Works Published in 2014
Displaying works 1 - 20 of 143 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration.
BMC Genomics, 9.
MeSH headings : Animals; Dehydration; Down-Regulation; Epithelial Sodium Channels / genetics; Epithelial Sodium Channels / metabolism; Gene Expression Profiling; Humans; Inflammation / genetics; Longitudinal Studies; Lung / metabolism; Macrophage Activation; Macrophages, Alveolar / metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mucus / metabolism; Oligonucleotide Array Sequence Analysis; Principal Component Analysis; Up-Regulation
TL;DR:
The robust signatures observed in Scnn1b-Tg lung macrophages highlight their critical role in disease pathogenesis and emphasize the importance of region-, cell-type-, and time-dependent analyses to fully dissect the natural history of disease and the consequences of disease on normal lung development.
(via Semantic Scholar)
bmcgenomics.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2014 journal article
ADAM19 and HTR4 variants and pulmonary function: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.
Circulation: Cardiovascular Genetics, 7(3), 350–358.
Contributors: S. London, W. Gao, S. Gharib, D. Hancock, J. Wilk, J. House* , R. Gibbs, D. Muzny
MeSH headings : ADAM Proteins / genetics; Aged; Aged, 80 and over; Aging / genetics; Cohort Studies; Female; Genetic Variation; Genome-Wide Association Study; Genomics; Heart Diseases / epidemiology; Heart Diseases / genetics; Heart Diseases / physiopathology; Humans; Lung / physiopathology; Male; Middle Aged; Polymorphism, Single Nucleotide; Sequence Analysis, DNA
TL;DR:
1 common variant associated with FEV1/FVC independent of the sentinel ADAM19 GWAS hit is identified and supports the original HTR4 GWAS findings, and rare variants do not seem to underlie GWAS associations with pulmonary function for common variants in ADAM 19 and HTR 4.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: April 11, 2023
2014 journal article
Highly specific and sensitive method for measuring nucleotide excision repair kinetics of ultraviolet photoproducts in human cells
Nucleic Acids Research.
Contributors: J. Choi *, S. Gaddameedhi* , S. Kim *, J. Hu *, M. Kemp * & A. Sancar *
MeSH headings : Animals; Cell Line; Cricetinae; Cricetulus; DNA Repair; Humans; Kinetics; Luminescent Measurements / methods; Oligonucleotides; Pyrimidine Dimers / analysis; Ultraviolet Rays
TL;DR:
The novel approach is robust, with essentially no signal in the absence of UV or a functional excision repair system, and allows for the sensitive detection of excision products within minutes following UV irradiation and does not require additional enrichment steps such as immunoprecipitation.
(via Semantic Scholar)
Source: ORCID
Added: November 14, 2022
2014 journal article
Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup.
PLoS Biology, 12(2), 1001799,
MeSH headings : Animals; Body Size / genetics; Female; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / metabolism; Gene Expression Regulation, Developmental; Genomic Imprinting; Karyopherins / physiology; Lactation / genetics; Mice; Mice, Knockout; Receptors, Cytoplasmic and Nuclear / physiology; STAT5 Transcription Factor / physiology
TL;DR:
A mouse genetic study reveals that a single gene acting in both mother and offspring has a central role in the uniquely mammalian phenomenon of nutrient provisioning through the placenta and the mammary gland.
(via Semantic Scholar)
Source: ORCID
Added: September 28, 2022
2014 journal article
Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1 genes.
BMC Biology, 12, 771,
author keywords: Adiposity; Body proportions; Genomic imprinting; Glucose-regulated metabolism; Growth; Mouse genetics
MeSH headings : Absorptiometry, Photon; Adipose Tissue / metabolism; Animals; Calcium-Binding Proteins; Cell Proliferation; Female; Fetal Development / genetics; Fibroblasts / metabolism; G2 Phase; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / metabolism; Genomic Imprinting; Glucose Tolerance Test; History, Ancient; Insulin-Like Growth Factor II / genetics; Insulin-Like Growth Factor II / metabolism; Intercellular Signaling Peptides and Proteins / genetics; Intercellular Signaling Peptides and Proteins / metabolism; Liver / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Size; S Phase; Triglycerides / blood
TL;DR:
Genetic and physiological evidence is presented that Dlk1 and Grb10 define a mammalian growth axis that is separate from the IGF pathway, yet also features an antagonistic imprinted gene pair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 28, 2022
2014 journal article
The Pesticides and Farmworker Health Toolkit: an innovative model for developing an evidence-informed program for a low-literacy, Latino immigrant audience
Journal of Extension, 52(3), 1–10.
