Works Published in 2015
Displaying works 1 - 20 of 154 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 conference paper
Characterization of atmospheric pressure rf discharges with aqueous plasma facing surfaces
ICOPS/BEAMS 2014 - 41st IEEE International Conference on Plasma Science and the 20th International Conference on High-Power Particle Beams.
Contributors: A. Lindsay n, B. Byrns n, D. Knappe n & S. Shannon n
TL;DR:
Novel pathways for both source scale up and liquid incorporation that can make plasma treatment of liquids more economically viable are presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: September 9, 2023
2015 journal article
Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.
PloS One.
MeSH headings : Animals; Animals, Newborn; Basic Helix-Loop-Helix Transcription Factors / deficiency; Basic Helix-Loop-Helix Transcription Factors / genetics; Gene Deletion; Gene Regulatory Networks; Genotype; Hypoxia-Inducible Factor 1, alpha Subunit / deficiency; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Lung / metabolism; Lung / pathology; Mice; Phenotype; Respiratory Distress Syndrome, Newborn / genetics; Respiratory Distress Syndrome, Newborn / metabolism; Respiratory Distress Syndrome, Newborn / pathology; Signal Transduction; Survival Analysis; Transcription, Genetic
TL;DR:
Investigation of the independent role of Hif-2α in lung epithelium and its ability to alter H IF-1α-mediated lung maturation suggests that modulation of hormone-mediated, NF-κB, C/EBPα, and c-MYC signaling are central to HIF-mediated changes in lung development.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2015 journal article
Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes.
Biochemistry, 6.
MeSH headings : Animals; Cell Hypoxia; Cells, Cultured; Clone Cells; Electron Transport Complex IV / antagonists & inhibitors; Electron Transport Complex IV / genetics; Electron Transport Complex IV / metabolism; Embryo, Mammalian / cytology; Embryo, Mammalian / metabolism; Enzyme Induction / drug effects; Enzyme Inhibitors / pharmacology; Gene Expression Profiling; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Mice; Mice, Transgenic; Mitochondria / drug effects; Mitochondria / enzymology; Mitochondria / metabolism; Oxidative Phosphorylation / drug effects; Oxygen Consumption / drug effects; RNA, Messenger / metabolism; Recombinant Proteins / metabolism; Transcriptional Activation / drug effects
TL;DR:
It is proposed that adaptation to hypoxic stress of CcO as the main cellular oxygen consumer is mediated by induction of hypoxia-sensitive tissue-specific isoforms, and it is suggested that HIF1 plays a central role in maintaining homeostasis in cellular respiration duringhypoxic stress via regulation of C c oxidase activity.
(via Semantic Scholar)
Source: ORCID
Added: August 2, 2023
2015 journal article
Angiotensin II-induced hypertensive renal inflammation is mediated through HMGB1-TLR4 signaling in rat tubulo-epithelial cells.
Experimental Cell Research, 7.
MeSH headings : Angiotensin II; Animals; Antihypertensive Agents / pharmacology; Cell Line; Epithelial Cells / immunology; Epithelial Cells / metabolism; HMGB1 Protein / metabolism; Hypertension / chemically induced; Hypertension / complications; Hypertension / metabolism; Kidney Failure, Chronic / etiology; Kidney Failure, Chronic / immunology; Kidney Failure, Chronic / metabolism; Kidney Tubules / pathology; Losartan / pharmacology; NF-kappa B / metabolism; Rats; Signal Transduction; Toll-Like Receptor 4 / metabolism
TL;DR:
A key role for HMGB1-TLR4 signaling is indicated in AngII-mediated inflammation in the renal epithelial cells, suggesting this pathway as a potential therapeutic target for hypertensive renal dysfunctions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2015 journal article
Quantitative Polymerase Chain Reaction Analysis of the Mouse Cyp2j Subfamily: Tissue Distribution and Regulation.
Drug Metabolism and Disposition, 43(8), 1169–1180.
Contributors: J. Graves*, A. Gruzdev *, J. Bradbury*, L. DeGraff*, H. Li *, J. House* , S. Hoopes*, M. Edin*, D. Zeldin *
MeSH headings : Animals; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System / biosynthesis; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; DNA Primers; DNA, Complementary / biosynthesis; DNA, Complementary / genetics; Female; Gene Expression Regulation, Enzymologic / genetics; Hypersensitivity / enzymology; Hypersensitivity / genetics; Kidney / enzymology; Lung / enzymology; Male; Mice; Mice, Inbred C57BL; Orthomyxoviridae Infections / enzymology; Pollen / immunology; Polymerase Chain Reaction; Tissue Distribution; Zea mays / immunology
TL;DR:
New methods and results for quantitative polymerase chain reaction (qPCR) analysis for the seven genes of the mouse Cyp2j subfamily of cytochrome P450 CYP2J subfamily are reported, and the Cyp2 j isoforms determined are determined, which confirmed similar patterns of expression between the two qPCR methods.
