Works Published in 2010
Displaying works 141 - 160 of 562 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2010 journal article
Cheminformatics Analysis of Assertions Mined from Literature That Describe Drug-Induced Liver Injury in Different Species
Chemical Research in Toxicology, 23(1), 171–183.
MeSH headings : Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship
TL;DR:
This is the first study for chemical toxicity prediction that applied QSAR modeling and other cheminformatics techniques to observational data generated by the means of automated text mining with limited manual curation, opening up new opportunities for generating and modeling chemical toxicology data.
(via Semantic Scholar)
europepmc.org (repository)
Source: Crossref
Added: August 28, 2020
2010 journal article
Quantitative Nanostructure−Activity Relationship Modeling
ACS Nano, 4(10), 5703–5712.
author keywords: nanoparticles; QSAR; cheminformatics; nanotoxicity; modeling
MeSH headings : Animals; Cell Line, Tumor; Humans; Metal Nanoparticles / chemistry; Microscopy, Atomic Force / methods; Models, Statistical; Models, Theoretical; Nanotechnology / methods; Oxides / chemistry; Quantitative Structure-Activity Relationship; Rats; Regression Analysis; Surface Properties; U937 Cells
TL;DR:
The results suggest that QNAR models can be employed for: (i) predicting biological activity profiles of novel nanomaterials, and (ii) prioritizing the design and manufacturing of nanom material toward better and safer products.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Applicability Domains for Classification Problems: Benchmarking of Distance to Models for Ames Mutagenicity Set
Journal of Chemical Information and Modeling, 50(12), 2094–2111.
MeSH headings : Benchmarking / methods; Classification / methods; Mutagenicity Tests / methods; Mutagenicity Tests / standards; Principal Component Analysis; Quantitative Structure-Activity Relationship
TL;DR:
This work demonstrates that the DMs based on an ensemble (consensus) model provide systematically better performance than other DMs and can be used to halve the cost of experimental measurements by providing a similar prediction accuracy.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Trust, But Verify: On the Importance of Chemical Structure Curation in Cheminformatics and QSAR Modeling Research
Journal of Chemical Information and Modeling, 50(7), 1189–1204.
MeSH headings : Animals; Models, Chemical; Molecular Structure; Organometallic Compounds / chemistry; Quantitative Structure-Activity Relationship
TL;DR:
The need for a standardized chemical data curation strategy that should be followed at the onset of any molecular modeling investigation is emphasized and it is demonstrated that in some cases rigorously developed QSAR models could be even used to correct erroneous biological data associated with chemical compounds.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Interactome analysis of longitudinal pharyngeal infection of cynomolgus macaques by group A Streptococcus
Proceedings of the National Academy of Sciences, 107(10), 4693–4698.
author keywords: epithelial growth factor receptor; host pathogen; microarray; Streptococcus pyogenes; transcriptome
MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Clathrin-Coated Vesicles / metabolism; Cytokines / metabolism; GTP Phosphohydrolases / genetics; GTP Phosphohydrolases / metabolism; Gene Expression Profiling; Host-Pathogen Interactions; Hyaluronic Acid / metabolism; Macaca fascicularis / genetics; Macaca fascicularis / metabolism; Macaca fascicularis / microbiology; Neutrophils / metabolism; Neutrophils / microbiology; Neutrophils / pathology; Oligonucleotide Array Sequence Analysis; Pharyngitis / genetics; Pharyngitis / microbiology; Pharynx / metabolism; Pharynx / microbiology; Pharynx / pathology; Reverse Transcriptase Polymerase Chain Reaction; Streptococcus pyogenes / genetics; Streptococcus pyogenes / metabolism; Streptococcus pyogenes / physiology
TL;DR:
These results are unique in providing a comprehensive understanding of the host–pathogen interactome during mucosal infection by a bacterial pathogen.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Use of Pharmaco-Metabonomics for Early Prediction of Acetaminophen-Induced Hepatotoxicity in Humans
Clinical Pharmacology & Therapeutics, 88(1), 45–51.
