* & J. Jansson *
TL;DR:
Key improvements in multi-omic environmental and human microbiome analyses are reviewed, and developments required to address current measurement shortcomings are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: December 5, 2019
2016 journal article
The fungal cultivar of leaf-cutter ants produces specific enzymes in response to different plant substrates
Molecular Ecology, 25(22), 5795–5805.
Contributors: L. Khadempour *, K. Burnum-Johnson *, E. Baker* , C. Nicora *, B. Webb-Robertson*, R. White *, M. Monroe *, E. Huang*, R. Smith *, C. Currie *
author keywords: fungi; leaf-cutter ants; metaproteomics; microbial ecology; symbiosis
MeSH headings : Agaricales / enzymology; Animals; Ants / microbiology; Flowers / metabolism; Fungal Proteins / metabolism; Plant Leaves / metabolism; Plants / metabolism; Proteomics; Symbiosis
TL;DR:
Flexible, substrate‐specific enzymatic response of the fungal cultivar allows leaf‐cutter ants to derive energy from a wide range of substrates, which likely contributes to their ability to be dominant generalist herbivores.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Surprising impact of remote groups on the folding-unfolding and dimer-chain equilibria of bifunctional H-bonding unimers (vol 52, pg 3773, 2016)
Chemical Communications, 52(29), 5205.
Contributors: R. Liu, S. Chen *, E. Baker* , R. Smith *, X. Zeng* & B. Gong *
Source: ORCID
Added: December 5, 2019
2016 journal article
SPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in biofluids
Clinical Mass Spectrometry, 2, 1–10.
Contributors: X. Zhang *, M. Romm*, X. Zheng *, E. Zink *, Y. Kim *, K. Burnum-Johnson *, D. Orton *, A. Apffel*
author keywords: Ion mobility spectrometry; Mass spectrometry; Metabolomics; Exposomics
TL;DR:
This SPE-IMS-MS platform overcomes many of the current challenges of large-scale metabolomic and exposomic analyses and offers a viable option for population and patient cohort screening in an effort to gain insights into disease processes and human environmental chemical exposure.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Surprising impact of remote groups on the folding-unfolding and dimer-chain equilibria of bifunctional H-bonding unimers
Chemical Communications, 52(19), 3773–3776.
Contributors: R. Liu, S. Cheng *, E. Baker* , R. Smith *, X. Zeng * & B. Gong *
MeSH headings : Amides / chemistry; Dimerization; Hydrogen Bonding; Proton Magnetic Resonance Spectroscopy
TL;DR:
Replacing the side chains and end groups ofligoamide 1 with derivatives that show the surprising impact of end groups on the folding and dimer-chain equilibria of the resultant molecules.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Squeezing of Ion Populations and Peaks in Traveling Wave Ion Mobility Separations and Structures for Lossless Ion Manipulations Using Compression Ratio Ion Mobility Programming
Analytical Chemistry, 88(23), 11877–11885.
Contributors: S. Garimella *, A. Hamid *, L. Deng *, Y. Ibrahim *, I. Webb *, E. Baker* , S. Prost*, R. Norheim*, G. Anderson*, R. Smith *
MeSH headings : Electrodes; Ions / chemistry; Ions / isolation & purification; Mass Spectrometry / instrumentation; Mass Spectrometry / methods; Molecular Structure
TL;DR:
This work collapses ion distributions in ion mobility (IM) separations into tighter packets providing higher sensitivity measurements in conjunction with mass spectrometry (MS), providing greatly enhanced IM resolution by reducing the detrimental effects of diffusional peak broadening and increasing peak widths.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Spatial Ion Peak Compression and its Utility in Ion Mobility Spectrometry
Journal of the American Society For Mass Spectrometry, 27(6), 1128–1135.
Contributors: S. Garimella *, Y. Ibrahim *, K. Tang *, I. Webb *, E. Baker* , A. Tolmachev *, T. Chen*, G. Anderson*, R. Smith *
author keywords: Ion mobility spectrometry; Diffusion; Peak compression; High resolution IMS
MeSH headings : Ion Mobility Spectrometry; Ions; Pressure
TL;DR:
A novel concept for ion spatial peak compression is described, and discussed primarily in the context of ion mobility spectrometry (IMS), which can be particularly useful for mitigating diffusion-driven peak broadening over very long path length separations and for achieving higher S/N and IMS resolution over a selected mobility range.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Simultaneous Proteomic Discovery and Targeted Monitoring using Liquid Chromatography, Ion Mobility Spectrometry, and Mass Spectrometry
Molecular &Amp; Cellular Proteomics, 15(12), 3694–3705.
