Works Published in 2014

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Displaying works 1 - 20 of 253 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2014 journal article

Synthesis, structure, photocatalytic and magnetic properties of an oxo-bridged copper dimer

RSC Advances, 4(41), 21195–21200.

Contributors: R. Ghosh*, K. Asha*, S. Pratik*, A. Datta*, R. Nath* & S. Mandal*

Source: ORCID
Added: January 19, 2024

2014 journal article

Modifying charge and hydrophilicity of simple Ru(II) polypyridyl complexes radically alters biological activities: Old complexes, surprising new tricks

Inorganic Chemistry, 53(19), 10370–10377.

Contributors: M. Dickerson*, Y. Sun*, B. Howerton* & E. Glazer*

TL;DR: The incorporation of negative charged ligands provides a simple chemical approach to modify the biological properties of light-activated Ru(II) cytotoxic agents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: November 30, 2023

2014 journal article

A new type of DNA "light-switch": A dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

Chemical Communications, 50(3), 311–313.

By: E. Wachter*, B. Howerton*, E. Hall*, S. Parkin* & E. Glazer*

Contributors: E. Wachter*, B. Howerton*, E. Hall*, S. Parkin* & E. Glazer*

TL;DR: Ru(bpy)2dppz, a well studied "light-switch" metal complex, transforms into a photochemical " light- switch" and DNA damaging agent by incorporating structural strain. (via Semantic Scholar)
Source: ORCID
Added: November 30, 2023

2014 journal article

A light-activated metal complex targets both DNA and RNA in a fluorescent in vitro transcription and translation assay

ChemBioChem, 15(4), 507–511.

Contributors: D. Heidary* & E. Glazer*

TL;DR: A coupled in vitro transcription and translation (IVTT) assay that uses GFP as a fluorescent reporter allowed the potency of a light‐activated cytotoxic ruthenium agent to be quantified. (via Semantic Scholar)
Source: ORCID
Added: November 30, 2023

2014 journal article

Photoactive Ru(II) complexes with dioxinophenanthroline ligands are potent cytotoxic agents

Inorganic Chemistry, 53(19), 10030–10032.

By: A. Hidayatullah*, E. Wachter*, D. Heidary*, S. Parkin* & E. Glazer*

Contributors: A. Hidayatullah*, E. Wachter*, D. Heidary*, S. Parkin* & E. Glazer*

TL;DR: The best compound exhibited a 1880-fold increase in cytotoxicity in human cancer cells upon light-activation and was 19-fold more potent than the well-known chemotherapeutic, cisplatin. (via Semantic Scholar)
Source: ORCID
Added: November 30, 2023

2014 journal article

Mechanistic study on the photochemical "light switch" behavior of [Ru(bpy)<inf>2</inf>dmdppz]<sup>2+</sup>

Journal of Physical Chemistry A, 118(45), 10474–10486.

By: E. Wachter* & E. Glazer*

Contributors: E. Wachter* & E. Glazer*

TL;DR: Results from these studies indicate that the mechanism of substitution is associative or interchange associative, in contrast with the dissociative mechanism of other photolabile Ru(II) polypyridyl complexes. (via Semantic Scholar)
Source: ORCID
Added: November 30, 2023

2014 journal article

Coordination of hydroxyquinolines to a ruthenium bis-dimethyl-phenanthroline scaffold radically improves potency for potential as antineoplastic agents

Journal of Medicinal Chemistry, 57(21), 8936–8946.

By: D. Heidary*, B. Howerton* & E. Glazer*

Contributors: D. Heidary*, B. Howerton* & E. Glazer*

TL;DR: A series of ruthenium coordination complexes containing hydroxyquinoline ligands were synthesized that exhibited radically improved potencies up to 86-fold greater than clioquinol, a known cytotoxic compound. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: November 30, 2023

2014 journal article

Stabilizing non-covalent interactions of ligand aromatic moieties and proline in ligand–protein systems

Monatshefte Für Chemie - Chemical Monthly, 146(2), 389–397.

By: M. Jovanović*, M. Gruden-Pavlović & M. Zlatović*

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 24, 2023

2014 conference paper

Strategy for enhancing the electric permittivity of organic semiconductors

Solid-State and Organic Lighting, SOLED 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-85118317270&partnerID=MN8TOARS

By: S. Torabi, F. Jahani Bahnamiri, I. Van Severen, S. Patil, R. Havenith, R. Chiechi, L. Lutsen, D. Vanderzande ...

