Works Published in 2008
Displaying works 61 - 80 of 95 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2008 journal article
Genetic basis for adverse events after smallpox vaccination (Journal of Infectious Diseases (2008) 198, (16-22))
Journal of Infectious Diseases, 198(5).
Contributors: D. Reif , B. McKinney & A. Motsinger
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2008 journal article
A comparison of analytical methods for genetic association studies
Genet. Epidemiol., 32(8), 767â778.
Contributors: A. Motsinger-Reif n, D. Reif* , T. Fanelli* & M. Ritchie *
author keywords: genetic association study; epistasis; multifactor dimensionality reduction; grammatical evolution neural networks; focused interaction testing framework
MeSH headings : Data Interpretation, Statistical; Epistasis, Genetic; Genetic Linkage; Genetic Techniques; Genome; Humans; Models, Genetic; Models, Statistical; Models, Theoretical; Neural Networks, Computer; Phenotype; Probability; Regression Analysis; Software
TL;DR:
This study compares the performance of six analytical approaches to detect both main effects and gene‐gene interactions in a range of genetic models and demonstrates the strengths and weaknesses of each and illustrates the importance of continued methods development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2008 conference paper
A balanced accuracy fitness function leads to robust analysis using grammatical evolution neural networks in the case of class imbalance
Proceedings of the 10th annual conference on Genetic and evolutionary computation - GECCO '08, 353–354.
Contributors: N. Hardison n, D. Reif* , T. Fanelli*, M. Ritchie *, S. Dudek * & A. Motsinger-Reif n
TL;DR:
It is shown that when using classification error, class imbalance greatly decreases the power of GENN, and balanced error has replaced classification error in the GENN algorithm.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2008 journal article
Assessing infection and immunity in zebrafish
Zebrafish, 5(3), 189–191.
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: February 13, 2019
2008 journal article
Workshop report - assessing infection and immunity in zebrafish
Zebrafish, 5, 189–191.
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Gene Silencing in Mammalian Cells with Light-Activated Antisense Agents
ChemBioChem, 9(18), 2937–2940.
author keywords: Antisense agents; caged compounds; DNA; gene regulation; RNA
MeSH headings : Animals; Base Sequence; Gene Silencing; Genes, Reporter; Light; Luciferases, Renilla / chemistry; Mice; NIH 3T3 Cells; Oligonucleotides, Antisense / chemistry; Oligonucleotides, Antisense / metabolism; Oligonucleotides, Antisense / radiation effects; Phosphorothioate Oligonucleotides / chemistry; Phosphorothioate Oligonucleotides / metabolism; Transfection
TL;DR:
Detailed knowledge of the external regulation of gene func-tion is a fundamental necessity in order to annotate sequencedgenomes and to understand biological processes in single cells and multicellular organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Calibration laws based on multiple linear regression applied to matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry
JOURNAL OF MASS SPECTROMETRY, 43(12), 1659–1663.
author keywords: multiple linear regression; polypropylene glycol; calibration; matrix-assisted laser desorption/ionization (MALDI); Fourier transform ion cyclotron mass spectrometry (FT-ICR-MS); space-charge effects
MeSH headings : Calibration; Cyclotrons; Fourier Analysis; Linear Models; Mass Spectrometry / methods; Multivariate Analysis; Peptide Mapping / methods; Peptide Mapping / statistics & numerical data; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR:
An evaluation of external mass calibration laws applied to MALDI-FT-ICR-MS is performed to achieve higher mass measurement accuracy (MMA) in Fourier transform ion cyclotron resonance mass spectrometry.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling
Blood, 112(12), 4694–4698.
MeSH headings : Antineoplastic Agents / therapeutic use; Cells, Cultured; Enzyme Inhibitors / therapeutic use; Farnesyltranstransferase / antagonists & inhibitors; Female; Humans; Hypertension, Pulmonary / drug therapy; Hypertension, Pulmonary / etiology; K562 Cells; Leukemia, Large Granular Lymphocytic / complications; Leukemia, Large Granular Lymphocytic / drug therapy; Leukemia, Large Granular Lymphocytic / genetics; Middle Aged; Quinolones / therapeutic use; Receptors, Natural Killer Cell / genetics; Signal Transduction / genetics; Treatment Outcome
TL;DR:
A genetic approach demonstrated that killing of pulmonary endothelial cells by patient NK cells was mediated by dysregulated balance in activating and inhibitory NK-receptor signaling, and suggested a causal relationship between the expanded lymphocyte population and these clinical manifestations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Backcalculation of Dynamic Modulus from Resilient Modulus of Asphalt Concrete with an Artificial Neural Network
TRANSPORTATION RESEARCH RECORD, (2057), 107–113.
