Works Published in 2018
Displaying works 1 - 20 of 141 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 journal article
Oxytocin Receptors in the Anteromedial Bed Nucleus of the Stria Terminalis Promote Stress-Induced Social Avoidance in Female California Mice
Biological Psychiatry, 83(3), 203–213.
TL;DR:
The results suggest that OTR activation in anteromedial BNST induces a vigilance response in which individuals avoid, yet attend to, unfamiliar social contexts, and may have unappreciated therapeutic potential for stress-induced psychiatric disorders.
(via Semantic Scholar)
europepmc.org (repository)
Source: ORCID
Added: January 28, 2024
2018 journal article
Effect of LysM+ macrophage depletion on lung pathology in mice with chronic bronchitis.
Physiological Reports, 4.
MeSH headings : Animals; Bronchitis, Chronic / pathology; Disease Models, Animal; Lung / pathology; Macrophages / pathology; Mice; Mice, Transgenic
TL;DR:
Dynamic roles of MΦ are identified in moderating, rather than exacerbating, the severity of lung disease in a model of CB, as indicated by an increased incidence of mucus plugging, mucous cells, airway inflammation, higher levels of cytokines/chemokines, and worsened alveolar airspace enlargement.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2018 journal article
Monoclonal antibodies against loggerhead sea turtle, Caretta caretta, IgY isoforms reveal differential contributions to antibody titers and relatedness among other sea turtles
Developmental and Comparative Immunology, 87, 12–15.
Contributors: M. Rodgers* & C. Rice *
MeSH headings : Animals; Antibodies, Monoclonal / immunology; Antibodies, Monoclonal / metabolism; Antibody Specificity / immunology; Enzyme-Linked Immunosorbent Assay; Female; Immunoblotting; Immunoglobulins / immunology; Immunoglobulins / metabolism; Mice, Inbred BALB C; Protein Isoforms / immunology; Protein Isoforms / metabolism; Species Specificity; Turtles / classification; Turtles / immunology
TL;DR:
Serum from loggerhead sea turtles, Caretta caretta, was collected from the southeast Atlantic Ocean during routine summer monitoring studies in 2017 to develop IgY isoform‐specific monoclonal antibodies (mAb), which recognize all Cheloniidae turtles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: April 6, 2023
2018 journal article
Deepwater Horizon oil alone and in conjunction with Vibrio anguillarum exposure modulates immune response and growth in red snapper (Lutjanus campechanus)
Aquatic Toxicology, 204, 91–99.
MeSH headings : Animals; Body Weight / drug effects; Cytochrome P-450 CYP1A1 / metabolism; Cytokines / genetics; Cytokines / metabolism; Environmental Exposure / analysis; Gene Expression Regulation / drug effects; Liver / drug effects; Liver / metabolism; Perciformes / anatomy & histology; Perciformes / growth & development; Perciformes / immunology; Perciformes / microbiology; Petroleum Pollution; Polycyclic Aromatic Hydrocarbons / toxicity; Spleen / drug effects; Spleen / metabolism; Vibrio / physiology; Water / chemistry; Water Pollutants, Chemical / toxicity
TL;DR:
The results suggest that cyp1a1 transcripts were upregulated in oil-exposed groups throughout the experiment, confirming oil exposure, and that all five immune gene transcripts wereUpregulated on day 8, but were generally downregulated or showed no differences from controls on days 10 and 17.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: April 6, 2023
2018 journal article
Humoral Immune Responses to Select Marine Bacteria in Loggerhead Sea Turtles Caretta caretta and Kemp's Ridley Sea Turtles Lepidochelys kempii from the Southeastern United States
Journal of Aquatic Animal Health, 30(1), 20–30.
MeSH headings : Animals; Bacteria / immunology; Bacterial Proteins / immunology; Enzyme-Linked Immunosorbent Assay; Immunity, Humoral; Immunoglobulins / blood; Southeastern United States; Turtles / immunology; Turtles / microbiology
TL;DR:
This study provides baseline information on antibody responses in healthy wild sea turtles by quantifying serum immunoglobulin Y recognition of lysate proteins from nine bacterial species and whole bacterium-specific IgY titers to these pathogens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: April 6, 2023
2018 journal article
Combined Effects of Deepwater Horizon Crude Oil and Environmental Stressors on Fundulus grandis Embryos
Environmental Toxicology and Chemistry, 4(7), 1916–1925.
MeSH headings : Animals; Cytochrome P450 Family 1 / genetics; Cytochrome P450 Family 1 / metabolism; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Fundulidae / embryology; Fundulidae / genetics; Gene Expression Regulation, Enzymologic / drug effects; Larva / drug effects; Petroleum / toxicity; Petroleum Pollution; Polycyclic Aromatic Hydrocarbons / analysis; Stress, Physiological; Water Pollutants, Chemical / analysis
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: April 6, 2023
2018 journal article
Circadian clock protects against radiation-induced dermatitis and cardiomyopathy in mice
Cancer Research.
Contributors: P. Dakup *, K. Porter *, Z. Cheng * & S. Gaddameedhi*
TL;DR:
It is suggested that the healthy circadian clock protects the whole body, skin, and heart from RT-induced toxicity, and genotoxicity in blood cells were significantly increased in RS and Per1/2 -/- mice relative to DS mice.
(via Semantic Scholar)
Source: ORCID
Added: November 14, 2022
2018 journal article
Circulating Plasma Exosomes May Signal Circadian Clock Misalignment to Peripheral Tissues
American Journal of Respiratory and Critical Care Medicine. https://publons.com/wos-op/publon/35726971/
Contributors: A. Khalyfa, H. Van Dongen, S. Gaddameedhi , D. Grant, Z. Qiao, E. Skornyakov, D. Gozal
Source: ORCID
Added: November 14, 2022
2018 chapter
Nuclear receptors
In R. C. Smart & E. Hodgson (Eds.), Molecular and Biochemical Toxicology (5th ed., pp. 293–326). Hoboken, NJ: John Wiley & Sons.
