Works Published in 2011
Displaying works 21 - 40 of 257 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 conference paper
Tuning the selectivity of GHRP-6 towards the CD36 vs GHS-R1a receptor by exploiting the reactivity of semicarbazones and aza-propargyl glycine in combinatorial azapeptide synthesis
Proulx, C., & Lubell, W. D. (2011, June 5). Presented at the 94th Canadian Society of Chemistry Conference, Montréal, Québec.
Event: 94th Canadian Society of Chemistry Conference at Montréal, Québec on June 5-9, 2011
Source: NC State University Libraries
Added: March 6, 2022
2011 conference paper
Synthesis of [Azaphenylglycine4]- and [Aza-1-phenyl-2,3-triazole-3-alanine4] Growth Hormone Releasing Peptide-6 and Comparison of their Conformations with [AzaPhe4]GHRP-6
In M. Lebl (Ed.), Peptides: Building Bridges. Proceedings of the 22nd American Peptide Symposium (pp. 80–81). San Diego, CA: Prompt Scientific Publishing.
Ed(s): M. Lebl
Event: 22nd American Peptide Symposium at Harbor Island, San Diego, CA on June 25-30, 2011
Source: NC State University Libraries
Added: March 6, 2022
2011 journal article
Formation of High-Quality Self-Assembled Monolayers of Conjugated Dithiols on Gold: Base Matters
J. Am. Chem. Soc., 133(13), 4930–4939.
Contributors: H. Valkenier *, E. Huisman, P. Van Hal*, D. De Leeuw*, R. Chiechi* & J. Hummelen
MeSH headings : Alkynes / chemistry; Ethers / chemistry; Ethylamines / chemical synthesis; Ethylamines / chemistry; Gold / chemistry; Membranes, Artificial; Molecular Structure; Solutions; Toluene / analogs & derivatives; Toluene / chemistry
TL;DR:
It is found that the optimal conditions to reproducibly form dense, high-quality monolayers are 9-15% triethylamine (Et(3)N) in THF and the importance of the equilibrium concentrations of (di)thiolate in solution on the quality of the SAM is shown.
(via Semantic Scholar)
Source: ORCID
Added: January 25, 2022
2011 journal article
Evidence for Quantum Interference in SAMs of Arylethynylene Thiolates in Tunneling Junctions with Eutectic Ga–In (EGaIn) Top-Contacts
J. Am. Chem. Soc., 133(24), 9556–9563.
Contributors: D. Fracasso*, H. Valkenier *, J. Hummelen *, G. Solomon * & R. Chiechi
TL;DR:
The theoretical predictions and experimental conclusions agree that linearly conjugated AC is significantly more conductive than either cross-conjugated AQ or broken conjugate AH and that AQ and AH cannot necessarily be easily differentiated from each other.
(via Semantic Scholar)
Source: ORCID
Added: January 25, 2022
2011 journal article
Using bis(pinacolato)diboron to improve the quality of regioregular conjugated co-polymers
J. Mater. Chem., 21(5), 1582.
Contributors: F. Brouwer*, J. Alma*, H. Valkenier *, T. Voortman*, J. Hillebrand*, R. Chiechi* , J. Hummelen
Source: ORCID
Added: January 25, 2022
2011 journal article
Azapeptides and their therapeutic potential
Future Medicinal Chemistry, 3(9), 1139–1164.
MeSH headings : Aza Compounds / chemical synthesis; Aza Compounds / chemistry; Aza Compounds / pharmacology; Aza Compounds / therapeutic use; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / pharmacology; Enzyme Inhibitors / therapeutic use; Humans; Molecular Conformation; Peptides / chemical synthesis; Peptides / chemistry; Peptides / pharmacology; Peptides / therapeutic use; Semicarbazides / chemical synthesis; Semicarbazides / chemistry; Semicarbazides / pharmacology; Semicarbazides / therapeutic use; Structure-Activity Relationship
TL;DR:
This review aims to provide a historical look at the development of azapeptide science along with a focus on recent developments and perspectives on the future of this useful tool for medicinal chemistry.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 16, 2021
2011 speech
Bringing biosensors to the bedside
Recruitment talk presented at the Department of Chemistry, Barry University, Miami, FL.
