Works Published in 2010

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Displaying works 201 - 220 of 562 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2010 journal article

Changes induced by two levels of cadmium toxicity in the 2-DE protein profile of tomato roots

Journal of Proteomics, 73(9), 1694–1706.

By: J. Rodríguez-Celma*, R. Rellán-Álvarez*, A. Abadía*, J. Abadía* & A. López-Millán*

Contributors: J. Rodríguez-Celma*

author keywords: Cadmium; Metabolism; Root; Tomato; Two-dimensional gel electrophoresis
MeSH headings : Cadmium / toxicity; Cadmium Poisoning / metabolism; Electrophoresis, Gel, Two-Dimensional; Gene Expression Profiling; Solanum lycopersicum / metabolism; Plant Proteins / drug effects; Plant Proteins / metabolism; Plant Roots / chemistry; Plant Roots / drug effects; Plant Roots / metabolism
TL;DR: The results suggests that the 10 microM Cd treatment elicits proteomic responses similar to those observed in Fe deficiency, including activation of the glycolytic pathway, TCA cycle and respiration, whereas the 100 microMCd treatment responses are more likely due to true Cd toxicity. (via Semantic Scholar)
Source: ORCID
Added: November 15, 2019

2010 journal article

Changes in the proteomic and metabolic profiles of Beta vulgaris root tips in response to iron deficiency and resupply

BMC Plant Biology, 10.

By: R. Rellan-Alvarez*, S. Andaluz*, J. Rodriguez-Celma*, G. Wohlgemuth*, G. Zocchi, A. Alvarez-Fernandez*, O. Fiehn*, A. Lopez-Millan*, J. Abadia*

Contributors: R. Rellan-Alvarez*

MeSH headings : Beta vulgaris / drug effects; Beta vulgaris / metabolism; Gene Expression Regulation, Plant / drug effects; Iron / pharmacology; Iron Deficiencies; Meristem / drug effects; Meristem / metabolism; Metabolome / drug effects; Multienzyme Complexes / metabolism; Oligosaccharides / metabolism; Plant Proteins / metabolism; Proteome / drug effects; Proteome / metabolism
TL;DR: The increases in DMRL synthase and in RFO sugars were the major changes induced by Fe deficiency and resupply in root tips of sugar beet plants, confirming the increase in proteins and metabolites related to carbohydrate metabolism and TCA cycle pathways. (via Semantic Scholar)
Source: ORCID
Added: November 15, 2019

2010 journal article

Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation

Journal of Cell Science, 123(13), 2179–2189.

By: W. Jones*, A. Chao*, M. Zavortink*, R. Saint* & A. Bejsovec*

author keywords: Tum; RacGAP; Pav; Wg; Wnt; Drosophila; Embryo; Signal transduction
MeSH headings : Animals; Armadillo Domain Proteins / genetics; Armadillo Domain Proteins / metabolism; Body Patterning / physiology; Cell Nucleus / metabolism; Cells, Cultured; Cytokinesis / physiology; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / cytology; Drosophila melanogaster / embryology; Epistasis, Genetic; GTPase-Activating Proteins / genetics; GTPase-Activating Proteins / metabolism; Genes, Reporter; Humans; Microtubule-Associated Proteins / genetics; Microtubule-Associated Proteins / metabolism; Phenotype; Signal Transduction / physiology; Transcription Factors / genetics; Transcription Factors / metabolism; Two-Hybrid System Techniques; Wings, Animal / anatomy & histology; Wings, Animal / physiology; Wnt Proteins / genetics; Wnt Proteins / metabolism; Wnt1 Protein / genetics; Wnt1 Protein / metabolism; beta Catenin / genetics; beta Catenin / metabolism
TL;DR: Two modulators of the Wnt pathway that have shared functions in cell division are identified, which hints at a possible link between cytokinesis and Wnt activity during tumorigenesis. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 11, 2019

2010 journal article

Joint Analysis of Near-Isogenic and Recombinant Inbred Line Populations Yields Precise Positional Estimates for Quantitative Trait Loci

The Plant Genome Journal, 3(3), 142.

