Works Published in 2011
Displaying works 81 - 100 of 608 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 report
Minnesota Nanotechnology : A report to the state legislature
St. Paul, MN: Minnesota State Legislature.
Source: NC State University Libraries
Added: February 20, 2021
2011 book
The wild life of our bodies: predators, parasites, and partners that shape who we are today
New York: Harper Collins.
Source: NC State University Libraries
Added: January 30, 2021
2011 journal article
Near-infrared-labeled tetracycline derivative is an effective marker of bone deposition in mice
Analytical Biochemistry, 416(2), 167–173.
author keywords: IRDye 800CW; Tetracycline derivative; Near-infrared; Molecular imaging; Whole animal imaging; Fluorescence microscopy; Immunofluorescent assay; Mineralization
MeSH headings : Animals; Biomarkers / analysis; Bone Remodeling; Calcification, Physiologic; Cell Line; Disease Models, Animal; Fluoresceins / chemistry; Indoles / chemistry; Mice; Mice, Nude; Microscopy, Fluorescence / methods; Osteoporosis / metabolism; Spectroscopy, Near-Infrared / methods; Tetracycline / analysis; Tetracycline / chemistry; Whole Body Imaging
TL;DR:
Evidence is provided that the NIR-labeled BoneTag agent is effective as a general marker of skeletal features and an indicator of the bone mineralization and remodeling processes.
(via Semantic Scholar)
Source: Crossref
Added: January 30, 2021
2011 journal article
Enzymatic Defects Underlying Hereditary Glutamate Cysteine Ligase Deficiency Are Mitigated by Association of the Catalytic and Regulatory Subunits
Biochemistry, 50(29), 6508–6517.
MeSH headings : Animals; Catalytic Domain; Enzyme Stability; Glutamate-Cysteine Ligase / chemistry; Glutamate-Cysteine Ligase / deficiency; Glutamate-Cysteine Ligase / metabolism; Glutathione / biosynthesis; Homozygote; Humans; Kinetics; Mice; Models, Biological; Mutant Proteins / metabolism; Mutation / genetics; Protein Binding; Protein Structure, Secondary; Recombinant Proteins / metabolism; Saccharomyces cerevisiae / metabolism; Structural Homology, Protein; Temperature
TL;DR:
Kinetic characterizations of the recombinant GCLC mutants indicated that the Arg127Cys, His370Leu, and Pro414Leu mutants have compromised enzymatic activity that can largely be rescued by the addition of GCLM, suggesting that heterodimer formation is needed for stability in vivo.
(via Semantic Scholar)
digitalcommons.unl.edu (repository)
Source: Crossref
Added: January 30, 2021
2011 journal article
Hyaluronan suppresses prostate tumor cell proliferation through diminished expression of N-cadherin and aberrant growth factor receptor signaling
Experimental Cell Research, 317(8), 1214–1225.
author keywords: Hyaluronan; Prostate cancer; Cadherin; Integrin; Cell adhesion; Cell cycle
MeSH headings : Antigens, CD / genetics; Antigens, CD / metabolism; Cadherins / genetics; Cadherins / metabolism; Cell Cycle / physiology; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases / antagonists & inhibitors; Cyclin-Dependent Kinases / metabolism; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases / metabolism; Focal Adhesion Protein-Tyrosine Kinases / antagonists & inhibitors; Focal Adhesion Protein-Tyrosine Kinases / metabolism; Humans; Hyaluronic Acid / metabolism; Male; Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinase Kinases / metabolism; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology; Proto-Oncogene Proteins c-akt / antagonists & inhibitors; Proto-Oncogene Proteins c-akt / metabolism; Receptors, Growth Factor / genetics; Receptors, Growth Factor / metabolism; Signal Transduction / physiology; beta Catenin / genetics; beta Catenin / metabolism
TL;DR:
Detailed characterization of cell cycle progression revealed that expression of Hyal1 accelerated cell cycle re-entry following synchronization, whereas HAS3 alone delayed entry, consistent with a model in which excess HA synthesis suppresses cell proliferation by promoting homotypic E-cadherin mediated cell-cell adhesion.
(via Semantic Scholar)
Source: Crossref
Added: January 30, 2021
2011 chapter
RNAi in Agriculturally-Important Arthropods
In P. Grabowski (Ed.), RNA Processing (pp. 157–180).
Ed(s): P. Grabowski
TL;DR:
The aim in this chapter is to provide an overview of the profound knowledge accumulated in recent years from invertebrate RNAi studies, but with a focus on agriculturally important arthropods, and the latest achievements in basic honey bee research.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 28, 2021
2011 journal article
A comparison of the low temperature transcriptomes and CBF regulons of three plant species that differ in freezing tolerance: Solanum commersonii, Solanum tuberosum, and Arabidopsis thaliana.
