Works Published in 2012
Displaying works 241 - 260 of 613 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
Mentor vs. Monolith
American Scientist, 100(6), 450.
Source: ORCID
Added: September 12, 2019
2012 journal article
Recombination Modulates How Selection Affects Linked Sites in Drosophila
PLoS Biology, 10(11), e1001422.
Ed(s): N. Barton
MeSH headings : Animals; Base Sequence; Chromosome Mapping; Chromosomes, Insect / genetics; Codon / genetics; Confidence Intervals; Conserved Sequence; Drosophila / genetics; Evolution, Molecular; Genetic Linkage; Genetic Variation; Genetics, Population / methods; Genome, Insect; Linear Models; Recombination, Genetic; Selection, Genetic; Species Specificity; Telomere / genetics
TL;DR:
Recombination rate in Drosophila species shapes the impact of selection in the genome and is positively correlated with nucleotide diversity.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: September 12, 2019
2012 book
Yeast as a window into changes in genome complexity due to polyploidization
In Polyploidy and Genome Evolution (Vol. 9783642314421, pp. 293–308).
Contributors: C. Hudson * & G. Conant*
TL;DR:
The role of the WGD in shaping several complex metabolic and regulatory phenotypes is explored, including the dosage balance hypothesis as it applies to the yeast WGD and the selective forces that act on the W GD-produced paralogs and shape their patterns of loss and retention.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2012 journal article
Metabolic and evolutionary costs of herbivory defense: Systems biology of glucosinolate synthesis
New Phytologist, 196(2), 596–605.
Contributors: M. Bekaert *, P. Edger *, C. Hudson *, J. Pires * & G. Conant*
author keywords: adaptation; Arabidopsis thaliana; costly traits; flux balance analysis; metabolic network
MeSH headings : Amino Acids / metabolism; Arabidopsis / genetics; Arabidopsis / immunology; Arabidopsis / metabolism; Biological Evolution; Biomass; Biosynthetic Pathways / genetics; Gene Duplication; Gene Expression Regulation, Plant; Glucosinolates / biosynthesis; Herbivory / genetics; Metabolome / genetics; Models, Biological; Photons; Systems Biology
TL;DR:
It is found that glucosinolate production can increase photosynthetic requirements by at least 15% and that this cost is specific to the suite of glucos inolates found in A. thaliana, with other combinations of glucOSinolates being even more costly.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2012 journal article
Cloning and characterization of the peptidoglycan recognition protein genes in the mosquito, Armigeres subalbatus (Diptera: Culicidae)
Journal of Medical Entomology, 49(3), 656–671.
Contributors: S. Wang *, G. Conant* , R. Ou* & B. Beerntsen *
author keywords: peptidoglycan recognition protein; Armigeres subalbatus; mosquito; AsPGRP; immune response
MeSH headings : Animals; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cloning, Molecular; Culicidae / genetics; Culicidae / physiology; Evolution, Molecular; Female; Insect Proteins / genetics; Insect Proteins / metabolism; Life Cycle Stages; Male; Phylogeny; Protein Isoforms / genetics; Protein Isoforms / metabolism; Sequence Alignment; Sequence Analysis, DNA
TL;DR:
Phylogenetic analysis indicated that PGRPs represent an ancient gene family that has primarily diverged through speciation events among these Dipterans, with only a limited number of lineage specific gene duplications.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2012 journal article
Very low rate of gene conversion in the yeast genome
Molecular Biology and Evolution, 29(12), 3817–3826.
Contributors: C. Casola *, G. Conant* & M. Hahn*
author keywords: gene duplication; Saccharomyces cerevisiae; interlocus gene conversion
MeSH headings : Base Sequence; Computational Biology; Evolution, Molecular; Gene Conversion / genetics; Gene Duplication / genetics; Genome, Fungal / genetics; Likelihood Functions; Models, Genetic; Molecular Sequence Data; Phylogeny; Saccharomyces cerevisiae / genetics; Sequence Alignment; Species Specificity
TL;DR:
This work applies four different methodologies-including one approach that closely mirrors Gao and Innan's method-to estimate the level of interlocus gene conversion in Scer, and points to a maximum conversion level of 13% between paralogs in this species, in close agreement with most estimates of IGC in eukaryotes.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2012 journal article
Long identical multispecies elements in plant and animal genomes
Proceedings of the National Academy of Sciences of the United States of America, 109(19).
