Center for Environmental and Health Effects of PFAS

Works Published in 2022

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Displaying works 41 - 60 of 87 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2022 article

Utilizing Skyline to analyze lipidomics data containing liquid chromatography, ion mobility spectrometry and mass spectrometry dimensions

Kirkwood, K. I., Pratt, B. S., Shulman, N., Tamura, K., MacCoss, M. J., MacLean, B. X., & Baker, E. S. (2022, July 13). NATURE PROTOCOLS, Vol. 7.

By: K. Kirkwood n, B. Pratt*, N. Shulman*, K. Tamura*, M. MacCoss*, B. MacLean*, E. Baker n

MeSH headings : Ion Mobility Spectrometry; Lipidomics; Chromatography, Liquid / methods; Mass Spectrometry / methods; Lipids
TL;DR: This protocol describes how to use the free, vendor-neutral software Skyline to process and annotate multidimensional lipidomic data by using expanded features such as predicted retention times, spectral libraries and ion mobility filtering. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: July 26, 2022

2022 journal article

Diffusion of benzene and tetrachloroethylene through saturated cement paste

CONSTRUCTION AND BUILDING MATERIALS, 329.

By: P. Hosseini n, A. McElroy n, D. Knappe n, M. Gabr n & M. Pour-Ghaz n

author keywords: Volatile organic compounds; Cement paste; Saturated state; Diffusion coefficient; Prediction model
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: July 18, 2022

2022 journal article

Knockdown of Transmembrane Protein 150A (TMEM150A) Results in Increased Production of Multiple Cytokines

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 42(7), 336–342.

By: J. Romanet n, K. Cupo n & J. Yoder n

author keywords: cell signaling; interleukin-8; interleukin-6; RANTES; TMEM150A; TLR4
MeSH headings : Cell Line; Cytokines / metabolism; Lipopolysaccharides / pharmacology; Signal Transduction; Toll-Like Receptor 4 / metabolism
TL;DR: Knockdown of TMEM150A in a lung epithelial cell line (H292) also led to increased cytokine levels in the unstimulated conditions suggesting TMEM 150A plays an important role in cellular homeostasis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: July 15, 2022

2022 article

Highlighting Functional Mass Spectrometry Imaging Methods in Bioanalysis

Mellinger, A. L., Muddiman, D. C., & Gamcsik, M. P. (2022, June 27). JOURNAL OF PROTEOME RESEARCH, Vol. 6.

author keywords: mass spectrometry imaging; kinetics; rate; isotope; metabolism; dynamics
MeSH headings : Magnetic Resonance Imaging; Mass Spectrometry / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: MSI exceeds some of the classic functional imaging methods, demonstrating the ability to provide functional data from the nanoscale (subcellular) to whole tissue or organ level, and this Perspective highlights several examples of how different MSI ionization and detection technologies can provide unprecedented detailed spatial maps of time-dependent biological processes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: July 11, 2022

2022 article

Genomic map of candidate human imprint control regions: the imprintome

Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, June 25). EPIGENETICS, Vol. 6.

By: D. Jima n, D. Skaar n, A. Planchart n, A. Motsinger-Reif n, S. Cevik n, S. Park n, M. Cowley n, F. Wright n ...

author keywords: Epigenetics; genomic imprinting; foetal origins; whole genome; methylation; imprint control regions
MeSH headings : Adult; Humans; Genomic Imprinting; DNA Methylation; Chromosome Mapping; Alleles; Genomics
TL;DR: This draft of the human imprintome will allow for the systematic determination of the role of early-acquired imprinting dysregulation in the pathogenesis of human diseases and developmental and behavioural disorders. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 11, 2022

2022 journal article

Pyrimethanil and chlorpyrifos air concentrations and pregnant women's urinary metabolites in the Infants' Environmental Health Study (ISA) Costa Rica ,

ENVIRONMENT INTERNATIONAL, 166.

By: A. Giffin n, J. Hoppin n, L. Cordoba*, K. Solano-Diaz*, C. Ruepert*, J. Penaloza-Castaneda*, C. Lindh*, B. Reich n, B. Joode*

author keywords: Urinary pesticide metabolites; Airborne pesticide exposure; Spatiotemporal model; Environmental exposure; Pesticides; Insecticides; Fungicides
TL;DR: The results suggest inhalation of pyrimethanil and chlorpyrifos is a pathway of environmental exposure, and passive air samplers seems a useful technique to monitor environmental current-use pesticide exposures. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: July 11, 2022

2022 journal article

Uncovering PFAS and Other Xenobiotics in the Dark Metabolome Using Ion Mobility Spectrometry, Mass Defect Analysis, and Machine Learning

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 56(12), 9133–9143.

