Works Published in 2009
Displaying works 41 - 60 of 91 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2009 journal article
Agricultural pesticide use and pancreatic cancer risk in the Agricultural Health Study Cohort
International Journal of Cancer, 124(10), 2495–2500.
Contributors: G. Andreotti *, L. Freeman*, L. Hou *, J. Coble*, J. Rusiecki *, J. Hoppin* , D. Silverman *, M. Alavanja*
author keywords: pancreatic cancer; pesticides; agriculture
MeSH headings : Aged; Agriculture; Carcinogens / toxicity; Case-Control Studies; Female; Humans; Male; Middle Aged; Occupational Exposure; Pancreatic Neoplasms / chemically induced; Pancreatic Neoplasms / epidemiology; Pesticides / toxicity; Prospective Studies; Registries; Surveys and Questionnaires; United States / epidemiology
TL;DR:
It is suggested that herbicides, particularly pendimethalin and EPTC, may be associated with pancreatic cancer.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref
Added: September 13, 2019
2009 journal article
Cancer incidence among pesticide applicators exposed to butylate in the Agricultural Health Study (AHS)
Environmental Research, 109(7), 860–868.
Contributors: S. Lynch *, R. Mahajan*, L. Beane Freeman*, J. Hoppin* & M. Alavanja*
author keywords: Butylate; Pesticide; Cancer; Agricultural Health Study
MeSH headings : Adult; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / epidemiology; Cohort Studies; Female; Humans; Iowa / epidemiology; Lymphoma, Non-Hodgkin / chemically induced; Lymphoma, Non-Hodgkin / epidemiology; Male; Middle Aged; North Carolina / epidemiology; Occupational Exposure / adverse effects; Pesticides / poisoning; Prevalence; Prospective Studies; Prostatic Neoplasms / chemically induced; Prostatic Neoplasms / epidemiology; Surveys and Questionnaires; Thiocarbamates / poisoning
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref
Added: September 13, 2019
2009 journal article
Cancer Incidence Among Paraquat Exposed Applicators in the Agricultural Health Study: A Prospective Cohort Study
International Journal of Occupational and Environmental Health, 15(3), 274–281.
MeSH headings : Adult; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / epidemiology; Female; Herbicides / toxicity; Humans; Incidence; Iowa / epidemiology; Lymphoma, Non-Hodgkin / chemically induced; Lymphoma, Non-Hodgkin / epidemiology; Male; Middle Aged; North Carolina / epidemiology; Paraquat / toxicity; Prospective Studies; Risk
TL;DR:
There was some suggestion of a possible link between paraquat exposure and NHL risk in humans, but the inconsistency in exposure level trend suggests that this could be a chance finding.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, ORCID
Added: September 13, 2019
2009 journal article
Text mining and manual curation of chemical-gene-disease networks for the Comparative Toxicogenomics Database (CTD)
BMC Bioinformatics, 10(1).
MeSH headings : Computational Biology / methods; Databases, Factual; Gene Regulatory Networks; Information Storage and Retrieval / methods; Toxicogenetics
TL;DR:
This text-mining project is unique in its integration of existing tools into a single workflow with direct application to CTD, which allowed us to measure the potential of these integrated tools to improve prioritization of journal articles for manual curation.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 10, 2019
2009 journal article
Perturbation of Defense Pathways by Low-Dose Arsenic Exposure in Zebrafish Embryos
Environmental Health Perspectives, 117(6), 981–987.
Contributors: C. Mattingly* , T. Hampton, K. Brothers, N. Griffin & A. Planchart*
author keywords: arsenic; Comparative Toxicogenomics Database; embryonic development; gene regulatory networks; immunity; microarray; toxicogenomics; transcriptional profiling; zebrafish
MeSH headings : Animals; Arsenic / toxicity; Embryo, Nonmammalian; Gene Expression / drug effects; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Water Pollutants, Chemical / toxicity; Zebrafish / metabolism
TL;DR:
It is demonstrated that arsenic significantly down-regulates expression levels of multiple genes potentially critical for regulating the establishment of an immune response, and provides molecular evidence consistent with phenotypic observations reported in other model systems.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 10, 2019
2009 journal article
Chemical databases for environmental health and clinical research
Toxicology Letters, 186(1), 62–65.
author keywords: Chemical; Drug; Database; Toxicogenomics
MeSH headings : Animals; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Environmental Exposure; Environmental Health; Environmental Medicine; Environmental Pollutants / toxicity; Humans; Toxicogenetics
TL;DR:
These databases and their associated resources are incrementally strengthening the expanding field of toxicogenomics-based research by providing centralized sources of manually and computationally curated datasets and highly sophisticated tools for the meta-analysis of continually increasing environmental chemical, drug and small-molecule datasets.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 10, 2019
2009 journal article
Genetic and environmental pathways to complex diseases
BMC Systems Biology, 3(1), 46.