Journal of Experimental Botany.
author keywords: Arabidopsis; CBF regulon; freezing tolerance; low temperature transcriptome; Solanum species
MeSH headings : Acclimatization; Arabidopsis / genetics; Arabidopsis / metabolism; Arabidopsis / physiology; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Core Binding Factors / genetics; Core Binding Factors / metabolism; Freezing; Gene Expression Regulation, Plant; Plant Proteins / genetics; Plant Proteins / metabolism; Regulon; Solanum / genetics; Solanum / metabolism; Solanum / physiology; Solanum tuberosum / genetics; Solanum tuberosum / metabolism; Solanum tuberosum / physiology; Species Specificity; Transcription Factors / genetics; Transcription Factors / physiology; Transcription, Genetic / genetics
TL;DR:
It seems likely that these conserved cold-regulated genes—many of which encode transcription factors and proteins of unknown function—have fundamental roles in plant growth and development at low temperature.
(via Semantic Scholar)
Source: ORCID
Added: January 25, 2021
2011 journal article
The interplay between microbiome dynamics and pathogen dynamics in a murine model of Clostridium difficile Infection
Gut Microbes, 2(3), 145–158.
author keywords: Clostridium difficile; colonization resistance; microbial ecology; antibiotic-associated diarrhea; C. difficile infection
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bacteria / classification; Bacteria / drug effects; Bacteria / genetics; Bacteria / isolation & purification; Clostridioides difficile / drug effects; Clostridioides difficile / genetics; Clostridioides difficile / isolation & purification; Clostridioides difficile / physiology; Clostridium Infections / microbiology; Colitis / microbiology; Disease Models, Animal; Gastrointestinal Tract / drug effects; Gastrointestinal Tract / microbiology; Humans; Metagenome / drug effects; Mice; Mice, Inbred C57BL
TL;DR:
The severity of colitis that arises in this system reflects the interplay between the expansion of C. difficile in the gut community and the ecologic dynamics of the indigenous microbes as it recovers from antibiotic perturbation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Crossref
Added: January 24, 2021
2011 journal article
Cefoperazone-treated mice as an experimental platform to assess differential virulence of Clostridium difficile strains
Gut Microbes, 2(6), 326–334.
MeSH headings : Animals; Blood Cell Count; Cecum / microbiology; Cecum / pathology; Cefoperazone / administration & dosage; Cefoperazone / pharmacology; Chlorocebus aethiops; Clostridioides difficile / pathogenicity; Colon / microbiology; Colon / pathology; Edema / microbiology; Edema / pathology; Enterocolitis, Pseudomembranous / drug therapy; Enterocolitis, Pseudomembranous / microbiology; Enterocolitis, Pseudomembranous / pathology; Female; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Male; Mice; Mice, Inbred C57BL; Models, Animal; Neutrophils / metabolism; Vero Cells; Virulence; Weight Loss
TL;DR:
Cefoperazone treated mice represent a useful model of C. difficile infection that will help to better understand the pathogenesis and virulence of this re-emerging pathogen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Crossref
Added: January 24, 2021
2011 journal article
A multidimensional study of endophytic fungal diversity
IMA Fungus, 2(1), 2–4.
Source: NC State University Libraries
Added: January 17, 2021
2011 journal article
Strong influence of regional species pools on continent-wide structuring of local communities
Proceedings of the Royal Society B: Biological Sciences, 279(1727), 266–274.
author keywords: regional species pool; community assembly; phylogenetics; tropical niche conservatism; diversity gradients; Formicidae
MeSH headings : Animals; Ants / physiology; Biodiversity; Climate; North America; Phylogeny; Population Dynamics; Temperature
TL;DR:
It is found that the average phylogenetic relatedness of species in ant communities decreases from tropical to temperate regions, but the strength of this relationship depends on the level of ecological realism in the definition of source pools.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science; OpenAlex)
Source: Crossref
Added: January 5, 2021
2011 journal article
Nuclear Factor κ-Light Chain-Enhancer of Activated B Cells is Activated by Radiotherapy and is Prognostic for Overall Survival in Patients With Rectal Cancer Treated With Preoperative Fluorouracil-Based Chemoradiotheraphy
International Journal of Radiation Oncology*Biology*Physics, 80(3), 705–711.
author keywords: Chemoradiotherapy; NF-kappa B; rectal cancer; prognostic markers; inducible resistance genes; TRAF1; Bcl-2; cIAP-2; interleukin 8
MeSH headings : Adult; Aged; Aged, 80 and over; Combined Modality Therapy / methods; Female; Genes, bcl-2 / genetics; Humans; Inhibitor of Apoptosis Proteins / genetics; Interleukin-8 / genetics; Male; Middle Aged; NF-kappa B / metabolism; Neoplasm Proteins / metabolism; Prognosis; Prospective Studies; Radiation Tolerance / genetics; Rectal Neoplasms / drug therapy; Rectal Neoplasms / genetics; Rectal Neoplasms / metabolism; Rectal Neoplasms / mortality; Rectal Neoplasms / radiotherapy; Retrospective Studies; TNF Receptor-Associated Factor 1 / genetics; Treatment Outcome
TL;DR:
NF-κB might play an important role in tumor metastasis but not to the resistance to chemoradiotherapy, and nuclear expression at baseline in rectal cancer was prognostic for overall survival but not predictive of the response to RT.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: January 4, 2021
2011 journal article
Oxidative stress in neurodegeneration
Advances in Pharmacological Sciences, 2011, 1–13.