Event: at Department of Chemistry, Barry University, Miami, FL on November 21, 2011
Source: NC State University Libraries
Added: September 11, 2021
2011 conference paper
Proteomics of Olfaction: Identification and Relative Quantification of Odorant Binding Proteins in the Antennae of Drosophila melanogaster
Presented at the American Society for Mass Spectrometry, Denver, CO.
Event: American Society for Mass Spectrometry at Denver, CO
Source: NC State University Libraries
Added: August 13, 2021
2011 conference paper
Functional Dissection of Odorant Binding Protein Genes in Drosophila melanogaster
Presented at the Center for Integrative Genomics (CIG) Symposium, Université de Lausanne, Lausanne, Switzerland.
Event: Center for Integrative Genomics (CIG) Symposium at Université de Lausanne, Lausanne, Switzerland
Source: NC State University Libraries
Added: August 13, 2021
2011 journal article
Monolayers and nanoparticles of terminal alkynes on gold: Investigation of their structure and behaviors
Polymer Preprints, 52, 836–837.
Source: NC State University Libraries
Added: August 13, 2021
2011 book review
Kenny B. Lipkowitz (ed): Reviews in computational chemistry, Volume 27
[Review of Reviews in computational chemistry, Volume 27, by K. B. Lipkowitz]. Structural Chemistry, 22(6), 1397–1399.
Source: Crossref
Added: August 8, 2021
2011 journal article
Selection of phage-displayed peptides on live adherent cells in microfluidic channels
Proceedings of the National Academy of Sciences, 108(17), 6909–6914.
MeSH headings : Bacteriophage T7 / genetics; Cell Line, Tumor; Humans; Microfluidic Analytical Techniques / methods; Neuropilin-1 / antagonists & inhibitors; Neuropilin-1 / genetics; Neuropilin-1 / metabolism; Peptide Library
TL;DR:
It is shown that, compared to conventional biopanning methods, microfluidic selection enables more efficient discovery of peptides with higher affinity and specificity by providing controllable and reproducible means for applying stringent selection conditions against minimal amounts of target cells without loss.
(via Semantic Scholar)
www.pnas.org (publisher PDF)
Sources: Crossref, NC State University Libraries
Added: July 11, 2021
2011 journal article
Genetic Analysis of H1N1 Influenza Virus from Throat Swab Samples in a Microfluidic System for Point-of-Care Diagnostics
Journal of the American Chemical Society, 133(23), 9129–9135.
MeSH headings : DNA, Single-Stranded / genetics; DNA, Single-Stranded / isolation & purification; Electrochemistry / instrumentation; Influenza A Virus, H1N1 Subtype / genetics; Influenza A Virus, H1N1 Subtype / isolation & purification; Limit of Detection; Magnetics; Microfluidic Analytical Techniques; Pharynx / virology; Point-of-Care Systems; Protein Denaturation; RNA, Viral / genetics; RNA, Viral / isolation & purification; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleoproteins / chemistry; Specimen Handling
TL;DR:
The Magnetic Integrated Microfluidic Electrochemical Detector (MIMED) is presented that integrates sample preparation and electrochemical sensors in a monolithic disposable device to detect RNA-based virus directly from throat swab samples and demonstrates the detection of influenza H1N1 in throat swabs at loads as low as 10 TCID(50), 4 orders of magnitude below the clinical titer for this virus.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 11, 2021
2011 journal article
Improving Aptamer Selection Efficiency through Volume Dilution, Magnetic Concentration, and Continuous Washing in Microfluidic Channels
Analytical Chemistry, 83(17), 6883–6889.
MeSH headings : Aptamers, Nucleotide / chemistry; Magnetics; Microfluidic Analytical Techniques / methods; SELEX Aptamer Technique; Streptavidin / analysis
TL;DR:
This method retrieves a small number of magnetic beads suspended in a large volume and concentrates them into a microfluidic chamber with minimal loss for continuous washing and obtained new DNA aptamer sequences with low nanomolar affinity that specifically bind to the SA proteins.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 11, 2021
2011 journal article
Probing the Limits of Aptamer Affinity with a Microfluidic SELEX Platform
PLoS ONE, 6(11), e27051.
