High-dimensional Integration of Biological Systems

Works Published in 2024

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Displaying all 14 works

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2024 journal article

Risk-Based Prioritization of PFAS Using Phenotypic and Transcriptomic Data from Human Induced Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 41(3), 363–381.

Source: Web Of Science
Added: September 23, 2024

2024 journal article

Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits

AMERICAN JOURNAL OF HUMAN GENETICS, 111(9).

By: K. Broadaway*, S. Brotman*, J. Rosen*, K. Currin*, A. Alkhawaja*, A. Etheridge*, F. Wright n, P. Gallins n ...

Sources: Web Of Science, NC State University Libraries
Added: September 23, 2024

2024 review

UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Source: Web Of Science
Added: September 16, 2024

2024 journal article

Characterizing PFAS hazards and risks: a human population-based in vitro cardiotoxicity assessment strategy

HUMAN GENOMICS, 18(1).

Sources: Web Of Science, NC State University Libraries
Added: September 9, 2024

2024 article

Informing Hazard Identification and Risk Characterization of Environmental Chemicals by Combining Transcriptomic and Functional Data from Human-Induced Pluripotent Stem-Cell-Derived Cardiomyocytes

Tsai, H.-H. D., Ford, L. C., Burnett, S. D., Dickey, A. N., Wright, F. A., Chiu, W. A., & Rusyn, I. (2024, July 24). CHEMICAL RESEARCH IN TOXICOLOGY.

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 5, 2024

2024 article

Time for CHANGE: system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology

Mathisen, G. H., Bearth, A., Jones, L. B., Hoffmann, S., Vist, G. E., Ames, H. M., … Whaley, P. (2024, June 14). ARCHIVES OF TOXICOLOGY.

Source: Web Of Science
Added: July 1, 2024

2024 review

A gene edited pig model for studying LGR5<SUP>+</SUP> stem cells: implications for future applications in tissue regeneration and biomedical research

[Review of ]. FRONTIERS IN GENOME EDITING, 6.

By: A. Hill n, Y. Murphy n, K. Polkoff n, L. Edwards, D. Walker n, A. Moatti n, A. Greenbaum n, J. Piedrahita n

author keywords: LGR5; gene edited pigs; organ stem cells; regenerative medicine; animal models
Source: Web Of Science
Added: July 1, 2024

2024 article

Two-Stage Machine Learning-Based Approach to Predict Points of Departure for Human Noncancer and Developmental/Reproductive Effects

Kvasnicka, J., Aurisano, N., Borries, K., Lu, E.-H., Fantke, P., Jolliet, O., … Chiu, W. A. (2024, May 2). ENVIRONMENTAL SCIENCE & TECHNOLOGY.

author keywords: QSAR model; machine learning; toxicity prediction; chemical risk assessment; high-throughput screening; life cycle impact assessment (LCIA)
Source: Web Of Science
Added: June 17, 2024

2024 journal article

Predicting Microbiome Growth Dynamics under Environmental Perturbations

Applied Microbiology.

By: G. Sun n & Y. Zhou n

Source: ORCID
Added: June 15, 2024

2024 journal article

Specific Inhibition of Orai1-mediated Calcium Signalling Resolves Inflammation and Clears Bacteria in an Acute Respiratory Distress Syndrome Model

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 209(6), 703–715.

By: S. Ahmad, J. Wrennall, A. Goriounova, M. Sekhri, J. Iskarpatyoti, A. Ghosh, S. Abdelwahab, A. Voeller ...

author keywords: peptide; ICRAC; ARDS; pneumonia; neutrophilia
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: May 20, 2024

2024 journal article

Hazard and risk characterization of 56 structurally diverse PFAS using a targeted battery of broad coverage assays using six human cell types

TOXICOLOGY, 503.

author keywords: PFAS; In vitro; Grouping; Risk characterization; Margin of exposure
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 7, 2024

2024 journal article

Control of false discoveries in grouped hypothesis testing for eQTL data

BMC BIOINFORMATICS, 25(1).

author keywords: eQTL; Grouped hypothesis testing; False discovery rate; Empirical Bayes
Sources: Web Of Science, NC State University Libraries
Added: April 22, 2024

2024 article

Genetic variation in severe cystic fibrosis liver disease is associated with novel mechanisms for disease pathogenesis

Stonebraker, J., Pace, R., Gallins, P., Dang, H., Aksit, M., Faino, A., … Knowles, M. (2024, March 27). HEPATOLOGY, Vol. 3.

By: J. Stonebraker*, R. Pace*, P. Gallins n, H. Dang*, M. Aksit*, A. Faino, W. Gordon*, S. Macparland* ...

author keywords: MAIT cells; whole genome sequencing; GWAS; TWAS; CFLD
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 15, 2024

2024 journal article

Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs

FRONTIERS IN PHARMACOLOGY, 15.

By: A. Moatti n, S. Connard n, N. De Britto n, W. Dunn*, S. Rastogi n, M. Rai, L. Schnabel n, F. Ligler* ...

author keywords: intratympanic; inner ear; fluid simulation; round window membrane; pigs; swine; pharmacokinetics
TL;DR: The potential of using pigs as a large animal model for studying inner ear pharmacokinetic studies of the inner ear using pigs is demonstrated and the diffusion time and drug concentrations reported align closely with the limited data available from human studies. (via Semantic Scholar)
Source: Web Of Science
Added: February 19, 2024

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