Genetics and Genomics Academy
Interdisciplinary Programs
Works Published in 2010
Displaying works 161 - 180 of 423 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2010 journal article
Neuronal Inactivation of Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Protects Mice from Diet-induced Obesity and Leads to Degenerative Lesions
Journal of Biological Chemistry, 285(50), 39087–39095.
MeSH headings : Animal Feed; Animals; Brain / metabolism; Constriction, Pathologic; Gene Expression Regulation; Liver / metabolism; Mice; Mice, Transgenic; Neurodegenerative Diseases / metabolism; Neurons / metabolism; Obesity / genetics; Oxygen Consumption; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Trans-Activators / metabolism; Transcription Factors; Transcription, Genetic; Triglycerides / metabolism
www.jbc.org (publisher PDF)
Source: Crossref
Added: July 28, 2019
2010 journal article
Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study
Metabolomics, 6(2), 191–201.
author keywords: Cardiovascular disease; Lipidomics; Metabolomics; Pharmacogenomics; Pharmacometabolomics; Simvastatin
Source: Crossref
Added: July 20, 2019
2010 journal article
TRPV1-lineage neurons are required for thermal sensation
The EMBO Journal, 30(3), 582–593.
author keywords: itch; pain; thermal; TRPM8; TRPV1
MeSH headings : Animals; Body Temperature; Body Temperature Regulation / genetics; Body Temperature Regulation / physiology; DNA, Complementary / genetics; Gene Expression Regulation, Developmental / genetics; Gene Expression Regulation, Developmental / physiology; In Situ Hybridization; Mice; Mice, Mutant Strains; Models, Biological; Nociceptors / metabolism; Oligonucleotide Array Sequence Analysis; Pain Measurement; Receptors, G-Protein-Coupled / metabolism; Rotarod Performance Test; TRPM Cation Channels / metabolism; TRPV Cation Channels / genetics; TRPV Cation Channels / metabolism; Thermoreceptors / metabolism
Source: Crossref
Added: July 20, 2019
2010 journal article
The Tight Junction Associated Signalling Proteins ZO-1 and ZONAB Regulate Retinal Pigment Epithelium Homeostasis in Mice
PLoS ONE, 5(12), e15730.
Ed(s): M. Klymkowsky
MeSH headings : Angiography / methods; Animals; Cell Adhesion; DNA-Binding Proteins / genetics; DNA-Binding Proteins / physiology; Epithelium / metabolism; Female; Homeostasis; Macular Degeneration / genetics; Membrane Proteins / metabolism; Mesoderm / metabolism; Mice; Mice, Inbred C57BL; Microscopy, Electron / methods; Phosphoproteins / metabolism; Retinal Diseases / genetics; Retinal Pigment Epithelium / metabolism; Signal Transduction; Transcription Factors; Zonula Occludens-1 Protein
Source: Crossref
Added: July 20, 2019
2010 journal article
HIF-1alpha and HIF-2alpha Are Differentially Activated in Distinct Cell Populations in Retinal Ischaemia
PLoS ONE, 5(6), e11103.
Ed(s): K. Koch
MeSH headings : Animals; Basic Helix-Loop-Helix Transcription Factors / metabolism; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Erythropoietin / metabolism; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Immunohistochemistry; Ischemia / metabolism; Mice; Retinal Vessels / metabolism; Vascular Endothelial Growth Factor A / metabolism
Source: Crossref
Added: July 20, 2019
2010 journal article
MicroRNA Expression and Virulence in Pandemic Influenza Virus-Infected Mice
Journal of Virology, 84(6), 3023–3032.
MeSH headings : Animals; Cyclic AMP Response Element-Binding Protein / metabolism; Disease Outbreaks; Gene Expression Profiling; Gene Expression Regulation; Humans; Influenza A Virus, H1N1 Subtype / genetics; Influenza A Virus, H1N1 Subtype / immunology; Influenza A Virus, H1N1 Subtype / pathogenicity; Influenza, Human / epidemiology; Influenza, Human / immunology; Influenza, Human / virology; Interferon Type I / immunology; Lung / immunology; Lung / physiology; Lung / virology; Mice; MicroRNAs / genetics; MicroRNAs / immunology; Oligonucleotide Array Sequence Analysis; Orthomyxoviridae / genetics; Orthomyxoviridae / immunology; Orthomyxoviridae / pathogenicity; Orthomyxoviridae Infections / epidemiology; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / virology
Sources: Crossref, ORCID
Added: July 20, 2019
2010 journal article
Lethal Dissemination of H5N1 Influenza Virus Is Associated with Dysregulation of Inflammation and Lipoxin Signaling in a Mouse Model of Infection
Journal of Virology, 84(15), 7613–7624.