(via Semantic Scholar)
Source: ORCID
Added: April 11, 2023
2015 journal article
Genetic variation in HTR4 and lung function: GWAS follow-up in mouse.
FASEB Journal, 29(1), 323–335.
Contributors: J. House* , H. Li *, L. DeGraff*, G. Flake*, D. Zeldin * & S. London *
MeSH headings : Airway Resistance / genetics; Airway Resistance / physiology; Allergens / administration & dosage; Animals; Antigens, Dermatophagoides / administration & dosage; Bleomycin / toxicity; Bronchial Hyperreactivity / chemically induced; Bronchial Hyperreactivity / genetics; Bronchial Hyperreactivity / physiopathology; Genome-Wide Association Study; Humans; Lung / immunology; Lung / physiology; Male; Mice; Mice, Knockout; Polymorphism, Single Nucleotide; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / genetics; Pulmonary Fibrosis / physiopathology; Receptors, Serotonin, 5-HT4 / deficiency; Receptors, Serotonin, 5-HT4 / genetics; Receptors, Serotonin, 5-HT4 / physiology; Respiratory Function Tests; Species Specificity
TL;DR:
The findings of altered baseline lung function and increased AHR in Htr4‐null mice support a causal relationship between genetic variation in HTR4 and pulmonary function identified in human GWAS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: April 11, 2023
2015 journal article
The Circadian Clock Controls Sunburn Apoptosis and Erythema in Mouse Skin
Journal of Investigative Dermatology.
Contributors: S. Gaddameedhi* , C. Selby *, M. Kemp *, R. Ye & A. Sancar *
MeSH headings : Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins / metabolism; Circadian Clocks; Cytokines / metabolism; DNA Damage; DNA Repair; Erythema / etiology; Immunohistochemistry; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Skin / metabolism; Skin / radiation effects; Skin Neoplasms / metabolism; Sunburn; Time Factors; Ultraviolet Rays
TL;DR:
Interestingly, it is observed that sunburn apoptosis, inflammatory cytokine induction, and erythema were maximal following an acute early morning exposure to UV and minimal following an afternoon exposure, the first evidence that the circadian clock plays an important role in the ery themal response in UV-irradiated skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: November 14, 2022
2015 journal article
Circadian Clock, Cancer, and Chemotherapy
Biochemistry.
Contributors: A. Sancar *, L. Lindsey-Boltz *, S. Gaddameedhi* , C. Selby *, R. Ye, Y. Chiou *, M. Kemp *, J. Hu *, J. Lee *, N. Ozturk *
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Apoptosis / drug effects; Circadian Clocks; DNA Damage / drug effects; DNA Repair / drug effects; DNA Repair Enzymes / metabolism; Drug Chronotherapy; Humans; Neoplasms / drug therapy; Neoplasms / epidemiology; Neoplasms / genetics; Neoplasms / metabolism; Risk Factors
TL;DR:
The circadian clock may affect the efficacy of cancer treatment by modulating the pharmacokinetics and pharmacodynamics of chemotherapeutic drugs as well as the activity of the DNA repair enzymes that repair the DNA damage caused by anticancer drugs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: November 14, 2022
2015 journal article
Coadaptation between mother and offspring: why not?
PLoS Biology, 13(3), 1002085,
MeSH headings : Animals; Body Size / genetics; Female; GRB10 Adaptor Protein / genetics
TL;DR:
A Formal Comment has challenged the interpretation of a study into an imprinted gene, maintaining that conflict, rather than mother-offspring co-adaptation, provides a better mechanistic explanation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 28, 2022
2015 book
Dictionary of Agromedicine
(1st ed.). http://appliedecology.cals.ncsu.edu/extension/toxicology/dictionary-of-agromedicine/
Ed(s): E. Hodgson & W. Cope
Source: NC State University Libraries
Added: September 16, 2022
2015 journal article
In vivo investigation of cilia structure and function using Xenopus.
Methods in Cell Biology.
MeSH headings : Animals; Axoneme / physiology; Basal Bodies / physiology; Cilia / physiology; Embryo, Nonmammalian / cytology; Fluorescent Antibody Technique / methods; Image Processing, Computer-Assisted; Microscopy, Confocal; Morpholinos / genetics; Oligonucleotides, Antisense / genetics; Staining and Labeling / methods; Tissue Fixation / methods; Xenopus laevis
TL;DR:
Embryological and cell biological methods for the investigation of cilia structure and function in Xenopus laevis are presented, with a focus on quantitative live and fixed imaging.