MeSH headings : Databases, Genetic; Disease / genetics; Environment; Evolution, Molecular; Gene Expression Regulation; Genome-Wide Association Study; Genotype; Humans; Mental Disorders / etiology; Mental Disorders / genetics; Mental Disorders / metabolism; Mental Disorders / pathology; Metabolic Diseases / etiology; Metabolic Diseases / genetics; Metabolic Diseases / metabolism; Metabolic Diseases / pathology; Phenotype; Transcription, Genetic
TL;DR:
This analysis identifies natural and synthetic retinoids, antipsychotic medications, Omega 3 fatty acids, and pyrethroid pesticides as potential environmental modulators of metabolic syndrome phenotypes through PPAR and adipocytokine signaling and organophosphate pesticides as potential environmental modulators of neuropsychiatric phenotypes.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 10, 2019
2009 journal article
Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical-gene-disease networks
Nucleic Acids Research, 37(Database), D786–D792.
MeSH headings : Databases, Factual; Disease / etiology; Disease / genetics; Environmental Exposure; Genes; Genomics; Hazardous Substances / toxicity; Humans; Models, Biological; Proteins / drug effects; Proteins / genetics; Systems Integration; Toxicogenetics
TL;DR:
The Comparative Toxicogenomics Database is a curated database that promotes understanding about the effects of environmental chemicals on human health by integrating data to be integrated to construct chemical–gene–disease networks.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 10, 2019
2009 journal article
GeneComps and ChemComps: a new CTD metric to identify genes and chemicals with shared toxicogenomic profiles
Bioinformation, 4(4), 173–174.
author keywords: gene; chemical; toxicogenomic; database; curation
TL;DR:
GeneComps and ChemComps are now provided for every curated gene and chemical in CTD and provide a novel way to view and classify genes and chemicals and will help advance testable hypotheses about environmental chemical-genedisease networks.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 10, 2019
2009 journal article
Sp2 Is a Maternally Inherited Transcription Factor Required for Embryonic Development
Journal of Biological Chemistry, 285(6), 4153–4164.
MeSH headings : Amino Acid Sequence; Animals; COS Cells; Chlorocebus aethiops; Chromosome Mapping; Embryo, Mammalian / embryology; Embryo, Mammalian / metabolism; Female; Gene Expression Regulation, Developmental; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Humans; In Situ Hybridization; Male; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Phylogeny; Promoter Regions, Genetic / genetics; RNA, Messenger, Stored / genetics; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sp2 Transcription Factor / classification; Sp2 Transcription Factor / genetics; Sp2 Transcription Factor / metabolism; Synteny; Transcription, Genetic; Zebrafish / embryology; Zebrafish / genetics; Zebrafish / growth & development; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
The role(s) played by Sp2 in early metazoan development is addressed by cloned and characterized Sp2 from zebrafish, and the intron/exon organization and amino acid sequence of Sp2 is closely conserved with its mammalian orthologues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: July 21, 2019
2009 journal article
Developmental and tissue-specific expression of NITRs
Immunogenetics, 62(2), 117–122.
author keywords: Innate immunity; Lymphocytes; Natural killer receptors
MeSH headings : Animals; Embryo, Nonmammalian / metabolism; Female; Gene Expression Regulation, Developmental; Organ Specificity; Ovary / metabolism; Receptors, Immunologic / genetics; Receptors, Immunologic / immunology; Zebrafish / embryology; Zebrafish / genetics; Zebrafish / immunology; Zebrafish / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / immunology
TL;DR:
The expression of multiple NITR genes in the zebrafish ovary and during embryogenesis is demonstrated and all 14 families of NITRs are shown to be expressed in the lymphocyte lineage, but not in the myeloid lineage, consistent with the hypothesis that N ITRs function as NKRs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: ORCID, Crossref
Added: May 17, 2019
2009 journal article
Profiling Chemicals Based on Chronic Toxicity Results from the U.S. EPA ToxRef Database
Environ Health Perspect, 117(3), 392â399.
Contributors: M. Martin*, R. Judson *, D. Reif* , R. Kavlock* & D. Dix*
author keywords: cancer; chronic toxicity; pesticides; relational database; toxicity profile
MeSH headings : Computational Biology / methods; Databases, Factual; Ecotoxicology / methods; Environmental Pollutants / classification; Environmental Pollutants / toxicity; Pesticides / classification; Pesticides / toxicity; United States; United States Environmental Protection Agency
TL;DR:
The resulting toxicity profile classifications demonstrate the utility of structuring legacy toxicity information and facilitating the computation of these data within ToxRefDB for ToxCast and other applications.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2009 journal article
In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project
Environ Health Perspect, 118(4), 485â492.
author keywords: in vitro screening; liver proliferative lesions; liver tumors; pathways; ToxCast
MeSH headings : Animals; Cell Line; Cells, Cultured; Computer Simulation; Environmental Pollutants / toxicity; Humans; Rats; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR:
A statistically significant inverse association between the number of pathways perturbed by a chemical at low in vitro concentrations and the lowest in vivo dose at which a chemical causes toxicity is found.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2009 journal article
A comparison of analytical methods for genetic association studies
Genet. Epidemiol., 33(8), 751â751.
