Center for Environmental and Health Effects of PFAS

Works Published in 2022

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Displaying works 61 - 80 of 87 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2022 journal article

A Preprocessing Tool for Enhanced Ion Mobility-Mass Spectrometry-Based Omics Workflows

JOURNAL OF PROTEOME RESEARCH, 21(3), 798–807.

By: A. Bilbao*, B. Gibbons*, S. Stow*, J. Kyle*, K. Bloodsworth*, S. Payne*, R. Smith*, Y. Ibrahim*, E. Baker n, J. Fjeldsted*

author keywords: mass spectrometry; ion mobility spectrometry; preprocessing software; time-of-flight detector saturation; data-independent acquisition; lipid annotation
MeSH headings : Chromatography, Liquid / methods; Humans; Ion Mobility Spectrometry / methods; Ions; Lipids; Mass Spectrometry / methods; Workflow
TL;DR: The PNNL PreProcessor is developed, a standalone and user-friendly software housing various algorithmic implementations to generate new MS-files with enhanced signal quality and in the same instrument format to extend the dynamic range of the detection system, while reducing file sizes for faster and memory-efficient downstream processing. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: May 2, 2022

2022 journal article

Multimodal Mass Spectrometry Imaging of Rat Brain Using IR-MALDESI and NanoPOTS-LC-MS/MS

JOURNAL OF PROTEOME RESEARCH, 21(3), 713–720.

By: C. Pace n, J. Simmons*, R. Kelly* & D. Muddiman n

author keywords: multimodal mass spectrometry imaging; multiomic analyses; IR-MALDESI; nanoPOTS-LC-MS/MS
MeSH headings : Animals; Brain / diagnostic imaging; Chromatography, Liquid / methods; Proteome; Proteomics; Rats; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Tandem Mass Spectrometry
TL;DR: A multiomic pathway integration showed a strong correlation between the two data sets when comparing average abundances of metabolites and corresponding enzymes in each brain region, and the first steps in the creation of a multimodal MSI technique that combines two highly sensitive and complementary imaging platforms are demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 2, 2022

2022 journal article

Multiple Infusion Start Time Mass Spectrometry Imaging of Dynamic SIL-Glutathione Biosynthesis Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization

JOURNAL OF PROTEOME RESEARCH, 21(3), 747–757.

By: A. Mellinger n, K. Garrard n, S. Khodjaniyazova n, Z. Rabbani n, M. Gamcsik n & D. Muddiman n

author keywords: IR-MALDESI; mass spectrometry imaging; stable isotope labeling; glutathione; kinetic metabolism
MeSH headings : Animals; Glutathione; Glycine; Lasers; Mice; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: A study combining a multiple infusion start time protocol, stable isotope labeling technology, infrared matrix-assisted laser desorption electrospray ionization, and high-resolution accurate mass-mass spectrometry imaging to study spatial changes in glutathione kinetics across in sectioned mouse liver tissues is presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 2, 2022

2022 article

The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior

Shankar, P., Garcia, G. R., LaDu, J. K., Sullivan, C. M., Dunham, C. L., Goodale, B. C., … Tanguay, R. L. (2022, April 4). TOXICOLOGICAL SCIENCES, Vol. 4.

By: P. Shankar*, G. Garcia*, J. LaDu*, C. Sullivan*, C. Dunham*, B. Goodale*, K. Waters*, S. Stanisheuski* ...

author keywords: aryl hydrocarbon receptor (AHR); zebrafish; TCDD; wfikkn1; transcriptomics; behavior
MeSH headings : Animals; Embryo, Nonmammalian; Polychlorinated Dibenzodioxins / toxicity; Polycyclic Aromatic Hydrocarbons / toxicity; Proteome / genetics; Proteome / metabolism; Receptors, Aryl Hydrocarbon / genetics; Receptors, Aryl Hydrocarbon / metabolism; Transcriptome; Zebrafish / genetics; Zebrafish / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR: Functional enrichment demonstrated wfikkn1 was involved in skeletal muscle development and played a role in neurological pathways after TCDD exposure, and was likely a necessary functional member of the AHR signaling cascade. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: May 2, 2022

2022 journal article

Exposure to common-use pesticides, manganese, lead, and thyroid function among pregnant women from the Infants' Environmental Health (ISA) study, Costa Rica

SCIENCE OF THE TOTAL ENVIRONMENT, 810.

