Works Published in 2021
Displaying works 1 - 20 of 141 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2021 journal article
Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors
Communications Biology, 4(1).
TL;DR:
It is shown loss of ASH1L in the developing mouse brain is sufficient to cause multiple developmental defects, core autistic-like behaviors, and impaired cognitive memory, and potential molecular mechanisms linking Ash1L mutations to brain functional abnormalities are established.
(via Semantic Scholar)
www.nature.com (publisher PDF)
Source: ORCID
Added: January 28, 2024
2021 journal article
Enriched laboratory housing increases sensitivity to social stress in female California mice (Peromyscus californicus)
Applied Animal Behaviour Science, 241, 105381.
TL;DR:
Assessing how different housing systems can affect California mouse behavior both in the home cage as well as the open field and social interaction tests before and after social defeat stress suggests that increasing social and environmental complexity affects home cage behaviors in male and female California mice without interfering with, but rather increasing the magnitude of, the effects of defeat stress on theopen field andsocial interaction tests.
(via Semantic Scholar)
Source: ORCID
Added: January 28, 2024
2021 journal article
Convergent neuroendocrine mechanisms of social buffering and stress contagion
Hormones and Behavior, 129, 104933.
TL;DR:
The extent to which the neuropeptides corticotropin releasing hormone and oxytocin are involved in contagion and stress buffering is considered and the importance that frontal cortical areas such as the anterior cingulate cortex and infralimbic cortex play is assessed.
(via Semantic Scholar)
Source: ORCID
Added: January 28, 2024
2021 journal article
Looking for Proof in the Wrong Generation?
Cancer Epidemiology, Biomarkers & Prevention, 30(8), 1459–1461.
TL;DR:
The article in this issue “Grandmaternal Perinatal Serum DDT in Relation to Granddaughter Early Menarche and Adult Obesity: Three Generations in the Child Health and Development Studies Cohort,” by Cirillo and colleagues, is the first to report multigenerational health effects in granddaughters stemming from early life exposures to the pesticide o,p'-DDT in grandmothers.
(via Semantic Scholar)
Source: ORCID
Added: October 28, 2023
2021 journal article
Latent, sex-specific metabolic health effects in CD-1 mouse offspring exposed to PFOA or HFPO-DA (GenX) during gestation
Emerging Contaminants, 7, 219–235.
TL;DR:
Prenatal exposure to 1mg/kg GenX and 1 mg/kg PFOA induces adverse metabolic outcomes in adult mice that are diet- and sex-dependent, suggesting that placental and potentially lactational transfer are important exposure routes for GenX.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: October 28, 2023
2021 journal article
Response to “Comment on Scientific Basis for Managing PFAS as a Chemical Class”
Response to “Comment on Scientific Basis for Managing PFAS as a Chemical Class.” Environmental Science & Technology Letters, 8(2), 195–197.
Source: ORCID
Added: September 9, 2023
2021 journal article
Longitudinal assessment of point‐of‐use carbon filters for removal of per‐ and polyfluoroalkyl substances from private well water
AWWA Water Science, 3(6).
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: September 9, 2023
2021 article
ZFP36L1 regulates <i>Fgf21</i> mRNA turnover and modulates alcoholic hepatic steatosis and inflammation in mice
Bathula, C. S., Chen, J., Blackshear, P. J., Saini, Y., & Patial, S. (2021, May).
TL;DR:
The results demonstrate that ZFP36L1 inactivation protects against alcohol-induced hepatic steatosis and liver injury, possibly by stabilizing Fgf21 mRNA and suggest that the modulation of ZFP 36L1 may be beneficial in the prevention or treatment of human alcoholic liver disease.
(via Semantic Scholar)
Source: ORCID
Added: August 2, 2023
2021 journal article
ZFP36L1 Regulates Fgf21 mRNA Turnover and Modulates Alcoholic Hepatic Steatosis and Inflammation in Mice.
The American Journal of Pathology, 2.
MeSH headings : 3' Untranslated Regions; Animals; Butyrate Response Factor 1 / genetics; Butyrate Response Factor 1 / metabolism; Fatty Liver, Alcoholic / genetics; Fatty Liver, Alcoholic / metabolism; Fatty Liver, Alcoholic / pathology; Fibroblast Growth Factors / genetics; Fibroblast Growth Factors / metabolism; Inflammation / genetics; Inflammation / metabolism; Inflammation / pathology; Liver / metabolism; Liver / pathology; Mice; Mice, Knockout; Mutation; RNA Stability
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2021 journal article
Vesicular and extravesicular protein analyses from the airspaces of ozone-exposed mice revealed signatures associated with mucoinflammatory lung disease.