Ed(s): R. Smart & E. Hodgson
Source: NC State University Libraries
Added: September 15, 2022
2018 journal article
Selenium, Mercury, and Their Molar Ratio in Sportfish from Drinking Water Reservoirs
International Journal of Environmental Research and Public Health, 15(9), 1864.
author keywords: mercury; selenium; selenium:mercury molar ratio; selenium health benefit value; reservoir; bluegill; crappie; largemouth bass; fish consumption; risk assessment
MeSH headings : Animals; Child; Drinking Water / chemistry; Environmental Monitoring; Fishes; Fresh Water; Humans; Mercury / analysis; North Carolina; Risk Assessment; Selenium / analysis; Water Pollutants, Chemical / analysis
TL;DR:
The findings suggest that the measures of Se protection may be unnecessarily conservative or that the USEPA Hg threshold may not be sufficiently protective of human health, especially the health of sensitive populations like pregnant or nursing mothers and young children.
(via Semantic Scholar)
Sources: ORCID, Crossref
Added: September 13, 2022
2018 book
Molecular and Biochemical Toxicology
(ed.). J. Wiley and Sons.
Source: ORCID
Added: May 12, 2022
2018 book
Molecular and Biochemical Toxicology
(5th ed.). Hoboken, NJ: J. Wiley and Sons.
Ed(s): R. Smart & E. Hodgson
Source: NC State University Libraries
Added: May 8, 2022
2018 chapter
Carcinogenesis
In R. C. Smart & E. Hodgson (Eds.), Molecular and Biochemical Toxicology (5th ed.). Hoboken, NJ: J Wiley and Sons.
Ed(s): R. Smart & E. Hodgson
Sources: NC State University Libraries, ORCID
Added: May 5, 2022
2018 chapter
Molecular Techniques in the Study of Gene Function
In R. C. Smart & E. Hodgson (Eds.), Molecular and Biochemical Toxicology (5th ed.). Hoboken, NJ: J Wiley and Sons.
Ed(s): R. Smart & E. Hodgson
Sources: NC State University Libraries, ORCID
Added: May 5, 2022
2018 chapter
Molecular and Biochemical Toxicology: Definition and Scope
In R. C. Smart & E. Hodgson (Eds.), Molecular and Biochemical Toxicology (5th ed.). Hoboken, NJ: J Wiley and Sons.
Ed(s): R. Smart & E. Hodgson
Sources: NC State University Libraries, ORCID
Added: May 5, 2022
2018 journal article
The circadian clock regulates cisplatin-induced toxicity and tumor regression in melanoma mouse and human models.
Oncotarget.
TL;DR:
Cisplatin chronopharmacology involves the circadian clock control of DNA repair as well as immune responses, and thus affects both cisplatin toxicity and tumor growth, which has important implications for chronochemotherapy in cancer patients and also suggests that influencing the circadian Clock may be explored as a tool to improve patient outcomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2018 journal article
Cardiac autonomic activity during simulated shift work.
Industrial Health.
author keywords: Night shift; Human sleep; Circadian misalignment; Parasympathetic nervous system; Sympathetic nervous system; Vagal tone; Heart rate variability
MeSH headings : Adult; Circadian Rhythm; Electrocardiography, Ambulatory; Exercise; Female; Heart Rate; Humans; Male; Shift Work Schedule / adverse effects; Young Adult
TL;DR:
The findings show systematic but complex, interacting effects of time of day, sleep/wake state, and physical activity on cardiac autonomic activity, and these effects need to be taken into account when evaluating HR and HRV in shift work settings and when interpreting these measures of cardiac autonomics activity as markers of cardiovascular disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2018 journal article
UV-B-Induced Erythema in Human Skin: The Circadian Clock Is Ticking.
The Journal of Investigative Dermatology.
Contributors: S. Sarkar * & S. Gaddameedhi*
MeSH headings : Animals; Circadian Clocks; Erythema; Humans; Mice; Skin; Sunburn; Ultraviolet Rays
TL;DR:
It is demonstrated that humans are more prone to sunburn erythema after evening exposure to solar UV-B radiation as compared with morning exposure.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2018 journal article
Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism
Proceedings of the National Academy of Sciences, 115(30), 7825–7830.
Contributors: D. Skene *, E. Skornyakov*, N. Chowdhury *, R. Gajula*, B. Middleton*, B. Satterfield*, K. Porter *, H. Van Dongen *, S. Gaddameedhi*
author keywords: circadian misalignment; gastrointestinal tract; liver; metabolomics; shift work
MeSH headings : Adult; Biological Clocks / physiology; Circadian Rhythm / physiology; Fasting / blood; Female; Gene Expression Regulation / physiology; Humans; Hydrocortisone / blood; Male; Melatonin / blood; Period Circadian Proteins / biosynthesis
TL;DR:
It is found that rhythms in many metabolites implicated in food metabolism dissociated from the SCN pacemaker rhythm, with the vast majority aligning with the preceding sleep/wake and feeding/fasting cycles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: December 22, 2021
2018 article
Cadmium Disrupts Vestibular Function by Interfering with Otolith Formation
BioRXiv.
TL;DR:
It is demonstrated that the addition of calcium rescues otolith malformation and reduces circling behavior but has no ameliorating effect on hyperactivity, suggesting that hyperactivity and balance disorders in human populations exposed to Cd are manifestations of separate underlying molecular pathways.
(via Semantic Scholar)
Source: ORCID
Added: March 16, 2021
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