Works Published in 2022
Displaying works 41 - 60 of 236 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2022 journal article
Effect of BIO-PLYTM, a Platelet-Rich Plasma Derived Biologic on PRRSV-2-Infected Macrophages
VIRUSES-BASEL, 14(12).
author keywords: antivirals; biologic; porcine macrophages; PRRSV
MeSH headings : Humans; Swine; Animals; Horses; Porcine respiratory and reproductive syndrome virus; Porcine Reproductive and Respiratory Syndrome / prevention & control; Macrophages; Biological Products
TL;DR:
The results show that BIO-PLYTM significantly reduces the amount of PRRSV viral load determined by RT-qPCR and the number of infectious viral particles measured by TCID50 in infected porcine alveolar and parenchymal macrophages.
(via Semantic Scholar)
www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 17, 2023
2022 journal article
Tailoring the AIE Chromogen 2-(2-Hydroxyphenyl)benzothiazole for Use in Enzyme-Triggered Molecular Brachytherapy
MOLECULES, 27(24).
author keywords: aggregation; cancer; insolubilization; molecular design; phosphodiester; precipitation; radiotherapy
MeSH headings : Prodrugs; Brachytherapy; Benzothiazoles; Polyethylene Glycols
TL;DR:
Several 2-(2-hydroxyphenyl)benzothiazole substrates that readily aggregate in aqueous solution (and afford AIE) were elaborated, taking a step forward on the long road toward molecular brachytherapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 17, 2023
2022 article
High-throughput quantitative binding analysis of DNA aptamers using exonucleases
Canoura, J., Alkhamis, O., Liu, Y., Willis, C., & Xiao, Y. (2022, December 30). NUCLEIC ACIDS RESEARCH, Vol. 12.
MeSH headings : Aptamers, Nucleotide / chemical synthesis; Aptamers, Nucleotide / chemistry; Exonucleases; Ligands; Nucleic Acids; SELEX Aptamer Technique / methods; Fentanyl / analysis; Robotics
TL;DR:
This work has developed a high-throughput method for accurately quantifying aptamer binding affinity, specificity, and cross-reactivity via the kinetics of aptamer digestion by exonucleases and this approach dramatically accelerates the aptamer characterization process and streamlines sensor development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 17, 2023
2022 article
Systematic Study of in Vitro Selection Stringency Reveals How To Enrich High-Affinity Aptamers
Alkhamis, O., & Xiao, Y. (2022, December 27). JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 12.
MeSH headings : Aptamers, Nucleotide / chemistry; SELEX Aptamer Technique / methods; Ligands
TL;DR:
By performing four separate trials of SELEX for the same small-molecule target, it is experimentally proved that the use of excessively high target concentrations promotes enrichment of low-affinity binders while also suppressing the enrichment of high-Affinity aptamers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 17, 2023
2022 journal article
Targeted enzyme modifications enable regioselective biosynthesis of fluorinated polyketides
CHEM CATALYSIS, 2(10), 2440–2443.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 17, 2023
2022 article
Parahydrogen-Induced Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation
Nelson, C., Schmidt, A. B., Adelabu, I., Nantogma, S., Kiselev, V. G., Abdurraheem, A., … Chekmenev, E. Y. (2022, December 19). ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol. 12.
author keywords: Carbon-13; Hyperpolarization; NMR Spectroscopy; Parahydrogen; RASER
MeSH headings : Hydrogen / chemistry; Protons; Magnetic Resonance Spectroscopy; Acetates / chemistry
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 9, 2023
2022 journal article
On the importance of color in mass spectrometry imaging
JOURNAL OF MASS SPECTROMETRY, 57(12).
author keywords: colormap; CVD; data visualization; MSI
MeSH headings : Humans; Mass Spectrometry
TL;DR:
Best practices for choosing a colormap to accurately display MSI data, improve readability, and accommodate all CVDs are presented.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 9, 2023
2022 journal article
The Challenges of Modeling Defect Behavior and Plasticity across Spatial and Temporal Scales: A Case Study of Metal Bilayer Impact
METALS, 12(12).
author keywords: molecular dynamics; dislocation density-based crystalline plasticity; dislocations; stacking faults; partial dislocation densities; spall
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: January 9, 2023
2022 journal article
Highly anisotropic 1/3-magnetization plateau in a ferrimagnet Cs2Cu3(SeO3)(4)center dot 2H(2)O: topology of magnetic bonding necessary for magnetization plateau
DALTON TRANSACTIONS, 52(1), 118–127.
Source: Web Of Science
Added: January 3, 2023
2022 journal article
Interrogating the Metabolomic Profile of Amyotrophic Lateral Sclerosis in the Post-Mortem Human Brain by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization (IR-MALDESI) Mass Spectrometry Imaging (MSI)
METABOLITES, 12(11).
author keywords: IR-MALDESI MSI; mass spectrometry imaging; Amyotrophic lateral sclerosis (ALS); neurodegenerative disease; multiomic
TL;DR:
This work is the first of its kind, reporting on the investigation of ALS post-mortem human brain tissue analyzed by multiomic MSI, and nearly 300 metabolites were identified across the sixteen samples where 25 were identified as dysregulated between disease cohorts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2023
2022 journal article
An experimental evaluation of the efficacy of perinatal sulforaphane supplementation to decrease the incidence and severity of vinclozolin-induced hypospadias in the mouse model
TOXICOLOGY AND APPLIED PHARMACOLOGY, 451.