Source: NC State University Libraries
Added: September 16, 2022
2014 journal article
Personal Goals and Perceived Barriers of Farmworker Pesticide Trainers: Implications for Workplace Safety and Health
Journal of Agricultural Safety and Health, 20(4), 267–282.
author keywords: Beliefs; Farmworkers; Goals; Pesticides; Trainers; Training
TL;DR:
It is suggested that the congruence of trainers’ goals provides a foundation for future collaborations to better meet farmworkers†needs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: September 15, 2022
2014 journal article
Coordinated genomic control of ciliogenesis and cell movement by RFX2.
ELife.
MeSH headings : Animals; Cell Movement / genetics; Cilia / metabolism; Computational Biology; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Databases, Genetic; Embryo, Nonmammalian / metabolism; Epithelial Cells / metabolism; Gene Expression Regulation, Developmental; Gene Regulatory Networks; Humans; Morphogenesis; Regulatory Factor X Transcription Factors; Signal Transduction; Transcription Factors / genetics; Transcription Factors / metabolism; Xenopus Proteins / genetics; Xenopus Proteins / metabolism; Xenopus laevis / embryology
TL;DR:
Rfx2 coordinates multiple, distinct gene expression programs in MCCs, regulating genes that control cell movement, ciliogenesis, and cilia function, and serves as a paradigm for understanding genomic control of cell biological processes that span from early cell morphogenetic events to terminally differentiated cellular functions.
(via Semantic Scholar)
Source: ORCID
Added: March 23, 2022
2014 journal article
Multiciliated cells.
Current Biology : CB.
MeSH headings : Biological Evolution; Cell Polarity; Cilia / metabolism; Eukaryota / cytology; Eukaryota / physiology; Humans; Microtubules / metabolism; Phylogeny
TL;DR:
The general phylogeny and physiology of multiciliation is reviewed and the current understanding of the developmental and cellular events underlying the specification, differentiation and function of multiciliated cells in vertebrates is detailed.
(via Semantic Scholar)
Source: ORCID
Added: March 23, 2022
2014 report
Evaluation of Available Scale-up Approaches for the Design of GAC Contactors
(Final Report No. 4235). Denver, Colorado: Water Research Foundation.
Source: NC State University Libraries
Added: December 24, 2021
2014 journal article
The circadian clock controls sunburn apoptosis and erythema in mouse skin.
The Journal of Investigative Dermatology.
MeSH headings : Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins / metabolism; Circadian Clocks; Cytokines / metabolism; DNA Damage; DNA Repair; Erythema / etiology; Immunohistochemistry; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Skin / metabolism; Skin / radiation effects; Skin Neoplasms / metabolism; Sunburn; Time Factors; Ultraviolet Rays
TL;DR:
Interestingly, it is observed that sunburn apoptosis, inflammatory cytokine induction, and erythema were maximal following an acute early morning exposure to UV and minimal following an afternoon exposure, the first evidence that the circadian clock plays an important role in the ery themal response in UV-irradiated skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2014 journal article
Circadian clock, cancer, and chemotherapy.
Biochemistry.
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Apoptosis / drug effects; Circadian Clocks; DNA Damage / drug effects; DNA Repair / drug effects; DNA Repair Enzymes / metabolism; Drug Chronotherapy; Humans; Neoplasms / drug therapy; Neoplasms / epidemiology; Neoplasms / genetics; Neoplasms / metabolism; Risk Factors
TL;DR:
The circadian clock may affect the efficacy of cancer treatment by modulating the pharmacokinetics and pharmacodynamics of chemotherapeutic drugs as well as the activity of the DNA repair enzymes that repair the DNA damage caused by anticancer drugs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2014 journal article
Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock.
Genes & Development.
Contributors: R. Ye, C. Selby *, Y. Chiou *, I. Ozkan-Dagliyan *, S. Gaddameedhi* & A. Sancar *
author keywords: circadian; Cryptochrome; Period; transcription; DNA binding
MeSH headings : ARNTL Transcription Factors / genetics; ARNTL Transcription Factors / metabolism; Active Transport, Cell Nucleus; Animals; CLOCK Proteins / genetics; CLOCK Proteins / metabolism; Cell Line; Circadian Clocks / genetics; Circadian Clocks / physiology; Cryptochromes / genetics; Cryptochromes / metabolism; Mice; Multiprotein Complexes; Mutation; Period Circadian Proteins / genetics; Period Circadian Proteins / metabolism; Protein Structure, Tertiary
TL;DR:
It is shown that CRY binds to CLOCK–BMAL1 at the promoter and inhibits CLock–BMal1-dependent transcription without dissociating the complex.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2014 journal article
DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair.
