Works Published in 2014
Displaying works 41 - 60 of 111 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Detecting and Removing Data Artifacts in Hadamard Transform Ion Mobility-Mass Spectrometry Measurements
The Journal of the American Society for Mass Spectrometry, 25(12), 2020–2027.
Contributors: S. Prost*, K. Crowell*, E. Baker* , Y. Ibrahim *, B. Clowers *, M. Monroe *, G. Anderson*, R. Smith *, S. Payne *
author keywords: Ion mobility; Computational proteomics; Hadamard transform; Bioinformatics; Sensitivity; Data analysis
MeSH headings : Algorithms; Artifacts; Fourier Analysis; Mass Spectrometry / methods; Proteomics
TL;DR:
Following application of the algorithm, IMS-MS measurement sensitivity is greatly increased and artifacts that previously limited the utility of applying the Hadamard transform to IMS are avoided.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 5, 2019
2014 journal article
Advancing the High Throughput Identification of Liver Fibrosis Protein Signatures Using Multiplexed Ion Mobility Spectrometry*
Molecular &Amp; Cellular Proteomics, 13(4), 1119–1127.
Contributors: E. Baker* , K. Burnum-Johnson *, J. Jacobs *, D. Diamond*, R. Brown *, Y. Ibrahim *, D. Orton *, P. Piehowski *
MeSH headings : Chromatography, Liquid; Humans; Ions / chemistry; Liver Cirrhosis / blood; Liver Cirrhosis / complications; Liver Cirrhosis / metabolism; Liver Transplantation; Mass Spectrometry; Proteome / metabolism; Proteomics / instrumentation; Proteomics / methods
TL;DR:
This work reports on the use of a new instrumental platform that addresses challenges of rapid gas phase multiplexed ion mobility spectrometry separations with liquid chromatography and MS to dramatically increase measurement sensitivity and throughput, further enabling future high throughput MS-based clinical applications.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2014 journal article
Improving Ion Mobility Measurement Sensitivity by Utilizing Helium in an Ion Funnel Trap
Analytical Chemistry, 86(11), 5295–5299.
Contributors: Y. Ibrahim *, S. Garimella *, A. Tolmachev *, E. Baker* & R. Smith *
MeSH headings : Algorithms; Buffers; Helium / analysis; Ions / chemistry; Mass Spectrometry; Nitrogen / chemistry; Protein Hydrolysates / chemistry; Serum Albumin, Bovine / chemistry
TL;DR:
Signal intensities for higher m/z species were improved and the effect of helium upon IMS resolving power was studied by introducing a He/N2 gas mixture into the drift cell, and in some cases, a slight improvement was observed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: ORCID
Added: December 5, 2019
2014 journal article
Prevalence of allergic sensitization in the United States: Results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006
Journal of Allergy and Clinical Immunology, 134(2), 350–359.
Contributors: P. Salo*, S. Arbes Jr., R. Jaramillo *, A. Calatroni*, C. Weir*, M. Sever*, J. Hoppin* , K. Rose*
author keywords: Allergen; allergy; allergic sensitization; serum IgE
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Allergens / immunology; Child; Child, Preschool; Cross Reactions; Cross-Sectional Studies; Female; Food Hypersensitivity / blood; Food Hypersensitivity / epidemiology; Food Hypersensitivity / ethnology; Food Hypersensitivity / immunology; Humans; Immunoglobulin E / blood; Infant; Male; Middle Aged; Nutrition Surveys; Prevalence; Racial Groups; Respiratory Hypersensitivity / blood; Respiratory Hypersensitivity / epidemiology; Respiratory Hypersensitivity / ethnology; Respiratory Hypersensitivity / immunology; United States / epidemiology
TL;DR:
The overall prevalence of allergic sensitization does not vary across US census regions, except in early life, although allergen-specific sensitization differs based on sociodemographic and regional factors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2014 journal article
Reliability of triclosan measures in repeated urine samples from Norwegian pregnant women
Journal of Exposure Science & Environmental Epidemiology, 24(5), 517–521.
Contributors: R. Bertelsen *, S. Engel *, T. Jusko *, A. Calafat *, J. Hoppin* , S. London *, M. Eggesbø *, H. Aase *
author keywords: biomarkers; MoBa; intraclass correlation coefficient; pregnancy; reliability; triclosan
MeSH headings : Anti-Infective Agents, Local / urine; Female; Humans; Norway; Pregnancy; Reproducibility of Results; Triclosan / urine
TL;DR:
The reliability of TCS concentrations in repeated urine samples from pregnant Norwegian women was reasonably good, suggesting a single urine sample can adequately represent TCS exposure during pregnancy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2014 journal article
Perfluoroalkyl Substances During Pregnancy and Validated Preeclampsia Among Nulliparous Women in the Norwegian Mother and Child Cohort Study
American Journal of Epidemiology, 179(7), 824–833.
