Chemical and Biomolecular Engineering

Works Published in 2015

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Displaying works 21 - 40 of 258 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2015 journal article

Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing

Angewandte Chemie International Edition, 54(41), 12029–12033.

By: W. Sun  n, W. Ji n, J. Hall n, Q. Hu  n, C. Wang  n, C. Beisel n, Z. Gu  n

author keywords: CRISPR-Cas9; DNA; drug delivery; genome editing; nanoparticles
MeSH headings : Animals; CRISPR-Associated Proteins / administration & dosage; CRISPR-Associated Proteins / chemistry; CRISPR-Associated Proteins / genetics; CRISPR-Cas Systems; Cell Line; Clustered Regularly Interspaced Short Palindromic Repeats; DNA / administration & dosage; DNA / chemistry; DNA / genetics; Green Fluorescent Proteins / genetics; Humans; Mice, Nude; Nanoparticles / chemistry; Neoplasms / genetics; Neoplasms / therapy; RNA, Guide, Kinetoplastida / administration & dosage; RNA, Guide, Kinetoplastida / chemistry; RNA, Guide, Kinetoplastida / genetics; Streptococcus pyogenes / chemistry; Streptococcus pyogenes / genetics
TL;DR: The biologically inspired vehicles were efficiently loaded with Cas9/sgRNA complexes and delivered the complexes to the nuclei of human cells, thus enabling targeted gene disruption while maintaining cell viability. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: February 24, 2020

2015 journal article

Cover Picture: Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing (Angew. Chem. Int. Ed. 41/2015)

Angewandte Chemie International Edition, 54(41), 11877–11877.

By: W. Sun  n, W. Ji n, J. Hall n, Q. Hu  n, C. Wang  n, C. Beisel n, Z. Gu  n

Source: Crossref
Added: February 24, 2020

2015 journal article

Elasticity of Nanoparticles Influences Their Blood Circulation, Phagocytosis, Endocytosis, and Targeting

ACS Nano, 9(3), 3169–3177.

By: A. Anselmo *, M. Zhang *, S. Kumar *, D. Vogus*, S. Menegatti* , M. Helgeson *, S. Mitragotri *

author keywords: elasticity; nanogel; nanoemulsion; biodistribution; circulation; targeting; nanomedicine; nanoparticles
MeSH headings : Animals; Blood / metabolism; Cell Line, Tumor; Elastic Modulus; Humans; Hydrogels / chemistry; Hydrogels / metabolism; Hydrogels / pharmacokinetics; Mice; Nanoparticles; Particle Size; Phagocytosis; Polyethylene Glycols / chemistry; Structure-Activity Relationship; Tissue Distribution
TL;DR: Tuning nanoparticle elasticity potentially offers a method to improve the biological fate of nanoparticles by offering enhanced circulation, reduced immune system uptake, and improved targeting. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: February 24, 2020

2015 journal article

Synthesis and Characterization of a Self-Fluorescent Hyaluronic Acid-Based Gel for Dermal Applications

Advanced Healthcare Materials, 4(15), 2297–2305.

By: S. Menegatti* , N. Ruocco*, S. Kumar *, M. Zakrewsky *, J. Sanchez De Oliveira*, M. Helgeson *, G. Leal*, S. Mitragotri *

MeSH headings : Animals; Biocompatible Materials / chemistry; Cell Line; Cell Proliferation / drug effects; Delayed-Action Preparations; Drug Liberation; Humans; Hyaluronic Acid / chemistry; Hydrogels / chemistry; Keratinocytes / drug effects; Keratinocytes / metabolism; Polymers; Rheology; Skin / drug effects; Skin / metabolism; Swine; Tissue Engineering
TL;DR: The presented results demonstrate the applicability of the binary mixture for in situ gelation and the potential of the proposed system for a variety of biomedical applications and the safety of the HA‐based conjugates is demonstrated on human keratinocytes. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: February 24, 2020

2015 journal article

Peptides as skin penetration enhancers: Mechanisms of action

Journal of Controlled Release, 199, 168–178.

By: S. Kumar *, M. Zakrewsky *, M. Chen *, S. Menegatti* , J. Muraski & S. Mitragotri *

author keywords: Cell penetrating peptide; Cyclosporine; Keratin; Transporter; Topical; Transcellular
MeSH headings : Cells, Cultured; Computer Simulation; Cyclosporine / administration & dosage; Cyclosporine / pharmacokinetics; Drug Carriers / adverse effects; Drug Carriers / chemistry; Drug Carriers / pharmacology; Humans; Keratinocytes / drug effects; Keratins / metabolism; Lipids / chemistry; Peptides / adverse effects; Peptides / chemistry; Peptides / pharmacology; Skin / chemistry; Skin / drug effects; Skin Absorption / drug effects; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Water Loss, Insensible / drug effects
TL;DR: Among the peptides tested, SPACE peptide was found to be least toxic to keratinocytes, and among the most effective at delivering CsA into the skin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, ORCID
Added: February 24, 2020

2015 journal article

Macromol. Rapid Commun. 5/2015

Macromolecular Rapid Communications, 36(5), 421–421.

By: K. Mineart  n, X. Jiang *, H. Jinnai *, A. Takahara * & R. Spontak n 

Sources: Crossref, ORCID
Added: February 5, 2020

2015 journal article

Microfluidics: Recapillarity: Electrochemically Controlled Capillary Withdrawal of a Liquid Metal Alloy from Microchannels (Adv. Funct. Mater. 5/2015)

Advanced Functional Materials, 25(5), 654–654.

