Center for Environmental and Health Effects of PFAS

Works Published in 2022

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Displaying works 21 - 40 of 87 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2022 journal article

Improved spatial resolution of infrared matrix-assisted laser desorption electrospray ionization mass spectrometry imaging using a reflective objective

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 36(23).

By: A. Joignant n, H. Bai n, J. Manni & D. Muddiman n

MeSH headings : Animals; Spectrometry, Mass, Electrospray Ionization / methods; Ice; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Lasers; Mammals
Sources: Web Of Science, NC State University Libraries
Added: October 17, 2022

2022 journal article

Impact of ozone-biologically active filtration on the breakthrough of Perfluoroalkyl acids during granular activated carbon treatment of municipal wastewater effluent

WATER RESEARCH, 223.

author keywords: Perfluoroalkyl acids; Municipal wastewater effluent; Ozonation; Biologically active filtration; Effluent organic matter; Potable reuse
MeSH headings : Charcoal / chemistry; Fluorocarbons / analysis; Ozone / chemistry; Wastewater / chemistry; Water Pollutants, Chemical / chemistry; Water Purification / methods
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: October 17, 2022

2022 article

Next-Generation Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Source for Mass Spectrometry Imaging and High-Throughput Screening

Knizner, K. T., Guymon, J. P., Garrard, K. P., Bouvree, G., Manni, J., Hauschild, J.-P., … Muddiman, D. C. (2022, September 29). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 9.

By: K. Knizner n, J. Guymon n, K. Garrard n, G. Bouvree, J. Manni, J. Hauschild*, K. Strupat*, K. Fort* ...

author keywords: IR-MALDESI; High-Throughput Screening; Mass Spectrometry Imaging; Orbitrap Mass Spectrometer; Design of Experiments
MeSH headings : High-Throughput Screening Assays; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Lasers
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: October 17, 2022

2022 article

Comparative Toxicogenomics Database (CTD): update 2023

Davis, A. P., Wiegers, T. C., Johnson, R. J., Sciaky, D., Wiegers, J., & Mattingly, C. J. (2022, September 28). NUCLEIC ACIDS RESEARCH, Vol. 9.

MeSH headings : Humans; Toxicogenetics; Databases, Factual; Phenotype
TL;DR: A 20% increase in overall CTD content is reported and CTD Tetramers, a novel tool that computationally generates four-unit information blocks connecting a chemical, gene, phenotype, and disease to construct potential molecular mechanistic pathways are presented. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: October 11, 2022

2022 journal article

Wildfires and extracellular vesicles: Exosomal MicroRNAs as mediators of cross-tissue cardiopulmonary responses to biomass smoke

ENVIRONMENT INTERNATIONAL, 167.

author keywords: Exosomes; Extracellular vesicles; Environmental exposures; Mixtures; Systems biology; Wildfires
MeSH headings : Animals; Biomass; Extracellular Vesicles / metabolism; Female; Hypoxia; Mice; MicroRNAs; Soil; Wildfires
TL;DR: A potential mechanism through which wildfire exposures induce cardiopulmonary responses is posited, highlighting the role of circulating plasma EVs in intercellular and systems-level communication between tissues. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: October 3, 2022

2022 article

A High-Throughput Ion Mobility Spectrometry-Mass Spectrometry Screening Method for Opioid Profiling

Butler, K. E., & Baker, E. S. (2022, September 22). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 9.

By: K. Butler n & E. Baker n

MeSH headings : Analgesics, Opioid; High-Throughput Screening Assays; Humans; Ion Mobility Spectrometry / methods; Mass Spectrometry / methods; Solid Phase Extraction
TL;DR: This SPE-IMS-MS approach enabled the rapid screening of urine samples for opioids and presents a major improvement in sample throughput compared to traditional chromatographic analyses coupled with MS, which routinely take several minutes per sample. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 3, 2022

2022 journal article

Evaluation of Metabolism of a Defined Pesticide Mixture through Multiple In Vitro Liver Models

TOXICS, 10(10).

author keywords: toxicokinetics; chemical mixtures; defined mixtures; human health risk assessment; nontargeted analyses; microphysiological systems
TL;DR: Findings suggest that iHep-based suspension assays maintain higher metabolic activity compared to 2D sandwich and OrganoPlate® 2-lane 96 model, and illustrates that IMS-MS can characterize in vitro metabolite formation following exposure to mixtures of environmental contaminants. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 2, 2022

2022 journal article

Developing transmission mode for infrared matrix-assisted laser desorption electrospray ionization mass spectrometry imaging

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 36(22).