Contributors: K. Burnum-Johnson *, S. Nie*, C. Casey *, M. Monroe *, D. Orton *, Y. Ibrahim *, M. Gritsenko *, T. Clauss*
MeSH headings : Animals; Breast Neoplasms / metabolism; Chromatography, Liquid / methods; Female; Humans; Mass Spectrometry / methods; Mice; Neoplasm Transplantation; Peptides / analysis; Proteome / isolation & purification; Proteomics / methods
TL;DR:
A new approach is described that performs both discovery and targeted monitoring (DTM) in a single analysis by combining liquid chromatography, ion mobility spectrometry and mass Spectrometry (LC-IMS-MS).
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Mobility-Selected Ion Trapping and Enrichment Using Structures for Lossless Ion Manipulations
Analytical Chemistry, 88(3), 1728–1733.
Contributors: T. Chen *, Y. Ibrahim *, I. Webb *, S. Garimella *, X. Zhang *, A. Hamid *, L. Deng *, W. Karnesky*
MeSH headings : Humans; Ions / chemistry; Mass Spectrometry / methods; Peptides / analysis; Protein Conformation
TL;DR:
An ion separation and trapping module and a method based upon SLIM that consists of a linear mobility ion drift region, a switch/tee and a trapping region that allows the isolation and accumulation of mobility-separated species are demonstrated.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Mass spectrometry-based monitoring of millisecond protein-ligand binding dynamics using an automated microfluidic platform
Lab on a Chip, 16(9), 1544–1548.
Contributors: Y. Cong *, S. Katipamula*, C. Trader*, D. Orton *, T. Geng *, E. Baker* , R. Kelly *
MeSH headings : Algorithms; Automation, Laboratory; Carbonic Anhydrase I / antagonists & inhibitors; Carbonic Anhydrase I / chemistry; Carbonic Anhydrase I / metabolism; Carbonic Anhydrase Inhibitors / chemistry; Carbonic Anhydrase Inhibitors / metabolism; Carbonic Anhydrase Inhibitors / pharmacology; Diffusion; Diuretics / chemistry; Diuretics / metabolism; Diuretics / pharmacology; Equipment Design; Furosemide / chemistry; Furosemide / metabolism; Humans; Kinetics; Lab-On-A-Chip Devices; Ligands; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization
TL;DR:
A novel microfluidic platform that features rapid mixing of protein and ligand solutions, variable incubation times, and an integrated electrospray ionization source for mass spectrometry-based monitoring of protein-ligand binding dynamics is presented.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Ion Mobility Separations of Isomers based upon Long Path Length Structures for Lossless Ion Manipulations Combined with Mass Spectrometry
Chemistryselect, 1(10), 2396–2399.
Contributors: L. Deng *, Y. Ibrahim *, E. Baker* , N. Aly*, A. Hamid *, X. Zhang *, X. Zheng *, S. Garimella *
author keywords: Structures for Lossless Ion Manipulations (SLIM); Ion Mobility Spectrometry; Mass Spectrometry; Isomers
TL;DR:
A new approach using Structures for Lossless Ion Manipulations (SLIM) to enable long serpentine path ion mobility spectrometry (IMS) separations followed by MS analyses, which provides previously unachieved resolution for biomolecular species, in conjunction with more effective ion utilization.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: December 5, 2019
2016 journal article
Greatly Increasing Trapped Ion Populations for Mobility Separations Using Traveling Waves in Structures for Lossless Ion Manipulations
Analytical Chemistry, 88(20), 10143–10150.
Contributors: L. Deng *, Y. Ibrahim *, S. Garimella *, I. Webb *, A. Hamid *, R. Norheim*, S. Prost*, J. Sandoval*, E. Baker* , R. Smith *
TL;DR:
Wide m/z range ion transmission is demonstrated, along with significant increases in the signal-to-noise ratios (S/N) due to the larger ion populations injected and a reduction in the chemical background, which was attributed to more efficient desolvation of solvent related clusters over the extended ion accumulation periods.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Development of an Ion Mobility Spectrometry-Orbitrap Mass Spectrometer Platform
Analytical Chemistry, 88(24), 12152–12160.
Contributors: Y. Ibrahim *, S. Garimella *, S. Prost*, R. Wojcik *, R. Norheim*, E. Baker* , I. Rusyn *, R. Smith *
MeSH headings : Algorithms; Animals; Artifacts; Cattle; Equipment Design; Ion Mobility Spectrometry / instrumentation; Ions / analysis; Mass Spectrometry / instrumentation; Petroleum / analysis; Phosphopyruvate Hydratase / chemistry; Proteomics / instrumentation; Serum Albumin, Bovine / chemistry
TL;DR:
The new IMS-Orbitrap MS platform was demonstrated by the analysis of proteomic and petroleum samples, where the integration of IMS and high mass resolution proved essential for accurate assignment of molecular formulas.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Achieving High Resolution Ion Mobility Separations Using Traveling Waves in Compact Multiturn Structures for Lossless Ion Manipulations
Analytical Chemistry, 88(18), 8949–8956.