MeSH headings : Acetaminophen / adverse effects; Acetaminophen / metabolism; Acetaminophen / pharmacology; Adolescent; Adult; Alanine Transaminase / blood; Analgesics, Non-Narcotic / adverse effects; Analgesics, Non-Narcotic / metabolism; Analgesics, Non-Narcotic / pharmacology; Biotransformation; Chemical and Drug Induced Liver Injury / diagnosis; Chemical and Drug Induced Liver Injury / genetics; Chemical and Drug Induced Liver Injury / urine; Cohort Studies; Data Interpretation, Statistical; Female; Humans; Least-Squares Analysis; Liver Function Tests; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Young Adult
TL;DR:
It is demonstrated that the pattern of endogenous metabolites in urine could predict susceptibility to acetaminophen‐induced liver injury in rats, and this “early‐intervention pharmaco‐metabonomics” approach should now be tested in clinical trials of other potentially hepatotoxic drugs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2010 journal article
An approximate Bayesian approach for quantitative trait loci estimation
Computational Statistics & Data Analysis, 54(2), 565–574.
TL;DR:
This paper presents a Bayesian linkage model that offers directly interpretable posterior densities or Bayes factors for linkage, and employs the Laplace approximation for integration over nuisance parameters in backcross (BC) and F2 intercross designs.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Synthesis and Evaluation of Selected Key Methyl Ether Derivatives of Vancomycin Aglycon
Journal of Medicinal Chemistry, 53(19), 7229–7235.
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / pharmacology; Drug Resistance, Bacterial; Enterococcus faecalis / drug effects; Hydrophobic and Hydrophilic Interactions; Methyl Ethers / chemical synthesis; Methyl Ethers / pharmacology; Microbial Sensitivity Tests; Peptidoglycan / chemistry; Staphylococcus aureus / drug effects; Stereoisomerism; Structure-Activity Relationship; Thermodynamics; Vancomycin / analogs & derivatives; Vancomycin / chemical synthesis; Vancomycin / pharmacology
TL;DR:
In these studies, methodology for selective derivatization of the A-, B-, and D-ring was developed that defines the relative reactivity of the four phenols of vancomycin aglycon, providing a foundation for future efforts for site-directed modification of the vancomYcin Aglycon core.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2010 journal article
Heterotaxin: A novel TGF-beta signaling inhibitor identified in a multi-phenotype profiling screen in Xenopus embryos
Developmental Biology, 344(1), 526.
TL;DR:
A small molecule screen for left-right asymmetry phenotypes in Xenopus embryos is performed and a novel pyridine analog, heterotaxin, is discovered, which disrupts both cardiovascular and digestive organ laterality and inhibits TGF-β-dependent left- right asymmetric gene expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2010 journal article
Differential response in foliar chemistry of three ash species to emerald ash borer adult feeding.
Journal of Chemical Ecology, 1.
author keywords: Agrilus planipennis; Fraxinus; Plant defense; Phenolics; Volatile organic compounds; VOCs; Coleoptera; Buprestidae
MeSH headings : Animals; Chromatography, High Pressure Liquid; Coleoptera / physiology; Feeding Behavior; Female; Fraxinus / chemistry; Fraxinus / parasitology; Plant Leaves / chemistry; Plant Leaves / parasitology; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Volatile Organic Compounds / analysis
TL;DR:
Although levels of total phenolics from black and green ash foliage were not affected by EAB adult feeding, they decreased significantly in white ash, and the possible ecological implications of these findings are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: August 24, 2020
2010 journal article
Development and environmental application of a genus-specific quantitative PCR approach for Pseudo-nitzschia species
Marine Biology, 157(5), 1161–1169.
TL;DR:
The method developed here quantifies Pseudo-nitzschia spp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: June 28, 2020
2010 journal article
Harmful algae and their potential impacts on desalination operations off southern California
Water Research, 44(2), 385–416.
author keywords: Harmful algal blooms; Desalination; Red tides; Phytoplankton; Phytotoxins
MeSH headings : California; Environmental Monitoring; Eukaryota / growth & development; Eukaryota / pathogenicity; Geography; Harmful Algal Bloom; Marine Toxins / analysis; Marine Toxins / toxicity; Plankton / growth & development; Plankton / pathogenicity; Seawater / chemistry; Water Pollutants / analysis; Water Pollution / statistics & numerical data; Water Purification / methods
TL;DR:
This review identifies the toxic substances, their known producers, and the present state of knowledge regarding the causes of toxic episodes, with a special focus on the Southern California Bight.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: June 28, 2020
2010 journal article
Phylogenetic Affiliations of Mesopelagic Acantharia and Acantharian-like Environmental 18S rRNA Genes off the Southern California Coast
Protist, 161(2), 197–211.
