Center for Environmental and Health Effects of PFAS

Works Published in 2010

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Displaying works 61 - 80 of 119 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2010 journal article

Body-Mass Index and Mortality among 1.46 Million White Adults

New England Journal of Medicine, 363(23), 2211–2219.

By: A. Berrington de Gonzalez*, P. Hartge*, J. Cerhan*, A. Flint*, L. Hannan*, R. MacInnis*, S. Moore*, G. Tobias* ...

Contributors: A. De Gonzalez*, P. Hartge*, J. Cerhan*, A. Flint*, L. Hannan*, R. MacInnis*, S. Moore*, G. Tobias* ...

MeSH headings : Adult; Body Mass Index; Cause of Death; Confounding Factors, Epidemiologic; Exercise; Female; Follow-Up Studies; Humans; Male; Mortality / ethnology; Overweight / mortality; Proportional Hazards Models; Smoking / adverse effects; Socioeconomic Factors; Thinness / mortality; White People / statistics & numerical data
TL;DR: In white adults, overweight and obesity (and possibly underweight) are associated with increased all-cause mortality and the hazard ratios for the men were similar. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019

2010 chapter

Understanding environment-disease connections: An introduction to the comparative toxicogenomics database (ctd)

In Nature Pathway Interaction Database.

By: C. Mattingly

Source: NC State University Libraries
Added: August 10, 2019

2010 journal article

2,3,7,8-Tetrachlorodibenzo-p-dioxin Upregulates FoxQ1b in Zebrafish Jaw Primordium

Chemical Research in Toxicology, 23(3), 480–487.

By: A. Planchart* & C. Mattingly*

Contributors: A. Planchart* & C. Mattingly*

MeSH headings : Animals; Embryo, Nonmammalian / metabolism; Enhancer Elements, Genetic; Environmental Pollutants / pharmacology; Forkhead Transcription Factors / genetics; Gene Expression Regulation, Developmental / drug effects; Jaw / metabolism; Jaw / pathology; Jaw Abnormalities / chemically induced; Polychlorinated Dibenzodioxins / pharmacology; Receptors, Aryl Hydrocarbon / metabolism; Up-Regulation / drug effects; Zebrafish / genetics; Zebrafish / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR: FoxQ1b is specifically expressed in the jaw primordium where it discretely outlines a developing jaw structure known as Meckel's cartilage--a conserved structure in all jawed vertebrates that develops abnormally in the presence of TCDD. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 10, 2019

2010 journal article

The Comparative Toxicogenomics Database: update 2011

Nucleic Acids Research, 39(Database), D1067–D1072.

By: A. Davis*, B. King*, S. Mockus*, C. Murphy*, C. Saraceni-Richards*, M. Rosenstein*, T. Wiegers*, C. Mattingly*

MeSH headings : Databases, Factual; Disease / etiology; Disease / genetics; Environmental Exposure; Gene Regulatory Networks; Genes; Hazardous Substances / toxicity; Humans; Software; Toxicogenetics
TL;DR: Since 2009, the content of CTD has dramatically increased the content to 1.4 million chemical–gene–disease data points and added many features, statistical analyses and analytical tools, including GeneComps and ChemComps, to help users generate testable hypotheses about the molecular mechanisms of environmental diseases. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 7, 2019

2010 journal article

In vitro screening of environmental chemicals for targeted testing prioritization: The toxcast project

Environmental Health Perspectives, 118(4), 485–492.

By: R. Judson*, K. Houck*, R. Kavlock*, T. Knudsen*, M. Martin*, H. Mortensen*, D. Reif*, D. Rotroff* ...

Contributors: R. Judson*, K. Houck*, R. Kavlock*, T. Knudsen*, M. Martin*, H. Mortensen*, D. Reif*, D. Rotroff* ...

author keywords: in vitro screening; liver proliferative lesions; liver tumors; pathways; ToxCast
MeSH headings : Animals; Cell Line; Cells, Cultured; Computer Simulation; Environmental Pollutants / toxicity; Humans; Rats; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR: A statistically significant inverse association between the number of pathways perturbed by a chemical at low in vitro concentrations and the lowest in vivo dose at which a chemical causes toxicity is found. (via Semantic Scholar)
Source: ORCID
Added: May 14, 2019

2010 journal article

Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals.

Journal of Toxicology and Environmental Health - Part B: Critical Reviews, 13(2-4), 329–346.

By: D. Rotroff*, A. Beam, D. Dix*, A. Farmer, K. Freeman, K. Houck*, R. Judson*, E. LeCluyse ...

