Works Published in 2017
Displaying works 41 - 60 of 115 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2017 journal article
Comparing identified and statistically significant lipids and polar metabolites in 15-year old serum and dried blood spot samples for longitudinal studies
Rapid Communications in Mass Spectrometry, 31(5), 447–456.
Contributors: J. Kyle *, C. Casey *, K. Stratton *, E. Zink *, Y. Kim *, X. Zheng *, M. Monroe *, K. Weitz *
TL;DR:
The difference in the number of statistically significant polar metabolites and lipids indicated that the lipids did not degrade to as great of a degree as the polar metabolites in the DBS samples and lipid quantitation was still possible.
(via Semantic Scholar)
europepmc.org (repository)
Source: ORCID
Added: December 5, 2019
2017 journal article
Organic solvent exposure and depressive symptoms among licensed pesticide applicators in the Agricultural Health Study
International Archives of Occupational and Environmental Health, 90(8), 849–857.
author keywords: Farmers; Organic solvent exposure; Depressive symptoms; CES-D; Epidemiology
MeSH headings : Aged; Agriculture; Depression / epidemiology; Humans; Iowa; Male; Middle Aged; North Carolina; Occupational Exposure / adverse effects; Organic Chemicals / adverse effects; Pesticides; Risk Factors; Solvents / adverse effects; Surveys and Questionnaires
TL;DR:
Efforts to limit exposure to organic solvents may reduce the risk of depressive symptoms among farmers after associations between questionnaire-based metrics of organic solvent exposure and depressive symptoms were examined.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 17, 2019
2017 journal article
Raw milk consumption and other early-life farm exposures and adult pulmonary function in the Agricultural Lung Health Study
Thorax, 73(3), 279–282.
author keywords: COPD epidemiology; Asthma Epidemiology; Allergic lung disease; Occupational Lung Disease; Respiratory Measurement
MeSH headings : Adult; Aged; Agriculture; Animals; Case-Control Studies; Child; Child, Preschool; Environmental Exposure; Farms / statistics & numerical data; Female; Humans; Lung / physiopathology; Male; Middle Aged; Milk / physiology; Prospective Studies; Respiratory Physiological Phenomena; Spirometry / methods; United States
TL;DR:
A novel association between raw milk consumption and higher pulmonary function that lasts into older adulthood is reported and did not find appreciable associations with other early-life farming exposures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref
Added: September 13, 2019
2017 article
Integrating Morphological and Behavioral Phenotypes in Developing Zebrafish
The Rights and Wrongs of Zebrafish: Behavioral Phenotyping of Zebrafish, pp. 259–272.
Contributors: G. Zhang n, L. Truong *, R. Tanguay * & D. Reif n
TL;DR:
It is concluded that appropriate design and analysis of integrated morphological and behavioral studies using zebrafish can elucidate new chemical bioactivity pathways, identify compounds eliciting a broad range of effects, and paint a more comprehensive picture of development than either class of phenotype alone.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2017 journal article
An introduction to terminology and methodology of chemical synergy-perspectives from across disciplines
Frontiers in Pharmacology, 8(APR).
Contributors: K. Roell n, D. Reif n & A. Motsinger-Reif n
author keywords: synergy; mixtures; non-additive; interactions; drug combinations
TL;DR:
The various terminology surrounding the idea of synergy is discussed, providing a comprehensive list of terms defined across numerous disciplines, including the two most prominent reference models for describing additive interactions: Loewe Additivity and Bliss Independence.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2017 journal article
A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades
Toxicology and Applied Pharmacology, 314, 109–117.
Contributors: G. Zhang n, K. Roell n, L. Truong *, R. Tanguay * & D. Reif n
author keywords: Zebrafish; High-dimensional; Bayesian; Developmental cascade; ToxRefDB; Risk assessment; Multiple endpoints; Multivariate; Scoring
MeSH headings : Animals; Models, Theoretical; Multivariate Analysis; Phenotype; Zebrafish / embryology
TL;DR:
The results suggest that developmental cascade effects triggered by chemical exposure can be recapitulated by analyzing the relationships among endpoints, and wAggE offers a powerful approach for analysis of multivariate phenotypes that can reveal underlying etiological processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 14, 2019
2017 journal article
A New Statistical Approach to Characterize Chemical-Elicited Behavioral Effects in High-Throughput Studies Using Zebrafish
PLOS ONE, 12(1).
