Works Published in 2020
Displaying works 41 - 60 of 790 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2020 journal article
A multiscale model of lignin biosynthesis for predicting bioenergy traits in <i>Populus trichocarpa</i>.
Computational and Structural Biotechnology Journal.
doi.org (publisher)
Source: ORCID
Added: August 9, 2023
2020 article
Vesicular and Extravesicular Protein Signatures From the Airspaces of Ozone-Exposed Mice Reflect Muco-Inflammatory Disturbances.
Choudhary, I., Vo, T., Paudel, K., Gupta, R., Kesimer, M., Patial, S., & Saini, Y. (2020, December).
TL;DR:
This study identified exosomal, secretory, and cell-specific proteins and biological pathways following sub-chronic exposure of mice to ozone, indicating the cellular sources of the proteins that are ferried in the exosomes upon ozone-induced lung injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2020 journal article
Tristetraprolin Overexpression in Non-hematopoietic Cells Protects Against Acute Lung Injury in Mice.
Frontiers in Immunology.
MeSH headings : Acute Lung Injury / chemically induced; Acute Lung Injury / prevention & control; Alveolar Epithelial Cells / metabolism; Animals; Bone Marrow Transplantation; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / cytology; Chemotaxis, Leukocyte; Cytokines / physiology; Endothelial Cells / metabolism; Female; Fibroblasts / metabolism; Lipopolysaccharides / toxicity; Male; Mice; Mice, Knockout; Neutrophil Infiltration; Neutrophils / immunology; Radiation Chimera; Tristetraprolin / biosynthesis; Tristetraprolin / deficiency; Tristetraprolin / genetics; Tristetraprolin / physiology; Up-Regulation
TL;DR:
It is suggested that non-HPCs-specific overexpression of TTP within the lungs protects against ALI via downregulation of neutrophil chemoattractants and reduction in neutrophilic infiltration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2020 journal article
The Tristetraprolin Family of RNA-Binding Proteins in Cancer: Progress and Future Prospects.
Cancers, 6.
TL;DR:
The various hallmark molecular traits of cancers that are reported to be regulated by the tristetraprolin family of RNA-binding proteins are summarized and the role of the TTP family RBPs in the regulation of trait-associated mRNA targets in relevant cancer types/cell lines is emphasized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2020 journal article
The Innate Lymphoid System Is a Critical Player in the Manifestation of Mucoinflammatory Airway Disease in Mice.
Journal of Immunology (Baltimore, Md. : 1950), 9.
MeSH headings : Animals; Cells, Cultured; Cystic Fibrosis / immunology; Disease Models, Animal; Epithelial Cells / metabolism; Epithelial Cells / pathology; Epithelial Sodium Channels / genetics; Homeodomain Proteins / genetics; Humans; Immunity, Innate; Inflammation / immunology; Metaplasia; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mucin-5B / genetics; Mucin-5B / metabolism; Respiratory Tract Diseases / immunology; Up-Regulation
TL;DR:
Collectively, these data indicate that, in the context of airway mucus obstruction, the adaptive immune system suppresses antibacterial macrophage activation, whereas the innate lymphoid system contributes to MCM, mucin production, and mucus obstruct.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2020 article
Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2
Vo, T., Paudel, K., Choudhary, I., Patial, S., & Saini, Y. (2020, November).
TL;DR:
The data indicate that the unhealthy levels of ozone in the environment may predispose individuals to severe SARS-CoV-2 infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2020 journal article
Lung macrophages: current understanding of their roles in Ozone-induced lung diseases.
Critical Reviews in Toxicology, 4.
MeSH headings : Air Pollutants / toxicity; Air Pollution / statistics & numerical data; Animals; Humans; Lung / physiopathology; Lung Diseases / epidemiology; Lung Diseases / etiology; Macrophages / drug effects; Macrophages / physiology; Ozone / toxicity; United States
TL;DR:
There is a vital need for additional policy-relevant scientific information, including mechanistic studies to further define the role of macrophages in response to O3, and a comprehensive list of currently known macrophage-specific roles in O3-induced lung diseases is included in this review.
(via Semantic Scholar)
Source: ORCID
Added: August 2, 2023
2020 journal article
Compartment-specific transcriptomics of ozone-exposed murine lungs reveals sex- and cell type-associated perturbations relevant to mucoinflammatory lung diseases.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 1.
Source: ORCID
Added: August 2, 2023
2020 journal article
Ablation of IL-33 Suppresses <i>Th2</i> Responses but Is Accompanied by Sustained Mucus Obstruction in the <i>Scnn1b</i> Transgenic Mouse Model.
Journal of Immunology (Baltimore, Md. : 1950), 3.