By: K. Kump n, J. Holland n, M. Jung*, P. Wolters* & P. Balint-Kurti n

TL;DR: Combined QTL analysis in which data from RIL populations is combined with data derived from NIL populations segregating for the same pair of alleles improves mapping resolution over the conventional approach with virtually no additional resources. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: ORCID
Added: October 23, 2019

2010 journal article

The Wheat Puroindoline Genes Confer Fungal Resistance in Transgenic Corn

Journal of Phytopathology, 159(3), 188–190.

author keywords: Puroindolines; corn; southern leaf blight resistance
TL;DR: Pina and Pinb are effective in vivo as antifungal proteins and could be valuable tools in corn SLB control. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: ORCID, Crossref
Added: October 23, 2019

2010 journal article

Mapping resistance quantitative trait loci for three foliar diseases in a maize recombinant inbred line population - Evidence for multiple disease resistance?

Phytopathology, 100(1), 72–79.

By: J. Zwonitzer, N. Coles, M. Krakowsky, C. Arellano, J. Holland*, M. McMullen, R. Pratt, P. Balint-Kurti*

Contributors: J. Zwonitzer, N. Coles, M. Krakowsky, C. Arellano, J. Holland*, M. McMullen, R. Pratt, P. Balint-Kurti*

MeSH headings : Fungi / growth & development; Immunity, Innate / genetics; Plant Diseases / genetics; Plant Diseases / microbiology; Quantitative Trait Loci / genetics; Quantitative Trait Loci / physiology; Zea mays / genetics; Zea mays / microbiology; Zea mays / physiology
TL;DR: The objectives of this study were to identify quantitative trait loci for resistance to these diseases in a maize recombinant inbred line (RIL) population derived from a cross between maize lines Ki14 and B73, and to evaluate the evidence for the presence of genes or loci conferring multiple disease resistance (MDR). (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: ORCID
Added: October 23, 2019

2010 journal article

Altered Gene Expression and DNA Damage in Peripheral Blood Cells from Friedreich's Ataxia Patients: Cellular Model of Pathology

PLoS Genetics, 6(1), e1000812.

By: A. Haugen*, N. Di Prospero*, J. Parker, R. Fannin*, J. Chou*, J. Meyer*, C. Halweg*, J. Collins* ...

Ed(s): C. Pearson

MeSH headings : Adolescent; Adult; Cells, Cultured; Child; Cohort Studies; DNA Damage; Female; Friedreich Ataxia / genetics; Friedreich Ataxia / pathology; Gene Expression; Humans; Iron-Binding Proteins / genetics; Male; Middle Aged; RNA / blood; RNA / genetics; Young Adult
TL;DR: The data suggest that patients with prolonged frataxin deficiency undergo a systemic survival response to chronic genotoxic stress and consequent DNA damage detectable in blood, which may have predictive value in future clinical trials. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID
Added: September 28, 2019

2010 journal article

The T box regulatory element controlling expression of the class i lysyl-tRNA synthetase of Bacillus cereus strain 14579 is functional and can be partially induced by reduced charging of asparaginyl-tRNA<sup>Asn</sup>

BMC Microbiology, 10.

By: N. Foy*, B. Jester*, G. Conant* & K. Devine*

Contributors: N. Foy*, B. Jester*, G. Conant* & K. Devine*

MeSH headings : Amino Acid Sequence; Bacillus cereus / chemistry; Bacillus cereus / enzymology; Bacillus cereus / genetics; Bacillus cereus / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Gene Expression Regulation, Enzymologic; Lysine-tRNA Ligase / chemistry; Lysine-tRNA Ligase / genetics; Lysine-tRNA Ligase / metabolism; Molecular Sequence Data; RNA, Transfer, Amino Acyl / metabolism; RNA, Transfer, Asn / metabolism; Regulatory Elements, Transcriptional; Sequence Alignment
TL;DR: The T box element controlling lysK (encoding LysRS1) expression in B. cereus strain 14579 is functional, but unusually responds to depletion of charged tRNALys and tRNAAsn. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: September 12, 2019

2010 journal article

Rapid reorganization of the transcriptional regulatory network after genome duplication in yeast

Proceedings of the Royal Society B: Biological Sciences, 277(1683), 869–876.

By: G. Conant*

Contributors: G. Conant*

author keywords: whole-genome duplication; network evolution; regulatory evolution
MeSH headings : Computational Biology; Evolution, Molecular; Gene Duplication; Gene Regulatory Networks / genetics; Gene Regulatory Networks / physiology; Genome, Fungal / genetics; Genome, Fungal / physiology; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / physiology
TL;DR: The reorganization of the yeast transcriptional regulatory network after whole-genome duplication is studied, and it is found that genes targeted by many TFs appear to be preferentially retained in duplicate after WGD, an effect I attribute to selection to maintain dosage balance in the regulatory networkAfter WGD. (via Semantic Scholar)
Source: ORCID
Added: September 12, 2019

2010 journal article

Nonrandom survival of gene conversions among yeast ribosomal proteins duplicated through genome doubling.

