Works Published in 2015

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Displaying works 181 - 200 of 761 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2015 journal article

Erratum: Gene expression in major depressive disorder

Molecular Psychiatry, 21(3), 444–444.

By: R. Jansen, B. Penninx*, V. Madar, K. Xia, Y. Milaneschi*, J. Hottenga, A. Hammerschlag*, A. Beekman ...

TL;DR: The authors noticed that the Supplementary Figure legends were not published with the paper, and the legends accompany this erratum. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2015 journal article

Gene expression in major depressive disorder

Molecular Psychiatry, 21(3), 339–347.

By: R. Jansen*, B. Penninx*, V. Madar*, K. Xia*, Y. Milaneschi*, J. Hottenga*, A. Hammerschlag*, A. Beekman* ...

MeSH headings : Adult; Anxiety Disorders / genetics; Cross-Sectional Studies; Depressive Disorder, Major / diagnosis; Depressive Disorder, Major / genetics; Female; Gene Expression / genetics; Gene Expression Regulation / genetics; Genetic Predisposition to Disease / genetics; Genome-Wide Association Study; Humans; Interleukin-6 / genetics; Interleukin-6 / metabolism; Killer Cells, Natural / metabolism; Longitudinal Studies; Male; Middle Aged; Polymorphism, Single Nucleotide / genetics; Signal Transduction / genetics
TL;DR: Multiple gene expression associations with MDD were identified and a measurable impact of current MDD state on gene expression is suggested, in line with the immune suppression and immune activation hypothesis of MDD. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: August 28, 2020

2015 journal article

Genetic basis of natural variation in body pigmentation in Drosophila melanogaster

Fly, 9(2), 75–81.

By: L. Dembeck n, W. Huang n, M. Carbone n & T. Mackay n

author keywords: Drosophila melanogaster Genetic Reference Panel; extreme QTL mapping; genome wide association study; quantitative genetics; replication study
MeSH headings : Abdomen; Animals; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Female; Gene Expression Regulation / physiology; Genome-Wide Association Study; Pigmentation / genetics; Pigmentation / physiology; Polymorphism, Single Nucleotide; Quantitative Trait Loci
TL;DR: The results of an extreme quantitative trait locus (xQTL) GWA analysis of female body pigmentation in an outbred population derived from light and dark DGRP lines are described. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2015 journal article

Progress and gaps in understanding mechanisms of ash tree resistance to emerald ash borer, a model for wood-boring insects that kill angiosperms.

The New Phytologist, 1.

By: C. Villari*, D. Herms*, J. Whitehill*, D. Cipollini* & P. Bonello*

author keywords: Agrilus planipennis; constitutive defense; emerald ash borer; Fraxinus; host defense mechanisms; induced defense; plant-insect interactions; wood-borers
MeSH headings : Acetates / pharmacology; Animals; Anti-Infective Agents / metabolism; Antibiosis; Coleoptera / physiology; Cyclopentanes / pharmacology; Fraxinus / immunology; Fraxinus / parasitology; Glucosides / metabolism; Larva; Lignin / metabolism; Magnoliopsida / immunology; Magnoliopsida / parasitology; Models, Biological; Oviposition; Oxylipins / pharmacology; Phenols / metabolism; Plant Growth Regulators / pharmacology; Species Specificity; Trypsin Inhibitors / metabolism; Wood
TL;DR: The finding that Manchurian ash is more resistant than evolutionarily naïve North American and European congeners to EAB suggests that these inherently susceptible species possess latent defenses that are not induced naturally by larval colonization, perhaps because they fail to recognize larval cues or respond quickly enough. (via Semantic Scholar)
Source: ORCID
Added: August 24, 2020

2015 journal article

Histology and cell wall biochemistry of stone cells in the physical defence of conifers against insects.

Plant, Cell & Environment, 8.