Contributors: A. Starling, S. Engel, D. Richardson, D. Baird, L. Haug, A. Stuebe, K. Klungsøyr, Q. Harmon
author keywords: Norwegian Mother and Child Cohort Study; perfluoroalkyl substances; perfluorooctanoic acid; perfluorooctane sulfonate; perfluoroundecanoic acid; preeclampsia
MeSH headings : Adolescent; Adult; Alkanesulfonic Acids / blood; Caprylates / blood; Cohort Studies; Environmental Exposure / adverse effects; Environmental Exposure / analysis; Environmental Pollutants / adverse effects; Environmental Pollutants / blood; Fatty Acids / blood; Female; Fluorocarbons / blood; Humans; Norway; Parity; Pre-Eclampsia / blood; Pre-Eclampsia / etiology; Pregnancy; Proportional Hazards Models; Young Adult
TL;DR:
The findings do not support an increased risk of preeclampsia among nulliparous Norwegian women with background levels of PFAS exposure, and an inverse association between preeClampsia and the highest quartile of perfluoroundecanoic acid concentration relative to the lowest quartile is found.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2014 journal article
Long-Term Exposure to Fine Particulate Matter: Association with Nonaccidental and Cardiovascular Mortality in the Agricultural Health Study Cohort
Environmental Health Perspectives, 122(6), 609–615.
Contributors: S. Weichenthal *, P. Villeneuve *, R. Burnett *, A. Donkelaar *, R. Martin *, R. Jones *, C. DellaValle*, D. Sandler *, M. Ward *, J. Hoppin*
MeSH headings : Adult; Agriculture / statistics & numerical data; Air Pollutants / analysis; Air Pollutants / toxicity; Cardiovascular Diseases / mortality; Cohort Studies; Environmental Exposure / analysis; Environmental Exposure / statistics & numerical data; Female; Humans; Iowa / epidemiology; Male; Mortality; North Carolina / epidemiology; Particulate Matter / analysis; Particulate Matter / toxicity; Risk Factors; Rural Population; Sex Factors
TL;DR:
Positive associations were observed between ambient PM2.5 and cardiovascular mortality among men, and these associations were strongest among men who did not move from their enrollment address, while similar associations were not observed among women.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2014 journal article
Exacerbation of symptoms in agricultural pesticide applicators with asthma
International Archives of Occupational and Environmental Health, 87(4), 423–432.
Contributors: P. Henneberger *, X. Liang *, S. London *, D. Umbach *, D. Sandler * & J. Hoppin*
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Agricultural Workers' Diseases / epidemiology; Agricultural Workers' Diseases / etiology; Asthma, Occupational / epidemiology; Asthma, Occupational / etiology; Female; Humans; Male; Middle Aged; Occupational Exposure / adverse effects; Pesticides / adverse effects; Risk Factors; Severity of Illness Index; Surveys and Questionnaires; United States; Young Adult
TL;DR:
The inverse associations with two pesticides and specific farm activities are consistent with the possibility that asthma cases prone to exacerbation may avoid exposures that trigger symptoms, and suggest that use of specific pesticides may contribute to exacerbate of asthma among individuals with allergies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: September 13, 2019
2014 journal article
Perfluoroalkyl substances and lipid concentrations in plasma during pregnancy among women in the Norwegian Mother and Child Cohort Study
Environment International, 62, 104–112.
Contributors: A. Starling *, S. Engel *, K. Whitworth *, D. Richardson *, A. Stuebe *, J. Daniels *, L. Haug *, M. Eggesbø *
author keywords: The Norwegian Mother and Child Cohort Study MoBa; Perfluoroalkyl substances; Perfluorooctanoic acid; Perfluorooctane sulfonate
MeSH headings : Adult; Alkanesulfonic Acids / blood; Cholesterol / blood; Cohort Studies; Cross-Sectional Studies; Environmental Pollutants / blood; Female; Fluorocarbons / blood; Humans; Linear Models; Lipids / blood; Mothers; Norway
TL;DR:
Plasma concentrations of PFASs were positively associated with HDL cholesterol, and PFOS was positivelyassociated with total cholesterol in this sample of pregnant Norwegian women, suggesting a mechanism by which PFAS exposure leads to certain adverse pregnancy outcomes, including preeclampsia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2014 journal article
Dietary fat intake, pesticide use, and Parkinson's disease
Parkinsonism & Related Disorders, 20(1), 82–87.