Genome Biology and Evolution, 2, 826–834. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952199263&partnerID=MN8TOARS

By: A. Evangelisti & G. Conant

Contributors: A. Evangelisti & G. Conant

Source: ORCID
Added: September 12, 2019

2010 journal article

Selective translocation of Ca2+/calmodulin protein kinase II  (CaMKII ) to inhibitory synapses

Proceedings of the National Academy of Sciences, 107(47), 20559–20564.

By: K. Marsden*, A. Shemesh*, K. Bayer* & R. Carroll*

MeSH headings : Animals; Calcineurin / metabolism; Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism; Hippocampus / cytology; Image Processing, Computer-Assisted; Immunohistochemistry; Long-Term Potentiation / physiology; Microscopy, Fluorescence; Neurons / metabolism; Rats; Receptors, GABA-A / metabolism; Receptors, N-Methyl-D-Aspartate / metabolism; Synapses / metabolism
TL;DR: It is shown that CaMKIIα translocates to inhibitory but not excitatory synapses in response to more moderate NMDAR-activating stimuli that trigger GABAA-receptor (GABAAR) insertion and enhance inhibitory transmission. (via Semantic Scholar)
Source: ORCID
Added: September 12, 2019

2010 journal article

Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation

Molecular and Cellular Neuroscience, 43(1), 157–163.

author keywords: Resiniferotoxin; TrpV1; Nociception; Pain; Thermal sensation
MeSH headings : Analgesics / pharmacology; Animals; Capsaicin / pharmacology; Diterpenes / pharmacology; Male; Mechanoreceptors / drug effects; Mechanoreceptors / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Nociceptors / cytology; Nociceptors / drug effects; Nociceptors / metabolism; Pain / physiopathology; Pain Measurement; Plant Oils / pharmacology; Sensory System Agents / pharmacology; Stress, Mechanical; TRPV Cation Channels / agonists; TRPV Cation Channels / genetics; TRPV Cation Channels / metabolism; Thermosensing / drug effects; Thermosensing / physiology; Trigeminal Nerve / drug effects; Trigeminal Nerve / metabolism
TL;DR: The data demonstrate that TrpV1 neurons are selectively tuned nociceptors that mediate responses to thermal but not mechanical pain and insinuate a labeled line model for somatosensory coding. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2019

2010 journal article

Parvalbumin Deficiency and GABAergic Dysfunction in Mice Lacking PGC-1α

Journal of Neuroscience, 30(21), 7227–7235.

By: E. Lucas*, S. Markwardt*, S. Gupta*, J. Meador-Woodruff*, J. Lin*, L. Overstreet-Wadiche*, R. Cowell*

MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Biophysics; Cells, Cultured; DNA-Binding Proteins / metabolism; Electric Stimulation / methods; GTP Phosphohydrolases / metabolism; Gene Expression Regulation, Developmental / genetics; Glutamate Decarboxylase / metabolism; Heart; High Mobility Group Proteins / metabolism; Hippocampus / cytology; Humans; Inhibitory Postsynaptic Potentials / drug effects; Inhibitory Postsynaptic Potentials / genetics; Interneurons / metabolism; Long-Term Potentiation / drug effects; Long-Term Potentiation / genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium / metabolism; Parvalbumins / deficiency; Patch-Clamp Techniques / methods; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; RNA, Messenger / metabolism; Shaw Potassium Channels / metabolism; Trans-Activators / deficiency; Trans-Activators / metabolism; Transcription Factors / metabolism; Transfection / methods; gamma-Aminobutyric Acid / metabolism
TL;DR: Findings indicate that PGC-1α is a novel regulator of interneuron gene expression and function and a potential therapeutic target for neurological disorders associated with Interneuron dysfunction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: September 9, 2019

2010 journal article

Model or meal? Farm animal populations as models for infectious diseases of humans

Nature Reviews Microbiology, 8(2), 139–148.

By: C. Lanzas*, P. Ayscue*, R. Ivanek* & Y. Gröhn*

Contributors: C. Lanzas*, P. Ayscue*, R. Ivanek* & Y. Gröhn*

MeSH headings : Animals; Animals, Domestic / microbiology; Animals, Domestic / virology; Communicable Diseases / microbiology; Communicable Diseases / transmission; Communicable Diseases / virology; Disease Models, Animal; Host-Pathogen Interactions; Humans; Models, Biological; Population
TL;DR: Farm animal populations can provide empirical models to study infectious diseases at the population level because they have been widely used as models at the organism level and are less appropriate for addressing issues at thepopulation level. (via Semantic Scholar)
Source: ORCID
Added: September 9, 2019

2010 journal article

Transmission dynamics of a multidrug-resistant salmonella typhimurium outbreak in a dairy farm

Foodborne Pathogens and Disease, 7(4), 467–474.