MeSH headings : Animals; Female; Gene Expression Regulation; Inflammation / immunology; Inflammation / pathology; Influenza A Virus, H1N1 Subtype / immunology; Influenza A Virus, H1N1 Subtype / pathogenicity; Influenza A Virus, H5N1 Subtype / immunology; Influenza A Virus, H5N1 Subtype / pathogenicity; Lipoxins / immunology; Lung / pathology; Lung / virology; Mice; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / mortality; Orthomyxoviridae Infections / pathology; Orthomyxoviridae Infections / virology; Signal Transduction; Survival Analysis; Virulence
Sources: Crossref, ORCID
Added: July 20, 2019
2010 journal article
Unique Signatures of Long Noncoding RNA Expression in Response to Virus Infection and Altered Innate Immune Signaling
MBio, 1(5).
Ed(s): N. Sonenberg & T. Dermody
MeSH headings : Animals; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Immunity, Innate; Mice; RNA, Untranslated / biosynthesis; Severe acute respiratory syndrome-related coronavirus / immunology; Severe acute respiratory syndrome-related coronavirus / pathogenicity; Severe Acute Respiratory Syndrome / immunology; Severe Acute Respiratory Syndrome / pathology; Severe Acute Respiratory Syndrome / virology; Signal Transduction; Transcription, Genetic
Sources: Crossref, ORCID
Added: July 20, 2019
2010 journal article
SAP1 is a critical post-transcriptional regulator of infectivity in malaria parasite sporozoite stages
Molecular Microbiology, 79(4), 929–939.
MeSH headings : Animals; Cytoplasm / metabolism; Female; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation; Genes, Protozoan; Malaria / parasitology; Mice; Mice, Inbred BALB C; Oligonucleotide Array Sequence Analysis; Plasmodium yoelii / genetics; Plasmodium yoelii / growth & development; Plasmodium yoelii / pathogenicity; Protozoan Proteins / genetics; Protozoan Proteins / metabolism; RNA Processing, Post-Transcriptional; RNA, Protozoan / genetics; Sporozoites / growth & development
Sources: Crossref, ORCID
Added: July 20, 2019
2010 journal article
IFN-α expression and antiviral effects are subtype and cell type specific in the cardiac response to viral infection
Virology, 396(1), 59–68.
author keywords: Interferon; Cardiac myocyte; Cardiac fibroblast; Myocarditis; Reovirus
MeSH headings : Animals; Base Sequence; Cells, Cultured; Interferon-alpha / classification; Interferon-alpha / genetics; Interferon-alpha / physiology; Mice; Molecular Sequence Data; Myocarditis / prevention & control; Myocarditis / virology; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors / genetics; Virus Diseases / prevention & control
Source: Crossref
Added: July 20, 2019
2010 journal article
In vitro screening of environmental chemicals for targeted testing prioritization: The toxcast project
Environmental Health Perspectives, 118(4), 485–492.
author keywords: in vitro screening; liver proliferative lesions; liver tumors; pathways; ToxCast
MeSH headings : Animals; Cell Line; Cells, Cultured; Computer Simulation; Environmental Pollutants / toxicity; Humans; Rats; Toxicity Tests / methods; United States; United States Environmental Protection Agency
Source: ORCID
Added: May 14, 2019
2010 journal article
Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals.
Journal of Toxicology and Environmental Health - Part B: Critical Reviews, 13(2-4), 329–346.