author keywords: Birth defects prevention; Hypospadias; Mechanisms of resilience; Preventive toxicology; Sulforaphane; Vinclozolin
MeSH headings : Animals; Dietary Supplements; Disease Models, Animal; Environmental Pollutants / adverse effects; Female; Humans; Hypospadias / chemically induced; Hypospadias / prevention & control; Incidence; Isothiocyanates / pharmacology; Male; Mice; NF-E2-Related Factor 2 / genetics; Oxazoles; Pregnancy; Sulfoxides
TL;DR:
Pregnant mice were exposed to the demasculinizing toxicant, vinclozolin, in combination with increasing doses of the NRF2 activator, sulforaphane, to test the hypothesis that pollutant-induced birth defects can be prevented and reduced in severity by augmenting natural mechanisms of resilience.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 3, 2023
2022 journal article
Syntheses and Properties of Metalated Tetradehydrocorrins
INORGANIC CHEMISTRY, 61(31), 12308–12317.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2023
2022 journal article
Probing the Effects of Electronic-Vibrational Resonance on the Rate of Excited-State Energy Transfer in Bacteriochlorin Dyads
JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 13(34), 7906–7910.
MeSH headings : Electronics; Energy Transfer; Porphyrins; Vibration
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2023
2022 article
A multiplicative structural nested mean model for zero-inflated outcomes
Yu, M., Lu, W., Yang, S., & Ghosh, P. (2022, August 19). BIOMETRIKA.
author keywords: Bidirectional asymptotics; Multiplicative structural nested mean model; Timewise randomization; Zero-inflated outcome
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 3, 2023
2022 article
CCS Predictor 2.0: An Open-Source Jupyter Notebook Tool for Filtering Out False Positives in Metabolomics
Rainey, M. A., Watson, C. A., Asef, C. K., Foster, M. R., Baker, E. S., & Fernandez, F. M. (2022, December 6). ANALYTICAL CHEMISTRY, Vol. 12.
MeSH headings : Metabolomics / methods; Mass Spectrometry / methods; Algorithms; Chromatography, High Pressure Liquid; Machine Learning
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2023
2022 article
Phyllobilins - Bioactive Natural Products Derived from Chlorophyll - Plant Origins, Structures, Absorption Spectra, and Biomedical Properties
Karg, C. A., Taniguchi, M., Lindsey, J. S., & Moser, S. (2022, December 8). PLANTA MEDICA, Vol. 12.
Contributors: C. Karg*, M. Taniguchi n , J. Lindsey n & S. Moser *
author keywords: Bioactivity; chlorophyll catabolites; micronutrients; phyllobilins; phytochemicals; spectral database
MeSH headings : Humans; Chlorophyll / analysis; Chlorophyll / chemistry; Chlorophyll / metabolism; Chlorophyll A / metabolism; Plants / metabolism; Oxidation-Reduction; Plant Extracts / chemistry; Phytochemicals / chemistry
TL;DR:
The present review describes the plant origin, molecular structure, and absorption and fluorescence features of the 73 phyllobilins, along with an overview of key medicinal properties, to provide an enabling tool for the community for the straightforward identification of phyll Mobilins in plant extracts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 3, 2023
2022 article
Improving Therapeutic Protein Secretion in the Probiotic YeastSaccharomyces boulardiiusing a Multifactorial Engineering Approach
Durmusoglu, D., Al’Abri, I., Williams, T. I., Collins, L. B., Martínez, J. L., & Crook, N. (2022, December 31). BioRxiv.
Contributors: D. Durmusoglu n, I. Al'Abri n, T. Williams n , L. Collins n, J. Martínez * & N. Crook n
Source: ORCID
Added: January 1, 2023
2022 journal article
Filtered Cerebrospinal Fluid From Patients With Amyotrophic Lateral Sclerosis Displays an Altered Proteome and Affects Motor Phenotype in a Mouse Model
Cureus, 12.
TL;DR:
The ability to filter proteins from the CSF of ALS patients and identified potentially pathologic proteins that were reduced in quantity is demonstrated and could be a novel solution for patients suffering from this deadly and irreversible condition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: December 29, 2022
2022 article
Transcriptional Inhibition of MicroRNA miR-122 by Small Molecules Reduces Hepatitis C Virus Replication in Liver Cells
Emanuelson, C., Ankenbruck, N., Kumbhare, R., Thomas, M., Connelly, C., Baktash, Y., … Deiters, A. (2022, November 30). JOURNAL OF MEDICINAL CHEMISTRY.
MeSH headings : Humans; Hepacivirus / genetics; MicroRNAs / metabolism; Hepatitis C / drug therapy; Liver Neoplasms / pathology; Virus Replication
TL;DR:
Preliminary mechanism-of-action studies suggest a role in the promoter-specific transcriptional inhibition of miR-122 expression through direct binding to the liver-enriched transcription factor hepatocyte nuclear factor 4α, and the developed inhibitors significantly reduce HCV replication in human liver cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 19, 2022
2022 article
Balancing Panchromatic Absorption and Multistep Charge Separation in a Compact Molecular Architecture br
Roy, A., Magdaong, N. C. M., Jing, H., Rong, J., Diers, J. R., Kang, H. S., … Holten, D. (2022, December 12). JOURNAL OF PHYSICAL CHEMISTRY A, Vol. 12.
Contributors: A. Roy *, N. Magdaong *, H. Jing n, J. Rong n, J. Diers *, H. Kang *, D. Niedzwiedzki, M. Taniguchi n
MeSH headings : Perylene; Porphyrins; Electron Transport; Imides
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 13, 2022
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