Works Published in 2017

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Displaying works 21 - 40 of 252 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2017 journal article

Nearest neighbor methods for testing reflexivity

Environmental and Ecological Statistics, 24(1), 69–108.

author keywords: Association; Completely mapped data; Complete spatial randomness; Habitat/niche specificity; Independence; Random labeling; Segregation; Sparse sampling
Source: Crossref
Added: January 5, 2021

2017 journal article

Genetic effects on gene expression across human tissues

Nature, 550(7675), 204–213.

By: F. Aguet, A. Brown*, S. Castel, J. Davis, Y. He*, B. Jo, P. Mohammadi, Y. Park ...

MeSH headings : Alleles; Chromosomes, Human / genetics; Disease / genetics; Female; Gene Expression Profiling; Gene Expression Regulation / genetics; Genetic Variation; Genome, Human / genetics; Genotype; Humans; Male; Organ Specificity / genetics; Quantitative Trait Loci / genetics
TL;DR: It is found that local genetic variation affects gene expression levels for the majority of genes, and inter-chromosomal genetic effects for 93 genes and 112 loci are identified, enabling a mechanistic interpretation of gene regulation and the genetic basis of disease. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 19, 2020

2017 journal article

Landscape of X chromosome inactivation across human tissues

Nature, 550(7675), 244–248.

MeSH headings : Chromosomes, Human, X / genetics; Female; Genes, X-Linked / genetics; Genome, Human / genetics; Genomics; Humans; Male; Organ Specificity / genetics; Phenotype; Sequence Analysis, RNA; Single-Cell Analysis; Transcriptome / genetics; X Chromosome Inactivation / genetics
TL;DR: It is shown that incomplete XCI affects at least 23% of X-chromosomal genes, identified seven genes that escape XCI with support from multiple lines of evidence and demonstrated that escape from XCI results in sex biases in gene expression, establishing incomplete X CI as a mechanism that is likely to introduce phenotypic diversity. (via Semantic Scholar)
Source: Crossref
Added: December 19, 2020

2017 journal article

Cell-specific and post-hoc spatial clustering tests based on nearest neighbor contingency tables

Journal of the Korean Statistical Society, 46(2), 219–245.

By: E. Ceyhan*

author keywords: Association; Asymptotic distribution; Completely mapped data; Complete spatial randomness; Overall tests; Random labeling; Segregation
Source: Crossref
Added: December 8, 2020

2017 journal article

Discussion of ’Random Projection Ensemble Classification’

[Review of Random Projection Ensemble Classification, by T. Cannings & R. Samworth]. Journal of the Royal Statistical Society, Series B, 79(4), 1021.

By: C. Shi, R. Song & W. Lu

Source: NC State University Libraries
Added: September 27, 2020

2017 journal article

The use of trazodone to facilitate calm behavior after elective orthopedic surgery in dogs: Results and lessons learned from a clinical trial

Journal of Veterinary Behavior, 22, 41–45.

By: M. Gruen n, S. Roe n, E. Griffith n & B. Sherman n

author keywords: serotonin antagonist/reuptake inhibitor; calming; confinement; randomized clinical trial
TL;DR: Although dogs in both groups were rated as improved on some behavioral measures, no difference was found between the trazodone and placebo groups in efficacy, and it was concluded that future work will be needed to address these factors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: August 28, 2020

2017 journal article

Inverse problems and techniques with applications in the biological sciences

Inverse Problems in Science and Engineering, 26(2), 151–151.

TL;DR: Each contribution to this special issue of Inverse Problems in Science and Engineering (IPSE) discusses some particular aspects of inverse problems and parameter estimation, from topics including mathematical model vs. statistical model misspecification, model discrepancy, uncertainty quantification in estimated parameters, to model identification vs. calibration, with applications to a wide variety of biological problems. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2017 journal article

Estimating the rate of prion aggregate amplification in yeast with a generation and structured population model

Inverse Problems in Science and Engineering, 26(2), 257–279.

author keywords: Structured population model; aggregate data; inverse problem; PDEs; prion; General biology and biomathematics
TL;DR: A mathematical and inverse problem formulation is developed to determine the amplification rate with prion aggregates from single-cell measurements observed in propagon amplification experiments, and results show that aggregate amplification rates for two prion variants are strongly bimodal, suggesting that the generational structure in the yeast population impacts the ability of prions aggregates to amplify. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: August 28, 2020

2017 journal article

Mathematical and statistical model misspecifications in modelling immune response in renal transplant recipients

Inverse Problems in Science and Engineering, 26(2), 203–222.