Contributors: F. Kamel, S. Goldman, D. Umbach, H. Chen, G. Richardson, M. Barber, C. Meng, C. Marras
author keywords: Parkinson's disease; Dietary fat; Polyunsaturated fatty acids; Pesticides
MeSH headings : Adult; Aged; Aged, 80 and over; Case-Control Studies; Diet; Dietary Fats; Fatty Acids, Omega-3; Female; Humans; Male; Middle Aged; Parkinson Disease / epidemiology; Pesticides / adverse effects; Risk Factors
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2014 journal article
Association between Class III Obesity (BMI of 40–59 kg/m2) and Mortality: A Pooled Analysis of 20 Prospective Studies
PLoS Medicine, 11(7), e1001673.
Contributors: C. Kitahara *, A. Flint*, A. Gonzalez *, L. Bernstein *, M. Brotzman*, R. MacInnis *, S. Moore *, K. Robien*
Ed(s): K. Khaw
MeSH headings : Australia / epidemiology; Body Mass Index; Humans; Life Expectancy; Obesity / mortality; Prospective Studies; Risk Factors; Sweden / epidemiology; United States / epidemiology
TL;DR:
In a pooled analysis of 20 prospective studies, Cari Kitahara and colleagues find that class III obesity is associated with excess rates of total mortality, particularly due to heart disease, cancer, and diabetes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2014 journal article
Neutralization of Mitochondrial Superoxide by Superoxide Dismutase 2 Promotes Bacterial Clearance and Regulates Phagocyte Numbers in Zebrafish
Infection and Immunity, 83(1), 430–440.
Ed(s): B. McCormick
MeSH headings : Animals; Immunity, Innate; Leukocyte Count; Macrophages / enzymology; Macrophages / immunology; Mitochondria / enzymology; Mitochondria / metabolism; Pseudomonas aeruginosa / immunology; Superoxide Dismutase / metabolism; Superoxides / metabolism; Zebrafish
TL;DR:
The roles of SOD2 and mitochondrial ROS regulation in the zebrafish innate immune response to P. aeruginosa infection are described and the use of mitochondrion-targeted ROS scavengers as potential adjuvant therapies during severe infections is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, Crossref
Added: May 17, 2019
2014 journal article
Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging
Acta Neuropathologica Communications, 2(1).
Contributors: A. Motsinger-Reif n, H. Zhu *, M. Kling*, W. Matson*, S. Sharma *, O. Fiehn *, D. Reif n , D. Appleby *
author keywords: Alzheimer's disease; Dementias; Metabolomics; Cerebrospinal fluid biomarkers; Stepwise logistic regression
MeSH headings : Aged; Aging / cerebrospinal fluid; Aging / drug effects; Aging / pathology; Alzheimer Disease / cerebrospinal fluid; Alzheimer Disease / diagnosis; Alzheimer Disease / drug therapy; Alzheimer Disease / pathology; Amyloid beta-Peptides / cerebrospinal fluid; Area Under Curve; Biomarkers / cerebrospinal fluid; Chromatography, Liquid; Cognition; Diagnosis, Differential; Female; Gas Chromatography-Mass Spectrometry; Humans; Logistic Models; Male; Metabolomics / methods; Neuropsychological Tests; tau Proteins / cerebrospinal fluid
TL;DR:
Several CSF small-molecule metabolites that discriminated especially well between clinically diagnosed AD and control groups appear to be suitable for further confirmatory and validation studies, and show the potential to provide predictive performance for AD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2014 journal article
Test driving ToxCast: Endocrine profiling for 1858 chemicals included in phase II
Current Opinion in Pharmacology, 19, 145–152.
Contributors: D. Filer*, H. Patisaul n, T. Schug*, D. Reif n & K. Thayer *
MeSH headings : Animals; Databases, Factual; Endocrine Disruptors / toxicity; High-Throughput Screening Assays; Humans; Models, Theoretical; Risk Assessment; United States; United States Environmental Protection Agency
TL;DR:
Results from this exercise suggest the spectrum of environmental chemicals with potential endocrine activity is much broader than indicated, and that some aspects of endocrine disruption are not fully covered in ToxCast.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: ORCID
Added: May 14, 2019
2014 journal article
Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway
Scientific Reports, 4.