author keywords: xenobiotics; per- and polyfluoroalkyl substances; ion mobility spectrometry; mass spectrometry; mass defect; machine learning; PFAS
MeSH headings : Fluorocarbons; Humans; Ion Mobility Spectrometry / methods; Machine Learning; Metabolome; Xenobiotics
TL;DR: A xenobiotic structural annotation workflow using ion mobility spectrometry coupled with MS (IMS-MS), mass defect filtering, and machine learning to uncover potential xenobiotics classes and species in large metabolomic feature lists is evaluated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: July 5, 2022

2022 journal article

Extraction and Matrix Cleanup Method for Analyzing Novel Per- and Polyfluoroalkyl Ether Acids and Other Per- and Polyfluoroalkyl Substances in Fruits and Vegetables

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70(16), 4792–4804.

By: P. Meng n, N. DeStefano n & D. Knappe n

author keywords: PFEAs; PFAS; method quantification limits; extraction and matrix cleanup method; fruits and vegetables
MeSH headings : Ether; Ethers; Fluorocarbons / analysis; Fruit / chemistry; Vegetables
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: June 27, 2022

2022 journal article

Stability of Per- and Polyfluoroalkyl Substances in Solvents Relevant to Environmental and Toxicological Analysis br

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 56(10), 6103–6112.

By: C. Zhang n, A. McElroy n, H. Liberatore*, N. Alexander n & D. Knappe n

author keywords: PFAS; fluoroethers; GenX; acetonitrile; acetone; dimethyl sulfoxide; degradation; high-resolution mass spectrometry
MeSH headings : Carbon; Carboxylic Acids; Ether; Ethers; Fluorocarbons / analysis; Solvents; Water; Water Pollutants, Chemical / analysis
TL;DR: PFEA degradation results highlight the importance of solvent choice when preparing dosing solutions and performing extractions for environmental and toxicological assessments of PFEAs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: June 20, 2022

2022 journal article

Normalization techniques for high-throughput screening by infrared matrix-assisted laser desorption electrospray ionization mass spectrometry

JOURNAL OF MASS SPECTROMETRY, 57(6).

author keywords: high-throughput screening; IR-MALDESI; normalization; Orbitrap mass spectrometer
MeSH headings : Drug Discovery; High-Throughput Screening Assays; Lasers; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: Optimal solvent compositions for increasing measured analyte abundances with direct analysis by IR‐MALDESI‐MS are reported and normalization strategies, such as adding a normalization standard that is similar or dissimilar in structure to the model target drug, are evaluated. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: June 20, 2022

2022 journal article

Surface Modified Nano-Electrospray Needles Improve Sensitivity for Native Mass Spectrometry

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 33(6), 1031–1037.

By: M. Kostelic*, C. Hsieh*, H. Sanders*, C. Zak*, J. Ryan n, E. Baker n, C. Aspinwall*, M. Marty*

author keywords: native mass spectrometry; charge detection mass spectrometry; electrospray ionization; silane chemistry
MeSH headings : Needles; Proteins / analysis; Spectrometry, Mass, Electrospray Ionization / methods
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: June 20, 2022

2022 journal article

Cupric Ions Selectively Modulate TRAAK-Phosphatidylserine Interactions

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 144(16), 7048–7053.

By: Y. Zhu*, S. Schrecke*, S. Tang*, M. Odenkirk n, T. Walker*, L. Stover*, J. Lyu*, T. Zhang* ...

MeSH headings : Cations, Divalent / metabolism; Phosphatidylserines; Potassium Channels, Tandem Pore Domain / chemistry; Potassium Channels, Tandem Pore Domain / metabolism
TL;DR: High-resolution native mass spectrometry enables the determination of equilibrium binding constants for distinct Cu2+-bound stoichiometries and uncovered the highest coupling factor corresponds to a 1:1 PS-to-Cu2+ ratio, which brings forth the role of cupric ions as an essential cofactor in selective TRAAK-PS interactions. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: June 6, 2022

2022 journal article

Per- and polyfluoroalkyl substances (PFAS) in river discharge: Modeling loads upstream and downstream of a PFAS manufacturing plant in the Cape Fear watershed, North Carolina

SCIENCE OF THE TOTAL ENVIRONMENT, 831.

author keywords: PFAS; Mass load; Model; Source tracking; Environmental monitoring; Drinking water
MeSH headings : Alkanesulfonic Acids / analysis; Drinking Water; Fluorocarbons / analysis; Humans; Manufacturing and Industrial Facilities; North Carolina; Water Pollutants, Chemical / analysis
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: May 31, 2022

2022 journal article

High-Resolution Demultiplexing (HRdm) Ion Mobility Spectrometry-Mass Spectrometry for Aspartic and Isoaspartic Acid Determination and Screening

ANALYTICAL CHEMISTRY, 94(16), 6191–6199.