Contributors: A. Hamid *, S. Garimella *, Y. Ibrahim *, L. Deng *, X. Zheng *, I. Webb *, G. Anderson*, S. Prost*
MeSH headings : Algorithms; Amino Acid Sequence; Bradykinin / analysis; Equipment Design; Ions / chemistry; Mass Spectrometry / methods; Peptides / analysis
TL;DR:
The combined attributes of flexible design, low voltage requirements and lossless ion transmission through multiple turns for the present TW-SLIM module provides a basis for SLIM devices capable of achieving much greater IM resolution via greatly extended ion path lengths and using compact serpentine designs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: ORCID
Added: December 5, 2019
2016 journal article
A Structures for Lossless Ion Manipulations (SLIM) Module for Collision Induced Dissociation
Journal of the American Society For Mass Spectrometry, 27(7), 1285–1288.
Contributors: I. Webb *, S. Garimella *, R. Norheim*, E. Baker* , Y. Ibrahim * & R. Smith *
author keywords: Collision induced dissociation; Ion mobility spectrometry; rf Confinement; Ion optics; Peptide fragmentation; Manipulation; Conveyor
TL;DR:
The SLIM CID module was mounted after an ion mobility (IM) drift tube to enable IM/CID/MS studies, and the efficiency of CID was studied by using the model peptide leucine enkephalin.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
A multi-omic future for microbiome studies
Nature Microbiology, 1(5).
Contributors: J. Jansson * & E. Baker*
MeSH headings : Gene Expression Profiling; Humans; Metabolomics; Metagenomics; Microbiota; Proteomics
TL;DR:
Integration of multiple ‘omics’ technologies will allow researchers to gain a more complete picture of the constituents and functions of microbial communities and provide far richer information for predictive modelling of community phenotypes.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Urinary Concentrations of Phthalate Metabolites and Bisphenol A and Associations with Follicular-Phase Length, Luteal-Phase Length, Fecundability, and Early Pregnancy Loss
Environmental Health Perspectives, 124(3), 321–328.
MeSH headings : Abortion, Spontaneous / chemically induced; Abortion, Spontaneous / urine; Adult; Benzhydryl Compounds / toxicity; Benzhydryl Compounds / urine; Environmental Pollutants / toxicity; Environmental Pollutants / urine; Female; Fertility / drug effects; Follicular Phase / drug effects; Humans; Luteal Phase / drug effects; Phenols / toxicity; Phenols / urine; Phthalic Acids / toxicity; Phthalic Acids / urine; Pregnancy; Pregnancy Trimester, First
TL;DR:
Menstrual cycle–specific estimates of urinary BPA and phthalate metabolites were not associated with detrimental alterations in follicular-phase length, time to pregnancy, or early pregnancy loss, and in fact, DEHP [di(2-ethylhexyl)phthalate] metabolites and ΣDEHP were associated with reduced early loss.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 17, 2019
2016 journal article
High pesticide exposure events and DNA methylation among pesticide applicators in the agricultural health study
Environmental and Molecular Mutagenesis, 58(1), 19–29.
author keywords: DNA methylation; pesticides; exposure; Agricultural Health Study; epigenetics
MeSH headings : Air Pollutants, Occupational / toxicity; Antigens, CD; Cadherins / genetics; DNA / blood; DNA Methylation / drug effects; DNA Methylation / genetics; DNA Modification Methylases / genetics; DNA Repair Enzymes / genetics; Farmers; Glutathione S-Transferase pi / genetics; Humans; Iowa; Male; North Carolina; Occupational Exposure / adverse effects; Occupational Exposure / analysis; Occupational Health; Pesticides / toxicity; Promoter Regions, Genetic; Prospective Studies; Surveys and Questionnaires; Tumor Suppressor Proteins / genetics
TL;DR:
Evaluated association between experiencing unusually high pesticide exposure events (HPEEs) and DNAm among pesticide applicators in the Agricultural Health Study, a prospective study of applicators from Iowa and North Carolina found non‐specific HPEEs may contribute to increasedDNAm in GSTp1, and in some groups, reduced DNAm in MGMT and LINE‐1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, Crossref
Added: September 13, 2019
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