Works Published in 2009
Displaying works 1 - 20 of 118 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2009 journal article
Transport and release of chemicals from plastics to the environment and to wildlife
Philosophical Transactions of the Royal Society B: Biological Sciences, 364(1526), 2027–2045.
Contributors: E. Teuten*, J. Saquing n, D. Knappe n, M. Barlaz n, S. Jonsson*, A. Björn*, S. Rowland*, R. Thompson *
TL;DR:
Model calculations and experimental observations consistently show that polyethylene accumulates more organic contaminants than other plastics such as polypropylene and polyvinyl chloride, and PCBs could transfer from contaminated plastics to streaked shearwater chicks.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Source: ORCID
Added: September 9, 2023
2009 journal article
Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 2.
MeSH headings : Animals; Asthma / chemically induced; Asthma / immunology; Body Weight; Bronchoalveolar Lavage Fluid / cytology; Cobalt / immunology; Cobalt / pharmacology; Cytokines / immunology; Gene Expression Profiling; Humans; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Inflammation / chemically induced; Inflammation / immunology; Lung / cytology; Lung / drug effects; Lung / immunology; Lung / pathology; Mice; Mice, Knockout; Mice, Transgenic; Th2 Cells / immunology
TL;DR:
The results suggest that epithelial-derived HIF signaling has a critical role in establishing a tissue's inflammatory response, and compromised HIF1alpha signaling biases the tissue towards a Th2-mediated reaction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2009 report
Water quality of rooftop runoff: implications for residential water harvesting systems
(Urban Waterways No. AG-588-18W). Raleigh: North Carolina State University Cooperative Extension Service Press.
Source: NC State University Libraries
Added: September 21, 2022
2009 journal article
Use of Medaka in Toxicity Testing
Current Protocols in Toxicology, 39(1).
MeSH headings : Animals; Biliary Tract / drug effects; Biliary Tract / pathology; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / pathology; Female; Liver / drug effects; Liver / pathology; Male; Models, Animal; Nervous System / drug effects; Oryzias / embryology; Oryzias / growth & development; Oryzias / physiology; Toxicity Tests / methods
TL;DR:
To illustrate the utility and breadth of toxicity testing possible using medaka fish, protocols for assessing neurotoxicity in developing embryos, evaluating toxicant effects on sexual phenotype after treatment with endocrine‐disrupting chemicals by sexual genotyping, and measuring hepatotoxicity in adult fish aftertreatment with a model hepatotoxicant are presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 13, 2022
2009 journal article
Loss of cryptochrome reduces cancer risk in p53 mutant mice.
Proceedings of the National Academy of Sciences of the United States of America.
Contributors: N. Ozturk *, J. Lee *, S. Gaddameedhi* & A. Sancar *
author keywords: apoptosis; circadian clock; DNA repair
MeSH headings : Animals; Cell Transformation, Neoplastic / genetics; Cryptochromes; Female; Flavoproteins / genetics; Genes, p53; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Mutant Strains; Neoplasms, Experimental / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2009 journal article
Association between the unfolded protein response, induced by 2-deoxyglucose, and hypersensitivity to cisplatin: a mechanistic study employing molecular genomics.
Journal of Cancer Research and Therapeutics.
Contributors: S. Gaddameedhi* & S. Chatterjee *
author keywords: Apoptosis; cisplatin sensitivity; glucose-regulated stress protein of molecular weight 78 kDa; unfolded protein response; 2-deoxyglucose
MeSH headings : Antineoplastic Agents / pharmacology; Apoptosis / drug effects; Apoptosis / genetics; Blotting, Western; Cell Line, Tumor; Cisplatin / pharmacology; DNA Fragmentation / drug effects; Deoxyglucose / pharmacology; Drug Resistance, Neoplasm / genetics; Endoplasmic Reticulum Chaperone BiP; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins / metabolism; Humans; Oligonucleotide Array Sequence Analysis; Signal Transduction / genetics; Unfolded Protein Response / drug effects; Unfolded Protein Response / genetics
TL;DR:
It is shown that cisplatin treatment after the induction of UPR/GRP78 is facilitating the mitochondria-mediated apoptotic cascades through the initial activation of caspase-2 and down-regulation of genes involved in DNA repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2009 journal article
The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation
PLoS One, 4(3), e4825.
Source: ORCID
Added: September 23, 2021
2009 journal article
Replication Protein A Stimulates the Werner Syndrome Protein Branch Migration Activity
Journal of Biological Chemistry, 284(50), 34682–34691.
