Works Published in 2010
Displaying works 221 - 240 of 562 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2010 journal article
Glycine and a Glycine Dehydrogenase (GLDC) SNP as Citalopram/Escitalopram Response Biomarkers in Depression: Pharmacometabolomics-Informed Pharmacogenomics
Clinical Pharmacology & Therapeutics, 89(1), 97–104.
MeSH headings : Biomarkers, Pharmacological / blood; Cell Line; Chromosomes, Human, Pair 9 / genetics; Citalopram / therapeutic use; DNA-Binding Proteins / metabolism; Depressive Disorder, Major / blood; Depressive Disorder, Major / drug therapy; Depressive Disorder, Major / genetics; Drug Monitoring / methods; Female; Genetic Association Studies; Glycine / blood; Glycine / metabolism; Glycine Dehydrogenase (Decarboxylating) / genetics; Humans; Introns / genetics; Linkage Disequilibrium; Male; Metabolome / drug effects; Nuclear Proteins / metabolism; Polymorphism, Single Nucleotide; Selective Serotonin Reuptake Inhibitors / therapeutic use
TL;DR:
A possible role for glycine in SSRI response is highlighted and the use of pharmacometabolomics‐informed pharmacogenomic research strategy to identify citalopram/escitaloprams treatment outcome biomarkers is illustrated to “inform” pharmacogenomics.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: July 28, 2019
2010 journal article
Neuronal Inactivation of Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Protects Mice from Diet-induced Obesity and Leads to Degenerative Lesions
Journal of Biological Chemistry, 285(50), 39087–39095.
MeSH headings : Animal Feed; Animals; Brain / metabolism; Constriction, Pathologic; Gene Expression Regulation; Liver / metabolism; Mice; Mice, Transgenic; Neurodegenerative Diseases / metabolism; Neurons / metabolism; Obesity / genetics; Oxygen Consumption; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Trans-Activators / metabolism; Transcription Factors; Transcription, Genetic; Triglycerides / metabolism
TL;DR:
A physiological role for neuronal PGC-1α in the control of energy balance is demonstrated and CaMKIIα-positive neurons as an important part of the neural circuitry that governs energy expenditure in vivo are implicate.
(via Semantic Scholar)
Source: Crossref
Added: July 28, 2019
2010 journal article
Hydrolysis of organophosphorus compounds by microbial enzymes
Applied Microbiology and Biotechnology, 89(1), 35–43.
author keywords: Organophosphorus compound; OP nerve agent; Pesticide; OPAA; OPH; Phosphotriesterase; Prolidase
MeSH headings : Aryldialkylphosphatase / chemistry; Aryldialkylphosphatase / genetics; Aryldialkylphosphatase / metabolism; Bacteria / chemistry; Bacteria / enzymology; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Biocatalysis; Hydrolysis; Kinetics; Organophosphorus Compounds / chemistry; Substrate Specificity
TL;DR:
An update of what is experimentally known about OPH and OPAA to include their structures, substrate specificity, and catalytic properties is provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
Source: Crossref
Added: July 28, 2019
2010 journal article
Evaluation of an in vitro telomeric repeat amplification protocol assay to detect telomerase activity in canine urine
American Journal of Veterinary Research, 71(12), 1468–1474.
MeSH headings : Animals; Carcinoma, Transitional Cell / enzymology; Carcinoma, Transitional Cell / urine; Carcinoma, Transitional Cell / veterinary; Cell Line, Tumor; Dog Diseases / enzymology; Dog Diseases / urine; Dogs / urine; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Fibroblasts / enzymology; Lung / enzymology; Polymerase Chain Reaction / methods; Telomerase / analysis; Telomerase / urine; Telomere / genetics
TL;DR:
The TRAP-based assay detected telomerase activity in the canine TCC cell line and revealed that the telomersase ribonucleoprotein complex was inherently unstable at various storage durations and conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: July 27, 2019
2010 journal article
Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study
Metabolomics, 6(2), 191–201.
author keywords: Cardiovascular disease; Lipidomics; Metabolomics; Pharmacogenomics; Pharmacometabolomics; Simvastatin
TL;DR:
There was no overlap of lipids whose changes correlated with LDL-C or CRP responses to simvastatin suggesting that distinct metabolic pathways govern statin effects on these two biomarkers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: July 20, 2019
2010 journal article
TRPV1-lineage neurons are required for thermal sensation
The EMBO Journal, 30(3), 582–593.