By: M. Khan  n, C. Trlica n & M. Dickey n 

Sources: Crossref, ORCID
Added: January 25, 2020

2015 journal article

Galactomannan binding agents for silicon anodes in Li-ion batteries

Journal of Materials Chemistry A, 3(22), 12023–12030.

By: M. Dufficy n, S. Khan n  & P. Fedkiw n 

UN Sustainable Development Goal Categories
Source: Crossref
Added: January 25, 2020

2015 journal article

Tin nanoparticle-loaded porous carbon nanofiber composite anodes for high current lithium-ion batteries

Journal of Power Sources, 278.

By: Z. Shen, Y. Hu, Y. Chen, X. Zhang , K. Wang & R. Chen

Source: ORCID
Added: August 15, 2019

2015 journal article

Pyrolytic carbon-coated silicon/carbon nanofiber composite anodes for high-performance lithium-ion batteries

Journal of Power Sources, 298.

By: Y. Chen, Y. Hu, J. Shao, Z. Shen, R. Chen, X. Zhang , X. He, Y. Song, X. Xing

Source: ORCID
Added: August 15, 2019

2015 journal article

Preparation of a graphene-loaded carbon nanofiber composite with enhanced graphitization and conductivity for biosensing applications

RSC Advances, 5.

By: D. Li, G. Li, P. Lv, N. Ullah, C. Wang, Q. Wang, X. Zhang , Q. Wei

Source: ORCID
Added: August 15, 2019

2015 journal article

Nanofiber-based membrane separators for lithium-ion batteries

Materials Research Society Symposium Proceedings, 1718.

By: M. Alcoutlabi, H. Lee & X. Zhang 

Source: ORCID
Added: August 15, 2019

2015 journal article

Metastable orientational order of colloidal discoids

Nature Communications, 6(1).

By: L. Hsiao* , B. Schultz*, J. Glaser *, M. Engel *, M. Szakasits *, S. Glotzer *, M. Solomon *

TL;DR: It is reported that colloidal oblate discoids initially self-assemble into short, metastable strands with orientational order—regardless of the final structure, which may guide self-assembly for anisotropic systems in which orientational Order is desired. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019

2015 journal article

Celebrating Soft Matter's 10th Anniversary: Sequential phase transitions in thermoresponsive nanoemulsions

Soft Matter, 11(43), 8426–8431.

By: L. Hsiao*  & P. Doyle *

TL;DR: The coexistence of stress-bearing percolation with arrested phase separation in a colloidal system of thermoresponsive nanoemulsions spanning a broad range of volume fractions and temperatures is reported and it is suggested that the formation of metastable gelled states not only depends on the attraction strength and volume fraction of the system, but is also sensitive to the rate at which the attractionstrength is increased. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019

2015 journal article

Analysis of human innate immune responses to PRINT fabricated nanoparticles with cross validation using a humanized mouse model

Nanomedicine: Nanotechnology, Biology and Medicine, 11(3), 589–599.

By: G. Robbins*, R. Roberts*, H. Guo*, K. Reuter *, T. Shen*, G. Sempowski *, K. McKinnon *, L. Su *, J. DeSimone n, J. Ting *

author keywords: PRINT; Nanoparticles; PEGylation; Humanized mice; Monocytes; Complement; Toxicity
MeSH headings : Animals; Cell Line, Tumor; Cytokines / immunology; Drug Delivery Systems; Drug Evaluation, Preclinical; Humans; Immunity, Innate; Immunization / methods; Lipopolysaccharide Receptors / immunology; Mice; Mice, Inbred NOD; Mice, Knockout; Monocytes / cytology; Monocytes / immunology; Nanoparticles / chemistry; Vaccines / chemistry; Vaccines / pharmacology
TL;DR: Hydrogel nanorods fabricated using the PRINT (Particle Replication In Nonwetting Templates) fabrication process tested the interaction of human immune cells with these particles and found no immunoreactivity, suggesting that monodisperse PRINT particles of identical shape and size could serve a variety of clinical applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: June 30, 2019

2015 chapter

Calibration-Quality Cancer Nanotherapeutics

In Cancer Treatment and Research (pp. 275–291).

By: J. Perry *, M. Kai n, K. Reuter *, C. Bowerman*, J. Christopher Luft* & J. DeSimone n

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Calibration; Drug Delivery Systems; Humans; Nanoconjugates / chemistry; Nanoconjugates / therapeutic use; Nanomedicine / methods; Neoplasms / drug therapy
TL;DR: This work has shown that translational efficacy improves as clinical tumor properties increase, and the field of nanomedicine will continue to have significant clinical impacts as the capabilities of nanoparticulate drug delivery are further enhanced. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: June 30, 2019

2015 journal article

Florescent silica PVA hybrids via sol–gel processing

Colloid and Polymer Science, 293(11), 3361–3368.

By: T. Pirzada*  & S. Shah*

Contributors: T. Pirzada*  & S. Shah*

author keywords: Florescent silica; PVA silica hybrids; R6G-doped silica; Fluorophores; Florescent organic-inorganic hybrids
Source: ORCID
Added: June 4, 2019

2015 conference paper

An Evaluation of Student Reflection as a Route to Improve Oral Communication

Proceedings of the ASEE National Meeting. Presented at the Seattle, WA.

By: K. Mineart & M. Cooper 

Event: at Seattle, WA

Source: NC State University Libraries
Added: April 17, 2019

2015 journal article

Student Initiated Design Projects

Chemical Engineering Education, 49(1).

By: L. Bullard  & S. Peretti

Source: NC State University Libraries
Added: April 11, 2019

2015 journal article

What’s Your Legacy?

Chemical Engineering Education, 49(3).

By: L. Bullard 

Source: NC State University Libraries
Added: April 11, 2019

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