TL;DR:
The role of oxidative stress in neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's diseases and amyotrophic lateral sclerosis is highlighted, and the role of oxidants and antioxidants causing deregulation of cyclin-dependent kinase 5 (Cdk5) hyperactivity associated with Neurodegeneration is described.
(via Semantic Scholar)
Source: Web Of Science
Added: December 28, 2020
2011 chapter
Vitellogenesis in Fishes
In A. P. Farrell (Ed.), Encyclopedia of Fish Physiology: From Genome to Environment (pp. 635–646). London: Elsevier.
Ed(s): A. Farrell
Source: NC State University Libraries
Added: December 26, 2020
2011 journal article
A Redesigned Vancomycin Engineered for Dual d-Ala-d-Ala and d-Ala-d-Lac Binding Exhibits Potent Antimicrobial Activity Against Vancomycin-Resistant Bacteria
Journal of the American Chemical Society, 133(35), 13946–13949.
MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / metabolism; Bacteria / metabolism; Binding Sites; Cell Wall / metabolism; Dipeptides / metabolism; Peptidoglycan / metabolism; Vancomycin / chemistry; Vancomycin / metabolism; Vancomycin Resistance
TL;DR:
A complementary single atom Exchange in the vancomycin core structure to counter the single atom exchange in the cell wall precursors of resistant bacteria (NH → O) reinstates potent antimicrobial activity and charts a rational path forward for the development of antibiotics for the treatment of vancomYcin-resistant bacterial infections.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: December 22, 2020
2011 journal article
Recombinant E. coli Prototype Strains for in Vivo Glycorandomization
ACS Chemical Biology, 6(1), 95–100.
MeSH headings : Biological Products / chemistry; Biological Products / metabolism; Carbohydrate Metabolism; Carbohydrates / chemistry; Catalysis; Escherichia coli / classification; Escherichia coli / enzymology; Escherichia coli / genetics; Escherichia coli / metabolism; Glycosylation; Glycosyltransferases / chemistry; Glycosyltransferases / metabolism; Nucleotidyltransferases / chemistry; Nucleotidyltransferases / metabolism; Protein Engineering; Recombinant Proteins; Substrate Specificity
TL;DR:
This work reports the construction of several recombinant E. coli prototype strains that allow the facile production of a range of small molecule glycosides and offers vast combinatorial potential by simple fermentation.
(via Semantic Scholar)
Sources: ORCID, Crossref
Added: December 15, 2020
2011 journal article
Inside Cover: Mutant Malonyl-CoA Synthetases with Altered Specificity for Polyketide Synthase Extender Unit Generation (ChemBioChem 15/2011)
ChemBioChem, 12(15), 2230–2230.
Sources: ORCID, Crossref
Added: December 15, 2020
2011 journal article
QTL controlling masculinization of ear tips in a maize (Zea mays L.) intraspecific cross
G3: Genes, Genomes, Genetics, 1(5), 337–341.
Contributors: J. Holland n & N. Coles n
author keywords: maize recombinant inbred lines; floral sex determination; quantitative trait loci
TL;DR:
Alleles conferring photoperiod sensitivity for delayed flowering at these QTL seem to enhance the production of staminate ear tips under long daylengths.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: ORCID
Added: December 8, 2020
2011 journal article
Genomic localization of the maize cross-incompatibility gene, Gametophyte factor 1 (ga1)
Maydica, 56(4), 379–387. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857675839&partnerID=MN8TOARS
Contributors: J. Bloom & J. Holland
Source: ORCID
Added: December 8, 2020
2011 journal article
Common motifs shared by conserved enhancers of Drosophila midline glial genes
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 316B(1), 61–75.
MeSH headings : Animals; Animals, Genetically Modified; Base Sequence; Biological Evolution; Conserved Sequence; Drosophila / embryology; Drosophila / genetics; Drosophila / metabolism; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Gene Expression Regulation / physiology; Genes, Reporter; Molecular Sequence Data; Neuroglia / metabolism; Phosphoproteins / genetics; Phosphoproteins / metabolism
TL;DR:
The highly conserved sequences appear to juxtapose positive and negative regulatory factors in a configuration that activates genes specifically in the midline glia, while maintaining them inactive in other tissues, including midline neurons and tracheal cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Crossref
Added: November 22, 2020
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