Works Published in 2018
Displaying works 41 - 60 of 100 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 journal article
Improved Sensitivity and Separations for Phosphopeptides using Online Liquid Chromotography Coupled with Structures for Lossless Ion Manipulations Ion Mobility-Mass Spectrometry
Analytical Chemistry, 90(18), 10889–10896.
Contributors: C. Chouinard *, G. Nagy *, I. Webb *, T. Shi *, E. Baker* , S. Prost*, T. Liu *, Y. Ibrahim *, R. Smith *
MeSH headings : Amino Acid Sequence; Bacterial Proteins / analysis; Bacterial Proteins / isolation & purification; Chromatography, Reverse-Phase / methods; Humans; Ion Mobility Spectrometry / methods; Isomerism; Mass Spectrometry / methods; Phosphopeptides / analysis; Phosphopeptides / isolation & purification; Shewanella / chemistry
TL;DR:
LC-SLIM IM-MS offers great potential for improving the sensitivity, separation, and throughput of phosphoproteomics analyses, with additional gains projected with the future use of longer path SLIM IM separations.
(via Semantic Scholar)
www.ncbi.nlm.nih.gov (repository)
Source: ORCID
Added: December 5, 2019
2018 journal article
Evaluating lipid mediator structural complexity using ion mobility spectrometry combined with mass spectrometry
Bioanalysis, 10(5), 279–289.
Contributors: J. Kyle *, N. Aly*, X. Zheng *, K. Burnum-Johnson *, R. Smith * & E. Baker*
author keywords: collision cross-section; ion mobility spectrometry; lipid mediators
MeSH headings : Animals; Arachidonic Acid / chemistry; Chromatography, Liquid; Docosahexaenoic Acids / analogs & derivatives; Docosahexaenoic Acids / chemistry; Humans; Influenza A virus / growth & development; Ion Mobility Spectrometry; Isomerism; Linoleic Acid / chemistry; Lung / virology; Mass Spectrometry; Mice; Tissue Extracts / chemistry
TL;DR:
Adding IMS separations to conventional LC-MS analyses show great utility for enabling better identification and characterization of LMs in complex biological samples.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2018 journal article
Editorial overview: Omics
Current Opinion in Chemical Biology, 42, A1–A2.
Contributors: P. Barran* & E. Baker*
MeSH headings : Genomics / methods; Humans; Ion Mobility Spectrometry / methods; Lipid Metabolism; Mass Spectrometry / methods; Metabolomics / methods; Proteomics / methods
Source: ORCID
Added: December 5, 2019
2018 journal article
An algorithm to correct saturated mass spectrometry ion abundances for enhanced quantitation and mass accuracy in omic studies
International Journal of Mass Spectrometry, 427, 91–99.
Contributors: A. Bilbao *, B. Gibbons*, G. Slysz*, K. Crowell*, M. Monroe *, Y. Ibrahim *, R. Smith *, S. Payne *, E. Baker*
author keywords: Mass spectrometry; Detector saturation; Analog-to-digital converter saturation; Saturation correction; Isotopic envelope; Isotopic ratios; Quantitation
TL;DR:
The isotopic envelope for each observed ion above the saturation threshold is compared to its expected theoretical isotopic distribution and the most intense isotopic peak for which saturation does not occur is utilized to re-calculate the precursor m/z and correct the intensity, resulting in both higher mass accuracy and greater dynamic range.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2018 journal article
A Customizable Flow Injection System for Automated, High Throughput, and Time Sensitive Ion Mobility Spectrometry and Mass Spectrometry Measurements
Analytical Chemistry, 90(1), 737–744.