By: H. Banks n, R. Everett n, S. Hu n, N. Murad n & H. Tran n

author keywords: Renal transplant; BK virus; polyomavirus nephropathy; inverse problems; pseudo measurement errors; difference-based methods; model misspecification; statistical error model; 62P10; 92B99; 62G99; 37N15
TL;DR: This work examines uncertainty in clinical data from a kidney transplant recipient infected with BK virus and investigates mathematical model and statistical model misspecifications in the context of least squares methodology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: August 28, 2020

2017 journal article

Shade response of bermudagrass accessions under different management practices

Urban Forestry & Urban Greening, 26, 169–177.

By: J. Dunne*, G. Miller*, C. Arellano*, R. Brandenburg*, A. Schoeman & S. Milla-Lewis*

author keywords: Bermudagrass; Shade tolerance; Management
TL;DR: Results suggest shade management recommendations should be dependent on genotype and site-specific considerations and the development and implementation of specific management plans for certain bermudagrass varieties will contribute to the more widespread use of Cynodon spp. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2017 journal article

How predictable is plastic damage at the atomic scale?

Applied Physics Letters, 110(9), 091902.

By: D. Li n, E. Bucholz n, G. Peterson n, B. Reich n, J. Russ n & D. Brenner n

TL;DR: This work combines image analysis with molecular dynamics simulation to quantify similarities between atomic structures of plastic damage in a database of strained copper bi-crystals, and shows that a manifold of different outcomes can originate ostensibly from the same initial structure. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2017 journal article

Correlating Local Chemistry and Local Cation Displacements in the Relaxor Ferroelectric PMN

Microscopy and Microanalysis, 23(S1), 1616–1617.

Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2017 journal article

Evaluation of serum cytokines in cats with and without degenerative joint disease and associated pain

Veterinary Immunology and Immunopathology, 183, 49–59.

By: M. Gruen n, K. Messenger n, A. Thomson n, E. Griffith n, L. Aldrich n, S. Vaden n, B. Lascelles n

author keywords: Biomarker; Immunoassay; Multiplex; Arthritis
MeSH headings : Animals; Cat Diseases / blood; Cat Diseases / physiopathology; Cats; Cytokines / blood; Female; Male; Osteoarthritis / blood; Osteoarthritis / diagnostic imaging; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain / veterinary; Radiography / veterinary
TL;DR: Evaluating the concentration of cytokines and chemokines in serum samples obtained from cats with and without degenerative joint disease and associated pain showed that cats with higher radiographic degenerative joints disease scores have higher serum concentrations of IL-4 and IL-8, while Cats with higher orthopedic exam pain scores haveHigher concentrations ofIL-8. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: Crossref
Added: February 24, 2020

2017 journal article

Continuous Structured Population Models for Daphnia magna

Bulletin of Mathematical Biology, 79(11), 2627–2648.

By: E. Rutter n, H. Banks n, G. LeBlanc n & K. Flores n

author keywords: Continuous structured population models; Inverse problems; Generalized least squares; Model selection; Information content; Residual plots
MeSH headings : Animals; Computer Simulation; Confidence Intervals; Daphnia / growth & development; Daphnia / physiology; Female; Fertility; Food; Least-Squares Analysis; Male; Mathematical Concepts; Models, Biological; Population Dynamics
TL;DR: The model is fit to experimental data using the generalized least-squares framework, and the authors use cross-validation and Akaike Information Criteria to select hyper-parameters and present the confidence intervals on parameter estimates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: February 24, 2020

2017 journal article

Characterizing Runoff from Roads: Particle Size Distributions, Nutrients, and Gross Solids

Journal of Environmental Engineering, 143(1), 04016074.

author keywords: Sediment; Highway; Runoff; Litter; Permeable friction course; Pollution; Particulate matter; Nutrients
UN Sustainable Development Goal Categories
Source: Crossref
Added: February 24, 2020

2017 journal article

A Powerful Test for SNP Effects on Multivariate Binary Outcomes Using Kernel Machine Regression

Statistics in Biosciences, 10(1), 117–138.

