Works Published in 2017
Displaying works 61 - 80 of 115 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2017 journal article
Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish
TOXICOLOGY AND APPLIED PHARMACOLOGY, 329, 148–157.
Contributors: A. Knecht*, L. Truong *, S. Marvel n, D. Reif n , A. Garcia*, C. Lu *, M. Simonich*, J. Teeguarden *, R. Tanguay *
author keywords: Zebrafish Benzo[a]pyrene; Transgenerational; Neurobehavioral; Developmental toxicity; Physiological deficits; Aryl hydrocarbon receptor
MeSH headings : Animals; Animals, Genetically Modified; Behavior, Animal / drug effects; Benzo(a)pyrene / toxicity; DNA Methylation / drug effects; DNA Modification Methylases / metabolism; Dose-Response Relationship, Drug; Epigenesis, Genetic / drug effects; Genotype; Heart Rate / drug effects; Heredity; Inheritance Patterns / drug effects; Learning / drug effects; Mitochondria / drug effects; Mitochondria / metabolism; Motor Activity / drug effects; Neurotoxicity Syndromes / genetics; Neurotoxicity Syndromes / metabolism; Neurotoxicity Syndromes / physiopathology; Phenotype; Repressor Proteins / agonists; Repressor Proteins / deficiency; Repressor Proteins / genetics; Respiration / drug effects; Risk Assessment; Social Behavior; Time Factors; Water Pollutants, Chemical / toxicity; Zebrafish / genetics; Zebrafish / growth & development; Zebrafish / metabolism; Zebrafish Proteins / agonists; Zebrafish Proteins / deficiency; Zebrafish Proteins / genetics
TL;DR:
Exposure to benzo[a]pyrene during development resulted in transgenerational inheritance of neurobehavioral and physiological deficiencies, and indirect evidence suggested the potential for an AHR2‐dependent epigenetic route.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
DRILL: An Electrospray Ionization-Mass Spectrometry Interface for Improved Sensitivity via Inertial Droplet Sorting and Electrohydrodynamic Focusing in a Swirling Flow
ANALYTICAL CHEMISTRY, 89(17), 8981–8987.
MeSH headings : Angiotensin I / analysis; Angiotensin I / metabolism; Angiotensin II / analysis; Angiotensin II / metabolism; Chromatography, High Pressure Liquid; Humans; Isotope Labeling; Limit of Detection; Peptides / analysis; Peptides / chemistry; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
This work experimentally demonstrates sensitivity improvement obtained via vortex-induced inertial sorting of electrosprayed droplets/ions: one possible mode of DRILL operation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Physiological responses to short-term thermal stress in mayfly (Neocloeon triangulifer) larvae in relation to upper thermal limits
JOURNAL OF EXPERIMENTAL BIOLOGY, 220(14), 2598–2605.
author keywords: Temperature; Aerobic scope; Hypoxia; Aquatic insect; Gene expression
MeSH headings : Acclimatization / physiology; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone / pharmacology; Ecosystem; Ephemeroptera / growth & development; Ephemeroptera / physiology; Gene Expression; Hot Temperature / adverse effects; Larva / growth & development; Larva / physiology; Oxygen / physiology; Oxygen Consumption / drug effects; Oxygen Consumption / physiology
TL;DR:
The results suggest that the chronic thermal limits of this species are likely not driven by oxygen limitation, but rather are determined by other factors, e.g. bioenergetics costs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Organic Food in the Diet: Exposure and Health Implications
Annual Review of Public Health, 38(1), 295–313.
author keywords: organic food; organic vegetables; naturalness; compositional differences; health effects
MeSH headings : Agriculture / methods; Diet; Food; Food Contamination / prevention & control; Food, Organic; Humans; Nutritive Value
TL;DR:
This review provides an update on market data and consumer preferences for organic food and summarizes the scientific evidence for compositional differences and health benefits of organic compared with conventionally produced food.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2017 journal article
Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling
Development, 144(16), 2925–2939.
author keywords: Transposon; DNA methylation; Uhrf1; Interferon; Antiviral
MeSH headings : Animals; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases / genetics; DNA (Cytosine-5-)-Methyltransferases / metabolism; DNA Methylation / genetics; DNA Methylation / physiology; Retroelements / genetics; Signal Transduction / genetics; Signal Transduction / physiology; Trans-Activators / genetics; Trans-Activators / metabolism; Zebrafish / embryology; Zebrafish / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
Activation of transposons in cells with global DNA hypomethylation mimics a viral infection by activating cytoplasmic DNA viral sensors suggests that antiviral pathways serve as surveillance of cells that have derepressed intragenomic parasites due to DNA hypometrichylations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2017 conference paper
Life-cycle modeling of municipal solid waste landfills
Geotechnical frontiers 2017: waste containment, barriers, remediation, and sustainable geoengineering, (276), 355–368.