MeSH headings : Animals; DNA Replication; DNA, Single-Stranded / chemistry; DNA, Single-Stranded / genetics; DNA, Single-Stranded / metabolism; Exodeoxyribonucleases / genetics; Exodeoxyribonucleases / metabolism; Humans; Nucleic Acid Conformation; RecQ Helicases / genetics; RecQ Helicases / metabolism; Recombination, Genetic; Replication Protein A / genetics; Replication Protein A / metabolism; Shelterin Complex; Telomere / metabolism; Telomere-Binding Proteins / genetics; Telomere-Binding Proteins / metabolism; Werner Syndrome / genetics; Werner Syndrome / metabolism; Werner Syndrome Helicase
TL;DR:
The results are consistent with cellular data that support RPA enhancement of branch migration during HR repair and POT1 limitation of inappropriate recombination and branch migration at telomeric ends and are, to the authors' knowledge, the first evidence that RPA can stimulate branch migration activity.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 23, 2021
2009 chapter
Overview of Endocrine Disruptor Ecotoxicity in Wildlife
In C. Ethridge & J. Stevens (Eds.), Endocrine Toxicology (3rd ed., pp. 280–312). London: Informa Healthcare.
Ed(s): C. Ethridge & J. Stevens
Source: NC State University Libraries
Added: March 18, 2021
2009 journal article
Oral-aboral axis specification in the sea urchin embryo. III. Role of mitochondrial redox signaling via H<inf>2</inf>O<inf>2</inf>
Developmental Biology, 330(1), 123–130.
Contributors: J. Coffman*, A. Coluccio*, A. Planchart* & A. Robertson *
author keywords: Axis specification; Nodal; Redox; ROS; Hydrogen peroxide; Mitochondria
MeSH headings : Animals; Body Patterning / genetics; Body Patterning / physiology; Catalase / metabolism; Embryo, Nonmammalian / metabolism; Female; Hydrogen Peroxide / metabolism; Mitochondria / metabolism; Mouth / embryology; Mouth / metabolism; Nodal Protein / genetics; Nodal Protein / metabolism; Reactive Oxygen Species / metabolism; Signal Transduction; Strongylocentrotus purpuratus / embryology; Strongylocentrotus purpuratus / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
It is shown that the spatial pattern of nodal activity also correlates with the mitochondrial gradient, and that the latter correlates with inhomogeneous levels of intracellular reactive oxygen species, and it is concluded that mitochondrial H(2)O(2), which functions as a redox signal to activate nodal, is rate-limiting for the initial activation of nodsal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: March 16, 2021
2009 journal article
Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: The case of bisphenol A
Environmental Health Perspectives, 117(3), 309–315.
Contributors: J. Myers, F. Saal *, B. Akingbemi *, K. Arizono *, S. Belcher* , T. Colborn*, I. Chahoud*, D. Crain*
author keywords: bisphenol A; endocrine disruptors; FDA; Food and Drug Administration; GLP; good laboratory practices; low-dose; nonmonotonic; positive control
MeSH headings : Benzhydryl Compounds; Clinical Laboratory Techniques / standards; Ecotoxicology / methods; Ecotoxicology / standards; Endocrine Disruptors / toxicity; Phenols / toxicity; Public Health Practice / standards; Risk Assessment / methods; Risk Assessment / standards
TL;DR:
Differences between industry-funded GLP studies of BPA conducted by commercial laboratories for regulatory purposes and non-GLP studies conducted in academic and government laboratories are reviewed to identify hazards and molecular mechanisms mediating adverse effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: ORCID
Added: March 5, 2021
2009 journal article
Good laboratory practices: Myers et al. respond
Environmental Health Perspectives, 117(11).
Contributors: J. Myers, F. Vom Saal *, J. Taylor *, B. Akingbemi *, K. Arizono *, S. Belcher* , T. Colborn*, I. Chahoud*
TL;DR:
The aim in writing the commentary was to show—through an analysis of the application of GLP data on bisphenol A (BPA) in regulatory proceedings—that GLP by itself is insufficient to guarantee valid and reliable science.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2009 journal article
Blockade of estrogen receptor signaling to improve outlook for medulloblastoma sufferers
Future Oncology, 5(6), 751–754.
Contributors: S. Belcher*
MeSH headings : Adolescent; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Antineoplastic Combined Chemotherapy Protocols; Cerebellar Neoplasms / drug therapy; Child; Child, Preschool; Drug Synergism; Estrogen Antagonists / therapeutic use; Humans; Infant; Medulloblastoma / drug therapy; Receptors, Estrogen / antagonists & inhibitors; Signal Transduction / drug effects; Young Adult
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
Source: ORCID
Added: March 5, 2021
2009 journal article
Blockade of estrogen receptor signaling inhibits growth and migration of medulloblastoma
Endocrinology, 150(3), 1112–1121.