Contributors: A. Motsinger-Reif n, D. Reif* , T. Fanelli* & M. Ritchie*
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 14, 2019
2009 journal article
Integrated analysis of genetic and proteomic data identifies biomarkers associated with adverse events following smallpox vaccination.
Genes and Immunity, 10(2), 112–119.
Contributors: D. Reif* , A. Motsinger-Reif n, B. McKinney *, M. Rock*, J. Crowe Jr. & J. Moore *
author keywords: smallpox; Random Forests; integrated analysis; genetic; proteomic; interactions
MeSH headings : Biomarkers / blood; Cytokines / blood; Cytokines / genetics; Decision Making, Computer-Assisted; Female; Humans; Inflammation / blood; Inflammation / chemically induced; Inflammation / genetics; Intercellular Adhesion Molecule-1 / blood; Intercellular Adhesion Molecule-1 / genetics; Male; Models, Biological; Polymorphism, Single Nucleotide; Proteomics / methods; Smallpox Vaccine / administration & dosage; Smallpox Vaccine / adverse effects; Vaccination
TL;DR:
This study built a comprehensive model of AE development that includes the cytokines intercellular adhesion molecule-1 (ICAM-1 or CD54), interleukin-10 (IL-10), and colony stimulating factor-3 (CSF-3 or G-CSF) and a genetic polymorphism in the cyokine gene interleUKin-4 (IL4).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 14, 2019
2009 journal article
Comparative microarray analysis and pulmonary changes in Brown Norway rats exposed to ovalbumin and concentrated air particulates.
Toxicological Sciences, 108(1), 207–221.
Contributors: B. Heidenfelder*, D. Reif* , J. Harkema*, E. Cohen Hubal *, E. Hudgens*, L. Bramble*, J. Wagner*, M. Morishita*
author keywords: ovalbumin; allergen; asthma; particulate matter; remodeling; inflammation; microarray
MeSH headings : Air Pollutants / toxicity; Allergens / administration & dosage; Allergens / immunology; Analysis of Variance; Animals; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / immunology; Bronchopneumonia / metabolism; Bronchopneumonia / pathology; Gene Expression / drug effects; Inflammation / immunology; Lung / drug effects; Lung / immunology; Lung / metabolism; Lung / pathology; Male; Oligonucleotide Array Sequence Analysis; Ovalbumin / administration & dosage; Ovalbumin / immunology; Particulate Matter / administration & dosage; Particulate Matter / toxicity; Principal Component Analysis; Rats; Respiratory Hypersensitivity / metabolism; Respiratory Hypersensitivity / pathology; Respiratory Mucosa / drug effects; Respiratory Mucosa / immunology; Respiratory Mucosa / metabolism; Respiratory Mucosa / pathology
TL;DR:
The broad-based histopathology and functional genomic analyses demonstrate that exposure to CAPs exacerbates rodents with allergic inflammation induced by an allergen and suggests that asthmatics may be at increased risk for air pollution effects.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2009 journal article
Application of Artificial Neural Networks for Estimating Dynamic Modulus of Asphalt Concrete
TRANSPORTATION RESEARCH RECORD, (2127), 173–186.
TL;DR:
Outcomes from a research effort to develop models for estimating the dynamic modulus (|E*|) of hot-mix asphalt (HMA) layers on long-term pavement performance test sections show that the predicted and measured |E* | values are in close agreement.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Evaluation of the ALiPHAT Method for PC-IDMS and Correlation of Limits-of-Detection with Nonpolar Surface Area
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 20(11), 2006–2012.
MeSH headings : Alkylation; Amino Acid Sequence; Calibration; Carbon Isotopes / chemistry; Chromatography, High Pressure Liquid / methods; Humans; Hydrophobic and Hydrophilic Interactions; Isotope Labeling / methods; Laminin / analysis; Laminin / chemistry; Male; Mass Spectrometry / methods; Nitrogen Isotopes / chemistry; Oligopeptides / analysis; Oligopeptides / chemistry; Prostate-Specific Antigen / chemistry; Reference Standards; Trypsin / analysis; Trypsin / chemistry
TL;DR:
While an increase in hydrophobicity was found to aid in decreasing LOD to an extent, beyond a certain hydrophOBicity, the number of decreases in LOD was observed, the authors observed a decrease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 journal article
Controls on Landfill Gas Collection Efficiency: Instantaneous and Lifetime Performance
JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION, 59(12), 1399–1404.
MeSH headings : Air Pollutants / analysis; Conservation of Natural Resources / methods; Environmental Monitoring; Methane / analysis; Models, Theoretical; Refuse Disposal / methods
TL;DR:
The authors suggest that the temporally weighted gas collection efficiency, which considers total gas production and collection over the landfill life, is the appropriate way to report collection efficiency.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 journal article
Effect of Free Chlorine Application on Microbial Quality of Drinking Water in Chloraminated Distribution Systems
Journal AWWA, 101(10), 60–70.
Contributors: E. Rosenfeldt, C. Baeza & D. Knappe
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
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