author keywords: itch; pain; thermal; TRPM8; TRPV1
MeSH headings : Animals; Body Temperature; Body Temperature Regulation / genetics; Body Temperature Regulation / physiology; DNA, Complementary / genetics; Gene Expression Regulation, Developmental / genetics; Gene Expression Regulation, Developmental / physiology; In Situ Hybridization; Mice; Mice, Mutant Strains; Models, Biological; Nociceptors / metabolism; Oligonucleotide Array Sequence Analysis; Pain Measurement; Receptors, G-Protein-Coupled / metabolism; Rotarod Performance Test; TRPM Cation Channels / metabolism; TRPV Cation Channels / genetics; TRPV Cation Channels / metabolism; Thermoreceptors / metabolism
TL;DR:
The results define and delimit the roles of TRPV1‐ and TRPM8‐neurons in thermosensation, thermoregulation and nociception, thus significantly extending the concept of labelled lines in somatosensory coding.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2010 journal article
An Organotypic Slice Assay for High-Resolution Time-Lapse Imaging of Neuronal Migration in the Postnatal Brain
Journal of Visualized Experiments, (46).
MeSH headings : Animals; Brain / anatomy & histology; Brain / cytology; Cell Movement / physiology; Image Processing, Computer-Assisted / methods; Lateral Ventricles / cytology; Mice; Neural Stem Cells / cytology; Neurogenesis / physiology; Neurons / cytology; Olfactory Bulb / cytology; Organ Culture Techniques / methods
TL;DR:
An organotypic slice assay optimized for postnatal brain tissue, in which the extracellular conditions closely mimic the in vivo environment for migrating neuroblasts within the RMS, is described.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2010 journal article
The Tight Junction Associated Signalling Proteins ZO-1 and ZONAB Regulate Retinal Pigment Epithelium Homeostasis in Mice
PLoS ONE, 5(12), e15730.
Ed(s): M. Klymkowsky
MeSH headings : Angiography / methods; Animals; Cell Adhesion; DNA-Binding Proteins / genetics; DNA-Binding Proteins / physiology; Epithelium / metabolism; Female; Homeostasis; Macular Degeneration / genetics; Membrane Proteins / metabolism; Mesoderm / metabolism; Mice; Mice, Inbred C57BL; Microscopy, Electron / methods; Phosphoproteins / metabolism; Retinal Diseases / genetics; Retinal Pigment Epithelium / metabolism; Signal Transduction; Transcription Factors; Zonula Occludens-1 Protein
TL;DR:
It is demonstrated that ZO-1 and ZONAB are critical for differentiation and homeostasis of the RPE monolayer and may be involved in RPE disorders such as proliferative vitroretinopathy and atrophic age-related macular degeneration.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2010 journal article
HIF-1alpha and HIF-2alpha Are Differentially Activated in Distinct Cell Populations in Retinal Ischaemia
PLoS ONE, 5(6), e11103.
Ed(s): K. Koch
MeSH headings : Animals; Basic Helix-Loop-Helix Transcription Factors / metabolism; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Erythropoietin / metabolism; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Immunohistochemistry; Ischemia / metabolism; Mice; Retinal Vessels / metabolism; Vascular Endothelial Growth Factor A / metabolism
TL;DR:
The findings suggest that HIF-2alpha activation plays a key role in regulating the response of Müller glia to hypoxia, consistent with differential roles in retinal ischaemia.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2010 journal article
MicroRNA Expression and Virulence in Pandemic Influenza Virus-Infected Mice
Journal of Virology, 84(6), 3023–3032.
MeSH headings : Animals; Cyclic AMP Response Element-Binding Protein / metabolism; Disease Outbreaks; Gene Expression Profiling; Gene Expression Regulation; Humans; Influenza A Virus, H1N1 Subtype / genetics; Influenza A Virus, H1N1 Subtype / immunology; Influenza A Virus, H1N1 Subtype / pathogenicity; Influenza, Human / epidemiology; Influenza, Human / immunology; Influenza, Human / virology; Interferon Type I / immunology; Lung / immunology; Lung / physiology; Lung / virology; Mice; MicroRNAs / genetics; MicroRNAs / immunology; Oligonucleotide Array Sequence Analysis; Orthomyxoviridae / genetics; Orthomyxoviridae / immunology; Orthomyxoviridae / pathogenicity; Orthomyxoviridae Infections / epidemiology; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / virology
TL;DR:
This is the first demonstration that cellular gene expression patterns in influenza virus-infected mice may be attributed in part to microRNA regulation and that such regulation may be a contributing factor to the extreme virulence of the r1918.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: July 20, 2019
2010 journal article
Lethal Dissemination of H5N1 Influenza Virus Is Associated with Dysregulation of Inflammation and Lipoxin Signaling in a Mouse Model of Infection
Journal of Virology, 84(15), 7613–7624.