TL;DR:
The population of a database of measured dynamic moduli with the corresponding predicted resilient moduli to train an artificial neural network (ANN) is proposed and the dynamic modulus predicted from the measured resilient modulus with the trained ANN were found to be reasonable compared with the measured dynamicmoduli.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Development of a coupled reactor model for prediction of organic contaminant fate in landfills
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 42(19), 7444–7451.
MeSH headings : Acetone / chemistry; Benzene / chemistry; Bioreactors; Computer Simulation; Gases / analysis; Models, Chemical; Time Factors; Toluene / chemistry; Water Pollutants, Chemical / chemistry
TL;DR:
The landfill coupled-reactor (LFCR) model developed in this work simulates a landfill as a series of fully mixed reactors, each representing a daily volume of waste, allowing time-variable input parameters such as gas generation, and cover type and thickness.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
C/EBP beta represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19(Arf)
CELL DEATH AND DIFFERENTIATION, 15(11), 1734–1744.
author keywords: apoptosis; p53; C/EBP beta; p19(Arf); DNA damage; keratinocytes
MeSH headings : Animals; Apoptosis / drug effects; CCAAT-Enhancer-Binding Protein-beta / deficiency; CCAAT-Enhancer-Binding Protein-beta / metabolism; Carcinogens / toxicity; Cell Survival / drug effects; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; Cyclophosphamide / administration & dosage; Cyclophosphamide / pharmacology; DNA Damage; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Injections, Intraperitoneal; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Mice; Oncogene Protein p21(ras) / metabolism; Protein Processing, Post-Translational / drug effects; Repressor Proteins / metabolism; Transcriptional Activation / drug effects; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
TL;DR:
Results suggest that inhibition of C/EBPβ may be a target for cancer cotherapy to increase the efficacy of alkylating chemotherapeutic agents and suggest that p19Arf represses p53 to promote cell survival downstream of DNA damage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Investigations with O-linked protein glycosylations by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry
JOURNAL OF MASS SPECTROMETRY, 43(9), 1215–1223.
author keywords: Fourier transform ion cyclotron mass spectrometry (FT-ICR-MS); matrix-assisted laser desorption/ionization (MALDI); mucin; O-linked glycans; protein glycosylations
MeSH headings : Angiotensins / chemistry; Animals; Glycosylation; Mucins / chemistry; Oligosaccharides / chemistry; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Spectroscopy, Fourier Transform Infrared / methods; Swine; Tandem Mass Spectrometry / methods
TL;DR:
A detailed examination of sample preparation and matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FT-ICR-MS) analysis of O-linked glycans globally cleaved from mucin glycoproteins is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Construction of a versatile high precision ambient Ionization source for direct analysis and imaging
Journal of the American Society for Mass Spectrometry, 19(10), 1527–1534.
MeSH headings : Bradykinin / chemistry; Cations / chemistry; Humans; Lasers; Melitten / chemistry; Muramidase / chemistry; Myoglobin / chemistry; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Ubiquitin / chemistry
TL;DR:
The design and construction of a high precision ambient ionization source matrix-assisted laser desorption electrospray ionization (MALDESI) and the computer controlled high precision motion control system and high repetition rate Explorer laser are demonstrated during MALDESI-FT-ICR analysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2008 journal article
Development and characterization of an ionization technique for analysis of biological macromolecules: Liquid matrix-assisted laser desorption electrospray ionization
ANALYTICAL CHEMISTRY, 80(17), 6773–6778.
MeSH headings : Organic Chemicals / chemistry; Peptides / analysis; Proteins / analysis; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Surface Properties
TL;DR:
An increase in ion abundance and a concurrent decrease in surface tension with an increase in the applied potential are demonstrated and a singly charged radical cation of an electrochemically active species indicating oxidation occurs for analytes and therefore water is observed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Top-down identification and quantification of stable isotope labeled proteins from Aspergillus flavus using online nano-flow reversed-phase liquid chromatography coupled to a LTQ-FTICR mass spectrometer
ANALYTICAL CHEMISTRY, 80(13), 4994–5001.