Contributors: D. Rotroff*, A. Beam, D. Dix*, A. Farmer, K. Freeman, K. Houck*, R. Judson*, E. Lecluyse ...

MeSH headings : Adult; Animals; Cell Shape / drug effects; Cells, Cultured; Cholesterol / biosynthesis; Environmental Pollutants / chemistry; Environmental Pollutants / metabolism; Environmental Pollutants / toxicity; Gene Expression Regulation / drug effects; Hepatocytes / cytology; Hepatocytes / drug effects; Hepatocytes / enzymology; Hepatocytes / metabolism; Humans; Male; Middle Aged; Models, Biological; Rats; Signal Transduction / drug effects; Xenobiotics / chemistry; Xenobiotics / metabolism; Xenobiotics / toxicity
TL;DR: Gene expression results identified various ToxCast chemicals that were potent or efficacious inducers of one or more of the 14 genes, and by inference the 5 nuclear receptor signaling pathways, as well as the five major receptor pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: May 14, 2019

2010 journal article

Research needs for community-based risk assessment: findings from a multi-disciplinary workshop

J Expos Sci Environ Epidemiol, 20(2), 186–195.

By: Y. Sanchez*, K. Deener*, E. Hubal*, C. Knowlton*, D. Reif* & D. Segal*

Contributors: Y. Sanchez*, K. Deener*, E. Hubal*, C. Knowlton*, D. Reif* & D. Segal*

author keywords: population-based studies; epidemiology; exposure modeling; analytical methods; empirical/statistical modeling; PBPK modeling
MeSH headings : Humans; Needs Assessment; Research; Risk Assessment; United States; United States Environmental Protection Agency
TL;DR: This paper summarizes an Environmental Protection Agency (EPA) sponsored workshop, “Research Needs for Community-Based Risk Assessment,” and presents identified research needs, and explores future research opportunities in this emerging field. (via Semantic Scholar)
Source: ORCID
Added: May 14, 2019

2010 journal article

Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.

Toxicological Sciences, 117(2), 348–358.

By: D. Rotroff*, B. Wetmore*, D. Dix*, S. Ferguson, H. Clewell*, K. Houck*, E. Lecluyse, M. Andersen* ...

Contributors: D. Rotroff*, B. Wetmore*, D. Dix*, S. Ferguson, H. Clewell*, K. Houck*, E. LeCluyse, M. Andersen* ...

author keywords: reverse dosimetry; human exposure; ToxCast; high-throughput screening
MeSH headings : Cells, Cultured; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Hepatocytes / drug effects; Hepatocytes / metabolism; High-Throughput Screening Assays / methods; Humans; Male; Metabolic Clearance Rate; Protein Binding / drug effects; Risk Assessment; Toxicity Tests; Xenobiotics / classification; Xenobiotics / metabolism; Xenobiotics / toxicity
Source: ORCID
Added: May 14, 2019

2010 journal article

Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.

Chemical Research in Toxicology, 23(3), 578–590.

By: M. Martin*, D. Dix*, R. Judson*, R. Kavlock*, D. Reif*, A. Richard*, D. Rotroff*, S. Romanov* ...

Contributors: M. Martin*, D. Dix*, R. Judson*, R. Kavlock*, D. Reif*, A. Richard*, D. Rotroff*, S. Romanov* ...

MeSH headings : Animals; Biosensing Techniques / economics; Biosensing Techniques / instrumentation; Biosensing Techniques / methods; Environmental Pollutants / adverse effects; Hep G2 Cells; Rabbits; Rats; Receptors, Cytoplasmic and Nuclear / genetics; Response Elements / drug effects; Transcription Factors / genetics; Transcription, Genetic / drug effects
TL;DR: A novel cellular biosensor system that enables rapid, high-content assessment of a compound's impact on gene regulatory networks and it is demonstrated that Nrf2 activity, a marker of oxidative stress, is highly correlated to the overall promiscuity of a chemical. (via Semantic Scholar)
Source: ORCID
Added: May 14, 2019

2010 journal article

Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data

Environ Health Perspect, 118(12), 1714–1720.