Scientific Reports, 12.
MeSH headings : Animals; Bronchoalveolar Lavage Fluid / chemistry; Cytokines / analysis; Female; Inflammation Mediators / analysis; Male; Mice; Mice, Inbred C57BL; Ozone / adverse effects; Pneumonia / diagnosis; Proteins / analysis
TL;DR:
Exosomal, secretory, and cell-specific proteins and biological pathways following repetitive exposure of mice to ozone are identified and significantly enhanced intracellular localization of mucoinflammatory proteins including MUC5B and FIZZ1 in ozone-exposed mice is revealed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2021 journal article
Postnatal Ozone Exposure Disrupts Alveolar Development, Exaggerates Mucoinflammatory Responses, and Suppresses Bacterial Clearance in Developing <i>Scnn1b</i>-Tg<sup>+</sup> Mice Lungs.
Journal of Immunology (Baltimore, Md. : 1950), 8.
MeSH headings : Animals; Bacteria / immunology; Cystic Fibrosis / immunology; Disease Models, Animal; Epithelial Sodium Channels / immunology; Inflammation / immunology; Lung / immunology; Macrophages / immunology; Mice; Mice, Transgenic; Mucus / immunology; Ozone / adverse effects; Postnatal Care
TL;DR:
Ozone exposure results in alveolar space remodeling during active phases of lung development and markedly exaggerates the mucoinflammatory outcomes of pediatric-onset lung disease, including bacterial infections, granulocytic inflammation, mucus obstruction, and alveolars space enlargement.
(via Semantic Scholar)
Source: ORCID
Added: August 2, 2023
2021 journal article
Myeloid-IL4Rα is an indispensable link in IL-33-ILCs-IL-13-IL4Rα axis of eosinophil recruitment in murine lungs.
Scientific Reports, 7.
MeSH headings : Alleles; Animals; Bronchoalveolar Lavage Fluid; Eosinophils / metabolism; Immunity, Innate; Interleukin-13 / metabolism; Interleukin-33 / metabolism; Ligands; Lung / metabolism; Lymphocytes / cytology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Myeloid Cells / metabolism; Pulmonary Eosinophilia; Receptors, Cell Surface / metabolism
TL;DR:
It is established that myeloid-IL4Rα is an indispensable component of the IL-33-ILCsIL-13-IL 4Rα axis of eosinophil recruitment.
(via Semantic Scholar)
Source: ORCID
Added: August 2, 2023
2021 journal article
Periconceptional Maternal Diet Characterized by High Glycemic Loading Is Associated with Offspring Behavior in NEST
Nutrients, 13(9), 3180.
MeSH headings : Child Behavior Disorders / etiology; DNA Methylation; Dental Anxiety / etiology; Diet / adverse effects; Dietary Carbohydrates / adverse effects; Female; Glycemic Load / physiology; Humans; Impulsive Behavior; Infant; Infant Behavior; Male; Maternal Nutritional Physiological Phenomena; Pregnancy; Prenatal Exposure Delayed Effects / metabolism; Sex Factors; Temperament
TL;DR:
Findings highlight the importance of maternal dietary patterns on offspring neurodevelopment, offering avenues for prevention options for mothers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: ORCID
Added: April 11, 2023
2021 journal article
Lrp1 regulation of pulmonary function follow-up of human GWAS in mice
American Journal of Respiratory Cell and Molecular Biology, 64(3), 368–378.
Contributors: C. Nichols*, J. House* , H. Li *, J. Ward, A. Wyss, J. Williams *, L. Deterding *, J. Bradbury*
MeSH headings : Animals; Bronchoalveolar Lavage Fluid; Genome-Wide Association Study; Humans; Lipopolysaccharides / pharmacology; Low Density Lipoprotein Receptor-Related Protein-1 / metabolism; Lung / physiology; Mice; Muscle, Smooth / drug effects; Muscle, Smooth / metabolism; Polymorphism, Single Nucleotide / genetics; Proteome / metabolism; Pyroglyphidae / physiology; Quantitative Trait Loci / genetics
TL;DR:
Investigation of the effect of genetic disruption of the Lrp1 gene in smooth muscle cells on pulmonary function in naïve animals and after exposure to bacterial lipopolysaccharide (LPS) or house dust mite extract (HDME) suggests dysregulation of LRP1 in smoother muscle cells affects baseline pulmonary function and airway responsiveness.