Contributors: S. Torabi, F. Jahani Bahnamiri, I. Van Severen, S. Patil, R. Havenith, R. Chiechi, L. Lutsen, D. Vanderzande ...

Source: ORCID
Added: May 23, 2023

2014 conference paper

Strategy for enhancing the electric permittivity of organic semiconductors

Optics for Solar Energy, OSE 2014.

By: S. Torabi*, F. Jahani Bahnamiri*, I. Van Severen*, S. Patil*, R. Havenith*, R. Chiechi*, L. Lutsen*, D. Vanderzande* ...

Contributors: S. Torabi*, F. Jahani Bahnamiri*, I. Van Severen*, S. Patil*, R. Havenith*, R. Chiechi*, L. Lutsen*, D. Vanderzande* ...

Source: ORCID
Added: May 23, 2023

2014 journal article

Indole and triisopropyl phenyl as capping units for a diketopyrrolopyrrole (DPP) acceptor central unit: An efficient D-A-D type small molecule for organic solar cells

RSC Advances, 4(2), 732–742.

By: G. Sharma*, M. Reddy*, K. Ganesh*, S. Singh* & M. Chandrasekharam*

Contributors: G. Sharma*, M. Reddy*, K. Ganesh*, S. Singh* & M. Chandrasekharam*

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: ORCID
Added: March 15, 2023

2014 journal article

Highly conjugated electron rich thiophene antennas on phenothiazine and phenoxazine-based sensitizers for dye sensitized solar cells

Synthetic Metals, 195, 208–216.

By: M. Anil Reddy*, B. Vinayak*, T. Suresh*, S. Niveditha*, K. Bhanuprakash*, S. Prakash Singh*, A. Islam*, L. Han*, M. Chandrasekharam*

Contributors: M. Anil Reddy*, B. Vinayak*, T. Suresh*, S. Niveditha*, K. Bhanuprakash*, S. Prakash Singh*, A. Islam*, L. Han*, M. Chandrasekharam*

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: ORCID
Added: March 15, 2023

2014 journal article

Synthesis and photovoltaic properties of D-A-D type small molecules containing diketopyrrolopyrrole (DPP) acceptor central unit with different donor terminal units

Organic Electronics, 15(9), 2116–2125.

By: M. Chandrasekharam*, M. Reddy*, K. Ganesh*, G. Sharma*, S. Singh* & J. Rao*

Contributors: M. Chandrasekharam*, M. Reddy*, K. Ganesh*, G. Sharma*, S. Singh* & J. Rao*

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: ORCID
Added: March 15, 2023

2014 journal article

Engineering of Ru(ii) dyes for interfacial and light-harvesting optimization

Dalton Transactions, 43(7), 2726–2732.

Contributors: M. Lobello*, K. Wu*, M. Reddy*, G. Marotta*, M. Grätzel*, M. Nazeeruddin*, Y. Chi*, M. Chandrasekharam*, G. Vitillaro*, F. De Angelis*

TL;DR: DFT/TDDFT calculations were performed on the new dye, revealing that the peculiar photovoltaic properties of the MC112 dye are related to its anchoring mode, and the new design rule thus allows us to engineer both light-harvesting and interfacial properties in the same dye. (via Semantic Scholar)
Source: ORCID
Added: March 15, 2023

2014 journal article

A novel carbazole-phenothiazine dyad small molecule as a non-fullerene electron acceptor for polymer bulk heterojunction solar cells

RSC Advances, 4(63), 33279–33285.

By: G. Sharma*, M. Anil Reddy*, D. Ramana* & M. Chandrasekharam*

Contributors: G. Sharma*, M. Anil Reddy*, D. Ramana* & M. Chandrasekharam*

Source: ORCID
Added: March 15, 2023

2014 journal article

Virtual screening and its experimental validation reveal novel compounds with promising anticancer activity among 4-thiazolidinone- pyrazoline- and isatin-based conjugates

Austin Journal of Bioorganic & Organic Chemistry, 1(1), 6.

By: O. Devinyak, D. Havrylyuk, S. Avdieiev, V. Chumak, R. Panchuk, R. Stoika, V. Kavsan, R. Lesyk

Source: NC State University Libraries
Added: February 18, 2023

2014 journal article

Computational search for possible mechanisms of 4-thiazolidinones anticancer activity: The power of visualization

Molecular Informatics, 33(3), 216–229.