Ed(s): M. Antopolsky
MeSH headings : Animals; Aptamers, Nucleotide / genetics; Aptamers, Nucleotide / metabolism; Base Sequence; Becaplermin; Microfluidic Analytical Techniques / methods; Protein Binding; Proto-Oncogene Proteins c-sis / metabolism; SELEX Aptamer Technique / instrumentation
TL;DR:
This work has developed a microfluidic selection process (M-SELEX) that can be used to obtain high affinity aptamers against diverse protein targets and discovers novel aptamer sequences that bind to platelet derived growth factor B and thrombin and a new aptamer that binds to apolipoprotein E3.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 11, 2021
2011 journal article
Polarity-Switching Electrochemical Sensor for Specific Detection of Single-Nucleotide Mismatches
Angewandte Chemie International Edition, 50(47), 11176–11180.
author keywords: DNA; electrochemistry; sensors; single-nucleotide mismatch
MeSH headings : Base Pair Mismatch; Biosensing Techniques / instrumentation; Biosensing Techniques / methods; DNA / analysis; DNA / genetics; DNA Probes; Electrochemistry / instrumentation; Electrochemistry / methods; Electrodes; Polymorphism, Single Nucleotide
TL;DR:
A single-step, room-temperature electrochemical sensor that detects single-nucleotide mismatches with a “polarity-switching” response and describes the design principles of the bipolar sensor and demonstrates its performance in discriminating SM and PM targets under various conditions.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 11, 2021
2011 journal article
Measurement of Aptamer–Protein Interactions with Back-Scattering Interferometry
Analytical Chemistry, 83(23), 8867–8870.
MeSH headings : Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / metabolism; Humans; Interferometry; Light; Protein Binding; Solutions / chemistry; Thrombin / chemistry; Thrombin / metabolism
TL;DR:
The quantitative measurement of aptamer-protein interactions using backscattering interferometry (BSI) is reported and it is shown that BSI can determine when distinct binding regions are accessed and preliminary modeling efforts suggest evidence for allosteric linkage between the two exosites.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 11, 2021
2011 journal article
Two-Step, PCR-Free Telomerase Detection by Using Exonuclease III-Aided Target Recycling
ChemBioChem, 12(18), 2745–2747.
author keywords: cancer; nucleic acid detection; signal amplification; telomerase
MeSH headings : Base Sequence; Cell Line; Chromatography, High Pressure Liquid; DNA Probes; Exodeoxyribonucleases / metabolism; Humans; Mass Spectrometry; Polymerase Chain Reaction / methods; Telomerase / metabolism
TL;DR:
The sensitive detection of telomerase activity is reported by using exonuclease III-aided target recycling to amplify the signal produced by a chimeric LNA-DNA molecular beacon in a single-measurement fluorescence assay.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 11, 2021
2011 chapter
N-Linked Global Glycan Profiling by NanoLC Mass Spectrometry
In Methods in Molecular Biology (pp. 87–97).
author keywords: N-linked glycans; NanoLC mass spectrometry; Glycoproteins; Glycosylation; Glycan profiling; Hydrophilic interaction chromatography; Glycobiology; Glycan algorithms
MeSH headings : Acetylglucosamine / metabolism; Asparagine; Blood Proteins / chemistry; Blood Proteins / metabolism; Chromatography, Liquid / methods; Glycoproteins / metabolism; Glycoside Hydrolases / metabolism; Hydrophobic and Hydrophilic Interactions; Mannose / metabolism; Mass Spectrometry / methods; Nanotechnology / methods; Nitrogen / chemistry; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase / metabolism; Polysaccharides / analysis; Polysaccharides / chemistry; Polysaccharides / isolation & purification; Polysaccharides / metabolism; Protein Denaturation; Solid Phase Extraction; Substrate Specificity; Tandem Mass Spectrometry
TL;DR:
Material, methods, and algorithms for the identification of both glycan composition and structure are summarized and potential problems and their resolutions are addressed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: February 12, 2021
2011 journal article
Synthesis of and structure-property relationships in zinc complexes of bis-metaphenylene semiquinone biradical species
Journal of Physical Organic Chemistry, 25(4), 314–321.
author keywords: bis(metaphenylene) semiquinone biradicals; electron paramagnetic resonance; SQUID magnetometry; substituent effects
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021
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