Works Published in 2022

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Displaying works 361 - 380 of 653 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2022 journal article

Cdc14 spatiotemporally dephosphorylates Atg13 to activate autophagy during meiotic divisions

JOURNAL OF CELL BIOLOGY, 221(5).

MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Anaphase; Autophagy; Autophagy-Related Proteins / genetics; Autophagy-Related Proteins / metabolism; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Meiosis; Protein Tyrosine Phosphatases / genetics; Protein Tyrosine Phosphatases / metabolism; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism
TL;DR: A meiosis-tailored mechanism of Cdc14 that governs autophagy is reported that stimulates Atg1 kinase activity and thus Autophagy at anaphases I and anaphase II to facilitate meiosis progression, meiosis exit, and sporulation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 11, 2022

2022 article

Epigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction

Simmers, M. D., Hudson, K. M., Baptissart, M., & Cowley, M. (2022, July 1). EPIGENETICS, Vol. 7.

By: M. Simmers n, K. Hudson n, M. Baptissart n & M. Cowley n

author keywords: Genomic imprinting; imprinted genes; DNA methylation; placenta; cadmium; foetal growth restriction; CDKN1C; toxic metal
TL;DR: It is concluded that the Cd-associated increase in Cdkn1c expression can be fully explained by alterations to placental structure, and it is shown that CdKn1c is expressed primarily in the placental labyrinth which is proportionally increased in size in response to Cd. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: July 11, 2022

2022 article

TwinEQTL: ultrafast and powerful association analysis for eQTL and GWAS in twin studies

Xia, K., Shabalin, A. A., Yin, Z., Chung, W., Sullivan, P. F., Wright, F. A., … Zou, F. (2022, June 11). GENETICS.

author keywords: Twin; eQTL; GWAS
MeSH headings : Humans; Gene Frequency; Genome-Wide Association Study / methods; Linear Models; Polymorphism, Single Nucleotide; Quantitative Trait Loci
Source: Web Of Science
Added: July 11, 2022

2022 journal article

Variation in upstream open reading frames contributes to allelic diversity in maize protein abundance

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(14).

author keywords: uORF; proteome; rare alleles; maize; gene expression
MeSH headings : 5' Untranslated Regions; Open Reading Frames / genetics; Protein Biosynthesis / genetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Ribosomes / genetics; Ribosomes / metabolism; Zea mays / genetics; Zea mays / metabolism
TL;DR: It is found that rare variants near the start codon of uORFs can repress or derepress mORF translation, causing allelic changes in protein abundance and providing evidence for the mechanisms by which natural sequence variation modulates gene expression, and ultimately, phenotype. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 11, 2022

2022 journal article

Comparative genomic analysis reveals contraction of gene families with putative roles in pathogenesis in the fungal boxwood pathogens Calonectria henricotiae and C. pseudonaviculata

BMC ECOLOGY AND EVOLUTION, 22(1).

By: L. Rogers n, A. Koehler*, J. Crouch*, M. Cubeta n & N. LeBlanc*

author keywords: Nectriaceae; Host range; Trophic lifestyle
MeSH headings : Buxus / microbiology; Ecosystem; Genomics; Hypocreales; Phylogeny; Plant Diseases / genetics
TL;DR: The results provide novel insight into gene family evolution within C. henricotiae and C. pseudonaviculata and suggest gene family contraction may have contributed to limited host-range expansion of these pathogens within the plant family Buxaceae. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 11, 2022

2022 article

Combined reduced expression of two gene families lowers nicotine content to ultra-low levels in cultivated tobacco

Kernodle, S. P., Webb, S., Steede, T. M., & Lewis, R. S. (2022, July 2). PLANT CELL REPORTS.

By: S. Kernodle n, S. Webb n, T. Steede n & R. Lewis n

author keywords: Tobacco; Nicotiana tabacum; Nicotine; Alkaloids; RNA interference; MPO; Methyl Putrescine Oxidase
MeSH headings : Gene Expression Regulation, Plant; Plant Leaves / genetics; Plant Leaves / metabolism; RNA Interference; Tobacco / genetics; Tobacco / metabolism; Tobacco Products
TL;DR: Tobacco genotypes expressing an RNAi construct designed to reduce expression of the Methyl Putrescine Oxidase (MPO) gene family associated with nicotine biosynthesis are produced and evaluated under field conditions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Source: Web Of Science
Added: July 11, 2022

2022 journal article

LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity

CELL REPORTS, 39(9).

By: X. Wei*, L. Zhang*, Y. Yang*, Y. Hou*, Y. Xu*, Z. Wang*, H. Su*, F. Han* ...