By: D. Reif*, M. Martin*, S. Tan*, K. Houck*, R. Judson*, A. Richard*, T. Knudsen*, D. Dix*, R. Kavlock*

Contributors: D. Reif*, M. Martin*, S. Tan*, K. Houck*, R. Judson*, A. Richard*, T. Knudsen*, D. Dix*, R. Kavlock*

author keywords: androgen; chemical prioritization; data integration; endocrine disruption; estrogen; screening; ToxCast; toxicity profile; ToxPi
MeSH headings : Decision Support Techniques; Endocrine Disruptors / classification; Endocrine Disruptors / toxicity; Endocrine System / drug effects; Environmental Pollutants / classification; Environmental Pollutants / toxicity; Signal Transduction / drug effects; Toxicity Tests / methods
TL;DR: A flexible method to facilitate the rational prioritization of chemicals for further evaluation is developed and its application as a candidate decision-support tool for EDSP is demonstrated. (via Semantic Scholar)
Source: ORCID
Added: May 14, 2019

2010 journal article

Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity.

Environmental Science and Technology, 44(15), 5979–5985.

By: R. Judson*, M. Martin*, D. Reif*, K. Houck*, T. Knudsen*, D. Rotroff*, M. Xia*, S. Sakamuru* ...

Contributors: R. Judson*, M. Martin*, D. Reif*, K. Houck*, T. Knudsen*, D. Rotroff*, M. Xia*, S. Sakamuru* ...

MeSH headings : Chemical Hazard Release; Endocrine Disruptors / analysis; Environmental Restoration and Remediation; Lipids / toxicity; Receptors, Estrogen / metabolism; Surface-Active Agents / toxicity; Water Pollutants, Chemical / toxicity
TL;DR: A series of in vitro high-throughput assays on eight commercial dispersants focused on the estrogen and androgen receptors (ER and AR), but also included a larger battery of assays probing other biological pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: May 14, 2019

2010 journal article

The phylogenetic origins of natural killer receptors and recognition: relationships, possibilities, and realities

Immunogenetics, 63(3), 123–141.

By: J. Yoder n & G. Litman*

author keywords: Marsupial; Monotreme; Chicken; Xenopus; Zebrafish; Innate immunity; Cytotoxicity
MeSH headings : Animals; Evolution, Molecular; Humans; Immunity, Innate; Killer Cells, Natural / immunology; Mammals / genetics; Mammals / immunology; Phylogeny; Receptors, Natural Killer Cell / genetics; Receptors, Natural Killer Cell / immunology; Receptors, Natural Killer Cell / metabolism; Vertebrates / genetics; Vertebrates / immunology
TL;DR: Several lines of evidence suggest that NK-type function or its equivalent has sustained a long evolutionary history throughout vertebrate species and likely reflects the influence of pathogens on their evolution. (via Semantic Scholar)
Sources: ORCID, NC State University Libraries, Crossref
Added: February 13, 2019

2010 journal article

Sp2 is a maternally inherited transcription factor required for embryonic development

Journal of Biological Chemistry, 285(6), 4153–4164.

By: J. Xie n, H. Yin n, T. Nichols n, J. Yoder n & J. Horowitz n

MeSH headings : Amino Acid Sequence; Animals; COS Cells; Chlorocebus aethiops; Chromosome Mapping; Embryo, Mammalian / embryology; Embryo, Mammalian / metabolism; Female; Gene Expression Regulation, Developmental; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Humans; In Situ Hybridization; Male; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Phylogeny; Promoter Regions, Genetic / genetics; RNA, Messenger, Stored / genetics; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sp2 Transcription Factor / classification; Sp2 Transcription Factor / genetics; Sp2 Transcription Factor / metabolism; Synteny; Transcription, Genetic; Zebrafish / embryology; Zebrafish / genetics; Zebrafish / growth & development; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR: The role(s) played by Sp2 in early metazoan development is addressed by cloned and characterized Sp2 from zebrafish, and the intron/exon organization and amino acid sequence of Sp2 is closely conserved with its mammalian orthologues. (via Semantic Scholar)
Source: ORCID
Added: February 13, 2019

2010 journal article

TCDD Induced Pericardial Edema and Relative COX-2 Expression in Medaka (Oryzias Latipes) Embryos

TOXICOLOGICAL SCIENCES, 118(1), 213–223.

By: W. Dong n, F. Matsumura n & S. Kullman n

author keywords: COX-2; TCDD; medaka; pericardial edema
MeSH headings : Animals; Arachidonic Acid / pharmacology; Cyclooxygenase 2 / biosynthesis; Cyclooxygenase 2 / genetics; Cyclooxygenase Inhibitors / pharmacology; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / enzymology; Gene Expression Regulation, Developmental / drug effects; Gene Silencing; Nitrobenzenes / pharmacology; Oryzias / physiology; Pericardial Effusion / chemically induced; Pericardial Effusion / genetics; Pericardial Effusion / pathology; Polychlorinated Dibenzodioxins / toxicity; RNA, Messenger / metabolism; Sulfonamides / pharmacology; Teratogens / toxicity
TL;DR: It is suggested that AhR activation results in stimulation of inflammation and "eicosanoid" pathways, which contribute to the observed developmental, cardiovascular phenotypes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Specific Resistance to Pseudomonas aeruginosa Infection in Zebrafish Is Mediated by the Cystic Fibrosis Transmembrane Conductance Regulator

Infection and Immunity, 78(11), 4542–4550.