Contributors: S. Belcher* , X. Ma* & H. Le*
MeSH headings : Adolescent; Animals; Cell Movement / drug effects; Cell Proliferation / drug effects; Cells, Cultured; Cerebellar Neoplasms / genetics; Cerebellar Neoplasms / metabolism; Cerebellar Neoplasms / pathology; Child; Child, Preschool; Down-Regulation / drug effects; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Antagonists / pharmacology; Female; Fulvestrant; Humans; Infant; Male; Medulloblastoma / genetics; Medulloblastoma / metabolism; Medulloblastoma / pathology; Mice; Mice, Nude; Rats; Rats, Sprague-Dawley; Receptors, Estrogen / antagonists & inhibitors; Receptors, Estrogen / genetics; Receptors, Estrogen / metabolism; Signal Transduction / drug effects; Signal Transduction / physiology; Xenograft Model Antitumor Assays
TL;DR:
It is demonstrated that the physiological actions of estrogens in MD are mediated by ERbeta, which has defined antiestrogen therapy as a potentially efficacious clinical approach to improve the long-term outcomes for MD patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 5, 2021
2009 journal article
IGF2Rpolymorphisms and risk of esophageal and gastric adenocarcinomas
International Journal of Cancer, 125(11), 2673–2678.
author keywords: genetic association; neoplasm; esophagus; gastric-cardia; gastric; insulin-like growth factors
MeSH headings : Adenocarcinoma / epidemiology; Adenocarcinoma / genetics; Adenocarcinoma / secondary; Aged; Case-Control Studies; Esophageal Neoplasms / epidemiology; Esophageal Neoplasms / genetics; Esophageal Neoplasms / pathology; Female; Genotype; Humans; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic / genetics; Prognosis; Receptor, IGF Type 2 / genetics; Risk Factors; Stomach Neoplasms / epidemiology; Stomach Neoplasms / genetics; Stomach Neoplasms / pathology; Survival Rate
TL;DR:
It is suggested that nonsynonymous polymorphisms in M6P/IGF2R may contribute to the risks of EGA and noncardia adenocarcinomas.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: January 24, 2021
2009 journal article
Effects of self-reported health conditions and pesticide exposures on probability of follow-up in a prospective cohort study
American Journal of Industrial Medicine, 53(5), n/a-n/a.
author keywords: selection bias; follow-up studies; prospective studies; cohort studies; pesticides; agriculture
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Agriculture; Confidence Intervals; Female; Humans; Iowa / epidemiology; Logistic Models; Male; Middle Aged; Multivariate Analysis; North Carolina / epidemiology; Occupational Diseases / epidemiology; Occupational Diseases / etiology; Occupational Exposure / adverse effects; Odds Ratio; Patient Acceptance of Health Care; Pesticides / toxicity; Probability; Prospective Studies; Risk Assessment; Risk Factors; Selection Bias; Surveys and Questionnaires; Time Factors; United States / epidemiology; Young Adult
TL;DR:
Differences between non-participants and participants in the follow-up interview were generally small, and significant evidence of selection bias was found, however, the extent of bias may depend on the specific exposure and outcome under study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021
2009 journal article
Genetic Modifiers of Liver Disease in Cystic Fibrosis
JAMA, 302(10), 1076–1083.
MeSH headings : Adolescent; Adult; Age Factors; Child; Child, Preschool; Cystic Fibrosis / complications; Cystic Fibrosis / genetics; Female; Glutathione S-Transferase pi / genetics; Humans; Hypertension, Portal / etiology; Hypertension, Portal / genetics; Infant; Liver Cirrhosis / etiology; Liver Cirrhosis / genetics; Liver Diseases / etiology; Liver Diseases / genetics; Logistic Models; Male; Mannose-Binding Lectin / genetics; Peptidyl-Dipeptidase A / genetics; Polymorphism, Genetic; Risk; Transforming Growth Factor beta1 / genetics; Young Adult; alpha 1-Antitrypsin / genetics
TL;DR:
The SERPINA1 Z allele is a risk factor for liver disease in CF and patients who carry the Z allele are at greater risk of developing severe liver disease with portal hypertension.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: January 17, 2021
2009 journal article
Occupational Risk Factors for Rhinitis Among Farmers in the Agricultural Health Study
Journal of Allergy and Clinical Immunology, 123(2), S266–S266.
TL;DR:
Handling hays and grains as well as farm maintenance activities may increase the risk of rhinitis in farmers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 10, 2020
2009 journal article
Cancer Incidence Among Pesticide Applicators Exposed to Methyl Bromide in the AHS
Annals of Epidemiology, 19(9), 662–663.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 10, 2020
2009 journal article
Urinary biomarker, dermal, and air measurement results for 2,4-D and chlorpyrifos farm applicators in the Agricultural Health Study
Journal of Exposure Science & Environmental Epidemiology, 20(2), 119–134.
author keywords: 2,4-D; chlorpyrifos; exposure measurement; farm applicator; occupational exposure; Agricultural Health Study
MeSH headings : 2,4-Dichlorophenoxyacetic Acid / analysis; 2,4-Dichlorophenoxyacetic Acid / urine; Biomarkers / urine; Chlorpyrifos / analysis; Chlorpyrifos / urine; Humans; Skin / chemistry
Sources: Crossref, NC State University Libraries
Added: September 2, 2020
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