Contributors: D. Orton *, M. Tfaily *, R. Moore *, B. Lamarche*, X. Zheng *, T. Fillmore *, R. Chu*, K. Weitz *
MeSH headings : Escherichia coli / chemistry; Escherichia coli Proteins / chemistry; Flow Injection Analysis / instrumentation; Flow Injection Analysis / methods; Hydrogen-Ion Concentration; Ion Mobility Spectrometry / instrumentation; Ion Mobility Spectrometry / methods; Mass Spectrometry / instrumentation; Mass Spectrometry / methods; Soil / chemistry
TL;DR:
An automated, customizable FIA system capable of operating at a range of flow rates to accommodate both low- and high-flow MS ionization sources and showing a highly robust and reproducible platform capable of providing consistent performance over many days without carryover.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2018 journal article
Guest editor's personal foreward
International Journal of Mass Spectrometry, 427, 1–3.
Contributors: E. Baker* & R. Ogorzalek Loo*
Source: ORCID
Added: December 5, 2019
2018 journal article
Distinguishing enantiomeric amino acids with chiral cyclodextrin adducts and structures for lossless ion manipulations
Electrophoresis, 39(24), 3148–3155.
Contributors: G. Nagy *, C. Chouinard *, I. Attah *, I. Webb *, S. Garimella *, Y. Ibrahim *, E. Baker* , R. Smith *
author keywords: Chiral separations; Cyclodextrins; Enantiomers; Ion mobility-mass spectrometry; Structures for lossless ion manipulations
MeSH headings : Amino Acids / analysis; Amino Acids / chemistry; Amino Acids / isolation & purification; Cyclodextrins / chemistry; Ions; Mass Spectrometry / methods; Models, Molecular; Stereoisomerism
TL;DR:
The SLIM was used to accumulate much larger ion populations than previously feasible for evaluation and therefore allow enantiomeric measurements of higher sensitivity, with gains in resolution from the ultralong path separation capabilities, than previously reported by any other IM–based approach.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2018 journal article
Comparing residential contamination in a Houston environmental justice neighborhood before and after Hurricane Harvey
PLoS ONE, 13(2).
Contributors: J. Horney *, G. Casillas *, E. Baker* , K. Stone *, K. Kirsch *, K. Camargo*, T. Wade *, T. McDonald *
MeSH headings : Cyclonic Storms; Environmental Pollutants / analysis; Gas Chromatography-Mass Spectrometry; Polycyclic Aromatic Hydrocarbons / analysis; Residence Characteristics; Texas
TL;DR:
A small longitudinal study to assess domestic exposure to PAHs among residents of Manchester, an environmental justice neighborhood located in the East End of Houston, TX, found evidence of redistribution ofPAHs due to extreme flooding associated with Hurricane Harvey.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2018 journal article
Cell type-resolved human lung lipidome reveals cellular cooperation in lung function
Scientific Reports, 8(1).
Contributors: J. Kyle *, G. Clair *, G. Bandyopadhyay *, R. Misra *, E. Zink *, K. Bloodsworth *, A. Shukla *, Y. Du *
MeSH headings : Databases, Protein; Female; Humans; Lipid Metabolism / physiology; Lung / cytology; Lung / physiology; Male
TL;DR:
Lipidomics analyses showed significant variations in the lipidome across major human lung cell types, with differences most evident at the subclass and intra-subclass level, and lipidomic signatures revealed an overarching posture of high cellular cooperation within the human lung to support critical functions.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2018 journal article
Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis
Tuberculosis, 112, 52–61.
Contributors: K. Kedia *, J. Wendler*, E. Baker* , K. Burnum-Johnson *, L. Jarsberg*, K. Stratton *, A. Wright *, P. Piehowski *
author keywords: Ion mobility spectrometry; Proteomics; Tuberculosis; Antibiotic treatment
MeSH headings : Adolescent; Adult; Antitubercular Agents / therapeutic use; Biomarkers / blood; Blood Proteins / metabolism; Child; Child, Preschool; Chromatography, Liquid; Drug Therapy, Combination; Female; High-Throughput Screening Assays; Host-Pathogen Interactions; Humans; Infant; Infant, Newborn; Ion Mobility Spectrometry; Male; Mass Spectrometry; Middle Aged; North America; Predictive Value of Tests; Prospective Studies; Protein Interaction Maps; Proteomics / methods; South Africa; Spain; Time Factors; Treatment Outcome; Tuberculosis, Pulmonary / blood; Tuberculosis, Pulmonary / diagnosis; Tuberculosis, Pulmonary / drug therapy; Tuberculosis, Pulmonary / microbiology; Uganda; Young Adult
TL;DR:
If validated in cohorts with long term follow-up to capture failure and relapse of TB, these protein markers could be developed for monitoring of treatment in clinical trials and in patient care.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 5, 2019
2018 journal article
Heavy Metal Exposure and Metabolic Syndrome: Evidence from Human and Model System Studies
Current Environmental Health Reports, 5(1), 110–124.