Contributors: G. Zhang n, L. Truong *, R. Tanguay * & D. Reif n
Ed(s): S. Neuhauss
MeSH headings : Animals; Biometry / methods; High-Throughput Screening Assays / methods; Models, Statistical; Zebrafish
TL;DR:
A novel, robust statistical approach to characterize chemical-elicited effects in behavioral data from high-throughput screening of all 1,060 Toxicity Forecaster chemicals across 5 concentrations at 120 hours post-fertilization (hpf) achieves a significant reduction in coefficient of variation compared to many traditional statistical modeling methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 14, 2019
2017 journal article
RealityConvert: a tool for preparing 3D models of biochemical structures for augmented and virtual reality
BIOINFORMATICS, 33(23), 3816–3818.
MeSH headings : Computational Biology / methods; Models, Molecular; Molecular Conformation; Software; Virtual Reality
TL;DR:
The RealityConvert software tool and associated website are presented, which allow users to easily convert molecular objects to high quality 3D models directly compatible for AR and VR applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Mass spectrometric detection of chlorophyll a and the tetrapyrrole secondary metabolite tolyporphin A in the filamentous cyanobacterium HT-58-2. Approaches to high-throughput screening of intact cyanobacteria
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 21(11), 759–768.
author keywords: IR-MALDESI-FTMS; MS/MS; MALDI-TOF-MS; chlorophyll; bacteriochlorin; high-throughput screening
TL;DR:
Examination by MALDI-TOF-MS of lipophilic crude extracts of small-scale HT-58-2 samples without chromatographic fractionation enabled semi-quantitation of tolyporphin A over a 41-day growth period.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Heat Generation and Accumulation in Municipal Solid Waste Landfills
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 51(21), 12434–12442.
MeSH headings : Biodegradation, Environmental; Hot Temperature; Refuse Disposal; Solid Waste; Waste Disposal Facilities
TL;DR:
A model to describe the generation, consumption and release of heat from landfills, to predict landfill temperatures, and to understand the relative importance of factors that contribute to heat generation and accumulation is developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Metabolomics reveal physiological changes in mayfly larvae (Neocloeon triangulifer) at ecological upper thermal limits
JOURNAL OF INSECT PHYSIOLOGY, 101, 107–112.
author keywords: Aquatic insects; Mayfly; Thermal limits; Metabolomics; Temperature
MeSH headings : Animals; Ecosystem; Ephemeroptera / growth & development; Ephemeroptera / physiology; Gas Chromatography-Mass Spectrometry; Hot Temperature / adverse effects; Larva / growth & development; Larva / physiology; Magnetic Resonance Spectroscopy; Metabolome; Metabolomics
TL;DR:
A metabolomics approach was used to gain insights into physiological changes associated with a short-term, sublethal thermal challenge in the mayfly Neocloeon triangulifer and limited evidence of anaerobic metabolism was observed in the heat treated larvae at 30°C, a temperature that is chronically lethal to larvae.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Spotted Gar and the Evolution of Innate Immune Receptors
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 328(7), 666–684.
MeSH headings : Amino Acid Sequence; Animals; Biological Evolution; Fishes / genetics; Fishes / immunology; Gene Expression Regulation / immunology; Immunity, Innate / genetics; Immunity, Innate / physiology
TL;DR:
It appears that both the total genome duplication and different patterns of genetic selection have influenced the derivation and stabilization of innate immune genes in a substantial manner during the course of vertebrate evolution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2017 journal article
Periphyton uptake and trophic transfer of coal fly-ash-derived trace elements
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 36(11), 2991–2996.
author keywords: Coal ash; Trace element; Periphyton; Mayfly; Accumulation
MeSH headings : Animals; Bioreactors; Coal Ash / chemistry; Ephemeroptera / metabolism; Food Chain; Hydrogen-Ion Concentration; Periphyton; Trace Elements / analysis; Water Pollutants, Chemical / toxicity
TL;DR:
To determine whether the bioavailability of trace elements derived from coal ash leachates varies with the geochemical conditions associated with their formation, periphyton bioaccumulation and subsequent trophic transfer to the mayfly Neocloeon triangulifer was quantified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Perfluorinated alcohol induced coacervates as extraction media for proteomic analysis
JOURNAL OF CHROMATOGRAPHY A, 1523, 293–299.