MeSH headings : Chromatography, Liquid; Ion Mobility Spectrometry / methods; Isoaspartic Acid / analysis; Mass Spectrometry / methods; Peptides
TL;DR: The rapid high-throughput HRdm DTIMS-MS method was presented to present the first application of HRdm for isoAsp and Asp assessment and demonstrate screening capabilities for isomeric peptides in complex samples, resulting in a workflow highly suitable for biopharmaceutical research needs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 23, 2022

2022 article

A highly diverse set of novel immunoglobulin-like transcript (NILT) genes in zebrafish indicates a wide range of functions with complex relationships to mammalian receptors

Wcisel, D. J., Dornburg, A., McConnell, S. C., Hernandez, K. M., Andrade, J., Jong, J. L. O., … Yoder, J. A. (2022, April 22). (Vol. 4). Vol. 4.

By: D. Wcisel, A. Dornburg*, S. McConnell, K. Hernandez*, J. Andrade, J. Jong, G. Litman*, J. Yoder*

UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: ORCID
Added: May 19, 2022

2022 journal article

Characterization of compositional variability in petroleum substances

FUEL, 317.

By: A. Roman-Hubers*, A. Cordova*, A. Rohde*, W. Chiu*, T. McDonald*, F. Wright*, J. Dodds n, E. Baker n, I. Rusyn*

author keywords: UVCB; Registration; Variability; IMS-MS
Sources: Web Of Science, NC State University Libraries
Added: May 10, 2022

2022 journal article

Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish

JOURNAL OF HAZARDOUS MATERIALS, 431.

By: L. Truong*, Y. Rericha*, P. Thunga n, S. Marvel n, D. Wallis n, M. Simonich*, J. Field*, D. Cao*, D. Reif n, R. Tanguay n

author keywords: PFAS; Developmental toxicity; Structure-activity relationship; Abnormal behavior; Zebrafish
MeSH headings : Animals; Fluorocarbons / analysis; Larva; Teratogens; Zebrafish
TL;DR: The results illustrate the power of a multi-dimensional in vivo platform to assess the developmental (neuro)toxicity of diverse PFAS and in the acceleration of PFAS safety research. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: May 10, 2022

2022 article

ToxPi*GIS Toolkit: creating, viewing, and sharing integrative visualizations for geospatial data using ArcGIS

Fleming, J., Marvel, S. W., Supak, S., Motsinger-Reif, A. A., & Reif, D. M. (2022, April 26). JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, Vol. 4.

author keywords: Visual analytics; Geographic information systems; Data integration
MeSH headings : Humans; Geographic Information Systems; COVID-19
TL;DR: The integration of ToxPi profiles with ArcGIS provides new avenues for geospatial analysis, visualization, and public sharing of multi-factor data that can support decisions that help address issues such as disease prevention, environmental health, natural disaster prevention, chemical risk, and many others. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: May 10, 2022

2022 article

Transcriptome annotation reveals minimal immunogenetic diversity among Wyoming toads, Anaxyrus baxteri

Carlson, K. B., Wcisel, D. J., Ackerman, H. D., Romanet, J., Christiansen, E. F., Niemuth, J. N., … Yoder, J. A. (2022, April 28). CONSERVATION GENETICS, Vol. 4.

By: K. Carlson n, D. Wcisel n, H. Ackerman n, J. Romanet n, E. Christiansen n, J. Niemuth n, C. Williams n, M. Breen n ...

author keywords: Amphibian; Bufonidae; Immunogenetics; MHC; TLR; Transcriptomics
TL;DR: Comparison transcriptomics is used to examine the diversity of toll-like receptors and major histocompatibility complex sequences across three individual Wyoming toads and finds reduced diversity at MHC genes compared to bufonid species with a similar history of bottleneck events. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: May 10, 2022

2022 article

Comparison of National Vulnerability Indices Used by the Centers for Disease Control and Prevention for the COVID-19 Response

Wolkin, A., Collier, S., House, J., Reif, D., Motsinger-Reif, A., Duca, L., & Sharpe, D. (2022, May 5). PUBLIC HEALTH REPORTS, Vol. 5.

author keywords: COVID-19; vulnerability; social vulnerability index; GIS; geographic information systems
MeSH headings : COVID-19 / epidemiology; COVID-19 / prevention & control; Centers for Disease Control and Prevention, U.S.; Humans; Pandemics / prevention & control; Public Health; United States / epidemiology
TL;DR: The indices can empower local and state public health officials with additional information to focus resources and interventions on disproportionately affected populations to combat the ongoing pandemic and plan for future pandemics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID
Added: May 6, 2022

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