Contributors: J. Reneker*, E. Lyons *, G. Conant* , J. Pires *, M. Freeling *, C. Shyu*, D. Korkin *
author keywords: extreme conservation; repetitive elements
MeSH headings : Amino Acid Sequence; Animals; Arabidopsis / genetics; Base Sequence; Cell Nucleus / genetics; Chromosome Mapping; Chromosomes, Mammalian / genetics; Chromosomes, Plant / genetics; Conserved Sequence / genetics; Evolution, Molecular; Gene Regulatory Networks; Genome / genetics; Genome, Mitochondrial / genetics; Genome, Plant / genetics; Humans; Mice; Models, Genetic; Molecular Sequence Data; Rats; Species Specificity; Synteny
TL;DR:
Despite the common presence of LIMEs in both animal and plant lineages, the evolutionary processes involved in the creation and maintenance of these elements differ in the two groups and are likely attributable to several mechanisms, including transfer of genetic material from organellar to nuclear genomes, de novo sequence manufacturing, and purifying selection.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2012 journal article
Altered patterns of fractionation and exon deletions in Brassica rapa support a two-step model of paleohexaploidy
Genetics, 190(4), 1563–1574.
Contributors: H. Tang *, M. Woodhouse *, F. Cheng *, J. Schnable *, B. Pedersen *, G. Conant* , X. Wang *, M. Freeling *, J. Pires *
MeSH headings : Arabidopsis / genetics; Brassica rapa / classification; Brassica rapa / genetics; Cell Nucleus / genetics; Chromosomes, Plant / genetics; Computer Simulation; DNA, Plant / genetics; Evolution, Molecular; Exons; Genome, Plant; Models, Genetic; Molecular Sequence Data; Phylogeny; Polyploidy; Recombination, Genetic; Repetitive Sequences, Nucleic Acid; Sequence Deletion
TL;DR:
It is concluded that the observed patterns of the triplicated regions in the Brassica genome are best explained by a two-step fractionation model, which could influence the potential to generate morphological diversity—a hallmark of the Brassicas genus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: September 12, 2019
2012 journal article
Bartonella spp. infection in healthy and sick horses and foals from the southeastern United States.
Journal of Veterinary Internal Medicine, 26(6), 1408–1412,
author keywords: Bartonella vinsonii; coinfection; foals; lameness
MeSH headings : Animals; Antibodies, Bacterial; Bacteremia / blood; Bacteremia / veterinary; Bartonella / isolation & purification; Bartonella Infections / epidemiology; Bartonella Infections / microbiology; Bartonella Infections / veterinary; Female; Fluorescent Antibody Technique, Indirect / veterinary; Horse Diseases / epidemiology; Horse Diseases / microbiology; Horses; Male; Polymerase Chain Reaction / veterinary; Serologic Tests; Southeastern United States
TL;DR:
Horses in the southeastern United States are naturally infected with B. berkhofii genotypes I and III, and a bacteria most similar to Candidatus Bartonella volans, and further investigation into the pathogenic potential of Bart onella spp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 9, 2019
2012 journal article
Mathematical model of plasmid-mediated resistance to ceftiofur in commensal enteric escherichia coli of cattle
PLoS ONE, 7(5).
Contributors: V. Volkova *, C. Lanzas* , Z. Lu * & Y. Gröhn *
MeSH headings : Animals; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / pharmacology; Cattle; Cephalosporins / pharmacokinetics; Cephalosporins / pharmacology; Escherichia coli / drug effects; Intestines / microbiology; Microbial Sensitivity Tests; Plasmids
TL;DR:
A deterministic mathematical model of the dynamics of ceftiofur-sensitive and resistant commensal enteric Escherichia coli in enteric commensals of cattle indicated that a low but stable fraction of resistant enteric E. coli could persist in the absence of immediate ceftofur pressure, being sustained by horizontal and vertical transfers of plasmids carrying resistance-genes.
(via Semantic Scholar)
Source: ORCID
Added: September 9, 2019
2012 journal article
Collaborative biocuration--text-mining development task for document prioritization for curation
Database, 2012(0), bas037–bas037.
MeSH headings : Cooperative Behavior; Data Mining / methods; Databases, Genetic; Disease; Documentation / methods; Genes; Humans; Internet; Toxicogenetics; User-Computer Interface
TL;DR:
A detailed description of the Critical Assessment of Information Extraction systems in Biology (BioCreAtIvE) challenge evaluation is presented and a summary of the results are presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: August 7, 2019
2012 journal article
MEDIC: a practical disease vocabulary used at the Comparative Toxicogenomics Database
Database, 2012(0), bar065–bar065.
MeSH headings : Databases, Factual; Disease / classification; Humans; Subject Headings; Toxicogenetics
TL;DR:
The construction, implementation, maintenance and use of MEDIC is described to raise awareness of this resource and to offer it as a putative scaffold in the formal construction of an official disease ontology.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 7, 2019
2012 journal article
Aquatic models, genomics and chemical risk management
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 155(1), 169–173.