MeSH headings : Antiviral Restriction Factors / immunology; Cathelicidins / immunology; Humans; Immunity, Innate; Interferons / immunology; Membrane Proteins / metabolism; Nucleotides, Cyclic
TL;DR: LL-37, a human host defense peptide, can function as a transporter of cGAMP and activates robust interferon responses and host antiviral immunity in a STING-dependent manner and suggests new strategies for immunotherapy. (via Semantic Scholar)
Source: Web Of Science
Added: July 11, 2022

2022 article

Genomic map of candidate human imprint control regions: the imprintome

Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, June 25). EPIGENETICS, Vol. 6.

By: D. Jima n, D. Skaar n, A. Planchart n, A. Motsinger-Reif n, S. Cevik n, S. Park n, M. Cowley n, F. Wright n ...

author keywords: Epigenetics; genomic imprinting; foetal origins; whole genome; methylation; imprint control regions
MeSH headings : Adult; Humans; Genomic Imprinting; DNA Methylation; Chromosome Mapping; Alleles; Genomics
TL;DR: This draft of the human imprintome will allow for the systematic determination of the role of early-acquired imprinting dysregulation in the pathogenesis of human diseases and developmental and behavioural disorders. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 11, 2022

2022 article

Photoactivated carbon dots inducing bacterial functional and molecular alterations

Dong, X., Wang, P., Rodriguez, C. E., Tang, Y., Kathariou, S., Sun, Y.-P., & Yang, L. (2022, June 29). MATERIALS ADVANCES.

Source: Web Of Science
Added: July 11, 2022

2022 article

Synthesis provides insight into a traditional medicine

Onuska, N. P. R., & Pierce, J. G. (2022, June 30). NATURE, Vol. 606, pp. 869–870.

By: N. Onuska n & J. Pierce n

author keywords: Chemical biology; Organic chemistry; Chemistry; Synthesis
MeSH headings : Chemistry Techniques, Synthetic; Medicine, Traditional; Molecular Targeted Therapy / trends
Sources: Web Of Science, ORCID
Added: July 11, 2022

2022 article

A single gene integrates sex and hormone regulators into sexual attractiveness

Chen, N., Liu, Y.-J., Fan, Y.-L., Pei, X.-J., Yang, Y., Liao, M.-T., … Li, S. (2022, July 4). NATURE ECOLOGY & EVOLUTION, Vol. 7.

By: N. Chen*, Y. Liu*, Y. Fan*, X. Pei*, Y. Yang*, M. Liao*, J. Zhong*, N. Li* ...

MeSH headings : Animals; Blattellidae / genetics; Female; Juvenile Hormones / genetics; Juvenile Hormones / metabolism; Juvenile Hormones / pharmacology; Male
TL;DR: It is shown that wild-type males prefer to court cockroaches with higher CYP4PC1 expression and CSP production in a dose-dependent manner, regardless of their sex, shed light on how sex-specific and high sexual attractiveness is conferred in insects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, ORCID
Added: July 11, 2022

2022 journal article

Clustered Regularly Interspaced Short Palindromic Repeats Genotyping of Multidrug-Resistant Salmonella Heidelberg Strains Isolated From the Poultry Production Chain Across Brazil

FRONTIERS IN MICROBIOLOGY, 13.

By: D. Monte*, M. Nethery n, H. Berman n, S. Keelara n, N. Lincopan*, P. Fedorka-Cray n, R. Barrangou n, M. Landgraf*

author keywords: antibiotic resistance; CRISPR; phylogeny; Salmonella Heidelberg; foodborne disease; WGS
TL;DR: The findings underscore the potential role of S. Heidelberg as a key pathogen disseminated from farm to fork in Brazil and reinforce the importance of CRISPR-based genotyping for salmonellae and emphasized the need for continuous mitigation programs to monitor the dissemination of this high-priority pathogen. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: July 11, 2022

2022 journal article

Evidence for a leptin-insulin axis in a fish, the tilapia (Oreochromis mossambicus)

JOURNAL OF ENDOCRINOLOGY, 253(1), 13–25.

author keywords: leptin; insulin; glucagon; Brockmann bodies; tilapia
MeSH headings : Animals; Blood Glucose / metabolism; Cells, Cultured; Fish Proteins / genetics; Fish Proteins / metabolism; Gene Expression Regulation; Glucagon / genetics; Glucagon / metabolism; Glucose / metabolism; Hepatocytes / metabolism; Insulin / genetics; Insulin / metabolism; Insulin Secretion; Leptin / genetics; Leptin / metabolism; Male; RNA, Messenger / genetics; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction / genetics; Tilapia / genetics; Tilapia / metabolism; Time Factors
TL;DR: Data indicate that a leptin-insulin axis may be conserved among vertebrates and is thus essential for regulating nutrient balance but that the relationship is likely much more dynamic in teleosts as glycaemia is not as tightly regulated as it is in mammals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: July 11, 2022

2022 journal article

Identifying patient-level risk factors associated with non-beta-lactam resistance outcomes in invasive MRSA infections in the United States using chain graphs

JAC-ANTIMICROBIAL RESISTANCE, 4(4).

