Center for Environmental and Health Effects of PFAS

Works Published in 2017

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Displaying works 101 - 115 of 115 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2017 review

Applying evolutionary genetics to developmental toxicology and risk assessment

[Review of ]. REPRODUCTIVE TOXICOLOGY, 69, 174–186.

By: M. Leung *, A. Procter n, J. Goldstone*, J. Foox*, R. DeSalle*, C. Mattingly n , M. Siddall*, A. Timme-Laragy *

author keywords: Evolutionary genetics; Developmental toxicology; Systems toxicology; Birth defects; Signaling pathways; High-throughput screening; Evo-Devo
MeSH headings : Animals; Computational Biology; Evolution, Molecular; Humans; Phylogeny; Risk Assessment; Systems Biology; Teratology
TL;DR: This synthesis can lead to novel applications in developmental toxicity and risk assessment, but also can pave the way for applying an evo-devo perspective to the study of developmental origins of health and disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 review

An introduction to terminology and methodology of chemical synergy-perspectives from across disciplines

[Review of ]. Frontiers in Pharmacology, 8.

By: K. Roell, D. Reif  & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Adverse drug reactions triggered by the common HLA-B*57:01 variant: A molecular docking study

Journal of Cheminformatics, 9.

By: G. Driessche & D. Fourches

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

The Comparative Toxicogenomics Database: update 2017

NUCLEIC ACIDS RESEARCH, 45(D1), D972–D978.

By: A. Davis n, C. Grondin n, R. Johnson n, D. Sciaky n, B. King *, R. McMorran*, J. Wiegers n, T. Wiegers n, C. Mattingly n 

MeSH headings : Computational Biology / methods; Databases, Chemical; Databases, Genetic; Gene Ontology; Humans; Search Engine; Signal Transduction; Toxicogenetics / methods; User-Computer Interface; Web Browser
TL;DR: This update describes the new exposure module (that harmonizes exposure science information with core toxicogenomic data) and introduces a novel dataset of GO-disease inferences (that identify common molecular underpinnings for seemingly unrelated pathologies). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

National Estimate of Per- and Polyfluoroalkyl Substance (PFAS) Release to US Municipal Landfill Leachate

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 51(4), 2197–2205.

By: J. Lang n, B. Allred*, J. Field *, J. Levis  n & M. Barlaz n 

MeSH headings : Environmental Monitoring; Refuse Disposal; Solid Waste; Waste Disposal Facilities; Wastewater; Water Pollutants, Chemical
TL;DR: The concentrations of 70 PFASs in 95 samples of leachate were measured in a survey of U.S. landfills of varying climates and waste ages and six PFAS demonstrated significant variation with climate. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 article

Imaging antiretroviral distribution within gastrointestinal tissues across pre-clinical species: implications for hiv eradication

Clinical Pharmacology & Therapeutics, Vol. 101, pp. S17–17.

By: C. Thompson, E. Rosen, M. Mathews, N. White, C. Sykes, Y. Fedoriw, P. Charlins, L. Mulder ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Relative Contributions of Agricultural Drift, Para-Occupational, and Residential Use Exposure Pathways to House Dust Pesticide Concentrations: Meta-Regression of Published Data

Environmental Health Perspectives, 125(3), 296–305.

By: N. Deziel *, L. Freeman*, B. Graubard *, R. Jones *, J. Hoppin n , K. Thomas *, C. Hines*, A. Blair* ...

MeSH headings : Agriculture; Air Pollutants / analysis; Air Pollution, Indoor / statistics & numerical data; Dust / analysis; Environmental Exposure / statistics & numerical data; Environmental Monitoring; Housing / statistics & numerical data; Humans; Occupational Exposure; Pesticides / analysis
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2017 article

Recent advances in glycomics, glycoproteomics and allied topics

Mechref, Y., & Muddiman, D. C. (2017, January). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 409, pp. 355–357.

By: Y. Mechref * & D. Muddiman n 

TL;DR: The understanding of the attributes of glycans in biological functions and the development and progression of diseases has been facilitated by mass-spectrometry-based glycomics and glycoproteomics, which are dynamic and are rapidly evolving through innovative technologies and bioinformatics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

N-linked glycosite profiling and use of Skyline as a platform for characterization and relative quantification of glycans in differentiating xylem of Populus trichocarpa

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 409(2), 487–497.

By: P. Loziuk n, E. Hecht n & D. Muddiman n 

author keywords: N-linked glycosite; Skyline; Populus trichocarpa; Monolignol; N-linked glycans
MeSH headings : Computational Biology / standards; Computational Biology / trends; Polysaccharides / analysis; Populus / chemistry; Xylem / chemistry
TL;DR: This study presents a novel workflow for identification of glycans using Individuality Normalization when Labeling with Isotopic Glycan Hydrazide Tags (INLIGHT™) strategy developed in the lab, and implements Skyline for relative glycan quantification for improved accuracy and precision of quantitative measurements over current processing tools. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Exposure to a PBDE/OH-BDE mixture alters juvenile zebrafish (Danio rerio) development

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 36(1), 36–48.