author keywords: 18S rRNA phylogeny; Acantharea; CARD-FISH; deep-sea protist; novel protistan lineage; sarcodine
MeSH headings : California; Cluster Analysis; DNA, Protozoan / chemistry; DNA, Protozoan / genetics; DNA, Ribosomal / chemistry; DNA, Ribosomal / genetics; Genes, rRNA; In Situ Hybridization, Fluorescence; Molecular Sequence Data; Phylogeny; RNA, Protozoan / genetics; RNA, Ribosomal, 18S / genetics; Rhizaria / genetics; Rhizaria / isolation & purification; Seawater; Sequence Analysis, DNA
TL;DR:
This analysis demonstrated strong support for two branches of unidentified organisms that are closely related to, but possibly distinct from the Acantharea, and found evidence of acantharian sequences from mesopelagic environments branching within the chaunacanthid clade.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: June 14, 2020
2010 book
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: May 7, 2020
2010 chapter
Plasmon-Resonant gold nanorods as multifunctional agents for diagnostics, imaging and photothermal therapy
In Handbook of Materials for Nanomedicine (pp. 585–631).
Contributors: Q. Wei & A. Wei
Source: ORCID
Added: April 10, 2020
2010 journal article
W1250 Genome-Wide Association Scan Reveals Polymorphisms in the P67phox Subunit (Ncf2) of the NADPH Oxidase Complex in Boxer Dogs With Adherent and Invasive E.Coli-Associated Granulomatous Colitis: A Potential Model of Chronic Granulomatous Disease
Gastroenterology, 138(5), S-683.
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2010 journal article
Genetics of Cardiac Disease in the Small Animal Patient
Veterinary Clinics of North America: Small Animal Practice, 40(4), 701–715.
author keywords: Familial; Mutation; Cardiomyopathy; Congenital heart disease
MeSH headings : Animals; Breeding; Cat Diseases / genetics; Cat Diseases / prevention & control; Cats; Dog Diseases / genetics; Dog Diseases / prevention & control; Dogs; Female; Genetic Diseases, Inborn / prevention & control; Genetic Diseases, Inborn / veterinary; Genetic Predisposition to Disease; Heart Diseases / genetics; Heart Diseases / prevention & control; Heart Diseases / veterinary; Male; Selection, Genetic
TL;DR:
Common forms of inheritance for veterinary diseases include autosomal recessive, autosomal dominant, X-linked recessives, and polygenic and their possible involvement in cardiac disease in small animals are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2010 journal article
Spatiotemporal regulation of cell-cycle genes by SHORTROOT links patterning and growth
Nature, 466(7302), 128–132.
MeSH headings : Arabidopsis / cytology; Arabidopsis / embryology; Arabidopsis / genetics; Arabidopsis / growth & development; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Body Patterning / genetics; Body Patterning / physiology; Cell Cycle / genetics; Cell Cycle / physiology; Cell Division / genetics; Cyclin D / genetics; Cyclin D / metabolism; Cyclin-Dependent Kinases / metabolism; Gene Expression Regulation, Plant; Genes, cdc / physiology; Organogenesis / genetics; Organogenesis / physiology; Plant Roots / cytology; Plant Roots / embryology; Plant Roots / genetics; Plant Roots / growth & development; Time Factors; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR:
This work shows, using cell-type-specific transcriptional effects of SHR and SCR combined with data from chromatin immunoprecipitation-based microarray experiments, that SHR regulates the spatiotemporal activation of specific genes involved in cell division.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: March 5, 2020
2010 chapter
Grammatical Evolution Decision Trees for Detecting Gene-Gene Interactions
In Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics (pp. 98–109).
Source: Crossref
Added: February 24, 2020
2010 journal article
Differential Cotton leaf crumple virus-VIGS-mediated gene silencing and viral genome localization in different Gossypium hirsutum genetic backgrounds
Physiological and Molecular Plant Pathology, 75(1-2), 13–22.
author keywords: Begomovirus; Cotton breeding; Cotton genetics; Genetic improvement; Geminivirus; Magnesium chelatase marker; Viral episome
TL;DR:
A Cotton leaf crumple virus (CLCrV)-based gene silencing vector containing a fragment of the Gossypium hirsutum Magnesium chelatase subunit I was used to establish endogenous genesilencing in cotton of varied genetic backgrounds, indicating successful phloem invasion in all cultivars tested.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
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