By: W. Love n, C. Wang n & C. Lanzas n

TL;DR: The differences in resistance phenotypes between patients with previous healthcare use or positive blood cultures, or from different states, may be useful to inform first-choice antibiotics to treat clinical MRSA cases. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: July 11, 2022

2022 journal article

Withaferin A Inhibits Neutrophil Adhesion, Migration, and Respiratory Burst and Promotes Timely Neutrophil Apoptosis

FRONTIERS IN VETERINARY SCIENCE, 9.

author keywords: neutrophil (PMN); Withaferin A (PubChem CID; 265237); equine; inflammation; phytochemical; veterinary medicine; novel therapeutic
TL;DR: The data demonstrate that WFA may reduce neutrophil-mediated inflammation through multiple mechanisms, including suppression of inflammatory responses and promotion of apoptosis, and additional research is needed to elucidate the molecular mechanisms for these effects. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 11, 2022

2022 article

Total Synthesis of Bipolamine I

Pierce, J. G., & Qiu, X. (2022, July 5). JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 7.

By: J. Pierce n & X. Qiu n

MeSH headings : Alkaloids; Biological Products; Polymers; Pyrroles; Stereoisomerism
TL;DR: A stereoselective 15-step synthesis of bipolamine I, a distinct member of the broader family, and through this work develop an intermediate that will serve to access other polypyrrole natural products and key analogues going forward. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: July 6, 2022

2022 journal article

Complete CFTR gene sequencing in 5,058 individuals with cystic fibrosis informs variant-specific treatment

JOURNAL OF CYSTIC FIBROSIS, 21(1), 463–470.

By: K. Raraigh*, M. Aksit*, K. Hetrick*, R. Pace*, H. Ling*, W. O'Neal*, E. Blue*, Y. Zhou n ...

author keywords: Whole genome sequencing; CFTR; Modulator therapy; Variant identification; Variant annotation
MeSH headings : Alleles; Cohort Studies; Cystic Fibrosis / diagnosis; Cystic Fibrosis / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Genotype; Humans; Mutation
TL;DR: Complete CFTR gene sequencing in 5,058 individuals with CF identified at least one DNA variant in 99.6% of the cohort that is targetable by current molecular or emerging gene-based therapeutic technologies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: July 5, 2022

2022 journal article

The Stickland Reaction Precursor trans-4-Hydroxy-l-Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia

MSPHERE, 7(2).

By: A. Reed n, J. Fletcher n, Y. Huang*, R. Thanissery n, A. Rivera n, R. Parsons n, A. Stewart n, D. Kountz* ...

author keywords: Clostridioides difficile; hydroxyproline; amino acids; Clostridia; Stickland reaction; colonization resistance; Stickland fermentation
MeSH headings : Animals; Clostridioides; Clostridioides difficile / genetics; Clostridium; Clostridium Infections / metabolism; Hydroxyproline / chemistry; Hydroxyproline / metabolism; Mice; Peptide Hydrolases; Proline / metabolism
TL;DR: A C. difficile ΔhypD mutant mutant was constructed and found that it was modestly impaired in fitness in a mouse model of infection, and was associated with an altered microbiota when compared to mice challenged with the wild-type strain. (via Semantic Scholar)
Source: Web Of Science
Added: July 5, 2022

2022 article

Governance of Gene-edited Plants: Insights from the History of Biotechnology Oversight and Policy Process Theory

Kuzma, J. (2022, June 23). SCIENCE TECHNOLOGY & HUMAN VALUES, Vol. 6.

By: J. Kuzma n

author keywords: genome editing; policy process theory; biotechnology; regulation; governance; GMO
TL;DR: The history of US biotechnology oversight for genetically modified plants is analyzed in the context of policy process theories to derive insights for contemporary governance of gene-edited plants and how to adapt oversight to future biotech products and emerging risks. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: July 5, 2022

2022 article

Ubiquitinated DA1 negatively regulates vascular cambium activity through modulating the stability of WOX4 in Populus

Tang, X., Wang, C., Chai, G., Wang, D., Xu, H., Liu, Y., … Zhou, G. (2022, June 15). PLANT CELL.

MeSH headings : Cambium; Gene Regulatory Networks; Populus; Transcription Factors; Ubiquitins; Wood; Xylem
TL;DR: A cambial regulatory protein complex, PagDA1-PagWOX4, is identified as a potential target for wood biomass improvement by identifying the ubiquitin receptor Pagda1 in hybrid poplar as a negative regulator of wood formation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Source: Web Of Science
Added: July 5, 2022

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