By: L. Macaulay*, M. Chernick *, A. Chen *, D. Hinton*, J. Bailey *, S. Kullman n , E. Levin *, H. Stapleton *

author keywords: Polybrominated diphenyl ether (PBDE); Mixture; Development; Juvenile; Zebrafish
MeSH headings : Adult; Animals; Dose-Response Relationship, Drug; Gene Expression / drug effects; Halogenated Diphenyl Ethers / metabolism; Halogenated Diphenyl Ethers / toxicity; Humans; Osteogenesis / drug effects; Osteogenesis / genetics; Polybrominated Biphenyls / metabolism; Polybrominated Biphenyls / toxicity; Thyroid Gland / drug effects; Thyroid Gland / metabolism; Thyroid Hormones / genetics; Thyroid Hormones / metabolism; Zebrafish / genetics; Zebrafish / growth & development; Zebrafish / metabolism
TL;DR: Exposure to PBDE/OH‐BDE mixtures adversely impact zebrafish maturation during metamorphosis, and assessment of thyroid and osteochondral gene regulatory networks demonstrated significantly increased expression of genes that regulate skeletal development and thyroid hormones. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Lifetime substance use as a predictor of postpartum mental health

ARCHIVES OF WOMENS MENTAL HEALTH, 20(1), 189–199.

By: B. Prevatt n, S. Desmarais  n & P. Janssen *

author keywords: Postpartum mental health; Alcohol use; Drug use; Screening
MeSH headings : Adult; Alcohol Drinking / epidemiology; Alcohol Drinking / psychology; Anxiety / epidemiology; Anxiety / psychology; Canada / epidemiology; Depression, Postpartum / diagnosis; Depression, Postpartum / epidemiology; Depression, Postpartum / psychology; Female; Humans; Interviews as Topic; Mood Disorders / epidemiology; Mood Disorders / psychology; Pregnancy; Risk Factors; Stress Disorders, Post-Traumatic / epidemiology; Stress Disorders, Post-Traumatic / psychology; Substance-Related Disorders / epidemiology; Substance-Related Disorders / psychology; Surveys and Questionnaires; Urban Population; Women's Health; Young Adult
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

High pesticide exposure events and DNA methylation among pesticide applicators in the agricultural health study

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 58(1), 19–29.

By: J. Rusiecki *, L. Freeman*, M. Bonner *, M. Alexander *, L. Chen*, G. Andreotti *, K. Barry *, L. Moore* ...

author keywords: DNA methylation; pesticides; exposure; Agricultural Health Study; epigenetics
MeSH headings : Air Pollutants, Occupational / toxicity; Antigens, CD; Cadherins / genetics; DNA / blood; DNA Methylation / drug effects; DNA Methylation / genetics; DNA Modification Methylases / genetics; DNA Repair Enzymes / genetics; Farmers; Glutathione S-Transferase pi / genetics; Humans; Iowa; Male; North Carolina; Occupational Exposure / adverse effects; Occupational Exposure / analysis; Occupational Health; Pesticides / toxicity; Promoter Regions, Genetic; Prospective Studies; Surveys and Questionnaires; Tumor Suppressor Proteins / genetics
TL;DR: Evaluated association between experiencing unusually high pesticide exposure events (HPEEs) and DNAm among pesticide applicators in the Agricultural Health Study, a prospective study of applicators from Iowa and North Carolina found non‐specific HPEEs may contribute to increasedDNAm in GSTp1, and in some groups, reduced DNAm in MGMT and LINE‐1. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Climate projections of spatial variations in coastal storm surges along the Gulf of Mexico and US east coast

JOURNAL OF OCEAN UNIVERSITY OF CHINA, 16(1), 1–7.

By: Z. Yao  n, Z. Xue *, R. He  n, X. Bao *, J. Xie * & Q. Ge *

author keywords: storm surge; sea surface winds; climate change; regional ocean
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Angiopellosis as an Alternative Mechanism of Cell Extravasation

STEM CELLS, 35(1), 170–180.

By: T. Allen n, D. Gracieux n , M. Talib n, D. Tokarz n, M. Hensley n, J. Cores n, A. Vandergriff n, J. Tang n ...

author keywords: Extravasation; Angiopellosis; Transmigration; Stem cell infusion; Diapedesis
MeSH headings : Animals; Blood Vessels / physiology; CD11 Antigens / metabolism; Cell Aggregation; Cell Membrane / metabolism; Cell Shape; Dogs; Extravasation of Diagnostic and Therapeutic Materials / pathology; Female; Humans; Injections; Intravital Microscopy; Male; Mesenchymal Stem Cells; Microspheres; Myocytes, Cardiac / cytology; Polymers / chemistry; Rats; Time Factors; Transendothelial and Transepithelial Migration; Zebrafish / metabolism
TL;DR: In injected cardiac and mesenchymal stem cells, the vascular wall undergoes an extensive remodeling to allow the cell to exit the lumen, while the injected cell remains distinctively passive in activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Battle of Water Networks DMAs: Multistage Design Approach

JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT, 143(10).

By: E. Salomons, O. Skulovich* & A. Ostfeld *

author keywords: Water distribution; Design; Optimization; Clustering; District metering areas (DMAs)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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