author keywords: Coacervation; Surfactants; Perfluorinated alcohol; Proteomics; Membrane proteins
MeSH headings : Membrane Proteins / isolation & purification; Propanols / chemistry; Proteome / analysis; Proteomics / methods; Saccharomyces cerevisiae / metabolism; Surface-Active Agents / chemistry
TL;DR:
A novel method for using hexafluoroisopropanol induced coacervates with a variety of surfactants to extract proteins from a yeast whole cell lysate and conduct a global proteomic investigation on the extracted proteins is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Insecticide Use and Breast Cancer Riskamong Farmers' Wives in the Agricultural Health Study
ENVIRONMENTAL HEALTH PERSPECTIVES, 125(9).
MeSH headings : Adult; Aged; Agriculture; Agrochemicals / metabolism; Agrochemicals / toxicity; Breast Neoplasms / epidemiology; Farmers; Female; Humans; Incidence; Insecticides / metabolism; Insecticides / toxicity; Middle Aged; Occupational Exposure / statistics & numerical data; Organophosphates / metabolism; Organophosphates / toxicity
TL;DR:
Use of several organophosphate insecticides was associated with elevated breast cancer risk among wives of pesticide applicators (farmers), but associations for the women’s and husbands’ use of these insecticides showed limited concordance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
House Dust Endotoxin and Periphera lLeukocyte Counts: Results from Two Large Epidemiologic Studies
ENVIRONMENTAL HEALTH PERSPECTIVES, 125(5).
MeSH headings : Asthma / epidemiology; Dust / analysis; Endotoxins / adverse effects; Endotoxins / analysis; Female; Humans; Leukocyte Count; Linear Models; Male; Nutrition Surveys; Pulmonary Disease, Chronic Obstructive / epidemiology; Toll-Like Receptor 4 / genetics
TL;DR:
There is a statistically significant, positive association between endotoxin concentration and total leukocyte number in the National Health and Nutrition Examination Survey 2005–2006 and the Agricultural Lung Health Study (ALHS), the first report of an association between house dust endotoxin and leukocytes count in a national survey.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Disruption of Trim9 function abrogates macrophage motility in vivo
Journal of Leukocyte Biology, 102(6), 1371–1380.
author keywords: chemotaxis; zebrafish; leukocyte; ubiquitin
MeSH headings : Animals; Cell Movement / genetics; Cell Shape; Chemotaxis; Humans; Macrophages / cytology; Macrophages / metabolism; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Tripartite Motif Proteins / genetics; Tripartite Motif Proteins / metabolism; U937 Cells; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
It is demonstrated that Trim9 mediates cellular movement and migration in Mϕs as well as neurons, and is implicated in axonal migration, and found that M ϕ chemotaxis and cellular architecture are subsequently impaired in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2017 journal article
Direct screening of enzyme activity using infrared matrix-assisted laser desorption electrospray ionization
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 31(22), 1868–1874.
MeSH headings : Drug Discovery / methods; Enzyme Assays / methods; High-Throughput Screening Assays / methods; Isocitrate Dehydrogenase / metabolism; Isocitrates / metabolism; Ketoglutaric Acids / metabolism; Models, Chemical; NADP / metabolism; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR:
The utility of infrared matrix-assisted laser desorption electrospray ionization for monitoring an enzymatic reaction directly from a biological buffer system with no sample cleanup and at high throughput is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Comparative proteomic analysis between nitrogen supplemented and starved conditions in Magnaporthe oryzae
Proteome Science, 15(1).
author keywords: Proteomics; Magnaporthe oryzae; Nitrogen starvation; Melanin biosynthesis; Extracellular protein
TL;DR:
A functional analysis of differentially expressed proteins revealed that during nitrogen starvation nitrogen catabolite repression, melanin biosynthesis, protein degradation and protein translation pathways underwent extensive alterations, consistent with observations of a link between nitrogen starvation and the development of pathogenicity in M. oryzae.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
A review of the airborne and waterborne emissions from uncontrolled solid waste disposal sites
Critical Reviews in Environmental Science and Technology, 47(12), 1003–1041.
author keywords: Environmental impacts; open burning; open dumps; solid waste; uncontrolled landfills
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
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