By: C. Davenport*, A. Maity n, P. Sullivan* & J. Tzeng n

author keywords: Correlated binary responses; Generalized estimating equations; IBS kernel; Kernel machine; Non-parametric regression
TL;DR: A score-based test using a non-parametric modeling framework that jointly models the global effect of the marker set and accounts for the non-linear effects and potentially complicated interaction between markers using reproducing kernels is developed. (via Semantic Scholar)
Source: Crossref
Added: February 21, 2020

2017 journal article

Targeted metabolomics and medication classification data from participants in the ADNI1 cohort

Scientific Data, 4(1).

By: L. St John-Williams*, C. Blach*, J. Toledo*, D. Rotroff n, S. Kim*, K. Klavins*, R. Baillie*, X. Han* ...

MeSH headings : Alzheimer Disease / drug therapy; Alzheimer Disease / genetics; Alzheimer Disease / metabolism; Cognitive Dysfunction; Cohort Studies; Humans; Metabolomics; Neuroimaging
TL;DR: This report presents quantitative metabolomics data generated on serum from 199 control, 356 mild cognitive impairment and 175 AD subjects enrolled in ADNI1 using AbsoluteIDQ-p180 platform, along with the pipeline for data preprocessing and medication classification for confound correction. (via Semantic Scholar)
Source: Crossref
Added: February 21, 2020

2017 journal article

GUT DERIVED BILE ACID METABOLITES CORRELATE WITH STRUCTURAL AND FUNCTIONAL NEUROIMAGING MEASURES IN ALZHEIMER’S DISEASE

Alzheimer's & Dementia, 13(7), P543–P544.

By: K. Nho n, S. Dehkordi, A. Motsinger-Reif*, R. Baillie, S. Bhattacharyya, J. Tenenbaum, J. Thompson, L. St. John Williams ...

TL;DR: It is discovered that in the pooled-sex network, sphingomyelins and amines correlated with Sex and phosphatidylcholines connects to AD progression (Dx). (via Semantic Scholar)
Source: Crossref
Added: February 21, 2020

2017 journal article

Metabolic network failures in Alzheimer's disease: A biochemical road map

Alzheimer's & Dementia, 13(9), 965–984.

author keywords: Metabolomics; Metabonomics; Pharmacometabolomics; Pharmacometabonomics; Biomarkers; Serum; Metabolism; Systems biology; Biochemical networks; Precision medicine; Alzheimer's disease; Dementia; Branched-chain amino acids; Sphingomyelins; Phospholipids; Acylcarnitines
MeSH headings : Aged; Aged, 80 and over; Aging / blood; Alzheimer Disease / blood; Alzheimer Disease / cerebrospinal fluid; Alzheimer Disease / complications; Alzheimer Disease / diagnostic imaging; Amino Acids / blood; Amyloid beta-Peptides / metabolism; Aniline Compounds / metabolism; Cognitive Dysfunction / blood; Cognitive Dysfunction / diagnostic imaging; Cognitive Dysfunction / etiology; Cohort Studies; Cross-Sectional Studies; Fasting; Female; Humans; Male; Metabolic Diseases / blood; Metabolic Diseases / cerebrospinal fluid; Metabolic Diseases / diagnostic imaging; Metabolic Diseases / etiology; Metabolic Networks and Pathways / physiology; Metabolomics / methods; Peptide Fragments / metabolism; Phosphatidylcholines / blood; Phosphatidylcholines / metabolism; Sphingomyelins / blood; Thiazoles / metabolism; tau Proteins / cerebrospinal fluid
Source: Crossref
Added: February 21, 2020

2017 journal article

Genetic Variants in HSD17B3 , SMAD3 , and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes

Clinical Pharmacology & Therapeutics, 103(4), 712–721.

MeSH headings : Aldehyde Reductase / genetics; Animals; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / genetics; Diabetes Mellitus, Type 2 / metabolism; Dyslipidemias / blood; Dyslipidemias / complications; Dyslipidemias / drug therapy; Dyslipidemias / genetics; Female; Fenofibrate / administration & dosage; Fenofibrate / pharmacokinetics; Gene Expression Profiling / methods; Genome-Wide Association Study; Humans; Hypolipidemic Agents / administration & dosage; Hypolipidemic Agents / pharmacokinetics; Lipid Metabolism / drug effects; Lipid Metabolism / genetics; Male; Mice; Middle Aged; Pharmacogenomic Testing / methods; Signal Transduction / drug effects; Smad3 Protein / genetics; beta Karyopherins / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: February 21, 2020

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