Contributors: R. Huang *, S. Sakamuru *, M. Martin*, D. Reif* , R. Judson *, K. Houck *, W. Casey *, J. Hsieh *
MeSH headings : Cell Line; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / antagonists & inhibitors; Genes, Reporter / drug effects; HEK293 Cells; High-Throughput Screening Assays / methods; Humans; Ligands; Protein Binding / drug effects; Signal Transduction / drug effects; Small Molecule Libraries / pharmacology; Structure-Activity Relationship
TL;DR:
The results demonstrate the feasibility of qHTS to identify environmental chemicals with the potential to interact with the ERα signaling pathway and the two different assay formats improve the confidence in correctly identifying these chemicals.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2014 journal article
Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses
Environmental Science and Technology, 48(15), 8706–8716.
Contributors: D. Rotroff *, M. Martin*, D. Dix*, D. Filer*, K. Houck *, T. Knudsen *, N. Sipes *, D. Reif*
MeSH headings : Algorithms; Animals; Biological Assay; Endocrine Disruptors / analysis; Estrogen Antagonists / analysis; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / antagonists & inhibitors; Estrogen Receptor beta / agonists; Estrogen Receptor beta / antagonists & inhibitors; Estrogens / analysis; High-Throughput Screening Assays; Humans; MCF-7 Cells; Models, Chemical; Pesticides; Signal Transduction
TL;DR:
A novel method for combining in vitro concentration response data from multiple assays and, when applied to a large set of ER data, accurately predicted estrogenic responses and demonstrated its utility for chemical prioritization is provided.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2014 journal article
Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms
Nature Biotechnology, 32(6), 583–591.
Contributors: N. Kleinstreuer *, J. Yang *, E. Berg*, T. Knudsen *, A. Richard *, M. Martin*, D. Reif* , R. Judson *
MeSH headings : Animal Testing Alternatives / methods; Animals; Computer Simulation; High-Throughput Screening Assays / methods; Humans; Mice; Models, Biological; Phenotype; Rats; Small Molecule Libraries; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR:
The results demonstrate that assaying complex biological pathways in primary human cells can identify potential chemical targets, toxicological liabilities and mechanisms useful for elucidating adverse outcome pathways.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2014 journal article
Multidimensional in vivo hazard assessment using zebrafish.
Toxicological Sciences, 137(1), 212–233.
Contributors: L. Truong *, D. Reif n , L. Mary *, M. Geier*, H. Truong* & R. Tanguay *
MeSH headings : Animals; Cluster Analysis; Computational Biology; Dose-Response Relationship, Drug; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Embryo, Nonmammalian / pathology; Embryonic Development / drug effects; Environmental Pollutants / toxicity; High-Throughput Screening Assays; Humans; Motor Activity / drug effects; Notochord / drug effects; Notochord / pathology; Reproducibility of Results; Risk Assessment; Toxicity Tests / methods; Zebrafish / embryology
TL;DR:
An experimental design for high-throughput characterization of multidimensional in vivo effects with the power to evaluate trends relating to commonly cited chemical predictors is described and it is demonstrated that the developmental zebrafish detects adverse responses that would be missed by less comprehensive testing strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 14, 2019
2014 journal article
Hierarchical dose-response modeling for high-throughput toxicity screening of environmental chemicals
Biom, 70(1), 237â246.
Contributors: A. Wilson n, D. Reif n & B. Reich n
author keywords: Bayesian; Computational toxicology; Dose-response; MCMC; Monotonicity; Semiparametric; ToxCast
MeSH headings : Algorithms; Bayes Theorem; Computer Simulation; Dose-Response Relationship, Drug; Environmental Pollutants / toxicity; Estrogen Receptor alpha / metabolism; Humans; Markov Chains; Models, Statistical; Monte Carlo Method; PPAR gamma / metabolism; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR:
This work proposes a semiparametric Bayesian model that borrows strength across chemicals and assays and demonstrates that the hierarchical method provides more accurate estimates of the probability of response, efficacy, and potency than separate curve estimation in a simulation study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: ORCID
Added: May 14, 2019
2014 journal article
Erratum to Incorporating human dosimetry and exposure into High-throughput in Vitro Toxicity Screening [Toxicological sciences 137, 2, (2014), 499]
Toxicological Sciences, 137(2).
Contributors: D. Rotroff, B. Wetmore, D. Dix, S. Ferguson, H. Clewell, K. Houck, E. LeCluyse, M. Andersen
Source: ORCID
Added: May 14, 2019
Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.
Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.