MeSH headings : Animals; Anti-Infective Agents / pharmacology; Bacterial Shedding; Cattle; Cattle Diseases / epidemiology; Cattle Diseases / microbiology; Cattle Diseases / transmission; Computer Simulation; Dairying / methods; Disease Outbreaks / veterinary; Drug Resistance, Multiple, Bacterial; Electrophoresis, Gel, Pulsed-Field / veterinary; Feces / microbiology; Longitudinal Studies; Microbial Sensitivity Tests / veterinary; Models, Statistical; Salmonella Infections, Animal / epidemiology; Salmonella Infections, Animal / microbiology; Salmonella Infections, Animal / transmission; Salmonella typhimurium / classification; Salmonella typhimurium / drug effects; Salmonella typhimurium / isolation & purification; Salmonella typhimurium / pathogenicity; Serologic Tests / veterinary; Serotyping / veterinary; Time Factors
TL;DR: Simulations of the transmission model indicated that salmonellosis outbreaks with few clinical cases were likely due to the extinction of the pathogen in the premises in the early phase of the outbreaks, and small population size and group structure within the farm decrease the on-farm persistence of the Pathogen. (via Semantic Scholar)
Source: ORCID
Added: September 9, 2019

2010 chapter

Understanding environment-disease connections: An introduction to the comparative toxicogenomics database (ctd)

In Nature Pathway Interaction Database.

By: C. Mattingly

Source: NC State University Libraries
Added: August 10, 2019

2010 journal article

2,3,7,8-Tetrachlorodibenzo-p-dioxin Upregulates FoxQ1b in Zebrafish Jaw Primordium

Chemical Research in Toxicology, 23(3), 480–487.

By: A. Planchart* & C. Mattingly*

Contributors: A. Planchart* & C. Mattingly*

MeSH headings : Animals; Embryo, Nonmammalian / metabolism; Enhancer Elements, Genetic; Environmental Pollutants / pharmacology; Forkhead Transcription Factors / genetics; Gene Expression Regulation, Developmental / drug effects; Jaw / metabolism; Jaw / pathology; Jaw Abnormalities / chemically induced; Polychlorinated Dibenzodioxins / pharmacology; Receptors, Aryl Hydrocarbon / metabolism; Up-Regulation / drug effects; Zebrafish / genetics; Zebrafish / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR: FoxQ1b is specifically expressed in the jaw primordium where it discretely outlines a developing jaw structure known as Meckel's cartilage--a conserved structure in all jawed vertebrates that develops abnormally in the presence of TCDD. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, ORCID
Added: August 10, 2019

2010 journal article

The Comparative Toxicogenomics Database: update 2011

Nucleic Acids Research, 39(Database), D1067–D1072.

By: A. Davis*, B. King*, S. Mockus*, C. Murphy*, C. Saraceni-Richards*, M. Rosenstein*, T. Wiegers*, C. Mattingly*

MeSH headings : Databases, Factual; Disease / etiology; Disease / genetics; Environmental Exposure; Gene Regulatory Networks; Genes; Hazardous Substances / toxicity; Humans; Software; Toxicogenetics
TL;DR: Since 2009, the content of CTD has dramatically increased the content to 1.4 million chemical–gene–disease data points and added many features, statistical analyses and analytical tools, including GeneComps and ChemComps, to help users generate testable hypotheses about the molecular mechanisms of environmental diseases. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 7, 2019

2010 conference paper

Evidence review and experts’ opinion on consumer acceptance of agrifood nanotechnology

Unpublished.

Contributors: R. Yawson & J. Kuzma

Source: ORCID
Added: August 1, 2019

2010 journal article

Gene-drive into insect populations with age and spatial structure: a theoretical assessment

Evolutionary Applications, 4(3), 415–428.

author keywords: age and spatial structure; engineered underdominance; gene drive; release threshold; theoretical assessment
TL;DR: This study demonstrates that to determine the best method of spatial release, and the total number of engineered insects that must be released, it is important to take into account the age and sex of the released insects and spatial structure of the population. (via Semantic Scholar)
Source: Crossref
Added: July 28, 2019

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