MeSH headings : Animals; Female; Gene Expression Regulation; Inflammation / immunology; Inflammation / pathology; Influenza A Virus, H1N1 Subtype / immunology; Influenza A Virus, H1N1 Subtype / pathogenicity; Influenza A Virus, H5N1 Subtype / immunology; Influenza A Virus, H5N1 Subtype / pathogenicity; Lipoxins / immunology; Lung / pathology; Lung / virology; Mice; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / mortality; Orthomyxoviridae Infections / pathology; Orthomyxoviridae Infections / virology; Signal Transduction; Survival Analysis; Virulence
TL;DR:
It is suggested that Vietnam/1203 is more pathogenic in mice as a consequence of several factors, including the early and sustained induction of the inflammatory response, the additive or synergistic effects of upregulated components of the immune response, and inhibition of lipoxin-mediated anti-inflammatory responses, which correlated with the ability of VN/ 1203 to disseminate to extrapulmonary organs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: July 20, 2019
2010 journal article
Unique Signatures of Long Noncoding RNA Expression in Response to Virus Infection and Altered Innate Immune Signaling
MBio, 1(5).
Ed(s): N. Sonenberg & T. Dermody
MeSH headings : Animals; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Immunity, Innate; Mice; RNA, Untranslated / biosynthesis; Severe acute respiratory syndrome-related coronavirus / immunology; Severe acute respiratory syndrome-related coronavirus / pathogenicity; Severe Acute Respiratory Syndrome / immunology; Severe Acute Respiratory Syndrome / pathology; Severe Acute Respiratory Syndrome / virology; Signal Transduction; Transcription, Genetic
TL;DR:
Using next-generation sequencing, a whole-transcriptome analysis of the host response to severe acute respiratory syndrome coronavirus infection across four founder mouse strains of the Collaborative Cross demonstrated that virus infection alters the expression of numerous long ncRNAs, suggesting that these RNAs may be a new class of regulatory molecules that play a role in determining the outcome of infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: July 20, 2019
2010 journal article
SAP1 is a critical post-transcriptional regulator of infectivity in malaria parasite sporozoite stages
Molecular Microbiology, 79(4), 929–939.
MeSH headings : Animals; Cytoplasm / metabolism; Female; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation; Genes, Protozoan; Malaria / parasitology; Mice; Mice, Inbred BALB C; Oligonucleotide Array Sequence Analysis; Plasmodium yoelii / genetics; Plasmodium yoelii / growth & development; Plasmodium yoelii / pathogenicity; Protozoan Proteins / genetics; Protozoan Proteins / metabolism; RNA Processing, Post-Transcriptional; RNA, Protozoan / genetics; Sporozoites / growth & development
TL;DR:
A global gene expression survey is used to more comprehensively identify transcripts that are affected by SAP1 deletion, which suggests that SAP1 is involved in a selective post‐transcriptional mechanism to regulate the abundance of transcripts critical to the infectivity of sporozoites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: July 20, 2019
2010 journal article
IFN-α expression and antiviral effects are subtype and cell type specific in the cardiac response to viral infection
Virology, 396(1), 59–68.
author keywords: Interferon; Cardiac myocyte; Cardiac fibroblast; Myocarditis; Reovirus
MeSH headings : Animals; Base Sequence; Cells, Cultured; Interferon-alpha / classification; Interferon-alpha / genetics; Interferon-alpha / physiology; Mice; Molecular Sequence Data; Myocarditis / prevention & control; Myocarditis / virology; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors / genetics; Virus Diseases / prevention & control
TL;DR:
It is demonstrated that IFN-alpha is induced in cardiac cells, that it is both subtype and cell type specific, and thatIt is likely important in the antiviral cardiac response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: July 20, 2019
2010 journal article
In vitro screening of environmental chemicals for targeted testing prioritization: The toxcast project
Environmental Health Perspectives, 118(4), 485–492.
Contributors: R. Judson *, K. Houck *, R. Kavlock*, T. Knudsen *, M. Martin*, H. Mortensen *, D. Reif* , D. Rotroff *
author keywords: in vitro screening; liver proliferative lesions; liver tumors; pathways; ToxCast
MeSH headings : Animals; Cell Line; Cells, Cultured; Computer Simulation; Environmental Pollutants / toxicity; Humans; Rats; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR:
A statistically significant inverse association between the number of pathways perturbed by a chemical at low in vitro concentrations and the lowest in vivo dose at which a chemical causes toxicity is found.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2010 journal article
Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals.