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2017 article
Informatics and Data Analytics to Support Exposome-Based Discovery for Public Health
ANNUAL REVIEW OF PUBLIC HEALTH, VOL 38, Vol. 38, pp. 279–294.
author keywords: exposures; bioinformatics; genomics; environment-wide association studies; data standards
MeSH headings : Biomedical Research; Computational Biology; Ecosystem; Environmental Exposure / adverse effects; Humans; Public Health; Risk Factors
TL;DR:
If an exposome data ecosystem is brought to fruition, it will likely play a role as central as genomic science has had in molding the current and new generations of biomedical researchers, computational scientists, and public health research programs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Construction and setup of a bench-scale algal photosynthetic bioreactor with temperature, light, and ph monitoring for kinetic growth tests
Jove-Journal of Visualized Experiments, (124).
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Assessing the Potential for Bias From Nonresponse to a Study Follow-up Interview: An Example From the Agricultural Health Study
American Journal of Epidemiology, 186(4), 395–404.
author keywords: attrition; epidemiologic methods; inverse probability weights; loss to follow-up; occupational/environmental epidemiology; prospective studies; selection bias
MeSH headings : Adult; Aged; Aged, 80 and over; Agricultural Workers' Diseases / epidemiology; Agricultural Workers' Diseases / etiology; Agricultural Workers' Diseases / prevention & control; Bias; Cause of Death; Epidemiologic Research Design; Farmers / statistics & numerical data; Female; Follow-Up Studies; Humans; Interviews as Topic; Iowa / epidemiology; Lost to Follow-Up; Male; Middle Aged; Neoplasms / epidemiology; North Carolina; Odds Ratio; Prospective Studies; Smoking / epidemiology
TL;DR:
This example provides a demonstration of investigating the influence of attrition in cohort studies using information that has been self-reported after enrollment, and the ability of inverse probability weighting (IPW) to reduce bias.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2017 journal article
Assessing the Exposome with External Measures: Commentary on the State of the Science and Research Recommendations
Annual Review of Public Health, 38(1), 215–239.
author keywords: exposome; external exposures; geographic information systems; remote sensing; global positioning systems; smartphones
MeSH headings : Environmental Exposure / adverse effects; Epigenomics; Geographic Information Systems; Health Behavior; Humans; Life Style; Research
TL;DR:
Major scientific and technological advances that inform external assessment of the exposome are described, including geographic information systems; remote sensing; global positioning system and geolocation technologies; portable and personal sensing; and self-reported questionnaire assessments, which increasingly rely on Internet-based platforms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2017 conference paper
A Model to Describe Heat Generation and Accumulation at Municipal Solid Waste Landfills
Geotechnical Frontiers 2017, (276), 281–288.
Event: Geotechnical Frontiers 2017 at Orlando, FL on March 12-15, 2017
Sources: NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Sulfate transport kinetics and toxicity are modulated by sodium in aquatic insects
AQUATIC TOXICOLOGY, 190, 62–69.
author keywords: Aquatic insects; Major ions; Physiology; Osmoregulation; Toxicity; Sulfate
MeSH headings : Animals; Aquatic Organisms / drug effects; Aquatic Organisms / metabolism; Ecosystem; Fresh Water / chemistry; Insecta / drug effects; Insecta / metabolism; Ion Transport / drug effects; Kinetics; Salinity; Sodium / analysis; Sodium / pharmacology; Sulfates / metabolism; Sulfates / toxicity; Water Pollutants, Chemical / metabolism; Water Pollutants, Chemical / toxicity
TL;DR:
The combination of elevated sulfate and low sodium commonly observed in streams affected by mountaintop coal mining has the potential to cause toxicity in sensitive aquatic insects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Greater Coronary Heart Disease Risk With Lower Intensity and Longer Duration Smoking Compared With Higher Intensity and Shorter Duration Smoking: Congruent Results Across Diverse Cohorts
NICOTINE & TOBACCO RESEARCH, 19(7), 817–825.
MeSH headings : Aged; Cohort Studies; Coronary Disease / epidemiology; Coronary Disease / mortality; Double-Blind Method; Finland / epidemiology; Humans; Male; Middle Aged; Risk Factors; Smoking / epidemiology; Smoking Cessation / methods; Time Factors; Tobacco Products / statistics & numerical data
TL;DR:
In inverse smoking intensity effects in multiple cohorts with differing smoking patterns and other characteristics are observed, suggesting a common underlying phenomenon that offers clues to better understanding biological mechanisms and reinforces the importance of cessation rather than smoking less to reduce CHD risk.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Evolutionary divergence of the vertebrate TNFAIP8 gene family: Applying the spotted gar orthology bridge to understand ohnolog loss in teleosts
PLOS ONE, 12(6), e0179517.