By: R. Phennicie*, M. Sullivan*, J. Singer*, J. Yoder n & C. Kim*

MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / metabolism; Disease Models, Animal; Humans; Immunity, Innate; Neutrophils / immunology; Pseudomonas Infections / immunology; Pseudomonas Infections / microbiology; Pseudomonas aeruginosa / genetics; Pseudomonas aeruginosa / metabolism; Pseudomonas aeruginosa / pathogenicity; Quorum Sensing; Trans-Activators / genetics; Trans-Activators / metabolism; Virulence; Zebrafish / immunology; Zebrafish / microbiology
TL;DR: The zebrafish system provides a multitude of advantages for studying the pathogenesis of P. aeruginosa and for understanding the role that innate immune cells, such as neutrophils, play in the host response to acute bacterial infections commonly associated with cystic fibrosis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2010 journal article

Grid-Enabled Simulation-Optimization Framework for Environmental Characterization

JOURNAL OF COMPUTING IN CIVIL ENGINEERING, 24(6), 488–498.

By: B. Mirghani n, M. Tryby n, R. Ranjithan n, N. Karonis n & K. Mahinthakumar n

author keywords: Simulation models
TL;DR: This paper reports and discusses the development and evaluation of the simulation-optimization approach to grid computing, particularly in environmental characterization involving natural systems, and the large number of such simulations involved. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Utilizing Spectral Counting To Quantitatively Characterize Tandem Removal of Abundant Proteins (TRAP) in Human Plasma

ANALYTICAL CHEMISTRY, 82(24), 10179–10185.

By: C. Shuford n, A. Hawkridge n, J. Burnett n & D. Muddiman n

MeSH headings : Biomarkers / analysis; Blood Proteins / analysis; Blood Proteins / isolation & purification; Humans
TL;DR: The data demonstrate that this method, tandem removal of abundant proteins or TRAP, provides superior removal efficiency compared to traditional applications and improves the depth of proteome coverage in plasma. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Monitoring Design for Source Identification in Water Distribution Systems

JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE, 136(6), 637–646.

By: M. Tryby n, M. Propato n & S. Ranjithan n

author keywords: Source identification; Monitoring design; Inverse problem; Experimental design; Water distribution systems; Water infrastructure security; Genetic algorithm; Optimization
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Manganese Bioconcentration in Aquatic Insects: Mn Oxide Coatings, Molting Loss, and Mn(II) Thiol Scavenging

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 44(23), 9182–9188.

MeSH headings : Animals; Coal Mining; Environmental Monitoring; Fresh Water / chemistry; Insecta / metabolism; Manganese / analysis; Manganese / chemistry; Manganese / metabolism; Manganese Compounds / analysis; Manganese Compounds / metabolism; Molting; Oxides / analysis; Oxides / metabolism; Sulfhydryl Compounds / chemistry; Sulfhydryl Compounds / metabolism; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / chemistry; Water Pollutants, Chemical / metabolism; Water Pollution, Chemical / statistics & numerical data
TL;DR: It is suggested that Mn exposure results in transient physiological stress in aquatic insects which is likely relieved, in part, during the molting process, as well as increased ambient calcium concentrations. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Does proximity to coal-fired power plants influence fish tissue mercury?

ECOTOXICOLOGY, 19(8), 1601–1611.

author keywords: Mercury; Selenium; Point-source; Coal-fired power plant; Fish
MeSH headings : Animals; Coal; Environmental Monitoring / methods; Fishes / metabolism; Food Contamination / analysis; Fresh Water; Geologic Sediments / chemistry; Humans; Mercury / metabolism; Mercury / toxicity; Power Plants; Selenium / metabolism; Species Specificity; Tissue Distribution; Water Pollutants, Chemical / metabolism; Water Pollutants, Chemical / toxicity
TL;DR: Although reduced fish tissue mercury in systems near power plants may decrease mercury-specific risks to human consumers, these benefits are highly localized and the relatively high selenium associated with these tissues may compromise ecological health. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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