Journal of Toxicology and Environmental Health - Part B: Critical Reviews, 13(2-4), 329–346.
Contributors: D. Rotroff *, A. Beam, D. Dix*, A. Farmer, K. Freeman, K. Houck *, R. Judson *, E. Lecluyse
MeSH headings : Adult; Animals; Cell Shape / drug effects; Cells, Cultured; Cholesterol / biosynthesis; Environmental Pollutants / chemistry; Environmental Pollutants / metabolism; Environmental Pollutants / toxicity; Gene Expression Regulation / drug effects; Hepatocytes / cytology; Hepatocytes / drug effects; Hepatocytes / enzymology; Hepatocytes / metabolism; Humans; Male; Middle Aged; Models, Biological; Rats; Signal Transduction / drug effects; Xenobiotics / chemistry; Xenobiotics / metabolism; Xenobiotics / toxicity
TL;DR:
Gene expression results identified various ToxCast chemicals that were potent or efficacious inducers of one or more of the 14 genes, and by inference the 5 nuclear receptor signaling pathways, as well as the five major receptor pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2010 journal article
Research needs for community-based risk assessment: findings from a multi-disciplinary workshop
J Expos Sci Environ Epidemiol, 20(2), 186â195.
Contributors: Y. Sanchez*, K. Deener*, E. Hubal*, C. Knowlton*, D. Reif* & D. Segal*
author keywords: population-based studies; epidemiology; exposure modeling; analytical methods; empirical/statistical modeling; PBPK modeling
MeSH headings : Humans; Needs Assessment; Research; Risk Assessment; United States; United States Environmental Protection Agency
TL;DR:
This paper summarizes an Environmental Protection Agency (EPA) sponsored workshop, “Research Needs for Community-Based Risk Assessment,” and presents identified research needs, and explores future research opportunities in this emerging field.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2010 journal article
Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.
Toxicological Sciences, 117(2), 348–358.
Contributors: D. Rotroff *, B. Wetmore *, D. Dix*, S. Ferguson, H. Clewell*, K. Houck *, E. LeCluyse, M. Andersen *
author keywords: reverse dosimetry; human exposure; ToxCast; high-throughput screening
MeSH headings : Cells, Cultured; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Hepatocytes / drug effects; Hepatocytes / metabolism; High-Throughput Screening Assays / methods; Humans; Male; Metabolic Clearance Rate; Protein Binding / drug effects; Risk Assessment; Toxicity Tests; Xenobiotics / classification; Xenobiotics / metabolism; Xenobiotics / toxicity
Source: ORCID
Added: May 14, 2019
2010 journal article
Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.
Chemical Research in Toxicology, 23(3), 578–590.
Contributors: M. Martin*, D. Dix*, R. Judson *, R. Kavlock*, D. Reif* , A. Richard *, D. Rotroff *, S. Romanov*
MeSH headings : Animals; Biosensing Techniques / economics; Biosensing Techniques / instrumentation; Biosensing Techniques / methods; Environmental Pollutants / adverse effects; Hep G2 Cells; Rabbits; Rats; Receptors, Cytoplasmic and Nuclear / genetics; Response Elements / drug effects; Transcription Factors / genetics; Transcription, Genetic / drug effects
TL;DR:
A novel cellular biosensor system that enables rapid, high-content assessment of a compound's impact on gene regulatory networks and it is demonstrated that Nrf2 activity, a marker of oxidative stress, is highly correlated to the overall promiscuity of a chemical.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2010 journal article
Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data
Environ Health Perspect, 118(12), 1714â1720.
Contributors: D. Reif* , M. Martin*, S. Tan*, K. Houck *, R. Judson *, A. Richard *, T. Knudsen *, D. Dix*, R. Kavlock*
author keywords: androgen; chemical prioritization; data integration; endocrine disruption; estrogen; screening; ToxCast; toxicity profile; ToxPi
MeSH headings : Decision Support Techniques; Endocrine Disruptors / classification; Endocrine Disruptors / toxicity; Endocrine System / drug effects; Environmental Pollutants / classification; Environmental Pollutants / toxicity; Signal Transduction / drug effects; Toxicity Tests / methods
TL;DR:
A flexible method to facilitate the rational prioritization of chemicals for further evaluation is developed and its application as a candidate decision-support tool for EDSP is demonstrated.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
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