Ed(s): P. Boudinot
TL;DR:
It is determined that teleost orthologs to human TNFAIP8 genes were likely lost in a genome inversion event after their divergence from their common ancestor with spotted gar, demonstrating the value of this enhanced approach to gene history analysis and support the development of teleost models to study complex questions related to an array of biomedical issues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2017 journal article
Estrogen and soy isoflavonoids decrease sensitivity of medulloblastoma and central nervous system primitive neuroectodermal tumor cells to chemotherapeutic cytotoxicity
BMC PHARMACOLOGY & TOXICOLOGY, 18(1).
Contributors: S. Belcher n , C. Burton*, C. Cookman*, M. Kirby*, G. Miranda*, F. Saeed*, K. Wray*
author keywords: Chemotherapy; Cytoprotection; Concentration-response; Estrogen; In vitro; Isoflavones; Medulloblastoma; Phytoestrogen
TL;DR:
It is demonstrated that E2 and environmental estrogens decrease sensitivity of MB to cytotoxic chemotherapeutic drugs, and that ERβ selective and non-selective inhibition of estrogen receptor activity blocks these cytoprotective actions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Effects of bisphenol A on incidence and severity of cardiac lesions in the NCTR-Sprague-Dawley rat: A CLARITY-BPA study
Toxicology Letters, 275, 123–135.
Contributors: R. Gear*, J. Kendziorski* & S. Belcher n
MeSH headings : Age Factors; Animals; Benzhydryl Compounds / toxicity; Body Weight / drug effects; Cardiomyopathies / chemically induced; Cardiomyopathies / pathology; Cardiotoxicity; Environmental Pollutants / toxicity; Female; Fibrosis; Male; Myocardium / pathology; Organ Size / drug effects; Phenols / toxicity; Rats, Sprague-Dawley; Severity of Illness Index; Sex Factors
TL;DR:
Across all exposure groups including vehicle controls, body weight of continuously dosed males was reduced compared to males dosed only until PND21, and heart weight was increased only in females exposed to EE, and consistent alterations in LV wall thickness were not observed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Early-life farm exposures and adult asthma and atopy in the Agricultural Lung Health Study
Journal of Allergy and Clinical Immunology, 140(1), 249–256.e14.
author keywords: Agriculture; agricultural workers' diseases; allergy and immunology; asthma; hygiene hypothesis; IgE; prenatal exposure delayed effects
MeSH headings : Aged; Asthma / epidemiology; Case-Control Studies; Environmental Exposure; Farms; Female; Humans; Hypersensitivity, Immediate / blood; Hypersensitivity, Immediate / epidemiology; Immunoglobulin E / blood; Iowa / epidemiology; Male; Middle Aged; North Carolina / epidemiology; Odds Ratio; Pulmonary Disease, Chronic Obstructive / epidemiology; Smoking / epidemiology
TL;DR:
In a large US farming population, early‐life farm exposures, particularly maternal farming activities while pregnant, were strongly associated with reduced risk of atopy in adults, suggesting that protective associations of early‐ life farming exposures on atopy endure across the life course.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Cheminformatics modeling of amine solutions for assessing their CO2 absorption properties
Molecular Informatics, 36(7).
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Characterizing the Chemical Space of ERK2 Kinase Inhibitors Using Descriptors Computed from Molecular Dynamics Trajectories
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 57(6), 1286–1299.
MeSH headings : Ligands; Mitogen-Activated Protein Kinase 1 / antagonists & inhibitors; Mitogen-Activated Protein Kinase 1 / chemistry; Mitogen-Activated Protein Kinase 1 / metabolism; Molecular Dynamics Simulation; Protein Conformation; Protein Kinase Inhibitors / chemistry; Protein Kinase Inhibitors / metabolism; Protein Kinase Inhibitors / pharmacology; Quantitative Structure-Activity Relationship; Solvents / chemistry; Temperature
TL;DR:
This study represents the largest attempt to utilize MD-extracted chemical descriptors to characterize and model a series of bioactive molecules and showed that MD descriptors had little correlation with conventionally used 2D/3D descriptors, and were able to distinguish the most active ERK2 inhibitors from the moderate/weak actives and inactives.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 personal communication
Response to Buchwalter et al. further considerations for modernizing water quality criteria in the United States and elsewhere reply
Source: NC State University Libraries
Added: August 6, 2018
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