By: J. Whitehill*, H. Henderson*, M. Schuetz*, O. Skyba*, M. Yuen*, J. King*, A. Samuels*, S. Mansfield*, J. Bohlmann*

author keywords: bark beetle; plant insect interaction; plant resistance; secondary cell wall; spruce; lignin; fluorescent-tagged coniferyl alcohol
MeSH headings : Animals; Carbohydrate Metabolism; Cell Wall / metabolism; Genotype; Herbivory; Lignin / biosynthesis; Phenotype; Picea / genetics; Picea / metabolism; Picea / ultrastructure; Weevils
TL;DR: Histological, biochemical and molecular differences in the stone cell phenotype of weevil resistant (R) or susceptible (S) Sitka spruce genotypes are identified and fortification of shoot tips in R trees is an effective strategy against insect feeding. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: August 24, 2020

2015 journal article

Modeling infectious disease dynamics in the complex landscape of global health

Science, 347(6227), aaa4339.

By: H. Heesterbeek*, R. Anderson*, V. Andreasen*, S. Bansal*, D. De Angelis*, C. Dye*, K. Eames*, W. Edmunds* ...

MeSH headings : Animals; Basic Reproduction Number; Coinfection; Communicable Disease Control; Communicable Diseases / epidemiology; Communicable Diseases / transmission; Communicable Diseases, Emerging / epidemiology; Communicable Diseases, Emerging / transmission; Disease Outbreaks; Global Health; Health Policy; Hemorrhagic Fever, Ebola / epidemiology; Humans; Models, Biological; Public Health; Zoonoses / epidemiology; Zoonoses / transmission
TL;DR: The development of mathematical models used in epidemiology are reviewed and how these can be harnessed to develop successful control strategies and inform public health policy, using the West African Ebola epidemic as an example. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: April 8, 2020

2015 journal article

Video-Rate Super Resolution Microscopy in Living Cells

Biophysical Journal, 108(2), 475a.

TL;DR: A set of specially designed methods that characterize an sCMOS camera for the first time and allow for unbiased and precise localization analysis are presented and demonstrate localization-based super-resolution microscopy in live cells by monitoring dynamics of protein clusters, vesicles and organelles at a temporal resolution from 2 to 30 frames per second. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Three Myosins Contribute Uniquely to the Assembly and Constriction of the Fission Yeast Cytokinetic Contractile Ring

Current Biology, 25(15), 1955–1965.

MeSH headings : Cell Cycle; Cell Division; Cytokinesis; Mutation; Myosin Heavy Chains / genetics; Myosin Heavy Chains / metabolism; Myosin Type II / genetics; Myosin Type II / metabolism; Myosins / genetics; Myosins / metabolism; Schizosaccharomyces / cytology; Schizosaccharomyces / genetics; Schizosaccharomyces / physiology; Schizosaccharomyces pombe Proteins / genetics; Schizosaccharomyces pombe Proteins / metabolism; Spindle Pole Bodies / metabolism
TL;DR: Three myosins function in a hierarchal, complementary manner to accomplish cytokinesis, with Myo2 and Myo51 taking the lead during contractile ring assembly and Myp2 making the greatest contribution to constriction. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

On-demand drug delivery from local depots

Journal of Controlled Release, 219, 8–17.

author keywords: Drug delivery; Depot; Polymer; Therapeutic; On-demand; Ultrasound; Magnetic; Electric; Light; Pharmaceutical; Nucleic acid; Stimulated
MeSH headings : Delayed-Action Preparations / administration & dosage; Delayed-Action Preparations / chemistry; Drug Delivery Systems; Humans; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / chemistry; Polymers / administration & dosage; Polymers / chemistry
TL;DR: This review highlights recent advances in the development of polymeric systems engineered for releasing therapeutic molecules through physical and pharmacological stimulation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID
Added: February 24, 2020

2015 journal article

In Vivo Targeting through Click Chemistry

ChemMedChem, 10(4), 617–620.