MeSH headings : Adult; Animals; Cell Shape / drug effects; Cells, Cultured; Cholesterol / biosynthesis; Environmental Pollutants / chemistry; Environmental Pollutants / metabolism; Environmental Pollutants / toxicity; Gene Expression Regulation / drug effects; Hepatocytes / cytology; Hepatocytes / drug effects; Hepatocytes / enzymology; Hepatocytes / metabolism; Humans; Male; Middle Aged; Models, Biological; Rats; Signal Transduction / drug effects; Xenobiotics / chemistry; Xenobiotics / metabolism; Xenobiotics / toxicity
Source: ORCID
Added: May 14, 2019
2010 journal article
Research needs for community-based risk assessment: findings from a multi-disciplinary workshop
J Expos Sci Environ Epidemiol, 20(2), 186â195.
author keywords: population-based studies; epidemiology; exposure modeling; analytical methods; empirical/statistical modeling; PBPK modeling
MeSH headings : Humans; Needs Assessment; Research; Risk Assessment; United States; United States Environmental Protection Agency
Source: ORCID
Added: May 14, 2019
2010 journal article
Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.
Toxicological Sciences, 117(2), 348–358.
author keywords: reverse dosimetry; human exposure; ToxCast; high-throughput screening
MeSH headings : Cells, Cultured; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Hepatocytes / drug effects; Hepatocytes / metabolism; High-Throughput Screening Assays / methods; Humans; Male; Metabolic Clearance Rate; Protein Binding / drug effects; Risk Assessment; Toxicity Tests; Xenobiotics / classification; Xenobiotics / metabolism; Xenobiotics / toxicity
Source: ORCID
Added: May 14, 2019
2010 journal article
Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.
Chemical Research in Toxicology, 23(3), 578–590.
MeSH headings : Animals; Biosensing Techniques / economics; Biosensing Techniques / instrumentation; Biosensing Techniques / methods; Environmental Pollutants / adverse effects; Hep G2 Cells; Rabbits; Rats; Receptors, Cytoplasmic and Nuclear / genetics; Response Elements / drug effects; Transcription Factors / genetics; Transcription, Genetic / drug effects
Source: ORCID
Added: May 14, 2019
2010 journal article
Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data
Environ Health Perspect, 118(12), 1714â1720.
author keywords: androgen; chemical prioritization; data integration; endocrine disruption; estrogen; screening; ToxCast; toxicity profile; ToxPi
MeSH headings : Decision Support Techniques; Endocrine Disruptors / classification; Endocrine Disruptors / toxicity; Endocrine System / drug effects; Environmental Pollutants / classification; Environmental Pollutants / toxicity; Signal Transduction / drug effects; Toxicity Tests / methods
Source: ORCID
Added: May 14, 2019
2010 journal article
Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity.
Environmental Science and Technology, 44(15), 5979–5985.
MeSH headings : Chemical Hazard Release; Endocrine Disruptors / analysis; Environmental Restoration and Remediation; Lipids / toxicity; Receptors, Estrogen / metabolism; Surface-Active Agents / toxicity; Water Pollutants, Chemical / toxicity
Source: ORCID
Added: May 14, 2019
2010 journal article
QTL mapping of internal heat necrosis in tetraploid potato
Theoretical and Applied Genetics, 122(1), 129–142.
author keywords: QTL; Internal heat necrosis; Linkage mapping; Potato; Tetraploid; Solanum tuberosum
MeSH headings : Agriculture; Chromosome Mapping / methods; Genetic Linkage; Genetic Markers; Hot Temperature; Necrosis; Plant Diseases / genetics; Quantitative Trait Loci / genetics; Quantitative Trait, Heritable; Solanum tuberosum / genetics; Tetraploidy
Source: ORCID
Added: May 13, 2019
2010 journal article
Identification of quantitative trait loci for dry-matter, starch, and β-carotene content in sweetpotato
Molecular Breeding, 28(2), 201–216.
author keywords: Ipomoea batatas; Sweetpotato; Sweetpotato breeding; QTL; Molecular marker; Molecular mapping; Polyploid mapping; Marker-assisted breeding; Vitamin A
Source: ORCID
Added: May 13, 2019
2010 conference paper
Identification of a QTL associated with reduced post-harvest aflatoxin accumulation in peanut (Arachis hypogaea L.)
Proceedings of the American Peanut Research and Education Society, 42, 85–86.
Source: NC State University Libraries
Added: February 23, 2019