The Journal of Biological Chemistry.
Contributors: M. Kemp *, S. Gaddameedhi* , J. Choi *, J. Hu * & A. Sancar *
MeSH headings : Cell Cycle Checkpoints; Cell Line, Tumor; Cell Nucleus / metabolism; DNA / biosynthesis; DNA Cleavage; DNA Repair; Humans; Polydeoxyribonucleotides / metabolism; Replication Protein A / metabolism; Transcription Factor TFIIH / metabolism
TL;DR:
It is demonstrated that sedDNAs are localized to the nucleus in two biochemically distinct forms, which include chromatin-associated, transcription factor II H-bound complexes and more readily solubilized, RPA-bound Complex.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2014 journal article
TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres
Nucleic Acids Research, 42(4), 2493–2504.
Source: ORCID
Added: September 23, 2021
2014 journal article
Assessing the Effectiveness of the Pesticides and Farmworker Health Toolkit: A Curriculum for Enhancing Farmworkers’ Understanding of Pesticide Safety Concepts
Journal of Agromedicine, 19(2), 222–223.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, ORCID
Added: August 16, 2021
2014 journal article
Actions of endocrine-disrupting chemicals on stem/progenitor cells during development and disease
Endocrine-Related Cancer, 21(2).
Contributors: E. Kopras *, V. Potluri*, M. Bermudez*, K. Williams *, S. Belcher* & S. Kasper*
author keywords: endocrine disruptors; stem cell/progenitor cell; cancer stem cell; organ development; steroid hormone receptors
MeSH headings : Adipogenesis / drug effects; Animals; Bone Development / drug effects; Disease; Endocrine Disruptors / toxicity; Environmental Pollutants / toxicity; Germ Cells / drug effects; Heart / drug effects; Humans; Immune System / drug effects; Male; Mammary Glands, Human / drug effects; Neurogenesis / drug effects; Prostate / drug effects; Stem Cells / drug effects
TL;DR:
The current status of the understanding of the molecular mechanisms by which endocrine disruptors alter embryonic stem cell and adult stem/progenitor cell fate, organ development, cancer stem cell activity, and tumorigenesis is reviewed.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2014 journal article
Carbohydrate intake, glycemic index and prostate cancer risk
The Prostate, 75(4), 430–439.
author keywords: carbohydrates; glycemic index; prostate cancer
MeSH headings : Aged; Black People; Case-Control Studies; Diet; Dietary Carbohydrates / administration & dosage; Dietary Carbohydrates / adverse effects; Glycemic Index; Humans; Male; Middle Aged; Prostatic Neoplasms / etiology; Risk; Surveys and Questionnaires; White People
TL;DR:
Reported associations between dietary carbohydrate and prostate cancer risk are poorly characterized by race and may be driven by different underlying mechanisms, including diet and age.
(via Semantic Scholar)
Source: Crossref
Added: January 21, 2021
2014 journal article
Editorial overview: Endocrine and metabolic diseases: Conversations on endocrine disruptors — rising above the din
Current Opinion in Pharmacology, 19, vi-vii.
Contributors: S. Belcher*
MeSH headings : Endocrine Disruptors / toxicity; Endocrine System Diseases; Environmental Exposure / adverse effects; Environmental Pollutants / toxicity; Humans; Metabolic Diseases; Risk Assessment
TL;DR:
Professorott Belcher is professor of Pharmacology d Cell Biophysics in the College of edicine at the University of Cincinnati and his search interests center on mechanisms involving estrogen ceptor beta action that influence cardiac thology and estrogen-responsive growth childhood brain tumors.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: December 21, 2020
2014 journal article
Loss of estrogen-mediated immunoprotection underlies female gender bias in experimental Crohn’s-like ileitis
Mucosal Immunology, 7(5), 1255–1265.
MeSH headings : Animals; Crohn Disease / drug therapy; Crohn Disease / immunology; Crohn Disease / physiopathology; Disease Models, Animal; Estrogens / pharmacology; Female; Flow Cytometry; Ileitis / drug therapy; Ileitis / physiopathology; Male; Mice; Sex Factors; T-Lymphocytes, Regulatory / drug effects
TL;DR:
Hormone signaling influences the expansion and function of GALT Tregs in an ER-dependent manner and contributes to gender-based differences in experimental CD.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
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