By: A. Joignant n, H. Bai n, J. Guymon n, K. Garrard n, M. Pankow n & D. Muddiman n

MeSH headings : Animals; Glycerol; Ice; Lasers; Mammals; Mice; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: This work has successfully demonstrated the adaptation of the NextGen IR‐MAL DESI source through the feasibility of tm‐IR‐MALDESI mass spectrometry imaging on mammalian tissue, expanding future biological applications of the method. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 26, 2022

2022 article

Impacts of Gestational FireMaster 550 (FM 550) Exposure on the Neonatal Cortex are Sex Specific and Largely Attributable to the Organophosphate Esters

Witchey, S. K., Doyle, M. G., Fredenburg, J. D., St Armour, G., Horman, B., Odenkirk, M. T., … Patisaul, H. B. (2022, September 8). NEUROENDOCRINOLOGY, Vol. 9.

By: S. Witchey n, M. Doyle n, J. Fredenburg n, G. St Armour n, B. Horman n, M. Odenkirk n, D. Aylor n, E. Baker n, H. Patisaul n

TL;DR: This study reveals multiple mechanisms by which the components of a common FR mixture are developmentally neurotoxic and that the OPFRs may be the compounds of greatest concern. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 26, 2022

2022 article

PFAS Challenges and Novel Research A Conversation With the Editorial Board of the AWWA Water Science Topical Collection on PFAS Analytics and Treatment

Crimi, M., Speth, T. F., Chowdhury, Z. K., Dickenson, E. R. V., Knappe, D. R. U., & Liu, J. (2022, September). JOURNAL AWWA, Vol. 114, pp. 13–22.

By: M. Crimi, T. Speth, Z. Chowdhury, E. Dickenson, D. Knappe* & J. Liu

Sources: Web Of Science, ORCID
Added: September 19, 2022

2022 article

Stability and Dissociation of Adeno-Associated Viral Capsids by Variable Temperature-Charge Detection-Mass Spectrometry

Kostelic, M. M., Ryan, J. P., Brown, L. S., Jackson, T. W., Hsieh, C.-C., Zak, C. K., … Marty, M. T. (2022, August 18). ANALYTICAL CHEMISTRY, Vol. 8.

By: M. Kostelic*, J. Ryan n, L. Brown*, T. Jackson*, C. Hsieh*, C. Zak*, H. Sanders*, Y. Liu* ...

MeSH headings : Capsid / chemistry; Capsid Proteins / chemistry; Dependovirus / chemistry; Mass Spectrometry; Temperature
TL;DR: This new approach better characterizes the thermal dissociation of AAVs, providing the simultaneous measurement of the stabilities and dissociation pathways of different subpopulations, and observed that pH stress caused a major decrease in thermal stability. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: September 12, 2022

2022 journal article

Drinking Water-Associated PFAS and Fluoroethers and Lipid Outcomes in the GenX Exposure Study

ENVIRONMENTAL HEALTH PERSPECTIVES, 130(9).

By: E. Rosen*, N. Kotlarz n, D. Knappe n, C. Lea*, D. Collier*, D. Richardson*, J. Hoppin n

MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Alkanesulfonic Acids; Child; Cholesterol; Cross-Sectional Studies; Drinking Water; Environmental Pollutants; Fluorocarbons; Humans; Lipids; Middle Aged; Young Adult
TL;DR: PFNA and PFOS were associated with higher levels of total and non-HDL cholesterol, with associations larger in magnitude among older adults, and fluoroethers appeared to be associated with HDL but not non- HDL lipid measures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 8, 2022

2022 journal article

An adaptive teosinte mexicana introgression modulates phosphatidylcholine levels and is associated with maize flowering time

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(27).

author keywords: phospholipid metabolism; maize genetics; highland adaptation; flowering time; selection
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 29, 2022

2022 article

Introducing the Lipidomics Minimal Reporting Checklist

McDonald, J. G., Ejsing, C. S., Kopczynski, D., Holcapek, M., Aoki, J., Arita, M., … Ekroos, K. (2022, August 8). NATURE METABOLISM, Vol. 8.