author keywords: Metabolic syndrome; Diabetes; Heavy metals; Cadmium; Pb; Mercury
MeSH headings : Animals; Cadmium / adverse effects; Disease Models, Animal; Humans; Lead / adverse effects; Mercury / adverse effects; Metabolic Syndrome / chemically induced; Metals, Heavy / adverse effects
TL;DR:
Assessment of potential causal links between heavy metal exposure and metabolic syndrome remains challenging as epidemiological data are largely cross-sectional; and variation in study design, including samples used for heavy metal measurements, age of subjects at which MS outcomes are measured, and the population demographics vary widely.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 7, 2019
2018 journal article
Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study
International Journal of Obesity, 42(7), 1285–1295.
Contributors: A. Green n, C. Hoyo n, C. Mattingly n , Y. Luo n, J. Tzeng n, S. Murphy *, D. Buchwalter n, A. Planchart n
MeSH headings : Adipogenesis / drug effects; Animals; Cadmium / adverse effects; Cadmium / analysis; Cadmium / blood; Disease Models, Animal; Environmental Exposure / adverse effects; Environmental Exposure / analysis; Female; Humans; Infant, Newborn; Male; Maternal Exposure / adverse effects; Metals, Heavy / adverse effects; Metals, Heavy / analysis; Pediatric Obesity / blood; Pediatric Obesity / chemically induced; Pediatric Obesity / epidemiology; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects / blood; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / epidemiology; Prospective Studies; Socioeconomic Factors; United States / epidemiology; Zebrafish / metabolism
TL;DR:
The findings identify Cd as a potential human obesogen, suggesting that the underlying mechanisms may be evolutionarily conserved, and that zebrafish may be a valuable model for uncovering pathways leading to Cd-mediated obesity in human populations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 7, 2019
2018 journal article
Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure.
Environmental Health Perspectives, 6(6).
Contributors: M. Balik-Meisner n, L. Truong *, E. Scholl n, J. La Du, R. Tanguay * & D. Reif n
MeSH headings : Animals; Embryo, Nonmammalian / drug effects; Embryonic Development / drug effects; Female; Gene-Environment Interaction; Genetic Variation; Genome-Wide Association Study; High-Throughput Screening Assays / methods; Ivermectin / analogs & derivatives; Ivermectin / toxicity; Male; Phenotype; Zebrafish / embryology; Zebrafish / genetics
TL;DR:
The results for Abamectin in zebrafish demonstrate that GxE associated with naturally occurring, population genetic variation play a significant role in mediating individual response to chemical exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 14, 2019
2018 journal article
Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon
Journal of Biological Chemistry, 293(16), 6187–6200.
MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Azepines / pharmacology; Cell Cycle Proteins; Cell Line, Tumor; Conserved Sequence; Cullin Proteins / metabolism; Humans; Immunologic Factors / metabolism; Immunologic Factors / pharmacology; Lenalidomide / pharmacology; Ligands; Mice; Molecular Probes; Nuclear Proteins / drug effects; Nuclear Proteins / metabolism; Peptide Hydrolases / chemistry; Peptide Hydrolases / metabolism; Proteasome Endopeptidase Complex / metabolism; Proteolysis; T-Lymphocytes / metabolism; Thalidomide / analogs & derivatives; Thalidomide / metabolism; Thalidomide / pharmacology; Transcription Factors / drug effects; Transcription Factors / metabolism; Triazoles / pharmacology; Ubiquitin / metabolism; Ubiquitin-Protein Ligases / metabolism
TL;DR:
It is shown that CRBN sequence variants retain their drug-binding properties to both classical immunomodulatory drugs and dBET1, a chemical compound and targeting ligand designed to degrade bromodomain-containing 4 via a CRBN-dependent mechanism, which provides a new understanding of CRBN's substrate-recruiting function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: ORCID, Crossref
Added: February 13, 2019
2018 journal article
Carbon dynamics of paper, engineered wood products and bamboo in landfills: evidence from reactor studies
CARBON BALANCE AND MANAGEMENT, 13.