MeSH headings : Arginine / chemistry; Arginine / metabolism; Aspergillus flavus / chemistry; Aspergillus flavus / metabolism; Carbon Radioisotopes / chemistry; Chromatography, Liquid / methods; Fourier Analysis; Fungal Proteins / analysis; Fungal Proteins / chemistry; Fungal Proteins / metabolism; Isotope Labeling; Tandem Mass Spectrometry / methods
TL;DR:
The qualitative and quantitative top-down characterization of proteins derived from SILAC-labeled Aspergillus flavus is described using nanoflow reversed-phase liquid chromatography directly coupled to a linear ion trap Fourier transform ion cyclotron resonance mass spectrometer (nLC-LTQ-FTICR-MS).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains
BMC Evolutionary Biology, 8(1), 177.
MeSH headings : Amino Acid Sequence; Animals; Conserved Sequence; Evolution, Molecular; Fish Proteins / genetics; Fish Proteins / immunology; Genetic Variation; Immunoglobulin Variable Region / genetics; Models, Genetic; Molecular Sequence Data; Multigene Family; Oryzias / genetics; Phylogeny; Protein Structure, Tertiary / genetics; Receptors, Immunologic / genetics; Species Specificity; Synteny; Zebrafish / genetics; Zebrafish / immunology
TL;DR:
Comprehensive phylogenetic analyses between the complete datasets of NITRs from medaka and zebrafish indicate multiple species-specific expansions of different families of NITS, consistent with recent birth-and-death events.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Temperature-dependent regulation of proteins in Aspergillus flavus: Whole organism stable isotope labeling by amino acids
JOURNAL OF PROTEOME RESEARCH, 7(7), 2973–2979.
author keywords: SILAC; mass spectrometry; proteomics; Aspergillus flavus; aflatoxin
MeSH headings : Aflatoxins / biosynthesis; Amino Acids / metabolism; Arginine / metabolism; Aspergillus flavus / metabolism; Carbon Isotopes; Chromatography, Liquid; Culture Media; Fungal Proteins / biosynthesis; Fungal Proteins / genetics; Gene Expression Regulation, Fungal; Isotope Labeling; Oligonucleotide Array Sequence Analysis; Tandem Mass Spectrometry; Temperature
TL;DR:
The utility of this procedure in quantifying changes in protein expression in response to environmental stimuli is shown, and the first reported labeling of a multicellular free-living prototroph using the SILAC procedure to compare (13)C(6)-arginine-labeled samples to (12)C (6-arginines-labeling samples for quantitative proteomics is reported.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Mass measurement accuracy comparisons between a double-focusing magnetic sector and a time-of-flight mass analyzer
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 22(10), 1563–1566.
MeSH headings : Equipment Design; Equipment Failure Analysis; Magnetics / instrumentation; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation
TL;DR:
A direct comparison of the mass measurement accuracies (MMAs) obtained on different mass spectrometry instrument types; a magnetic sector as the 'gold standard' and an electrospray ionization time-of-flight (ESI-TOF) instrument.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Differential exposure, duration, and sensitivity of unionoidean bivalve life stages to environmental contaminants
JOURNAL OF THE NORTH AMERICAN BENTHOLOGICAL SOCIETY, 27(2), 451–462.
author keywords: freshwater mussel; habitat; pollution; Unionidae; water quality
TL;DR:
Additional research is needed to understand interactions of life history, habitat, and long-term exposure to contaminants through water, pore water, sediment, and diet so that the risks of environmental exposures can be properly assessed and managed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Ambient aerodynamic ionization source for remote analyte sampling and mass spectrometric analysis
ANALYTICAL CHEMISTRY, 80(13), 5266–5271.
MeSH headings : Acetaminophen / antagonists & inhibitors; Acetaminophen / chemistry; Caffeine / analysis; Caffeine / chemistry; Natriuretic Peptide, Brain / analysis; Natriuretic Peptide, Brain / chemistry; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Ubiquitin / analysis; Ubiquitin / chemistry
TL;DR:
This novel aerodynamic device, herein termed remote analyte sampling, transport, and ionization relay (RASTIR) was used to remotely sample neutral species in the ambient and entrain them into an electrospray plume where they were subsequently ionized and detected using a linear ion trap Fourier transform mass spectrometer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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