MeSH headings : Checklist; Lipid Metabolism; Lipidomics; Mass Spectrometry
TL;DR: The creation of a dynamic checklist summarizing key details of lipidomic analyses using a common language has the potential to harmonize the field by improving both traceability and reproducibility. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 22, 2022

2022 article

Allergic and non-allergic wheeze among farm women in the Agricultural Health Study (2005-2010)

Islam, J. Y., Mohamed, A., Umbach, D. M., London, S. J., Henneberger, P. K., Freeman, L. E. B., … Hoppin, J. A. (2022, August 8). OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, Vol. 8.

author keywords: Allergy; Pesticides; Respiratory System
TL;DR: Use of specific pesticides and certain farm activities may contribute to wheeze among farm women, as evaluated in the Agricultural Health Study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 9, 2022

2022 journal article

Novel matrix strategies for improved ionization and spatial resolution using IR-MALDESI mass spectrometry imaging

JOURNAL OF MASS SPECTROMETRY, 57(8).

author keywords: energy-absorbing matrix; glycerol; IR-MALDESI; mass spectrometry imaging
MeSH headings : Animals; Glycerol; Ice; Lipids; Rats; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: It was observed that utilizing a 50% glycerol matrix without ice provides improved spatial resolution with lipid abundances and annotations comparable to the ice matrix standard, while decreasing the time required to complete an IR‐MALDESI tissue imaging experiment. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 8, 2022

2022 journal article

Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance

CELL METABOLISM, 34(7), 1042-+.

By: Y. Wu, C. Wong, E. Chiles, A. Mellinger*, H. Bae, S. Jung, T. Peterson, J. Wang ...

MeSH headings : Blood Glucose; Diabetes Mellitus, Type 2; Diet, High-Fat / adverse effects; Dietary Fats / pharmacology; Fructose / metabolism; Glucose / metabolism; Glucose Intolerance / metabolism; Humans; Insulin / metabolism; Islets of Langerhans / metabolism
TL;DR: It is reported that dietary fat enhances intestinal fructose metabolism, which releases glycerate into the blood, which provides a link between dietary fructose and diabetes that is modulated by dietary fat. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 8, 2022

2022 article

Nonylphenol Polyethoxylates Enhance Adipose Deposition in Developmentally Exposed Zebrafish (vol 10, 99, 2022)

Kassotis, C. D., LeFauve, M. K., Chiang, Y.-T. T., Knuth, M. M., Schkoda, S., & Kullman, S. W. (2022, July). TOXICS, Vol. 10.

Sources: Web Of Science, ORCID
Added: August 8, 2022

2022 article

Comparative assessment of blood mercury in American alligators (Alligator mississippiensis) from Coastal North Carolina and Florida

Belcher, S. M., Guillette, M. P., Robb, F., & Rock, K. D. (2022, August 3). ECOTOXICOLOGY, Vol. 8.

author keywords: Bioaccumulation; Biomonitoring; Ecotoxicology; Mercury; Metals; Reptile
MeSH headings : Alligators and Crocodiles; Animals; Ecosystem; Environmental Monitoring; Florida; Humans; Mercury / analysis; North Carolina
TL;DR: It is revealed that local environmental factors greatly impact Hg bioaccumulation in alligators, and findings that reaffirm local contaminant biomonitoring in alligator populations will be critical for affective management and determination of guidelines for safe consumption of harvested alligators. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: August 3, 2022

2022 article

A highly diverse set of novel immunoglobulin-like transcript (NILT) genes in zebrafish indicates a wide range of functions with complex relationships to mammalian receptors

Wcisel, D. J., Dornburg, A., McConnell, S. C., Hernandez, K. M., Andrade, J., Jong, J. L. O., … Yoder, J. A. (2022, July 23). IMMUNOGENETICS, Vol. 7.

author keywords: Innate immunity; Gene content variation; Alternative immune haplotypes; Gene family evolution; Mammalian CD300 (CMRF35); Mammalian NCR2 (NKp44)
MeSH headings : Animals; Zebrafish / genetics; Amino Acid Sequence; Receptors, Immunologic / genetics; Genome / genetics; Immunoglobulins / genetics; Phylogeny; Mammals / genetics
TL;DR: A higher level of genetic complexity, interindividual variation, and sequence diversity for NILTs than previously described is revealed, suggesting that this gene family likely plays multiple roles in host immunity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 1, 2022

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