Contributors: K. Cheng *, D. Hinton*, C. Mattingly* & A. Planchart*
author keywords: Aquatic toxicology; Phenome project; Zebrafish; Genomics; Atlas
MeSH headings : Animals; Computational Biology / methods; Databases, Factual; Ecotoxicology; Environmental Exposure / analysis; Environmental Monitoring / methods; Fishes / anatomy & histology; Fishes / genetics; Fishes / physiology; Gene-Environment Interaction; Genomics / methods; Internet; Models, Animal; Risk Factors; User-Computer Interface
TL;DR:
It is concluded that automation, database generation, and web-based accessibility, facilitated by genomic/transcriptomic data and high-performance and cloud computing, will potentiate the unique and potentially key roles that aquatic models play in advancing systems biology, drug development, and environmental risk management.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 7, 2019
2012 journal article
Disease model curation improvements at Mouse Genome Informatics
Database, 2012(0), bar063–bar063.
MeSH headings : Animals; Database Management Systems; Databases, Factual; Disease Models, Animal; Genome; Humans; Mice / genetics; Molecular Sequence Annotation; User-Computer Interface
TL;DR:
The merged Medical Subject Headings (MeSH) and OMIM disease vocabulary created by the Comparative Toxicogenomics Database (CTD) project is evaluated and an extended version of the vocabulary is created to meet the genetic disease-specific curation needs at MGI.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 7, 2019
2012 journal article
The Comparative Toxicogenomics Database: update 2013
Nucleic Acids Research, 41(D1), D1104–D1114.
MeSH headings : Computer Graphics; Databases, Chemical; Disease / genetics; Internet; Software; Toxicogenetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 7, 2019
2012 journal article
Denoising PCR-amplified metagenome data
BMC Bioinformatics, 13(1), 283.
Sources: NC State University Libraries, ORCID
Added: July 28, 2019
2012 journal article
Disruption of Purkinje cell function prior to huntingtin accumulation and cell loss in an animal model of Huntington Disease
Experimental Neurology, 236(1), 171–178.
author keywords: Cerebellum; Gene expression; Motor impairment; Stereology; Glutamic acid decarboxylase 67; Calbindin; Parvalbumin; Loose patch electrophysiology
MeSH headings : Age Factors; Animals; Disease Models, Animal; Huntingtin Protein; Huntington Disease / genetics; Huntington Disease / metabolism; Huntington Disease / pathology; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Phenotype; Purkinje Cells / pathology
TL;DR:
Qualitative real time PCR, Western blot analysis, and immunohistochemistry experiments suggest that early PC dysfunction potentially contributes to motor impairment in this model of HD.
(via Semantic Scholar)
Source: Crossref
Added: July 28, 2019
2012 journal article
Developmental Alterations in Motor Coordination and Medium Spiny Neuron Markers in Mice Lacking PGC-1α
PLoS ONE, 7(8), e42878.
Ed(s): M. Coleman
MeSH headings : Animals; Biomarkers / metabolism; Chromatography, High Pressure Liquid; Corpus Striatum / metabolism; Dopamine / metabolism; Gene Expression Profiling; Huntington Disease / metabolism; Huntington Disease / physiopathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons / metabolism; Neurons / physiology; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Psychomotor Performance; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction; Rotarod Performance Test; Trans-Activators / genetics; Trans-Activators / physiology; Transcription Factors; Transcription, Genetic
TL;DR:
It is shown that young P GC-1α −/− mice exhibit severe rotarod deficits, decreased rearing behavior, and increased occurrence of tremor in addition to the previously described hindlimb clasping, and that developmental disruption of PGC-1 α leads to long-term alterations in motor functioning.
(via Semantic Scholar)
Source: Crossref
Added: July 28, 2019
2012 journal article
Notes on the Distribution of 31 Species of Sarcophagidae (Diptera) in Australia, Including new Records in Australia for Eight Species
Transactions of the Royal Society of South Australia, 136(1), 56–64.
TL;DR:
Using locality information obtained from broad Australian taxon sampling and pinned museum specimens, new distributional information for 31 species known from Australia is presented.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019
2012 journal article
Comprehensive evaluation of DNA barcoding for the molecular species identification of forensically important Australian Sarcophagidae (Diptera)
Invertebrate Systematics, 26(6), 515.
author keywords: COI; forensic entomology
TL;DR:
DNA barcoding was validated as a suitable method for molecular identification of Australian Sarcophagidae, which will aid in the implementation of this fauna in forensic entomology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019
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