By: A. Vargas*, J. Castaneda*, E. Liljedahl*, A. Mora*, J. Menezes-Filho*, D. Smith*, D. Mergler*, B. Reich n ...

author keywords: Thyroid function; Endocrine disruptors; Pesticides; Metals; Latin America
MeSH headings : Bayes Theorem; Costa Rica; Environmental Exposure / adverse effects; Female; Humans; Infant; Lead / adverse effects; Manganese / adverse effects; Pesticides / adverse effects; Pregnancy; Pregnant Women; Thyroid Gland / physiopathology; Thyrotropin; Thyroxine; Triiodothyronine
TL;DR: Mancozeb (ETU) and pyrimethanil may inhibit FT4 secretion (hypothyroidism-like effect), while chlorpyrifos, pyrethroids, MnB, MnH, PbB and Mn showed hyperthyroidism -like effects. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2022

2022 journal article

Mechanisms of orthophosphate removal from water by lanthanum carbonate and other lanthanum-containing materials

SCIENCE OF THE TOTAL ENVIRONMENT, 820.

author keywords: Lanthanum containing material; Lanthanum carbonate; Phosphorus removal; Wastewater treatment; Mineral precipitation
MeSH headings : Adsorption; Lanthanum / chemistry; Phosphates / chemistry; Water; Water Pollutants, Chemical
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2022

2022 review

Per- and polyfluoroalkyl substances in the environment

[Review of ]. SCIENCE, 375(6580), 512-+.

MeSH headings : Animals; Biodegradation, Environmental; Drinking Water / chemistry; Environmental Exposure; Environmental Pollutants / analysis; Environmental Pollutants / chemistry; Environmental Pollutants / toxicity; Environmental Restoration and Remediation; Fluorocarbon Polymers / analysis; Fluorocarbon Polymers / chemistry; Fluorocarbon Polymers / toxicity; Fluorocarbons / analysis; Fluorocarbons / chemistry; Fluorocarbons / toxicity; Halogenation; Humans; Water Pollution, Chemical / analysis
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 4, 2022

2022 journal article

Development and validation of a high resolving power absolute quantitative per- and polyfluoroalkyl substances method incorporating Skyline data processing

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 36(11).

By: J. Enders n, R. Weed n, E. Griffith n & D. Muddiman n

MeSH headings : Chromatography, Liquid; Fluorocarbons; Mass Spectrometry / methods; Reproducibility of Results; Software
TL;DR: This method demonstrates the feasibility of performing reproducible absolute quantitation of PFAS on an HRAM platform and does so using an open-source vendor-neutral data processing software to facilitate sharing of data across labs and institutions. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2022

2022 journal article

Per- and Polyfluoroalkyl Substances (PFAS) in Facemasks: Potential Source of Human Exposure to PFAS with Implications for Disposal to Landfills

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, 9(4), 320–326.

author keywords: PFAS; facemasks; Covid-19; total fluorine; LC-qTOF; GC-MS; exposure; landfill
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 31, 2022

2022 article

Respiratory and allergic outcomes among 5-year-old children exposed to pesticides

Islam, J. Y., Hoppin, J., Mora, A. M., Soto-Martinez, M. E., Cordoba Gamboa, L., Penaloza Castaneda, J. E., … Joode, B. (2022, February 24). THORAX, Vol. 2.

By: J. Islam n, J. Hoppin n, A. Mora*, M. Soto-Martinez*, L. Cordoba Gamboa*, J. Penaloza Castaneda*, B. Reich n, C. Lindh*, B. Joode*

author keywords: asthma epidemiology; paediatric asthma; respiratory infection
MeSH headings : Infant; Pregnancy; Female; Humans; Child, Preschool; Pesticides / toxicity; Cough; Asthma; Rhinitis, Allergic; Respiratory Tract Infections; Pyrethrins; Exanthema
TL;DR: Current pyrethroid exposure may affect children’s respiratory and allergic health at 5 years of age as pyrethroids are broadly used in home environments and agriculture and mancozeb in agriculture. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 28, 2022

2022 journal article

Environmental Health Literacy as Knowing, Feeling, and Believing: Analyzing Linkages between Race, Ethnicity, and Socioeconomic Status and Willingness to Engage in Protective Behaviors against Health Threats

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 19(5).

By: A. Binder n, K. May n, J. Murphy n, A. Gross* & E. Carlsten n

author keywords: environmental health literacy; health disparities; COVID-19; PFAS; race and ethnicity; socioeconomic status; efficacy; knowledge sufficiency; factual knowledge
MeSH headings : COVID-19 / prevention & control; Environmental Health; Ethnicity; Humans; SARS-CoV-2; Social Class
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 28, 2022

2022 journal article

Nonylphenol Polyethoxylates Enhance Adipose Deposition in Developmentally Exposed Zebrafish

Toxics, 10(2), 99.

author keywords: endocrine disrupting chemicals; adipogenesis; alkylphenol ethoxylates; ethoxylated surfactants; mixtures; obesogen
TL;DR: Consistent adipogenic effects are demonstrated in two separate human bone-marrow-derived mesenchymal stem cell models and that nonylphenol and its ethoxylates promoted weight gain and increased adipose deposition in developmentally exposed zebrafish. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 14, 2022

2022 article

Combining Isotopologue Workflows and Simultaneous Multidimensional Separations to Detect, Identify, and Validate Metabolites in Untargeted Analyses

Dodds, J. N., Wang, L., Patti, G. J., & Baker, E. S. (2022, January 28). ANALYTICAL CHEMISTRY, Vol. 1.