(via Semantic Scholar)
Source: ORCID
Added: April 11, 2023
2021 article
Glucose dynamics during ozone exposure measured using radiotelemetry: Stress drivers
Henriquez, A. R., Snow, S. J., Jackson, T. W., House, J. S., Motsinger-Reif, A. A., Ward-Caviness, C. K., … Kodavanti, U. P. (2021, December 9). (Vol. 12). Vol. 12.
TL;DR:
The temporality of neuroendocrine-stress-mediated biological sequalae responsible for ozone-induced metabolic dysfunction as exposure occurs is demonstrated for the first time.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: April 11, 2023
2021 journal article
Peripheral metabolic effects of ozone exposure in healthy and diabetic rats on normal or high-cholesterol diet
Toxicology and Applied Pharmacology, 415, 115427.
Contributors: S. Snow *, A. Henriquez *, A. Fisher*, B. Vallanat*, J. House* , M. Schladweiler *, C. Wood*, U. Kodavanti *
MeSH headings : Adipose Tissue, White / drug effects; Adipose Tissue, White / metabolism; Adipose Tissue, White / pathology; Air Pollutants / toxicity; Animals; Biomarkers / blood; Blood Glucose / drug effects; Blood Glucose / metabolism; Body Composition / drug effects; Cholesterol, Dietary / metabolism; Cholesterol, Dietary / toxicity; Diabetes Mellitus, Type 2 / blood; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / genetics; Diet, High-Fat / adverse effects; Disease Models, Animal; Energy Metabolism / drug effects; Gene Expression Regulation; Inhalation Exposure; Insulin / blood; Lipids / blood; Liver / drug effects; Liver / metabolism; Liver / pathology; Male; Ozone / toxicity; Rats, Wistar; Species Specificity
TL;DR:
Findings indicate that peripheral metabolic alterations induced by diabetes and high-cholesterol diet can enhance susceptibility to the metabolic effects of inhaled pollutants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref
Added: April 11, 2023
2021 journal article
The Role of Hepatic Vagal Tone in Ozone-Induced Metabolic Dysfunction in the Liver
Toxicological Sciences, 181(2), 229–245.
Contributors: C. Colonna*, A. Henriquez *, J. House* , A. Motsinger-Reif *, D. Alewel *, A. Fisher*, H. Ren*, S. Snow *
MeSH headings : Air Pollutants / toxicity; Animals; Liver; Male; Ozone / toxicity; Rats; Rats, Inbred WKY; Transcriptome
TL;DR:
Parasympathetic innervation modulated ozone-induced liver transcriptional responses for cell growth and regeneration without affecting stress-mediated metabolic changes, which could collectively contribute to adverse effects of air pollutants on the liver.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: April 11, 2023
2021 article
Isolating and growing fibroblast cells from threespine stickleback (Gasterosteus aculeatus) v2
Le, G. Q., Steinel, N., Fuess, L., Rodgers, M., & Bolnick, D. (2021, December 13). (Vol. 12). Vol. 12.
TL;DR:
This protocol goes through the process of isolating and growing fibroblast cells from threespine stickleback and shows the importance of knowing the carrier and removal status of canine coronavirus.
(via Semantic Scholar)
Source: ORCID
Added: April 6, 2023
2021 journal article
The impact of salinity and dissolved oxygen regimes on transcriptomic immune responses to oil in early life stage Fundulus grandis
Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 37.
Contributors: M. Rodgers* , J. Serafin*, M. Sepúlveda * & R. Griffitt*
MeSH headings : Animals; Fundulidae / genetics; Fundulidae / growth & development; Fundulidae / immunology; Gene Expression Regulation, Developmental / drug effects; Immunity / drug effects; Larva / drug effects; Larva / genetics; Larva / growth & development; Larva / immunology; Oxygen / immunology; Oxygen / metabolism; Petroleum Pollution / adverse effects; Salinity; Transcriptome / drug effects; Water Pollutants, Chemical / adverse effects
TL;DR:
Examination of transcriptional patterns of immune genes and pathways in Fundulus grandis larvae to various oil, salinity, and DO regimes suggests that oil under certain environmental conditions has the potential to further modulate immune-related genes, pathways, and responses in fish.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: April 6, 2023
2021 journal article
Isolating and growing fibroblast cells from threespine stickleback (Gasterosteus aculeatus)
Protocols.io.
Source: ORCID
Added: April 6, 2023
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