(via Semantic Scholar)
Source: ORCID
Added: March 23, 2022
2015 report
Removal of perfluoroalkyl substances by PAC adsorption and anion exchange
(Executive Summary No. 4344). Denver, Colorado: Water Research Foundation.
Source: NC State University Libraries
Added: December 24, 2021
2015 journal article
Oncogenic BRAF(V600E) Induces Clastogenesis and UVB Hypersensitivity.
Cancers.
Contributors: D. Simpson, N. Lemonie, D. Morgan, S. Gaddameedhi* & W. Kaufmann
author keywords: BRAF(V600E); melanocytes; UVB; melanoma
TL;DR:
It is demonstrated that expression of BRAF(V600E) is not only clastogenic, but synergizes for clastogenesis caused by exposure to ultraviolet radiation in the 300 to 320 nM (UVB) range and the importance of preventing sunburns in children with developing moles is emphasized.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2015 journal article
Development and validation of a new transgenic hairless albino mouse as a mutational model for potential assessment of photocarcinogenicity.
Mutation Research. Genetic Toxicology and Environmental Mutagenesis.
Contributors: M. Manjanatha*, S. Shelton*, Y. Chen *, S. Gaddameedhi* , P. Howard* & M. Boudreau*
author keywords: Transgenic Hairless albino mouse; gpt-Delta mouse; Spi(-) selection assay; Mutant frequency; Mutation frequency
MeSH headings : Animals; Dose-Response Relationship, Radiation; Epidermis / metabolism; Epidermis / radiation effects; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Female; Male; Mice; Mice, Hairless; Mice, Inbred C57BL; Mice, Transgenic / genetics; Models, Animal; Mutagenicity Tests; Mutation Rate; Pentosyltransferases / genetics; Pentosyltransferases / metabolism; Ultraviolet Rays
TL;DR:
The results suggest that the newly developed THA mice are a useful and reliable model for testing UVB-induced mutagenicity in skin tissue and solar-induced skin carcinogenicity is presently under investigation.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2015 journal article
Commentary: Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure.
Frontiers in Physiology.
Contributors: R. Gajula* & S. Gaddameedhi*
author keywords: dark CPDs; melanin; melanoma; oxidative DNA damage; UV radiation
TL;DR:
It is found that UV induction of melanin contributes to melanomagenesis only by UVA and not by UVB radiation, which suggests that melanin might contribute to additional DNA damage and might further lead to increased risk of skin cancers.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2015 journal article
Determining the DNA Diffusion Behavior of SA2 on Various DNA Substrates
Biophysical Journal, 108(2), 397a.
TL;DR:
It is proposed that 1-D sliding and sequence dependent pausing by SA1 provides binding specificity and stability during the cohesion process at telomeres, while SA2 alone, lacking the AT hook domain, uses different DNA binding mechanisms.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 12, 2021
2015 journal article
Single-Molecule Imaging Reveals Dynamics of SA1-TRF1 Interactions on Telomeric DNA
Biophysical Journal, 108(2), 206a.
TL;DR:
The cohesin complex plays a crucial role in accurate chromosome segregation, organization of interphase chromatin, DNA replication, and post replicative DNA repair in part by promoting DNA-DNA pairing.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 12, 2021
2015 journal article
Revealing Structure and Dynamics of Telomere Maintenance Proteins on DNA: One Molecule at a Time
Biophysical Journal, 108(2), 7a.
TL;DR:
Three complementary single-molecule imaging platforms are established: a newly developed Dual-Resonance-frequency-Enhanced Electrostatic force Microscopy technique capable of revealing DNA paths in protein-DNA complexes, fluorescence imaging of quantum dot-labeled proteins for tracking dynamics of proteins on DNA tightropes, and a nanochannel based imaging platform for studying protein-mediated DNA-DNA pairing/looping in real time.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 12, 2021
2015 journal article
Interference of ATP with the fluorescent probes YOYO-1 and YOYO-3 modifies the mechanical properties of intercalator-stained DNA confined in nanochannels
Microchimica Acta, 182(7-8), 1561–1565.
author keywords: DNA; ATP; Intercalating dye; YOYO-1; DAPI; Nanofluidics
TL;DR:
Investigation of the mechanical properties of DNA stained with the fluorescent intercalating dyes YOYO-1 and YoyO-3 as a function of ATP concentrations by stretching single molecules in nanofluidic channels finds negligible effects if DNA is visualized with the minor groove-binding probe 4′,6-diamidino-2-phenylindole.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: September 23, 2021
2015 report
Removal of volatile organic contaminants (VOCs) from drinking water via granular activated carbon treatment
(Final Report No. 4440). Denver, Colorado: Water Research Foundation.
Source: NC State University Libraries
Added: August 16, 2021
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