author keywords: Carbon; Engineered wood products; Paper; Decay; Methane; Landfill; Greenhouse gas inventory
TL;DR:
The new suggested combined decay factor for wood and EWPs represents a significant reduction from the current factor used in the Australian greenhouse gas inventory; whereas the suggested Decay factor for paper is similar to the current decay factor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 14, 2019
2018 journal article
Chemistry-Wide Association Studies (CWAS): A Novel Framework for Identifying and Interpreting Structure-Activity Relationships
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 58(11), 2203–2213.
MeSH headings : Databases, Factual; Drug Discovery / methods; Drug-Related Side Effects and Adverse Reactions / etiology; Humans; Models, Biological; Mutagenicity Tests / methods; Pharmaceutical Preparations / chemistry; Quantitative Structure-Activity Relationship; Stevens-Johnson Syndrome / etiology
TL;DR:
It is demonstrated that CWAS provides a new framework to interpret predictive QSAR models and derive refined structural alerts for more effective design and safety assessment of drugs and drug candidates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 17, 2018
2018 journal article
The Good, the Bad, and the Lethal: Gene Expression and Metabolomics Reveal Physiological Mechanisms Underlying Chronic Thermal Effects in Mayfly Larvae (Neocloeon triangulifer)
FRONTIERS IN ECOLOGY AND EVOLUTION, 6.
author keywords: aquatic insects; mayfly; thermal limits; metabolomics; temperature
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: December 17, 2018
2018 journal article
Evaluation of Digital Image Recognition Methods for Mass Spectrometry Imaging Data Analysis
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 29(12), 2467–2470.
author keywords: Mass spectrometry imaging; Image recognition; SSIM
MeSH headings : Algorithms; Animals; Image Processing, Computer-Assisted / methods; Lymph Nodes / chemistry; Lymph Nodes / metabolism; Macaca mulatta; Maraviroc / pharmacokinetics; Mass Spectrometry / methods; Models, Theoretical; Molecular Imaging / methods; Plant Leaves / chemistry; Tissue Distribution
TL;DR:
A method for comprehensive, semi-targeted discovery of molecular distributions of interest from mass spectrometry imaging data, using widely available image similarity scoring algorithms to rank images by spatial correlation is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 10, 2018
2018 journal article
Neonatal mice exposed to a high-fat diet in utero influence the behaviour of their nursing dam
Contributors: M. Baptissart n, H. Lamb n, K. To n, C. Bradish n , J. Tehrani n, D. Reif n , M. Cowley n
MeSH headings : Animals; Animals, Newborn / physiology; Diet, High-Fat; Female; Maternal Behavior / physiology; Maternal Exposure; Mice / physiology; Mice, Inbred C57BL; Pregnancy
TL;DR:
In utero exposure to HF diet programmes physiological changes in the offspring which influence the maternal behaviours of their dam after birth are suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: December 10, 2018
2018 journal article
Exploring drug space with ChemMaps.com
BIOINFORMATICS, 34(21), 3773–3775.
MeSH headings : Computational Biology; Databases, Pharmaceutical; Molecular Structure; Software; Web Browser
TL;DR:
This work developed the ChemMaps.com webserver to easily browse, navigate and mine chemical space, which features more than 8000 approved, in development, and rejected drugs, as well as over 47 000 environmental chemicals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 3, 2018
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