By: J. Dodds n, L. Wang*, G. Patti* & E. Baker n

MeSH headings : Chromatography, Liquid; Ion Mobility Spectrometry; Metabolomics / methods; Tandem Mass Spectrometry; Workflow
TL;DR: The analytical utility of incorporating ion mobility spectrometry (IMS) as an additional separation mechanism into standard LC-MS/MS isotopologue workflows is evaluated to highlight the enhanced separation space and increased annotation confidence afforded by IMS for metabolic characterization and provide a unique perspective for future developments in isotopically labeled MS experiments. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: March 14, 2022

2022 article

Empowering women and addressing underrepresentation in the field of mass spectrometry

Rampler, E., Baker, E. S., Kirkwood, K. I., Schwaiger-Haber, M., Tam, M., Jones, M. A., & Sherman, M. (2022, February 16). EXPERT REVIEW OF PROTEOMICS, Vol. 2.

author keywords: FeMS; ASMS; mass spectrometry; women; diversity
MeSH headings : Female; Humans; Mass Spectrometry; Power, Psychological
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: March 7, 2022

2022 journal article

Demonstrating a systems approach for integrating disparate data streams to inform decisions on children's environmental health

BMC PUBLIC HEALTH, 22(1).

By: E. Hubal*, N. DeLuca*, A. Mullikin*, R. Slover*, J. Little* & D. Reif n

author keywords: Chemical exposure; ANOVA; ToxPi; Children's health; Environmental health; Systems approach; Multivariate analysis; Data-driven
MeSH headings : Child; Child Health; Child, Preschool; Environmental Health; Humans; Lead; Public Health; Systems Analysis
TL;DR: This analysis demonstrated how systems science principles can be used to synthesize holistic insights for decision making using publicly available data and computational tools, focusing on a children’s environmental health example. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 7, 2022

2022 journal article

Optimized C-Trap Timing of an Orbitrap 240 Mass Spectrometer for High-Throughput Screening and Native MS by IR-MALDESI

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 33(2), 328–334.

By: K. Knizner n, M. Bagley n, K. Garrard n, J. Hauschild*, F. Pu*, N. Elsen*, J. Williams*, D. Muddiman n

author keywords: high-throughput screening; IR-MALDESI; Orbitrap mass spectrometer; C-trap
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: March 7, 2022

2022 article

Weak differences in sensitivity to major ions by different larval stages of the mayfly Neocloeon triangulifer

Orr, S. E., Cochran, J. K., Wallace, I. G., Gray, R. W., Overmyer, G. E., & Buchwalter, D. B. (2022, June 1). FRESHWATER SCIENCE.

author keywords: salinity; aquatic insects; mayflies; ontogenetic; major ions; toxicity; freshwater salinization; life stage sensitivity; model organism
TL;DR: The results indicate that younger N. triangulifer larvae may be more sensitive to major ions than mature larvae, and should be considered when experimentally using larger, late-stage N. TriangULifer larvae to study the physiological effects and acute toxicity of salinity. (via Semantic Scholar)
Source: Web Of Science
Added: March 7, 2022

2022 journal article

Assessing the P-crit in relation to temperature and the expression of hypoxia associated genes in the mayfly, Neocloeon triangulifer

SCIENCE OF THE TOTAL ENVIRONMENT, 808.

author keywords: Hypoxia; Pcrit; Gene expression; Temperature; Mayfly
MeSH headings : Animals; Ecosystem; Ephemeroptera; Hypoxia; Oxygen; Temperature
TL;DR: The hypothesis that the Pcrit is positively correlated with temperature in the mayfly, Neocloeon triangulifer, is tested and modest support for traditional interpretation of the P Criteria as a physiologically meaningful shift from aerobic to anaerobic metabolism in N. triangULifer is provided. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science)
Source: Web Of Science
Added: February 28, 2022

2022 article

Gestational Cd Exposure in the CD-1 Mouse Sex-Specifically Disrupts Essential Metal Ion Homeostasis

Jackson, T. W., Baars, O., & Belcher, S. M. (2022, February 25). TOXICOLOGICAL SCIENCES, Vol. 2.

By: T. Jackson n, O. Baars n & S. Belcher n

author keywords: gestation; epigenetic; essential metals; metallothionein; placenta
MeSH headings : Animals; Cadmium / toxicity; Cation Transport Proteins / genetics; Cation Transport Proteins / metabolism; Female; Homeostasis; Iron / metabolism; Liver / metabolism; Male; Manganese / metabolism; Manganese / toxicity; Metallothionein / genetics; Metallothionein / metabolism; Mice; Placenta / metabolism; Pregnancy; Zinc / toxicity
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 26, 2022

2022 journal article

Utilizing Pine Needles to Temporally and Spatially Profile Per- and Polyfluoroalkyl Substances (PFAS)

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 56(6), 3441–3451.

author keywords: Biomonitoring; contamination; per- and polyfluoroalkyl substances; fluoroethers; ion mobility; mass spectrometry; PFAS
MeSH headings : Alkanesulfonic Acids / analysis; Chromatography, Liquid; Fluorocarbons / analysis; United States; United States Environmental Protection Agency
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 18, 2022

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