By: Y. Brudno*, R. Desai*, B. Kwee*, N. Joshi*, M. Aizenberg & D. Mooney*

author keywords: bioorthogonal chemistry; click chemistry; drug delivery; drug targeting; gels
MeSH headings : Alginates / chemistry; Alkynes / administration & dosage; Alkynes / chemistry; Animals; Azides; Benzene Derivatives / administration & dosage; Benzene Derivatives / chemistry; Click Chemistry / methods; Cyclooctanes / administration & dosage; Cyclooctanes / chemistry; Drug Delivery Systems / methods; Fluorescent Dyes / chemistry; Glucuronic Acid / chemistry; Heterocyclic Compounds, 1-Ring / chemistry; Hexuronic Acids / chemistry; Hydrogels / chemistry; Mice; Muscles / metabolism
TL;DR: It is demonstrated that bioorthogonal click chemistry can be used to target circulating small molecules to hydrogels resident intramuscularly in diseased tissues and that small molecules can be repeatedly targeted to the diseased area over the course of at least one month. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID
Added: February 24, 2020

2015 journal article

Amino acid sequence of Japanese quail (Coturnix japonica) and northern bobwhite (Colinus virginianus) myoglobin

Food Chemistry, 181, 256–262.

author keywords: Japanese quail; Northern bobwhite; Myoglobin; Primary structure; Commix japonica; Colinus virginianus
MeSH headings : Amino Acid Sequence; Animals; Avian Proteins / chemistry; Avian Proteins / genetics; Avian Proteins / metabolism; Colinus / genetics; Colinus / metabolism; Coturnix / genetics; Coturnix / metabolism; DNA, Complementary / genetics; DNA, Complementary / metabolism; Molecular Sequence Data; Myocardium / chemistry; Myocardium / metabolism; Myoglobin / chemistry; Myoglobin / genetics; Myoglobin / metabolism; Sequence Alignment
TL;DR: The amino acid sequences of Japanese quail and northern bobwhite myoglobin were deduced by cDNA cloning of the coding sequence from mRNA by verifying sequence identity and corroborating the deduced protein amino acid sequence at the protein level. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Chromatin regulation at the frontier of synthetic biology

Nature Reviews Genetics, 16(3), 159–171.

MeSH headings : Animals; Cell Engineering / methods; Chromatin / chemistry; Chromatin / metabolism; Epigenesis, Genetic; Genome; Histones / chemistry; Histones / metabolism; Humans; Plants / genetics; Plants / metabolism; RNA, Untranslated / chemistry; RNA, Untranslated / metabolism; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Synthetic Biology; Systems Biology
TL;DR: These studies lay the foundation for biomedical and biotechnological engineering applications that could take advantage of the unique combinatorial and spatiotemporal layers of chromatin regulation to create synthetic systems of unprecedented sophistication. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Nectar yeasts in Delphinium nuttallianum (Ranunculaceae) and their effects on nectar quality

Fungal Ecology, 18, 100–106.

author keywords: Delphinium nuttallianum; Floral nectar; Metschnikowia reukaufii; Nectar composition; Nectar yeasts; Pollination
TL;DR: It is documented that yeasts form species-poor communities in populations of this hermaphroditic perennial, in addition to highlighting their spatio-temporal dynamics and effects on nectar quality. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Effects of fragmentation on a distinctive coastal sage scrub bee fauna revealed through incidental captures by pitfall traps

Journal of Insect Conservation, 19(1), 175–179.

author keywords: Anthophila; Pollinators; By-catch; Habitat fragmentation; Museum records
TL;DR: The effects of urbanization-induced habitat fragmentation on the native bee fauna inhabiting coastal sage scrub habitats of San Diego County, California, USA, a hotspot of bee biodiversity is examined. (via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities (OpenAlex)
Source: Crossref
Added: February 24, 2020

2015 journal article

Number of X-chromosome genes influences social behavior and vasopressin gene expression in mice

Psychoneuroendocrinology, 51, 271–281.