By: O. Devinyak*, D. Havrylyuk*, B. Zimenkovsky* & R. Lesyk

Contributors: O. Devinyak*, D. Havrylyuk*, B. Zimenkovsky* & R. Lesyk

author keywords: Activity patterns; Anticancer activity; Database mining; 4-Thiazolidinones; Visualization
TL;DR: The novel protocol of NCI databases mining where inferences are based on the visualization is presented and utilized with the aim to identify putative biological routes of 4‐thiazolidinones anticancer effect, and the obtained results bring medicinal chemistry closer to the understanding of basic nature of 4-thiazol‐2‐ones effect on cancer cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: January 23, 2023

2014 journal article

Bradykinin antagonists and thiazolidinone derivatives as new potential anti-cancer compounds

Bioorganic and Medicinal Chemistry, 22(15), 3815–3823.

By: S. Avdieiev*, L. Gera*, D. Havrylyuk*, R. Hodges*, R. Lesyk*, V. Ribrag*, Y. Vassetzky*, V. Kavsan*

Contributors: S. Avdieiev*, L. Gera*, D. Havrylyuk*, R. Hodges*, R. Lesyk*, V. Ribrag*, Y. Vassetzky*, V. Kavsan*

author keywords: Multitargeted complex therapy; Glioblastoma; Mantle cell lymphoma; Bradykinin antagonists; Thiazolidinones
MeSH headings : Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Bradykinin / antagonists & inhibitors; Bradykinin / metabolism; Cell Line, Tumor; Cell Survival / drug effects; Dacarbazine / analogs & derivatives; Dacarbazine / chemistry; Dacarbazine / pharmacology; HEK293 Cells; Humans; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3 / metabolism; Phosphorylation / drug effects; Proto-Oncogene Proteins c-akt / metabolism; Temozolomide; Thiazolidines / chemical synthesis; Thiazolidines / chemistry; Thiazolidines / pharmacology; Tyrosine / analogs & derivatives; Tyrosine / chemistry; Tyrosine / pharmacology
TL;DR: A strong synergistic effect after combinatorial treatment by BKM-570 together with TMZ that drastically increased cytotoxic action of this drug in rat and human glioma cells is demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: January 23, 2023

2014 journal article

Synthesis of pyrazoline-thiazolidinone hybrids with trypanocidal activity

European Journal of Medicinal Chemistry, 85, 245–254.

By: D. Havrylyuk*, B. Zimenkovsky*, O. Karpenko*, P. Grellier* & R. Lesyk

Contributors: D. Havrylyuk*, B. Zimenkovsky*, O. Karpenko*, P. Grellier* & R. Lesyk

author keywords: Synthesis; Pyrazolines; 4-Thiazolidinones; Antitrypanosomal activity
MeSH headings : Animals; Cell Line; Chemistry Techniques, Synthetic; Drug Design; Pyrazoles / chemistry; Rats; Structure-Activity Relationship; Thiazolidines / chemical synthesis; Thiazolidines / chemistry; Thiazolidines / pharmacology; Thiazolidines / toxicity; Trypanocidal Agents / chemical synthesis; Trypanocidal Agents / chemistry; Trypanocidal Agents / pharmacology; Trypanocidal Agents / toxicity; Trypanosoma brucei brucei / drug effects
TL;DR: It was shown that methyl or aryl substitution at the thiazolidinone N3-position is crucial for trypanocidal activity, and these compounds, as well as 6d and 6e had selectivity index higher than 50, and were more selective than nifurtimox. (via Semantic Scholar)
Source: ORCID
Added: January 23, 2023

2014 journal article

Study of antineoplastic action of novel isomeric derivatives of 4-thiazolidinone

Ukrainian Biochemical Journal, 86(6), 96–105. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938071889&partnerID=MN8TOARS

By: V. Chumak, M. Fil, R. Panchuk, B. Zimenkovsky, D. Havrylyuk, R. Lesyk, R. Stoika

Contributors: V. Chumak, M. Fil, R. Panchuk, B. Zimenkovsky, D. Havrylyuk, R. Lesyk, R. Stoika

Source: ORCID
Added: January 23, 2023

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