MeSH headings : Animals; Bronchoalveolar Lavage Fluid / cytology; Bronchoalveolar Lavage Fluid / immunology; Cystic Fibrosis / diagnosis; Cystic Fibrosis / genetics; Cystic Fibrosis / immunology; Cystic Fibrosis / pathology; Disease Models, Animal; Eosinophils / immunology; Eosinophils / metabolism; Epithelial Sodium Channels / genetics; Humans; Interleukin-33 / genetics; Interleukin-33 / metabolism; Lung / cytology; Lung / immunology; Lung / pathology; Mice; Mice, Knockout; Mice, Transgenic; Mucin 5AC / metabolism; Mucus / immunology; Mucus / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / immunology; Respiratory Mucosa / metabolism; Th2 Cells / immunology; Th2 Cells / metabolism
TL;DR:
Although IL- 33 modulates Th2 inflammatory responses and MUC5AC protein production, mucus obstruction is not dependent on IL-33, and histological features, including subepithelial airway inflammation and alveolar space enlargement, were somewhat exaggerated inIL-33KO/Tg+ mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2020 journal article
Clickable, acid labile immunosuppressive prodrugs for in vivo targeting
Biomaterials Science, 8(1), 266–277.
TL;DR:
Dibenzocyclooctyne-modified prodrugs of the immunosuppressive drugs tacrolimus, rapamycin and mycophenolic acid are developed and targeted conjugation both in vitro and in vivo to azido-modified hydrogels via Click chemistry is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: July 8, 2023
2020 journal article
Click cross-linking improves retention and targeting of refillable alginate depots
Acta Biomaterialia, 112, 112–121.
MeSH headings : Alginates; Biocompatible Materials; Click Chemistry; Cross-Linking Reagents; Hydrogels; Tissue Engineering
Source: ORCID
Added: July 8, 2023
2020 report
Complete list of requirements for a nano-specific risk governance framework
[Deliverable]. caLIBRAte European project, Horizon 2020 research and innovation program.
Source: NC State University Libraries
Added: July 2, 2023
2020 chapter
Nanomaterials: Regulation and Risk Assessment
In Managing Human and Social Systems (2nd ed.). Boca Raton: CRC Press.
Source: NC State University Libraries
Added: July 2, 2023
2020 journal article
Pandemics Call for Systems Approaches to Research and Funding
Issues in Science and Technology. https://issues.org/pandemics-call-for-systems-approaches/
Source: NC State University Libraries
Added: July 2, 2023
2020 article
Deep learning-enabled phenotyping reveals distinct patterns of neurodegeneration induced by aging and cold-shock
Saberi-Bosari, S., Flores, K. B., & San-Miguel, A. (2020, March 9).
TL;DR:
It is identified that acute cold-shock-induced neurodegeneration is reversible and depends on rearing temperature, and importantly, that aging andcold-shock induce distinct neuronal beading patterns.
(via Semantic Scholar)
Source: ORCID
Added: May 31, 2023
2020 journal article
An inexpensive programmable optogenetic platform for controlled neuronal activation regimens inC. elegans
APL Bioengineering, 4(1), 016101.
TL;DR:
An accessible platform that enables controlled optogenetic stimulation of Caenorhabditis elegans in two modes, composed of inexpensive components, while providing the illumination strength of high-end systems, which require expensive lasers, shutters, or automated stages is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: May 31, 2023
2020 journal article
A reference map of the human binary protein interactome
Nature, 580(7803), 402–408.
MeSH headings : Extracellular Space / metabolism; Humans; Organ Specificity; Protein Interaction Mapping; Proteome / metabolism
TL;DR:
The utility of HuRI is demonstrated in identifying the specific subcellular roles of protein–protein interactions and in identifying potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases.
(via Semantic Scholar)
Source: ORCID
Added: May 31, 2023
2020 journal article
Accessing Legacy Phosphorus in Soils
Soil Systems, 4(4), 74.
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
Sources: Crossref, ORCID
Added: May 22, 2023
2020 journal article
Ten Years of the Maize Nested Association Mapping Population: Impact, Limitations, and Future Directions
The Plant Cell, 32(7), 2083–2093.
Contributors: J. Gage*
MeSH headings : Chromosome Mapping; Crops, Agricultural; Plant Breeding; Quantitative Trait Loci; Zea mays / genetics
TL;DR:
A retrospective will summarize the design and intentions behind the NAM population; its application, the discoveries it has enabled, and its influence in other systems; and use the past decade of hindsight to consider whether and how it will remain useful in a new age of genomics.
(via Semantic Scholar)
Source: ORCID
Added: April 18, 2023
2020 article
A Maize Practical Haplotype Graph Leverages Diverse NAM Assemblies
Franco, J. A. V., Gage, J. L., Bradbury, P. J., Johnson, L. C., Miller, Z. R., Buckler, E. S., & Romay, M. C. (2020, August 31). [], Vol. 8.
Contributors: J. Gage*
TL;DR:
The pangenome was leveraged to accurately impute haplotypes and genotypes of taxa using various kinds of sequence data, ranging from WGS to extremely-low coverage GBS, and provided an initial estimate of structural diversity of maize.
(via Semantic Scholar)
Source: ORCID
Added: April 18, 2023
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