By: K. Cox*, K. Quinnies*, A. Eschendroeder*, P. Didrick*, E. Eugster* & E. Rissman*

author keywords: Turner syndrome; Klinefelter syndrome; Sexual differentiation; Sex differences; Social behavior; Anxiety; Social anxiety
MeSH headings : Amygdala / metabolism; Animals; Behavior, Animal / physiology; Child; Female; Gene Dosage; Gene Expression Regulation / genetics; Genes, X-Linked; Humans; Male; Mice; Social Behavior; Turner Syndrome / blood; Turner Syndrome / genetics; Vasopressins / genetics; Vasopressins / metabolism; X Chromosome / genetics
TL;DR: Novel findings link sex chromosome genes with social behavior via concentrations of AVP in brain, adding to the understanding of sex differences in neurobehavioral disorders. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization and their application to identify potentially hazardous compounds

Toxicology and Applied Pharmacology, 284(2), 262–272.

author keywords: Skin sensitization; QSAR; Virtual screening; Skin toxicants
MeSH headings : Databases, Factual; Dermatitis, Allergic Contact / etiology; Dermatitis, Allergic Contact / immunology; Hazardous Substances / poisoning; Humans; Models, Chemical; Models, Immunological; Quantitative Structure-Activity Relationship; Skin / drug effects; Skin / immunology; Software
TL;DR: This study aims to compile, curate, and integrate the largest publicly available dataset related to chemically-induced skin sensitization, use this data to generate rigorously validated and QSAR models for skin sensitized individuals, and employ these models as a virtual screening tool for identifying putative sensitizers among environmental chemicals. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Materials Cartography: Representing and Mining Materials Space Using Structural and Electronic Fingerprints

Chemistry of Materials, 27(3), 735–743.

TL;DR: The issue of scientific discovery in materials databases is addressed by introducing novel analytical approaches based on structural and electronic materials fingerprints, which contribute to the emerging field of materials informati... (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization

Toxicology and Applied Pharmacology, 284(2), 273–280.

author keywords: Skin sensitization; Skin permeability; QSAR; Virtual screening; Skin toxicants
MeSH headings : Computer Simulation; Databases, Factual; Dermatitis, Allergic Contact / etiology; Dermatitis, Allergic Contact / immunology; Dermatitis, Allergic Contact / metabolism; Hazardous Substances / poisoning; Humans; Models, Theoretical; Permeability; Quantitative Structure-Activity Relationship; Skin / drug effects; Skin / immunology; Skin / metabolism; Skin Absorption / physiology; Software
TL;DR: The models reported herein as well as those developed in the companion paper on skin sensitization suggest that it may be possible to rationally design compounds with the desired high skin permeability but low sensitization potential. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Crossref
Added: February 24, 2020

2015 journal article

Drug Side Effect Profiles as Molecular Descriptors for Predictive Modeling of Target Bioactivity

Molecular Informatics, 34(2-3), 160–170.

author keywords: Side effects; Machine learning; QSAR; Drug repurposing
MeSH headings : Animals; Data Mining / methods; Dopamine Antagonists / adverse effects; Humans; MEDLINE; Models, Biological; Serotonin Antagonists / adverse effects
TL;DR: The results demonstrate that side effect profiles can be utilized to predict a drug’s unknown molecular activity, thus representing a valuable opportunity in repositioning the drug for a new indications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: Crossref
Added: February 24, 2020

2015 journal article

Prediction of human population responses to toxic compounds by a collaborative competition

Nature Biotechnology, 33(9), 933–940.

By: F. Eduati, L. Mangravite, T. Wang, H. Tang, J. Bare, R. Huang, T. Norman, M. Kellen ...

MeSH headings : Computer Simulation; Dose-Response Relationship, Drug; Genetic Predisposition to Disease / genetics; Genetics, Population; Hazardous Substances / toxicity; High-Throughput Screening Assays / methods; Humans; Incidence; Lymphocytes / cytology; Lymphocytes / drug effects; Lymphocytes / physiology; Models, Genetic; Risk Assessment / methods; Toxicity Tests / methods
TL;DR: The results from a community-based DREAM challenge to predict toxicities of environmental compounds with potential adverse health effects for human populations highlight the possibility of predicting health risks associated with unknown compounds, although risk estimation accuracy remains suboptimal. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

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